Page last updated: 2024-08-07 13:37:05
P2X purinoceptor 7
A P2X purinoceptor 7 that is encoded in the genome of rat. [OMA:Q64663, PRO:DNx]
Synonyms
P2X7;
ATP receptor;
P2Z receptor;
Purinergic receptor
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
Compounds (9)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| sb 203580 | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| kn 62 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| az 11645373 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| ce 224,535 | Rattus norvegicus (Norway rat) | IC50 | 0.4700 | 1 | 1 |
| a-438079 | Rattus norvegicus (Norway rat) | IC50 | 0.4321 | 5 | 5 |
| a-438079 | Rattus norvegicus (Norway rat) | Ki | 0.2000 | 1 | 1 |
| gsk1482160 | Rattus norvegicus (Norway rat) | IC50 | 0.8225 | 3 | 3 |
| gsk1482160 | Rattus norvegicus (Norway rat) | Ki | 0.5100 | 1 | 1 |
| a-839977 | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| jnj-47965567 | Rattus norvegicus (Norway rat) | IC50 | 0.0339 | 2 | 2 |
| jnj-47965567 | Rattus norvegicus (Norway rat) | Ki | 0.0500 | 2 | 2 |
Drugs with Activation Measurements
Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.Journal of medicinal chemistry, , 04-22, Volume: 64, Issue:8, 2021
Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 21, Issue:11, 2011
Antagonists of the P2X(7) receptor. From lead identification to drug development.Journal of medicinal chemistry, , May-28, Volume: 52, Issue:10, 2009
Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 18, Issue:6, 2008
Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.Journal of medicinal chemistry, , 04-22, Volume: 64, Issue:8, 2021
Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.Journal of medicinal chemistry, , 04-22, Volume: 64, Issue:8, 2021
Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists.ACS medicinal chemistry letters, , Apr-11, Volume: 4, Issue:4, 2013