An ectonucleotide pyrophosphatase/phosphodiesterase family member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13822]
E-NPP 2;
EC 3.1.4.39;
Autotaxin;
Extracellular lysophospholipase D;
LysoPLD
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 15 (75.00) | 24.3611 |
| 2020's | 4 (20.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| evans blue | Homo sapiens (human) | IC50 | 0.9220 | 1 | 1 |
| evans blue | Homo sapiens (human) | Ki | 0.8240 | 1 | 1 |
| congo red | Homo sapiens (human) | IC50 | 1.3100 | 1 | 1 |
| congo red | Homo sapiens (human) | Ki | 1.8900 | 1 | 1 |
| benzeneboronic acid | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 3-aminobenzeneboronic acid | Homo sapiens (human) | IC50 | 12.5892 | 1 | 1 |
| dioctanoylphosphatidic acid | Homo sapiens (human) | IC50 | 1.6440 | 1 | 1 |
| 4-methoxyphenylboronic acid | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| lysophosphatidic acid | Homo sapiens (human) | IC50 | 0.4709 | 2 | 2 |
| lysophosphatidic acid | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
| ubistatin a | Homo sapiens (human) | IC50 | 7.4000 | 1 | 1 |
| ursodoxicoltaurine | Homo sapiens (human) | IC50 | 10.3000 | 1 | 1 |
| pf 8380 | Homo sapiens (human) | IC50 | 0.0096 | 15 | 16 |
| ono-8430506 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
This protein enables 9 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleic acid binding | molecular function | Binding to a nucleic acid. [GOC:jl] |
| lysophospholipase activity | molecular function | Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine. [EC:3.1.1.5] |
| scavenger receptor activity | molecular function | Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| hydrolase activity | molecular function | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. [ISBN:0198506732] |
| polysaccharide binding | molecular function | Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:mah] |
| alkylglycerophosphoethanolamine phosphodiesterase activity | molecular function | Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate. [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN] |
| phosphodiesterase I activity | molecular function | Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. [EC:3.1.4.1] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| chemotaxis | biological process | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732] |
| immune response | biological process | Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add] |
| phospholipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| positive regulation of epithelial cell migration | biological process | Any process that activates or increases the frequency, rate or extent of epithelial cell migration. [GOC:BHF, GOC:dph, GOC:tb] |
| vesicle-mediated transport | biological process | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. [GOC:ai, GOC:mah, ISBN:08789310662000] |
| sphingolipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732] |
| regulation of cell migration | biological process | Any process that modulates the frequency, rate or extent of cell migration. [GOC:go_curators] |
| phosphatidylcholine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:jp] |
| cell motility | biological process | Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] |
| positive regulation of peptidyl-tyrosine phosphorylation | biological process | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai] |
| positive regulation of lamellipodium morphogenesis | biological process | Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis. [GOC:BHF, GOC:mah] |