oleandrin has been researched along with Necrosis* in 2 studies
2 other study(ies) available for oleandrin and Necrosis
| Article | Year |
|---|---|
Comparative Cardiotoxicity of Low Doses of Digoxin, Ouabain, and Oleandrin.
Topics: Animals; Antioxidants; Cardenolides; Cardiotoxicity; Digoxin; Dose-Response Relationship, Drug; Heart; Heart Diseases; Heart Rate; Male; Myocytes, Cardiac; Necrosis; Ouabain; Oxidative Stress; Rats, Wistar; Reactive Oxygen Species; Ventricular Remodeling | 2020 |
Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases.
Decrease in caspase activity is a common phenomenon in drug resistance. For effective therapeutic intervention, detection of such agents, which affects other pathway independent of caspases to promote cell death, might be important. Oleandrin, a polyphenolic glycoside induced cell death through activation of caspases in a variety of human tumour cells. In this report we provide evidence that besides caspases activation, oleandrin interacts with plasma membrane, changes fluidity of the membrane, disrupts Na(+)/K(+)-ATPase pump, enhances intracellular free Ca(2+) and thereby activates calcineurin. Calcineurin, in turns, activates nuclear transcription factor NF-AT and its dependent genes such as FasL, which induces cell death as a late response of oleandrin. Cell death at early stages is mediated by caspases where inhibitors partially protected oleandrin-mediated cell death in vector-transfected cells, but almost completely in Bcl-xL-overexpressed cells. Overall, our data suggest that oleandrin might be important therapeutic molecule in case of tumors where cell death pathway occurs due to deregulation of caspase-mediated pathway. Topics: Antibodies; Apoptosis; bcl-X Protein; Calcineurin; Calcineurin Inhibitors; Calcium; Cardenolides; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Nucleus; Cyclosporine; Dactinomycin; DNA; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Lipids; Membrane Fluidity; Necrosis; NFATC Transcription Factors; Oligopeptides; Protein Transport; Sodium-Potassium-Exchanging ATPase | 2007 |