clobenpropit has been researched along with Necrosis in 1 studies
clobenpropit: histamine H3 receptor antagonist
clobenpropit : An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using the histamine H3 receptor antagonist clobenpropit, the roles of histamine H3 receptors in NMDA-induced necrosis were investigated in rat cultured cortical neurons." | 3.74 | The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. ( Chen, Z; Dai, H; Fu, Q; Hu, W; Leurs, R; Shen, Y; Timmerman, H; Zhang, Z, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, H | 1 |
| Fu, Q | 1 |
| Shen, Y | 1 |
| Hu, W | 1 |
| Zhang, Z | 1 |
| Timmerman, H | 1 |
| Leurs, R | 1 |
| Chen, Z | 1 |
1 other study available for clobenpropit and Necrosis
| Article | Year |
|---|---|
The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons.
Topics: Animals; Animals, Newborn; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyc | 2007 |