Proteins > Cytochrome P450 1B1
Page last updated: 2024-08-07 23:53:45

Cytochrome P450 1B1

A cytochrome P450 1B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16678]

Synonyms

EC 1.14.14.1;
CYPIB1;
Hydroperoxy icosatetraenoate dehydratase;
4.2.1.152

Research

Bioassay Publications (35)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (11.43)29.6817
2010's23 (65.71)24.3611
2020's8 (22.86)2.80

Compounds (85)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
melatoninHomo sapiens (human)Ki14.000011
4-aminobenzoic acidHomo sapiens (human)IC50120.000011
berberineHomo sapiens (human)IC500.974733
berberineHomo sapiens (human)Ki0.044011
5-methoxypsoralenHomo sapiens (human)IC5015.300011
carvedilolHomo sapiens (human)IC501.100011
donepezilHomo sapiens (human)IC5015.240011
fluoxetineHomo sapiens (human)IC50475.000011
furafyllineHomo sapiens (human)Ki200.000011
khellinHomo sapiens (human)IC5034.600011
1,4-phenylenebis(methylene)selenocyanateHomo sapiens (human)IC500.130011
estroneHomo sapiens (human)IC5050.000011
1,2,5,6-dibenzanthraceneHomo sapiens (human)IC500.009011
alizarinHomo sapiens (human)Ki0.500011
purpurinHomo sapiens (human)IC502.200011
purpurinHomo sapiens (human)Ki0.700011
1,3-diphenyl-1-triazeneHomo sapiens (human)IC502.000011
naphthazarinHomo sapiens (human)IC5010.000011
plumbaginHomo sapiens (human)IC506.150011
imperatorinHomo sapiens (human)Ki1.000012
flavoneHomo sapiens (human)IC500.600011
perillyl alcoholHomo sapiens (human)Ki2.000011
3-hydroxyflavoneHomo sapiens (human)IC500.090011
alpha-naphthoflavoneHomo sapiens (human)IC5010.87873434
alpha-naphthoflavoneHomo sapiens (human)Ki0.016011
erythromycinHomo sapiens (human)IC5040.000011
tranylcypromineHomo sapiens (human)IC506.200011
pyreneHomo sapiens (human)IC500.002022
4,5'-dimethylangelicinHomo sapiens (human)Ki7.460011
3,4,5,3',4'-pentachlorobiphenylHomo sapiens (human)IC500.011011
proadifen hydrochlorideHomo sapiens (human)IC5019.000011
rutecarpineHomo sapiens (human)IC500.055022
2-methoxyestradiolHomo sapiens (human)Ki36.000011
pinocembrinHomo sapiens (human)IC501.679011
isopimpinellinHomo sapiens (human)IC506.380011
isopimpinellinHomo sapiens (human)Ki11.000012
isoimperatorinHomo sapiens (human)Ki6.000012
5-hydroxyflavoneHomo sapiens (human)IC500.210011
4-methoxyestradiolHomo sapiens (human)Ki149.000011
pirlindoleHomo sapiens (human)IC5036.000011
hesperetinHomo sapiens (human)IC500.511011
homoeriodictyolHomo sapiens (human)IC500.978022
eupatorinHomo sapiens (human)Ki0.035022
phellopterinHomo sapiens (human)IC500.220011
karanjinHomo sapiens (human)IC502.065022
benzyl selenocyanateHomo sapiens (human)IC500.130011
16-fluoro-5-androsten-17-oneHomo sapiens (human)IC501.500022
5-hydroxy-3',4',6,7-tetramethoxyflavoneHomo sapiens (human)IC502.500011
cirsiliolHomo sapiens (human)Ki0.800011
isosakuranetinHomo sapiens (human)IC501.024011
demethyleneberberineHomo sapiens (human)IC509.900011
naringeninHomo sapiens (human)IC503.656011
eriodictyolHomo sapiens (human)IC501.284011
resveratrolHomo sapiens (human)IC5028.200022
resveratrolHomo sapiens (human)Ki3.231844
cannabidiolHomo sapiens (human)Ki3.630011
pongamolHomo sapiens (human)IC506.040011
thalifendineHomo sapiens (human)IC504.100011
uccf-029Homo sapiens (human)IC500.009311
quercetinHomo sapiens (human)IC501.110855
quercetinHomo sapiens (human)Ki0.023022
acacetinHomo sapiens (human)IC500.011033
acacetinHomo sapiens (human)Ki0.007022
apigeninHomo sapiens (human)IC500.192522
apigeninHomo sapiens (human)Ki0.064011
luteolinHomo sapiens (human)IC500.219522
luteolinHomo sapiens (human)Ki1.228022
pinosylvinHomo sapiens (human)Ki0.074311
chrysoeriolHomo sapiens (human)IC500.019822
kaempferolHomo sapiens (human)IC500.047011
kaempferolHomo sapiens (human)Ki0.043011
baicaleinHomo sapiens (human)Ki0.260011
chrysinHomo sapiens (human)IC500.152022
chrysinHomo sapiens (human)Ki0.016022
diosmetinHomo sapiens (human)IC500.029011
diosmetinHomo sapiens (human)Ki0.016022
galanginHomo sapiens (human)IC500.014022
genkwaninHomo sapiens (human)Ki2.340011
3-methylquercetinHomo sapiens (human)IC500.017011
kaempferideHomo sapiens (human)IC500.015522
myricetinHomo sapiens (human)Ki0.027022
scutellareinHomo sapiens (human)Ki0.220011
tamarixetinHomo sapiens (human)IC500.020011
trans-2,3',4,5'-tetrahydroxystilbeneHomo sapiens (human)IC5034.000022
pterostilbeneHomo sapiens (human)Ki0.910011
7-hydroxyflavoneHomo sapiens (human)IC500.250011
2,4,3',5'-tetramethoxystilbeneHomo sapiens (human)IC500.006044
2,4,3',5'-tetramethoxystilbeneHomo sapiens (human)Ki0.003011
3,3',4,5'-tetramethoxy-trans-stilbeneHomo sapiens (human)IC503.000011
3,4',5-trimethoxystilbeneHomo sapiens (human)IC500.790011
bergamottinHomo sapiens (human)Ki587.000012
pinostilbeneHomo sapiens (human)Ki0.900011
3,5-dihydroxy-4'-methoxystilbeneHomo sapiens (human)Ki2.060011
indacaterolHomo sapiens (human)IC5059.200011
eupatorin-5-methyl etherHomo sapiens (human)Ki0.670011
pifithrin-alphaHomo sapiens (human)IC500.020611
pifithrin-alphaHomo sapiens (human)Ki0.004411
kaf156Homo sapiens (human)IC506.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
alpha-naphthoflavoneHomo sapiens (human)EC5026.700033
quercetinHomo sapiens (human)EC501.100011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
imidazoleHomo sapiens (human)Ks1,255.000011
alpha-naphthoflavoneHomo sapiens (human)Ks0.700011

Enables

This protein enables 8 target(s):

TargetCategoryDefinition
monooxygenase activitymolecular functionCatalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. [ISBN:0198506732]
iron ion bindingmolecular functionBinding to an iron (Fe) ion. [GOC:ai]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenmolecular functionCatalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]
heme bindingmolecular functionBinding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
aromatase activitymolecular functionCatalysis of the reduction of an aliphatic ring to yield an aromatic ring. [GOC:cb]
estrogen 16-alpha-hydroxylase activitymolecular functionCatalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O. [GOC:BHF]
hydroperoxy icosatetraenoate dehydratase activitymolecular functionA hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H2O. [PMID:12881489, RHEA:55556]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
mitochondrioncellular componentA semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
intracellular membrane-bounded organellecellular componentOrganized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Involved In

This protein is involved in 55 target(s):

TargetCategoryDefinition
angiogenesisbiological processBlood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
trabecular meshwork developmentbiological processThe progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor. [PMID:20568247]
DNA modificationbiological processThe covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. [GOC:jl, GOC:ma]
xenobiotic metabolic processbiological processThe chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
nitric oxide biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. [GOC:ai]
cell adhesionbiological processThe attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
response to nutrientbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:go_curators]
steroid metabolic processbiological processThe chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
estrogen metabolic processbiological processThe chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]
negative regulation of cell population proliferationbiological processAny process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
male gonad developmentbiological processThe process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid]
intrinsic apoptotic signaling pathway in response to oxidative stressbiological processThe series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. [GOC:ai, GOC:mtg_apoptosis]
toxin metabolic processbiological processThe chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. [GOC:cab2]
positive regulation of vascular endothelial growth factor productionbiological processAny process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. [GOC:BHF, GOC:rl]
positive regulation of smooth muscle cell migrationbiological processAny process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. [CL:0000192, GOC:mtg_muscle]
sterol metabolic processbiological processThe chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [ISBN:0198547684]
arachidonic acid metabolic processbiological processThe chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732]
epoxygenase P450 pathwaybiological processThe chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. [GOC:mah, PMID:17979511]
collagen fibril organizationbiological processAny process that determines the size and arrangement of collagen fibrils within an extracellular matrix. [GOC:mah, ISBN:0815316194]
adrenal gland developmentbiological processThe process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. [GOC:dgh]
negative regulation of cell migrationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators]
negative regulation of NF-kappaB transcription factor activitybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. [GOC:dph, GOC:rl, GOC:tb]
response to follicle-stimulating hormonebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. [GOC:mah]
response to estradiolbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123]
negative regulation of cell adhesion mediated by integrinbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]
benzene-containing compound metabolic processbiological processThe chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. [GOC:jl]
retinol metabolic processbiological processThe chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]
retinal metabolic processbiological processThe chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. [ISBN:0198506732]
positive regulation of apoptotic processbiological processAny process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
blood vessel endothelial cell migrationbiological processThe orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. [PMID:11166264]
endothelial cell migrationbiological processThe orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:go_curators]
estrous cyclebiological processA type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. [GOC:jl, Wikipedia:Estrous_cycle]
positive regulation of translationbiological processAny process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:dph, GOC:go_curators, GOC:tb]
positive regulation of angiogenesisbiological processAny process that activates or increases angiogenesis. [GOC:go_curators]
positive regulation of receptor signaling pathway via JAK-STATbiological processAny process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. [GOC:bf]
membrane lipid catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. [GOC:ai]
response to arsenic-containing substancebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. [GOC:hjd, ISBN:0721662544]
blood vessel morphogenesisbiological processThe process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. [GOC:jid]
retinal blood vessel morphogenesisbiological processThe process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. [GOC:BHF, GOC:dph]
ganglion developmentbiological processThe process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. [GOC:dph]
cellular response to hydrogen peroxidebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [CHEBI:16240, GOC:mah]
cellular response to cAMPbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:mah]
cellular response to tumor necrosis factorbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah]
cellular response to luteinizing hormone stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus. [GOC:mah]
cellular response to cortisol stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions. [GOC:mah]
cellular response to progesterone stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. [GOC:mah]
response to dexamethasonebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. [GOC:mah, GOC:yaf]
endothelial cell-cell adhesionbiological processThe attachment of an endothelial cell to another endothelial cell via adhesion molecules. [GOC:BHF]
response to indole-3-methanolbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus. [GOC:mah, GOC:yaf]
cellular response to toxic substancebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:pr]
omega-hydroxylase P450 pathwaybiological processThe chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation. [GOC:mw, PMID:10681399]
response to 3-methylcholanthrenebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771]
regulation of reactive oxygen species metabolic processbiological processAny process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]
positive regulation of reactive oxygen species metabolic processbiological processAny process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]
positive regulation of DNA biosynthetic processbiological processAny process that activates or increases the frequency, rate or extent of DNA biosynthetic process. [GOC:obol]