Proteins > 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
Page last updated: 2024-08-07 22:40:42

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

A 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y231]

Synonyms

EC 2.4.1.152;
Fucosyltransferase 9;
Fucosyltransferase IX;
Fuc-TIX;
FucT-IX;
Galactoside 3-L-fucosyltransferase

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (2)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
guanosine diphosphateHomo sapiens (human)IC5059.000011
guanosine diphosphateHomo sapiens (human)Ki77.900011
guanosine triphosphateHomo sapiens (human)IC5094.000011
guanosine triphosphateHomo sapiens (human)Ki80.700011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
fucosyltransferase activitymolecular functionCatalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activitymolecular functionCatalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R. [EC:2.4.1.152, RHEA:14257]
protein homodimerization activitymolecular functionBinding to an identical protein to form a homodimer. [GOC:jl]
alpha-(1->3)-fucosyltransferase activitymolecular functionCatalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage. [GOC:ai]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
Golgi membranecellular componentThe lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
Golgi apparatuscellular componentA membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
trans-Golgi networkcellular componentThe network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. [GOC:vw, ISBN:0815316194]
trans-Golgi network membranecellular componentThe lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. [GOC:mah]

Involved In

This protein is involved in 16 target(s):

TargetCategoryDefinition
polysaccharide biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:go_curators]
carbohydrate metabolic processbiological processThe chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732]
protein glycosylationbiological processA protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:curators, GOC:pr]
protein N-linked glycosylationbiological processA protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]
protein O-linked glycosylationbiological processA protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
glycosphingolipid biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [GOC:go_curators]
oligosaccharide biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]
positive regulation of neuron projection developmentbiological processAny process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]
neuron differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]
fucosylationbiological processThe covalent attachment of a fucosyl group to an acceptor molecule. [GOC:sart, PMID:19948734]
N-glycan fucosylationbiological processThe process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains. [GOC:sart, PMID:19948734]
neuronal stem cell divisionbiological processThe self-renewing division of a neuronal stem cell. [CL:0000047, GOC:nhn]
L-fucose catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose). [GOC:jl]
Lewis x epitope biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of a Lewis x epitope, a trisaccharide (beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-beta-D-glucosamine) expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system. The related Lewis x epitope is formed by alpha(1,3) fucosylation of the N-acetylglucosaminyl residue of a type 2 histo-blood group antigen precursor disaccharide. [PMID:16973732, PMID:23000574]
regulation of leukocyte cell-cell adhesionbiological processAny process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
regulation of leukocyte tethering or rollingbiological processAny process that modulates the frequency, rate or extent of leukocyte tethering or rolling. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]