Tryptase beta-2

A tryptase beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20231]

Tryptase-2;
EC 3.4.21.59;
Tryptase II

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bis(5-amidino-2-benzimidazolyl)methane	Homo sapiens (human)	Ki	238.7599	1	12
1,2-Dihydroquinolin-2-imine	Homo sapiens (human)	Ki	390.0000	1	2
2-aminobenzimidazole	Homo sapiens (human)	Ki	155.0000	1	2
2,4-diaminoquinazoline	Homo sapiens (human)	Ki	1,466.6667	1	3
4-hydroxyquinoline	Homo sapiens (human)	Ki	2,000.0000	1	2
1-aminoisoquinoline	Homo sapiens (human)	Ki	495.0000	1	2
2-amino-1-methylbenzimidazole	Homo sapiens (human)	Ki	1,085.0000	1	2
benzamidine	Homo sapiens (human)	Ki	201.4444	2	9
benzyloxycarbonyl-phe-ala-fluormethylketone	Homo sapiens (human)	IC50	100.0000	1	1

This protein enables 3 target(s):

Target	Category	Definition
serine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
serine-type peptidase activity	molecular function	Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]

This protein is located in 1 target(s):

Target	Category	Definition
collagen-containing extracellular matrix	cellular component	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617]

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

This protein is involved in 1 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]