Cystic fibrosis transmembrane conductance regulator

A cystic fibrosis transmembrane conductance regulator that is encoded in the genome of human. [PRO:CNA, UniProtKB:P13569]

Synonyms

CFTR;
ATP-binding cassette sub-family C member 7;
Channel conductance-controlling ATPase;
5.6.1.6;
cAMP-dependent chloride channel

Research

Bioassay Publications (17)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (23.53)	29.6817
2010's	9 (52.94)	24.3611
2020's	4 (23.53)	2.80

Compounds (13)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
glyburide	Homo sapiens (human)	IC50	15.0000	1	1
3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone	Homo sapiens (human)	IC50	0.3267	3	3
apigenin	Homo sapiens (human)	Ki	81.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
methyl anthranilate	Homo sapiens (human)	EC50	30.0000	1	1
telmisartan	Homo sapiens (human)	Kd	189.3000	1	1
tadalafil	Homo sapiens (human)	Kd	175.0000	1	1
7-n-butyl-6-(4'-hydroxyphenyl)-5h-pyrrolo(2,3b)pyrazine	Homo sapiens (human)	EC50	0.1337	3	3
uccf-029	Homo sapiens (human)	EC50	3.5000	1	1
quercetin	Homo sapiens (human)	Kd	25.6000	1	1
apigenin	Homo sapiens (human)	EC50	9.0000	1	1
rutin	Homo sapiens (human)	Kd	65.8000	1	1
genistein	Homo sapiens (human)	EC50	8.2900	5	5
vx-770	Homo sapiens (human)	EC50	0.1761	13	13
lumacaftor	Homo sapiens (human)	EC50	2.5926	4	4
lumacaftor	Homo sapiens (human)	Kd	60.3000	2	2

Enables

This protein enables 17 target(s):

Target	Category	Definition
chloride channel activity	molecular function	Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
intracellularly ATP-gated chloride channel activity	molecular function	Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. [PMID:24727426, PMID:9922375]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
bicarbonate transmembrane transporter activity	molecular function	Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. [GOC:ai]
chloride transmembrane transporter activity	molecular function	Enables the transfer of chloride ions from one side of a membrane to the other. [GOC:ai]
isomerase activity	molecular function	Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. [ISBN:0198506732]
ATP hydrolysis activity	molecular function	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065]
chloride channel regulator activity	molecular function	Binds to and modulates the activity of a chloride channel. [GOC:mah]
chloride channel inhibitor activity	molecular function	Binds to and stops, prevents, or reduces the activity of a chloride channel. [GOC:mah]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
PDZ domain binding	molecular function	Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595]
ATPase-coupled inorganic anion transmembrane transporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in). [GOC:mlg]
protein-folding chaperone binding	molecular function	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443]
Sec61 translocon complex binding	molecular function	Binding to a Sec61 translocon complex. [GOC:pga, PMID:9792704]
ABC-type transporter activity	molecular function	Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. [PMID:26517899]
ATPase-coupled transmembrane transporter activity	molecular function	Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729]

Located In

This protein is located in 16 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
early endosome	cellular component	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
endosome membrane	cellular component	The lipid bilayer surrounding an endosome. [GOC:mah]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
Golgi-associated vesicle membrane	cellular component	The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. [GOC:mah]
clathrin-coated endocytic vesicle membrane	cellular component	The lipid bilayer surrounding a clathrin-coated endocytic vesicle. [GOC:mah]
early endosome membrane	cellular component	The lipid bilayer surrounding an early endosome. [GOC:pz]
recycling endosome	cellular component	An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
recycling endosome membrane	cellular component	The lipid bilayer surrounding a recycling endosome. [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]
chloride channel complex	cellular component	An ion channel complex through which chloride ions pass. [GOC:mah]

Involved In

This protein is involved in 21 target(s):

Target	Category	Definition
cholesterol biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai]
vesicle docking involved in exocytosis	biological process	The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]
bicarbonate transport	biological process	The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
cholesterol transport	biological process	The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah, ISBN:0198506732]
response to endoplasmic reticulum stress	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:cjm, GOC:mah]
transepithelial water transport	biological process	The directed movement of water (H2O) from one side of an epithelium to the other. [GOC:yaf]
positive regulation of insulin secretion involved in cellular response to glucose stimulus	biological process	Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:bf, GOC:yaf]
positive regulation of exocytosis	biological process	Any process that activates or increases the frequency, rate or extent of exocytosis. [GOC:go_curators]
sperm capacitation	biological process	A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]
multicellular organismal-level water homeostasis	biological process	A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. [GOC:dph, GOC:tb]
intracellular pH elevation	biological process	Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion. [GOC:ai]
establishment of localization in cell	biological process	Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
transmembrane transport	biological process	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]
membrane hyperpolarization	biological process	The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. [GOC:dph]
positive regulation of enamel mineralization	biological process	Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. [GOC:BHF, GOC:mah]
cellular response to cAMP	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:mah]
amelogenesis	biological process	The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346]
positive regulation of cyclic nucleotide-gated ion channel activity	biological process	Any process that activates or increases the frequency, rate or extent of cyclic nucleotide-gated ion channel activity. [GOC:TermGenie, PMID:11420311]
chloride transmembrane transport	biological process	The process in which chloride is transported across a membrane. [GOC:TermGenie, GOC:vw]
positive regulation of voltage-gated chloride channel activity	biological process	Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324]
cellular response to forskolin	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:15937517]