Corticotropin-releasing factor receptor 2

A corticotropin-releasing factor receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13324]

CRF-R-2;
CRF-R2;
CRFR-2;
Corticotropin-releasing hormone receptor 2;
CRH-R-2;
CRH-R2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
palmidrol	Homo sapiens (human)	Ki	5.0000	1	1
capsaicin	Homo sapiens (human)	Ki	10.0000	1	1
anandamide	Homo sapiens (human)	Ki	0.1680	1	1
n-oleoylethanolamine	Homo sapiens (human)	Ki	10.0000	1	1
nitd 609	Homo sapiens (human)	IC50	30.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
peptide hormone binding	molecular function	Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732]
corticotrophin-releasing factor receptor activity	molecular function	Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. [PMID:12032352]
G protein-coupled peptide receptor activity	molecular function	Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb]
corticotropin-releasing hormone receptor activity	molecular function	Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity. [GOC:signaling, ISBN:0838577016, PMID:11027914, PMID:15134857]

This protein is located in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 3 target(s):

Target	Category	Definition
axon terminus	cellular component	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. [GOC:dph, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]

This protein is involved in 4 target(s):

Target	Category	Definition
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
cellular response to corticotropin-releasing hormone stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response. [GOC:mah]
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). [GOC:mah, GOC:signaling, ISBN:0815316194]
long-term synaptic potentiation	biological process	A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph]