Proteins > Metallo-beta-lactamase type 2
Page last updated: 2024-08-07 16:18:17
Metallo-beta-lactamase type 2
[no definition available]
Synonyms
EC 3.5.2.6;
B2 metallo-beta-lactamase;
Beta-lactamase II;
Carbapenem and cephamycin resistance;
CCRA;
Cephalosporinase;
Imipenem-cefoxitin hydrolyzing enzyme;
Metallo-beta-lactamase type II;
Penicillinase;
Zinc-requiri
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tazobactam | Bacteroides fragilis | IC50 | 2,725.0000 | 4 | 4 |
| sulbactam | Bacteroides fragilis | IC50 | 100.0000 | 1 | 1 |
| tazobactam sodium | Bacteroides fragilis | IC50 | 400.0000 | 1 | 1 |
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.Journal of medicinal chemistry, , Jul-27, Volume: 49, Issue:15, 2006
Mechanism of inactivation of beta-lactamases by novel 6-methylidene penems elucidated using electrospray ionization mass spectrometry.Journal of medicinal chemistry, , Jul-01, Volume: 47, Issue:14, 2004
Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-23, Volume: 11, Issue:8, 2001
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996