A voltage-dependent L-type calcium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08289]
CAB2;
Calcium channel voltage-dependent subunit beta 2;
Lambert-Eaton myasthenic syndrome antigen B;
MYSB
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| tacrine | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| nimodipine | Homo sapiens (human) | IC50 | 7.0149 | 2 | 2 |
| ith 4012 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated calcium channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729] |
| calcium channel activity | molecular function | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| actin filament binding | molecular function | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. [ISBN:0198506732] |
| voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels | molecular function | Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels. [GOC:dos, PMID:15548655] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| photoreceptor ribbon synapse | cellular component | A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon. [PMID:15626493] |
| presynapse | cellular component | The part of a synapse that is part of the presynaptic cell. [GOC:dos] |
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|---|---|
| L-type voltage-gated calcium channel complex | cellular component | A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. [GOC:ame, PMID:12946355] |
| voltage-gated calcium channel complex | cellular component | A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah] |
This protein is involved in 15 target(s):
| Target | Category | Definition |
|---|---|---|
| visual perception | biological process | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai] |
| positive regulation of muscle contraction | biological process | Any process that activates or increases the frequency, rate or extent of muscle contraction. [GOC:go_curators] |
| positive regulation of calcium ion transport | biological process | Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| calcium ion import | biological process | The directed movement of calcium ions into a cell or organelle. [GOC:mah] |
| calcium ion transmembrane transport | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah] |
| protein localization to plasma membrane | biological process | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah] |
| membrane depolarization during AV node cell action potential | biological process | The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| regulation of heart rate by cardiac conduction | biological process | A cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane depolarization during atrial cardiac muscle cell action potential | biological process | The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] |
| regulation of presynaptic cytosolic calcium ion concentration | biological process | Any process that regulates the concentration of calcium in the presynaptic cytosol. [GOC:dos] |
| positive regulation of high voltage-gated calcium channel activity | biological process | Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254] |
| positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | biological process | Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel. [GO_REF:0000058, GOC:TermGenie, PMID:23071515] |
| regulation of voltage-gated calcium channel activity | biological process | Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity. [GOC:BHF, GOC:TermGenie] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| neuromuscular junction development | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. [GOC:mtg_OBO2OWL_2013] |