Proteins > Transient receptor potential cation channel subfamily A member 1
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Transient receptor potential cation channel subfamily A member 1
A transient receptor potential cation channel TRPA1 that is encoded in the genome of rat. [OMA:Q6RI86, PRO:DNx]
Synonyms
Ankyrin-like with transmembrane domains protein 1;
Wasabi receptor
Research
Bioassay Publications (19)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 14 (73.68) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
Compounds (34)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 25, Issue:5, 2015
Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 22, Issue:4, 2012
Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
Cannabitwinol, a Dimeric Phytocannabinoid from Hemp, Journal of natural products, , 09-25, Volume: 83, Issue:9, 2020
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: a promising approach for treating pain and inflammation.Bioorganic & medicinal chemistry, , Mar-01, Volume: 20, Issue:5, 2012
Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 22, Issue:2, 2012
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.Proceedings of the National Academy of Sciences of the United States of America, , Aug-14, Volume: 104, Issue:33, 2007
Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).Journal of natural products, , Sep-23, Volume: 74, Issue:9, 2011
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010