Advanced glycosylation end product-specific receptor

An advanced glycosylation end product-specific receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15109]

Synonyms

Receptor for advanced glycosylation end products

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	1 (50.00)	2.80

Compounds (5)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
vilazodone	Homo sapiens (human)	IC50	200.0000	1	1
fps-zm1	Homo sapiens (human)	Ki	0.1070	4	4

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
quinolinic acid	Homo sapiens (human)	Kd	0.0430	1	1
matrine	Homo sapiens (human)	Kd	23,961.9000	2	2
n(delta)-(5-methyl-4-oxo-2-imidazolin-2-yl)ornithine	Homo sapiens (human)	Kd	0.0300	1	1

Enables

This protein enables 11 target(s):

Target	Category	Definition
amyloid-beta binding	molecular function	Binding to an amyloid-beta peptide/protein. [GOC:hjd]
transmembrane signaling receptor activity	molecular function	Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. [GOC:go_curators, Wikipedia:Transmembrane_receptor]
scavenger receptor activity	molecular function	Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
signaling receptor activity	molecular function	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
S100 protein binding	molecular function	Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]
protein-containing complex binding	molecular function	Binding to a macromolecular complex. [GOC:jl]
advanced glycation end-product receptor activity	molecular function	Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins). [GOC:signaling, PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812, Wikipedia:RAGE_(receptor)]
molecular adaptor activity	molecular function	The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]
laminin receptor activity	molecular function	Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. [GOC:ai, PMID:2970671]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
fibrillar center	cellular component	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
cell junction	cellular component	A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]
postsynapse	cellular component	The part of a synapse that is part of the post-synaptic cell. [GOC:dos]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 46 target(s):

Target	Category	Definition
response to hypoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
microglial cell activation	biological process	The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949]
regulation of T cell mediated cytotoxicity	biological process	Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]
positive regulation of protein phosphorylation	biological process	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
learning or memory	biological process	The acquisition and processing of information and/or the storage and retrieval of this information over time. [GOC:jid, PMID:8938125]
response to wounding	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. [GOC:go_curators]
glucose mediated signaling pathway	biological process	The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes. [GOC:sm]
neuron projection development	biological process	The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:mah]
negative regulation of interleukin-10 production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. [GOC:mah]
positive regulation of chemokine production	biological process	Any process that activates or increases the frequency, rate, or extent of chemokine production. [GOC:mah]
positive regulation of interleukin-1 beta production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]
positive regulation of interleukin-12 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. [GOC:mah]
positive regulation of interleukin-6 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
positive regulation of tumor necrosis factor production	biological process	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120]
positive regulation of heterotypic cell-cell adhesion	biological process	Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion. [GOC:add]
positive regulation of activated T cell proliferation	biological process	Any process that activates or increases the rate or extent of activated T cell proliferation. [GOC:jl]
transcytosis	biological process	The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. [ISBN:0716731363]
positive regulation of JNK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
astrocyte activation	biological process	A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813]
regulation of synaptic plasticity	biological process	A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]
induction of positive chemotaxis	biological process	Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai]
positive regulation of NF-kappaB transcription factor activity	biological process	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
positive regulation of monocyte chemotactic protein-1 production	biological process	Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1. [GOC:mah]
protein localization to membrane	biological process	A process in which a protein is transported to, or maintained in, a specific location in a membrane. [GOC:mah]
regulation of spontaneous synaptic transmission	biological process	Any process that modulates the frequency, rate or extent of spontaneous synaptic transmission. [GOC:aruk, GOC:bc, PMID:15457210]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
regulation of long-term synaptic potentiation	biological process	Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]
negative regulation of long-term synaptic potentiation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]
negative regulation of long-term synaptic depression	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of long term synaptic depression. [GOC:BHF, GOC:TermGenie]
regulation of p38MAPK cascade	biological process	Any process that modulates the frequency, rate or extent of p38MAPK cascade. [GOC:TermGenie]
positive regulation of p38MAPK cascade	biological process	Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. [GOC:TermGenie]
regulation of non-canonical NF-kappaB signal transduction	biological process	Any process that modulates the frequency, rate or extent of the non-canonical NF-kappaB signaling cascade. [GOC:TermGenie]
positive regulation of non-canonical NF-kappaB signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade. [GOC:TermGenie]
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	biological process	Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224]
negative regulation of blood circulation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
positive regulation of endothelin production	biological process	Any process that activates or increases the frequency, rate or extent of endothelin production. [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
response to amyloid-beta	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
cellular response to amyloid-beta	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
positive regulation of monocyte extravasation	biological process	Any process that activates or increases the frequency, rate or extent of monocyte extravasation. [GOC:obol]
regulation of CD4-positive, alpha-beta T cell activation	biological process	Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. [GOC:obol]
positive regulation of dendritic cell differentiation	biological process	Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation. [GOC:obol]
regulation of inflammatory response	biological process	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai]