Page last updated: 2024-10-27

gentamicin and Necrosis

gentamicin has been researched along with Necrosis in 118 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to investigate the role of inducible nitric oxide synthase (iNOS) in gentamicin-induced acute tubular necrosis in rats using the iNOS inhibitor L-N6-(1-iminoethyl) lysine (L-NIL)."7.74The effects of inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl) lysine in gentamicin-induced acute tubular necrosis in rats. ( Avdagić, N; Hadzović-Dzuvo, A; Nakas-Ićindić, E; Rasić, S; Valjevac, A; Zaciragić, A, 2007)
"Local prophylaxis with hLF1-11 effectively reduced development of osteomyelitis in a rabbit model, but gentamicin resulted in a larger number of sterile femora."7.72Osteomyelitis prevention in rabbits using antimicrobial peptide hLF1-11- or gentamicin-containing calcium phosphate cement. ( Bronckers, AL; Faber, C; Nieuw Amerongen, AV; Stallmann, HP; Wuisman, PI, 2004)
"Extensive necrosis was evident in the proximal tubes in each fish injected with gentamicin at every time period, regardless of route of administration."5.08Evaluation of gentamicin-induced nephrotoxicosis in toadfish. ( Chamie, SJ; Kinnel, M; Reimschuessel, R, 1996)
" Necrosis, apoptosis and inflammation are commonly considered as the leading mechanism in acute kidney injury (AKI) induced by gentamicin (GEN), which is a useful antibiotic for treating the infection of Gram-negative bacterial."4.12Protective effect of inhibiting necroptosis on gentamicin-induced nephrotoxicity. ( Chen, SQ; Feng, XW; Gong, Q; Hu, BF; Li, C; Li, J; Liu, MM; Ma, WX; Meng, XM; Wang, F; Wang, JN; Wang, XF; Wen, JG; Yue, L, 2022)
" The aim of this study was to determine effects of inhibiting hydrogen sulphide biosynthesis by DL-propargyl glycine (an irreversible inhibitor of cystathionine gamma-lyase) on inflammation, necrosis and renal function, following treatment with gentamicin in rats."3.78Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity. ( Dam, VP; Kinobe, RT; Ross, A; Scott, JL, 2012)
"Gentamicin significantly increased serum creatinine, malondialdehyde, and tubular necrosis, and decreased creatinine clearance, volume density of the proximal convoluted tubules, renal glutathione, glutathione peroxidase, catalase, and superoxide dismutase compared with the control group."3.78Inhibitory effect of olive leaf extract on gentamicin-induced nephrotoxicity in rats. ( Ahmadvand, H; Tavafi, M; Toolabi, P, 2012)
"The aim of this study was to investigate the role of inducible nitric oxide synthase (iNOS) in gentamicin-induced acute tubular necrosis in rats using the iNOS inhibitor L-N6-(1-iminoethyl) lysine (L-NIL)."3.74The effects of inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl) lysine in gentamicin-induced acute tubular necrosis in rats. ( Avdagić, N; Hadzović-Dzuvo, A; Nakas-Ićindić, E; Rasić, S; Valjevac, A; Zaciragić, A, 2007)
"Local prophylaxis with hLF1-11 effectively reduced development of osteomyelitis in a rabbit model, but gentamicin resulted in a larger number of sterile femora."3.72Osteomyelitis prevention in rabbits using antimicrobial peptide hLF1-11- or gentamicin-containing calcium phosphate cement. ( Bronckers, AL; Faber, C; Nieuw Amerongen, AV; Stallmann, HP; Wuisman, PI, 2004)
" Gentamicin (GE) acts mainly in proximal tubular cells, where it is uptake via organic anion transport system and it induces a high incidence of nephrotoxicity, which is characterized by tubular necrosis [5] leading to acute renal failure in 10 to 50% of patients."3.71Effects of gentamicin, lipopolysaccharide, and contrast media on immortalized proximal tubular cells. ( Cunha, MA; Schor, N, 2002)
" Gentamicin (80 mg/kg/day intramuscularly for 6 days) produced the typical pattern of nephrotoxicity as shown by increases in serum creatinine and urea concentrations, and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity and proximal renal tubular necrosis."3.69Effect of fish oil treatment on gentamicin nephrotoxicity in rats. ( Ali, BH; Bashir, AA, 1994)
"The nerve agent soman, as well as other organophosphates such as paraoxon and phospholine in concentrations that caused cholinergic symptoms induced a progressive dose-related necrosis in rat skeletal muscle fibers."3.67Pesticide induced muscle necrosis: mechanisms and prevention. ( Dettbarn, WD, 1984)
"We found the implantation of Gentamicin beads a simple and very inexpensive method for long-term management of malignant (necrotizing) otitis externa."3.67Necrotizing otitis externa (a new aid to management). ( Couldery, AD; Sharma, PL, 1988)
"After an initial episode of acute tubular necrosis, apparent resistance to gentamicin nephrotoxicity develops in rats during prolonged drug administration."3.67Chronic gentamicin nephrotoxicity. Continued tubular injury with preserved glomerular filtration function. ( Bennett, WM; Gilbert, DN; Houghton, DC; Lee, D, 1986)
"Acquired insensitivity to the nephrotoxic effects of gentamicin develops in Fischer 344 rats after 10 to 14 days' treatment after development of histologic acute tubular necrosis in a setting of extensive histologic regeneration."3.66Gentamicin nephrotoxicity. II. Definition of conditions necessary to induce acquired insensitivity. ( Baines-Hunter, J; Bennett, WM; Elliott, WC; Gilbert, DN; Houghton, DC, 1982)
"Twelve patients with extremely severe uveitis and two patients with necrotizing (chorio-)retinitis were treated with a combination of antibiotics consisting of penicillin G, gentamicin and metronidazole."3.66[High-dosage combination antibiotic treatment in severe therapy-resistant uveitis and necrotizing (chorio)retinitis]. ( Dietze, U; Fricke, HJ; Heydenreich, A; Illéssy, A; Schröder, D, 1983)
"Gentamicin (GM) is an aminoglycoside antibiotic that induces nephrotoxicity."1.91L-cysteine protective effects against platelet disaggregation and echinocyte occurrence in gentamicin-induced kidney injury. ( Fočak, M; Mitrašinović-Brulić, M; Suljević, D, 2023)
"Gentamicin (GM) is an aminoglycoside antibiotic that despite its antibacterial effects, its use is restricted due to numerous side effects."1.62Human umbilical cord blood serum attenuates gentamicin-induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats. ( Baharvand, F; Hosseini, A; Mirazi, N; Moghadasali, R; Nourian, A, 2021)
"Gentamicin (GM) is a low-cost, low-resistance antibiotic commonly used to treat gram-negative bacterial diseases."1.62Assessment of gentamicin and cisplatin-induced kidney damage mediated via necrotic and apoptosis genes in albino rats. ( Abouzed, TK; Aldhahrani, A; Barakat, MES; Dorghamm, DA; Eldomany, E; Khailo, K; Nasr, NE; Sadek, KM; Sherif, EAE, 2021)
"Acute renal failure is one of the most frequent effects observed after taking medicine."1.48In vitro evaluation of biomarkers of nephrotoxicity through gene expression using gentamicin. ( Campos, MAA; de Almeida, LA; Grossi, MF; Tagliati, CA, 2018)
" Blood and 16-h urine samples were collected on Days -7, -3, 2, 4, 7, and at the end of the dosing period."1.43Evaluation of novel biomarkers of nephrotoxicity in Cynomolgus monkeys treated with gentamicin. ( Boitier, E; Detilleux, P; Filali-Ansary, A; Gautier, JC; Guizon, I; Gury, T; Joos, T; Léonard, JF; Li, B; Palazzi, X; Poetz, O; Qu, Z; Slaoui, M; van den Berg, BHJ; Veeranagouda, Y; Wang, J; Yang, Y; Zhang, T; Zhou, X, 2016)
"Melatonin has a dose dependent protective effect on the structural alterations of proximal tubules of the kidney induced by gentamicin."1.40A histological study of the effect of exogenous melatonin on gentamicin induced structural alterations of proximal tubules in rats. ( Ćosović, E; Kapić, D; Mornjaković, Z; Šahinović, M, 2014)
" The nephrotoxin gentamicin was given to rats once on each of three days and the animals were killed during dosing or over the following 42 days."1.37Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats. ( Espandiari, P; Rosenzweig, BA; Rouse, RL; Sadrieh, NK; Stewart, SR; Zhang, J, 2011)
"On histopathological findings, a chloroma was diagnosed on the wall of a mass."1.37Necrotic intramuscular chloroma with infection: magnetic resonance imaging features. ( Cho, B; Im, SA; Park, GS; Yun, DY, 2011)
"Osteomyelitis is an extremely unusual complication of invasive otitis externa."1.33[Temporomandibular osteomyelitis secondary to progressive necrotizing otitis externa]. ( Boulaïch, M; Filali, A; Jamal, H; Kzadri, M; Lazrak, A; Nazih, N; Oujilal, A, 2006)
"Gentamicin (GM) is an antibiotic whose clinical use is limited by its nephrotoxicity."1.32Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats. ( Barrera, D; Cerón, A; Hernández-Pando, R; Maldonado, PD; Medina-Campos, ON; Pedraza-Chaverrí, J, 2003)
"Kidney histology of the tissue from GM-treated rats showed necrosis and desquamation of tubular epithelial cells in renal cortex as well as interstitial nephritis."1.31Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats. ( Al-Majed, AA; Al-Rikabi, AC; Al-Shabanah, OA; Mostafa, AM, 2002)
"Gentamicin treatment produced significant elevation in serum total cholesterol, which was greater in animals fed with CSD."1.31Effect of high dietary cholesterol on gentamicin-induced nephrotoxicity in rabbits. ( Abdel-Gayoum, AA; Abu-Spetan, KA, 2001)
"Necrotizing fasciitis caused by Streptococcus pyogenes has become more frequent in the last few years and has often been accompanied by severe systemic complications."1.29[Systemic infection due to group A Streptococcus pyogenes]. ( Adams, S; Hertel, A; Hör, G; Koch, U; Pohl, TS; Shah, PM; Usadel, KH; Wenisch, HC, 1995)
"Gentamicin treated rats exhibited a 63% increase in blood urea nitrogen (BUN), a 124% increase in uric acid, and a 63% decrease in serum potassium levels on day 15."1.29Nephrotoxicity of gentamicin and co-trimoxazole combination in rats. ( Ayça, B; Cevikbaş, U; Izzettin, FV; Stohs, SJ; Uras, F; Uysal, V; Yardimci, T, 1994)
"01) compared with rats dosed with GT alone."1.28Epidermal growth factor accelerates renal tissue repair in a model of gentamicin nephrotoxicity in rats. ( Beauchamp, D; Bergeron, MG; Heuson-Stiennon, JA; Laurent, G; Morin, NJ; Nonclercq, D; Toubeau, G, 1992)
"Necrotizing fasciitis is a potentially fatal, acute bacterial infection characterized by extensive fascial and subcutaneous tissue necrosis."1.28Fatal necrotizing fasciitis of dental origin. ( Beecroft, WA; Cogan, AG; Stoykewych, AA, 1992)
"Four major mechanisms are discussed: an Arthus reaction, a thrombotic process, a direct toxicity of aminosides for subcutaneous tissue, or a pyoderma-like neutrophilic reaction."1.28Skin necrosis after injection of aminosides. Arthus reaction, local toxicity, thrombotic process or pathergy? ( Andrac, L; Bonerandi, JJ; Follana, J; Grob, JJ; Legre, R; Mege, JL, 1990)
"05) differences were not detected in pharmacokinetic values of either group."1.28Phenolsulfonphthalein pharmacokinetics and renal morphologic changes in adult pony mares with gentamicin-induced nephrotoxicosis. ( Cooley, AJ; Hinchcliff, KW; MacWilliams, PS; McGuirk, SM, 1989)
"Nephrotoxicity of cefodizime sodium (THR-221), a new cephem antibiotic, was studied in rats by comparing its toxic effect with those of other cephem antibiotics including cephaloridine (CER), cefazolin (CEZ) and cefmetazol (CMZ)."1.27[Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration]. ( Hayashi, T; Irimura, K; Kuwata, M; Maruden, A; Morita, K, 1988)
"Gentamicin, 120 mg/kg, was given at the start of the hypoperfusion period."1.27Gentamicin nephrotoxicity in the setting of acute renal hypoperfusion. ( Zager, RA, 1988)
" Muscle irritation experiment was carried out with a single dosage of 100 mg HAPA-B, 100 mg amikacin (AMK), saline, 0."1.27[Local irritation study with isepamicin]. ( Kobayashi, Y; Kohira, T; Yamamoto, H; Yano, J, 1986)
"Necrotizing fasciitis must be considered in a diabetic with cutaneous ulceration."1.27Limb salvage in a diabetic with necrotizing fasciitis: case report and literature review. ( Carlow, SB; Jacobs, RL; Vedder, DK, 1986)
" S86451 was found at least 2-5 times less toxic than gentamicin."1.27A 2'guanidyl derivative of gentamicin (S86451) with reduced nephrotoxicity studies at low and medium dose levels in the rat. ( Carlier, MB; Laurent, G; Maldague, P; Tulkens, P, 1984)
"Amiloride, 2 mg/kg/day, was given to groups of 8-12 Fischer 344 rats receiving gentamicin, 20 mg/kg b."1.27Effect of amiloride on experimental gentamicin nephrotoxicity. ( Bennett, WM; Houghton, DC; Porter, GA; Purnell, J, 1985)
"The etiology of acute renal failure has changed in recent years due to the recognition of drug nephrotoxicity as a more common cause."1.26Pathogenesis of renal failure due to aminoglycosides and contrast media used in roentgenography. ( Bennett, WM; Luft, F; Porter, GA, 1980)
"Gentamicin sulphate was administered to male Wistar rats by intramuscular injection at varying dosage and for varying periods."1.26Renal damage caused by gentamicin: a study of the effects on renal morphology and urinary enzyme excretion. ( Lovell, D; Thompson, AE; Tighe, JR; Wellwood, JM, 1976)
"Gentamicin sulfate was tested for nephrotoxicity in B6D2F1 hybrid mice after s."1.26[Nephrotoxicity of gentamicin in mice]. ( Walzl, HL, 1982)

Research

Studies (118)

TimeframeStudies, this research(%)All Research%
pre-199057 (48.31)18.7374
1990's19 (16.10)18.2507
2000's19 (16.10)29.6817
2010's17 (14.41)24.3611
2020's6 (5.08)2.80

Authors

AuthorsStudies
Abouzed, TK1
Sherif, EAE1
Barakat, MES1
Sadek, KM1
Aldhahrani, A1
Nasr, NE1
Eldomany, E1
Khailo, K1
Dorghamm, DA1
Suljević, D1
Mitrašinović-Brulić, M1
Fočak, M1
Ali, A1
Khan, H1
Kahrizi, D1
Pervez, S1
Alotaibi, G1
Rastrelli, L1
Hu, BF1
Gong, Q1
Chen, SQ1
Yue, L1
Ma, WX1
Wang, F1
Feng, XW1
Wang, JN1
Li, C1
Liu, MM1
Wang, XF1
Meng, XM1
Li, J1
Wen, JG1
Wang, L1
Yang, J1
Peng, SY1
Li, GQ1
Tu, ZW1
Mirazi, N1
Baharvand, F1
Moghadasali, R1
Nourian, A1
Hosseini, A1
Campos, MAA1
de Almeida, LA1
Grossi, MF1
Tagliati, CA1
Abdelhafez, M1
Elnegouly, M1
Hasab Allah, MS1
Elshazli, M1
Mikhail, HM1
Yosry, A1
Conway, H1
Dix, KJ1
McDonald, JD1
Miller, RA1
Wall, HG1
Wolff, RK1
Reed, MD1
Kapić, D1
Mornjaković, Z1
Ćosović, E1
Šahinović, M1
Kuwae, A1
Momose, F1
Nagamatsu, K1
Suyama, Y1
Abe, A1
Gautier, JC1
Zhou, X1
Yang, Y1
Gury, T1
Qu, Z1
Palazzi, X1
Léonard, JF1
Slaoui, M1
Veeranagouda, Y1
Guizon, I1
Boitier, E1
Filali-Ansary, A1
van den Berg, BHJ1
Poetz, O1
Joos, T1
Zhang, T1
Wang, J1
Detilleux, P1
Li, B1
Sieber, M1
Hoffmann, D1
Adler, M1
Vaidya, VS1
Clement, M1
Bonventre, JV1
Zidek, N1
Rached, E1
Amberg, A1
Callanan, JJ1
Dekant, W1
Mally, A1
Pessoa, EA1
Convento, MB1
Silva, RG1
Oliveira, AS1
Borges, FT1
Schor, N2
Celebi, G1
Büyükateş, M1
Doğan, SM1
Pişkin, N1
Aydemir, H1
Oztoprak, N1
Aktaş, E1
Bektaş, S1
Keskin, A1
Akduman, D1
Stojiljković, N3
Veljković, S3
Mihailović, D3
Stoiljković, M3
Ranković, G1
Jovanović, I1
Randjelović, P2
González Robledo, J1
Pérez Losada, ME1
Ballesteros Herráez, JC1
Rodríguez Encinas, A1
Le Falher, G1
Makinson, A1
Eden, A1
Lesnik, A1
Le Moing, V1
Reynes, J1
Rouse, RL1
Zhang, J1
Stewart, SR1
Rosenzweig, BA1
Espandiari, P1
Sadrieh, NK1
García-Vilanova-Comas, A1
Fuster-Diana, C1
Cubells-Parrilla, M1
Pérez-Ferriols, MD1
Pérez-Valles, A1
Roig-Vila, JV1
Castillo, RF1
Cañadas-De la Fuente, GA1
Husein-Elahmed, H1
Cantero-Hinojosa, J1
Yun, DY1
Im, SA1
Cho, B1
Park, GS1
Wu, G1
Cai, Y1
Wei, H1
Wei, A1
Xiong, C1
Fu, W1
Ruan, J1
Tavafi, M1
Ahmadvand, H1
Toolabi, P1
Dam, VP1
Scott, JL1
Ross, A1
Kinobe, RT1
Ahmad, QZ1
Jahan, N1
Ahmad, G1
Dunn, KW1
Sandoval, RM1
Kelly, KJ1
Dagher, PC1
Tanner, GA1
Atkinson, SJ1
Bacallao, RL1
Molitoris, BA1
Al-Majed, AA1
Mostafa, AM1
Al-Rikabi, AC1
Al-Shabanah, OA1
Cunha, MA1
Maldonado, PD2
Barrera, D2
Rivero, I1
Mata, R1
Medina-Campos, ON2
Hernández-Pando, R2
Pedraza-Chaverrí, J2
Cerón, A1
Stallmann, HP1
Faber, C1
Bronckers, AL1
Nieuw Amerongen, AV1
Wuisman, PI1
Servais, H1
Van Der Smissen, P1
Thirion, G1
Van der Essen, G1
Van Bambeke, F1
Tulkens, PM1
Mingeot-Leclercq, MP1
Ekor, M2
Farombi, EO2
Emerole, GO1
Nazih, N1
Filali, A1
Boulaïch, M1
Jamal, H1
Oujilal, A1
Lazrak, A1
Kzadri, M1
Avdagić, N1
Nakas-Ićindić, E1
Rasić, S1
Hadzović-Dzuvo, A1
Zaciragić, A1
Valjevac, A1
Yee-Guardino, S1
Kumar, D1
Abughali, N1
Tuohy, M1
Hall, GS1
Kumar, ML1
Radovanović, D1
Randelović, P1
Elliott, WC2
Houghton, DC9
Gilbert, DN6
Baines-Hunter, J2
Bennett, WM10
Taillandier, J1
Manigand, G1
Fixy, P1
Dumont, D1
Penso, D1
Delfraissy, JF1
Pham Van, T1
Dormont, J1
Katz, NN1
Wadud, SA1
Ayazuddin, M1
Uri, N1
Kitzes, R1
Meyer, W1
Schuchman, G1
Maldague, P1
Laurent, G2
Carlier, MB1
Tulkens, P1
Fricke, HJ1
Heydenreich, A1
Dietze, U1
Illéssy, A1
Schröder, D1
D'Amico, DJ1
Libert, J1
Kenyon, KR1
Hanninen, LA1
Caspers-Velu, L1
Dettbarn, WD1
Kohlhepp, SJ2
Loveless, MO1
Kohnen, PW2
Berger, SA1
Barza, M1
Haher, J1
Bell, D1
Waintraub, S1
Burtyk, ML1
Kane, A1
Walzl, HL1
Luft, F1
Porter, GA4
Parker, RA1
Ali, BH3
Bashir, AA3
Pohl, TS1
Shah, PM1
Hertel, A1
Adams, S1
Koch, U1
Wenisch, HC1
Hör, G1
Usadel, KH1
Abdel-Gayoum, AA2
Abdel-Razig, KM1
Ghywarsha, K1
Izzettin, FV1
Ayça, B1
Uras, F1
Uysal, V1
Cevikbaş, U1
Yardimci, T1
Stohs, SJ1
Ben Ismail, TH1
Rivas-Cabañero, L1
Rodriguez-Barbero, A1
Arévalo, M1
López-Novoa, JM1
Reimschuessel, R1
Chamie, SJ1
Kinnel, M1
Fadel, AA1
Larkin, HA1
Nomori, H1
Horio, H1
Kobayashi, R1
Komuro, A1
Hodge, DO1
Gores, GJ1
Bourne, WM1
Wright, AJ1
Lall, A1
Gransden, WR1
Joyce, MR1
Rowsell, A1
Clark, G1
Abu-Spetan, KA1
Zulauf, M1
Jordan, P1
Steiner, A1
Grylack, L1
Scanlon, JW1
Treister, G1
Frankl, O1
Cohen, S1
Stein, R1
Horwitz, MJ1
Templeton, TP1
Balis, JU1
Paterson, JF1
Shelley, SA1
Larson, CH1
Fareed, J1
Gerber, LI1
John, AC1
Hopkin, NB1
Plamp, CE1
DeFehr, JM1
Porter, G1
Gilbert, D1
da Silva Trevisan, MA1
de Faria, JL1
Nunamaker, DM1
Bennett, RG1
Petrozzi, JW1
Colgrove, GS1
Sawa, TR1
Brown, JT1
McDowel, PF1
Nachtigall, PE1
Wellwood, JM1
Lovell, D1
Thompson, AE1
Tighe, JR1
Gouvea, W1
Vaamonde, CM1
Owens, B1
Alpert, H1
Pardo, V1
Vaamonde, CA1
Morin, NJ1
Nonclercq, D1
Toubeau, G1
Heuson-Stiennon, JA1
Bergeron, MG1
Beauchamp, D1
Stoykewych, AA1
Beecroft, WA1
Cogan, AG1
Davison, CR1
Tuft, SJ1
Dart, JK1
Smetana, S1
Khalef, S1
Hurwitz, N1
Bar-Khayim, Y1
Birk, Y1
Grob, JJ1
Mege, JL1
Follana, J1
Legre, R1
Andrac, L1
Bonerandi, JJ1
Thompson, JR1
Simonsen, R1
Spindler, MA1
Southern, PM1
Cronin, RE1
Lutsevich, EV1
Lychkovskiĭ, RM1
Hinchcliff, KW1
McGuirk, SM1
MacWilliams, PS1
Cooley, AJ1
Wood, CA1
Finkbeiner, HC1
Lindsley, J1
Plonka, AJ1
Schentag, JJ1
Messinger, S1
Adelman, MH1
Francis, KL1
Williams, JS1
Zager, RA3
Prior, RB1
Hayashi, T1
Maruden, A1
Irimura, K1
Kuwata, M1
Morita, K1
Couldery, AD1
Sharma, PL1
Palla, R1
Paternoster, G1
Galigani, P1
Giovannini, L1
Bertelli, AA1
Romano, MR1
Alessandrì, MG1
Bertelli, A1
Kohira, T1
Yano, J1
Kobayashi, Y1
Yamamoto, H1
Schatz, H1
McDonald, HR1
Frazier, DL1
Carver, MP1
Dix, LP1
Thompson, CA1
Riviere, JE1
Schwertz, DW1
Troyer, DA1
Kreisberg, JI1
Venkatachalam, MA1
Carlow, SB1
Jacobs, RL1
Vedder, DK1
Lee, D1
Purnell, J1
Pulliam, JP1
Duterque, M1
Hubert-Asso, AM1
Corrard, A1
Thorsteinsson, SB1
Minuth, JN1
Musher, DM1
Artz, CP1
Yarbrough, DR1
Van Wingerden, GI1
Lolans, V1
Jackson, GG1
Fillastre, JP1
Dubois, D1
Robert, M1
Graybill, JR1
Pierson, DN1
Charache, P1
Lloyd, DA1
Cywes, S1
Roback, SA1
Foker, J1
Frantz, IF1
Hunt, CE2
Engel, RR1
Leonard, AS1
Hill, HR1
Matsen, JM1
Bray, DA1
Kosek, JC1
Mazze, RI1
Cousins, MJ1
Marsden, HB1
Braude, AI1

Reviews

2 reviews available for gentamicin and Necrosis

ArticleYear
Pathology and pathogenesis of nephrotoxic membrane damage.
    Transplantation proceedings, 1985, Volume: 17, Issue:4 Suppl 1

    Topics: Acute Kidney Injury; Animals; Cell Membrane; Cells, Cultured; Epithelium; Gentamicins; Kidney Tubule

1985
Topical burn wound therapy.
    Surgery annual, 1974, Volume: 6

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Antisepsis; Bacillus subtilis; Bacterial In

1974

Trials

3 trials available for gentamicin and Necrosis

ArticleYear
Evaluation of gentamicin-induced nephrotoxicosis in toadfish.
    Journal of the American Veterinary Medical Association, 1996, Jul-01, Volume: 209, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Female; Fish Diseases; Fishes; Gentamicins; Injections, Intramuscula

1996
Fenestration of the abaxial hoof wall and implantation of gentamicin-impregnated collagen sponges for the treatment of septic arthritis of the distal interphalangeal joint in cattle.
    The Veterinary record, 2001, Oct-27, Volume: 149, Issue:17

    Topics: Animals; Anti-Bacterial Agents; Arthritis, Infectious; Cattle; Cattle Diseases; Collagen; Foot Disea

2001
Prevention of necrotising enterocolitis with gentamicin.
    Lancet (London, England), 1977, Sep-03, Volume: 2, Issue:8036

    Topics: Administration, Oral; Clinical Trials as Topic; Enterocolitis, Pseudomembranous; Gentamicins; Humans

1977

Other Studies

113 other studies available for gentamicin and Necrosis

ArticleYear
Assessment of gentamicin and cisplatin-induced kidney damage mediated via necrotic and apoptosis genes in albino rats.
    BMC veterinary research, 2021, Nov-16, Volume: 17, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Biomar

2021
L-cysteine protective effects against platelet disaggregation and echinocyte occurrence in gentamicin-induced kidney injury.
    Molecular and cellular biochemistry, 2023, Volume: 478, Issue:1

    Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Creatinine; Cysteine; Gentamicins; Kidney; Male

2023
Nephroprotective effects of Helianthus annuus seeds extract in gentamicin induced nephrotoxic male mice.
    Cellular and molecular biology (Noisy-le-Grand, France), 2022, May-22, Volume: 68, Issue:1

    Topics: Acute Kidney Injury; Animals; Antioxidants; Creatinine; Gentamicins; Helianthus; Kidney; Male; Mice;

2022
Protective effect of inhibiting necroptosis on gentamicin-induced nephrotoxicity.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022, Volume: 36, Issue:9

    Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Apoptosis; Gentamicins; Inflammation; Necroptos

2022
Microbial etiology, susceptibility profile of postradiation nasopharyngeal necrosis patients with nasopharyngeal carcinoma.
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2020, Volume: 24, Issue:2

    Topics: Adult; Aged; Anti-Bacterial Agents; Candida albicans; Ciprofloxacin; Female; Gentamicins; Humans; Le

2020
Human umbilical cord blood serum attenuates gentamicin-induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats.
    Basic & clinical pharmacology & toxicology, 2021, Volume: 128, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Cytokines;

2021
In vitro evaluation of biomarkers of nephrotoxicity through gene expression using gentamicin.
    Journal of biochemical and molecular toxicology, 2018, Volume: 32, Issue:9

    Topics: Acute Kidney Injury; Animal Use Alternatives; Anti-Bacterial Agents; Apoptosis; Biomarkers, Pharmaco

2018
Transluminal retroperitoneal endoscopic necrosectomy with the use of hydrogen peroxide and without external irrigation: a novel approach for the treatment of walled-off pancreatic necrosis.
    Surgical endoscopy, 2013, Volume: 27, Issue:10

    Topics: Adult; Aged; Anti-Bacterial Agents; Blood Loss, Surgical; Cholangiopancreatography, Endoscopic Retro

2013
Comparison of inhalation toxicity studies of gentamicin in rats and dogs.
    Inhalation toxicology, 2013, Volume: 25, Issue:13

    Topics: Administration, Inhalation; Animals; Anti-Bacterial Agents; Dogs; Female; Gentamicins; Kidney Tubule

2013
A histological study of the effect of exogenous melatonin on gentamicin induced structural alterations of proximal tubules in rats.
    Bosnian journal of basic medical sciences, 2014, Volume: 14, Issue:1

    Topics: Animals; Antioxidants; Cytoplasm; Dose-Response Relationship, Drug; Gentamicins; Injections, Intrape

2014
BteA Secreted from the Bordetella bronchiseptica Type III Secetion System Induces Necrosis through an Actin Cytoskeleton Signaling Pathway and Inhibits Phagocytosis by Macrophages.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Actin Cytoskeleton; Amino Acids; Animals; Bacterial Proteins; Bacterial Secretion Systems; Bordetell

2016
Evaluation of novel biomarkers of nephrotoxicity in Cynomolgus monkeys treated with gentamicin.
    Toxicology and applied pharmacology, 2016, 07-15, Volume: 303

    Topics: Acetylglucosaminidase; Alanine Transaminase; Alpha-Globulins; Animals; Anti-Bacterial Agents; Aspart

2016
Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 109, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Biomarkers; Cell Adhesion Molecules; Clusterin

2009
Gentamicin-induced preconditioning of proximal tubular LLC-PK1 cells stimulates nitric oxide production but not the synthesis of heat shock protein.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2009, Volume: 42, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Blotting, Western; Cell Proliferation; Endothelin-1; Gent

2009
[Necrotising endocarditis of mitral valve due to Staphylococcus lugdunensis].
    Mikrobiyoloji bulteni, 2009, Volume: 43, Issue:2

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Bacteremia; Chemotherapy, Adjuvant; Drug Therapy, Combinat

2009
Pentoxifylline ameliorates glomerular basement membrane ultrastructural changes caused by gentamicin administration in rats.
    Bosnian journal of basic medical sciences, 2009, Volume: 9, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Basement Membrane; Gentamicins; Kidney Diseases; Kidney G

2009
Cytoprotective effect of vitamin C against gentamicin-induced acute kidney injury in rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2012, Volume: 64, Issue:1-2

    Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Antioxidants; Ascorbic Acid; Cell Nucleus; Cyto

2012
[Septic shock due to primary myonecrosis of psoas].
    Medicina intensiva, 2011, Volume: 35, Issue:3

    Topics: Alcoholism; Anti-Bacterial Agents; Bacteremia; Cerebrovascular Disorders; Cloxacillin; Combined Moda

2011
[Two cases of pulmonary gangrene in HIV-infected patients: favorable outcome without surgery].
    Medecine et maladies infectieuses, 2011, Volume: 41, Issue:2

    Topics: Acetamides; Adult; Alcoholism; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Gangre

2011
Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats.
    Kidney international, 2011, Volume: 79, Issue:11

    Topics: Acute Kidney Injury; Animals; Apoptosis; Biomarkers; Cell Adhesion Molecules; Clusterin; Gentamicins

2011
Nicolau syndrome after lidocaine injection and cold application: a rare complication of breast core needle biopsy.
    International journal of dermatology, 2011, Volume: 50, Issue:1

    Topics: Amoxicillin; Anesthetics, Local; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bac

2011
Pyoderma gangrenosum developing over an arteriovenous fistula scar.
    Internal medicine journal, 2011, Volume: 41, Issue:5

    Topics: Abscess; Arteriovenous Shunt, Surgical; Betamethasone Valerate; Drug Therapy, Combination; Gentamici

2011
Necrotic intramuscular chloroma with infection: magnetic resonance imaging features.
    Japanese journal of radiology, 2011, Volume: 29, Issue:10

    Topics: Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Child; Contrast Media; Cytarabine; Diagnosis

2011
Nephroprotective activity of Macrothelypteris oligophlebia rhizomes ethanol extract.
    Pharmaceutical biology, 2012, Volume: 50, Issue:6

    Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Antioxidants; Dose-Response Relationship, Drug;

2012
Inhibitory effect of olive leaf extract on gentamicin-induced nephrotoxicity in rats.
    Iranian journal of kidney diseases, 2012, Volume: 6, Issue:1

    Topics: Analysis of Variance; Animals; Antioxidants; Catalase; Creatinine; Gentamicins; Glutathione; Glutath

2012
Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity.
    European journal of pharmacology, 2012, Jun-15, Volume: 685, Issue:1-3

    Topics: Alkynes; Animals; Anti-Bacterial Agents; Cystathionine gamma-Lyase; Female; Gentamicins; Glycine; Hy

2012
Nephroprotective effect of Kabab chini (Piper cubeba) in gentamycin-induced nephrotoxicity.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2012, Volume: 23, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Creatinine; Fruit; Gentamicins; Kidney; Kidney Glomerulus; Kidney Tu

2012
Functional studies of the kidney of living animals using multicolor two-photon microscopy.
    American journal of physiology. Cell physiology, 2002, Volume: 283, Issue:3

    Topics: Animals; Apoptosis; Cell Nucleus; Coloring Agents; DNA; Endocytosis; Fluorescent Dyes; Gentamicins;

2002
Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats.
    Pharmacological research, 2002, Volume: 46, Issue:5

    Topics: Administration, Oral; Animals; Gentamicins; Gum Arabic; Injections, Intraperitoneal; Kidney Tubules,

2002
Effects of gentamicin, lipopolysaccharide, and contrast media on immortalized proximal tubular cells.
    Renal failure, 2002, Volume: 24, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Calcium; Contrast Media; Disease Models, Animal; Gentamic

2002
Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage.
    Free radical biology & medicine, 2003, Aug-01, Volume: 35, Issue:3

    Topics: Acetylglucosaminidase; Animals; Anti-Bacterial Agents; Antioxidants; Body Weight; Cysteine; Free Rad

2003
Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats.
    Molecular and cellular biochemistry, 2003, Volume: 254, Issue:1-2

    Topics: Acetylglucosaminidase; Allyl Compounds; Animals; Anti-Bacterial Agents; Antioxidants; Blood Urea Nit

2003
Osteomyelitis prevention in rabbits using antimicrobial peptide hLF1-11- or gentamicin-containing calcium phosphate cement.
    The Journal of antimicrobial chemotherapy, 2004, Volume: 54, Issue:2

    Topics: Abscess; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bone Cements; Calcium Phosphates; Co

2004
Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria.
    Toxicology and applied pharmacology, 2005, Aug-15, Volume: 206, Issue:3

    Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Caspases; Cytochromes c; Dose-Response Relationship, Drug;

2005
Modulation of gentamicin-induced renal dysfunction and injury by the phenolic extract of soybean (Glycine max).
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:3

    Topics: Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Disease Models, Animal; Dose-Response

2006
[Temporomandibular osteomyelitis secondary to progressive necrotizing otitis externa].
    Revue de stomatologie et de chirurgie maxillo-faciale, 2006, Volume: 107, Issue:3

    Topics: Aged; Anti-Bacterial Agents; Ciprofloxacin; Gentamicins; Humans; Male; Necrosis; Osteomyelitis; Otit

2006
Curcumin attenuates gentamicin-induced renal oxidative damage in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2006, Volume: 44, Issue:9

    Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Antioxidants; Curcumin; Disease Models, Animal

2006
The effects of inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl) lysine in gentamicin-induced acute tubular necrosis in rats.
    Bosnian journal of basic medical sciences, 2007, Volume: 7, Issue:4

    Topics: Animals; Enzyme Inhibitors; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Lysine; Mal

2007
Recognition and treatment of neonatal community-associated MRSA pneumonia and bacteremia.
    Pediatric pulmonology, 2008, Volume: 43, Issue:2

    Topics: Anti-Bacterial Agents; Antitubercular Agents; Bacteremia; Community-Acquired Infections; Drug Admini

2008
The effect of calcium channel blocker verapamil on gentamicin nephrotoxicity in rats.
    Bosnian journal of basic medical sciences, 2008, Volume: 8, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Calcium Channel Blockers; Gentamicins; Kidney;

2008
Gentamicin nephrotoxicity. I. Degree and permanence of acquired insensitivity.
    The Journal of laboratory and clinical medicine, 1982, Volume: 100, Issue:4

    Topics: Acute Kidney Injury; Animals; Gentamicins; Inulin; Kidney; Kidney Cortex; Male; Necrosis; Niacinamid

1982
[Skin necrosis induced by subcutaneous gentamicin].
    Presse medicale (Paris, France : 1983), 1984, Jun-16, Volume: 13, Issue:25

    Topics: Aged; Female; Gentamicins; Humans; Injections, Subcutaneous; Necrosis; Skin

1984
[Skin necrosis following administration of subcutaneous gentamicin].
    Presse medicale (Paris, France : 1983), 1984, Jun-16, Volume: 13, Issue:25

    Topics: Aged; Female; Gentamicins; Humans; Injections, Subcutaneous; Necrosis; Skin

1984
Corneal ulcer disease in Bangladesh.
    Annals of ophthalmology, 1983, Volume: 15, Issue:9

    Topics: Atropine; Bacitracin; Bangladesh; Combined Modality Therapy; Corneal Transplantation; Corneal Ulcer;

1983
Necrotizing external otitis. The importance of prolonged drug therapy.
    The Journal of laryngology and otology, 1984, Volume: 98, Issue:11

    Topics: Aged; Carbenicillin; Female; Gentamicins; Humans; Necrosis; Otitis Externa; Time Factors

1984
A 2'guanidyl derivative of gentamicin (S86451) with reduced nephrotoxicity studies at low and medium dose levels in the rat.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1984, Volume: 7

    Topics: Animals; DNA; Gentamicins; Kidney; Kidney Cortex; Kidney Tubules, Proximal; Lysosomes; Necrosis; Rat

1984
[High-dosage combination antibiotic treatment in severe therapy-resistant uveitis and necrotizing (chorio)retinitis].
    Klinische Monatsblatter fur Augenheilkunde, 1983, Volume: 183, Issue:3

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Chorioretinitis; Drug Therapy, Combination; Female; Gentam

1983
Retinal toxicity of intravitreal gentamicin. An electron microscopic study.
    Investigative ophthalmology & visual science, 1984, Volume: 25, Issue:5

    Topics: Animals; Gentamicins; Lysosomes; Microscopy, Electron; Necrosis; Pigment Epithelium of Eye; Rabbits;

1984
Pesticide induced muscle necrosis: mechanisms and prevention.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2

    Topics: Acetylcholine; Animals; Atropine; Cholinesterase Inhibitors; Echothiophate Iodide; Gentamicins; Inse

1984
Nephrotoxicity of the constituents of the gentamicin complex.
    The Journal of infectious diseases, 1984, Volume: 149, Issue:4

    Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Creatinine; Gentamicins; Kidney; Kidney

1984
Penetration of antibiotics into decubitus ulcers.
    The Journal of antimicrobial chemotherapy, 1981, Volume: 7, Issue:2

    Topics: Anti-Bacterial Agents; Cefazolin; Female; Gentamicins; Humans; Male; Necrosis; Pressure Ulcer; Pseud

1981
[Nephrotoxicity of gentamicin in mice].
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:10

    Topics: Animals; Female; Gentamicins; Injections, Intraperitoneal; Injections, Subcutaneous; Kidney Diseases

1982
Gentamicin nephrotoxicity. II. Definition of conditions necessary to induce acquired insensitivity.
    The Journal of laboratory and clinical medicine, 1982, Volume: 100, Issue:4

    Topics: Acute Kidney Injury; Animals; Gentamicins; Kidney Cortex; Kidney Tubules; Male; Necrosis; Rats; Rats

1982
[Chronic and insidious infections].
    Hefte zur Unfallheilkunde, 1982, Volume: 157

    Topics: Adult; Bone and Bones; Chronic Disease; Follow-Up Studies; Fracture Fixation, Internal; Fractures, C

1982
Pathogenesis of renal failure due to aminoglycosides and contrast media used in roentgenography.
    The American journal of medicine, 1980, Volume: 69, Issue:5

    Topics: Acute Kidney Injury; Aminoglycosides; Animals; Contrast Media; Dogs; Gentamicins; Humans; Kidney Tub

1980
Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats.
    Antimicrobial agents and chemotherapy, 1980, Volume: 18, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Gentamicins; Kidney; Kidney Function Tests; Male; Necrosis; Netilmic

1980
Effect of fish oil treatment on gentamicin nephrotoxicity in rats.
    Annals of nutrition & metabolism, 1994, Volume: 38, Issue:6

    Topics: Acetylglucosaminidase; Animals; Creatinine; Dose-Response Relationship, Drug; Fish Oils; Gentamicins

1994
[Systemic infection due to group A Streptococcus pyogenes].
    Deutsche medizinische Wochenschrift (1946), 1995, May-12, Volume: 120, Issue:19

    Topics: Fasciitis; Female; Gallium Radioisotopes; Gentamicins; Humans; Injections, Intravenous; Middle Aged;

1995
Effect of gentamicin-induced nephrotoxicity on some carbohydrate metabolic pathways in the rat renal cortex.
    Archives of toxicology, 1994, Volume: 68, Issue:10

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Creatinine; Dose-Response Relationship,

1994
Nephrotoxicity of gentamicin and co-trimoxazole combination in rats.
    General pharmacology, 1994, Volume: 25, Issue:6

    Topics: Animals; Blood Urea Nitrogen; Drug Therapy, Combination; Gentamicins; Kidney; Necrosis; Potassium; R

1994
Influence of iron, deferoxamine and ascorbic acid on gentamicin-induced nephrotoxicity in rats.
    General pharmacology, 1994, Volume: 25, Issue:6

    Topics: Animals; Ascorbic Acid; Blood Urea Nitrogen; Creatinine; Deferoxamine; Dose-Response Relationship, D

1994
Effect of NG-nitro-L-arginine methyl ester on nephrotoxicity induced by gentamicin in rats.
    Nephron, 1995, Volume: 71, Issue:2

    Topics: Animals; Arginine; Blood Pressure; Creatinine; Enzyme Inhibitors; Gentamicins; Kidney; Kidney Diseas

1995
Gentamicin-induced nephrotoxicosis in lambs.
    Research in veterinary science, 1996, Volume: 61, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Blood Cell Count; Creatinine; Edema; Female; Gentamicins; Hemorrhage

1996
Descending necrotizing mediastinitis secondary to pharyngitis. A case report.
    Scandinavian cardiovascular journal : SCJ, 1997, Volume: 31, Issue:4

    Topics: Adult; Clindamycin; Combined Modality Therapy; Drainage; Drug Therapy, Combination; Female; Gentamic

1997
Cell death during corneal storage at 4 degrees C.
    Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:12

    Topics: Adult; Apoptosis; Child, Preschool; Chondroitin Sulfates; Complex Mixtures; Cornea; Cryopreservation

1999
A case of Fournier gangrene complicating idiopathic nephrotic syndrome of childhood.
    Pediatric nephrology (Berlin, Germany), 1999, Volume: 13, Issue:9

    Topics: Amoxicillin; Child; Fournier Gangrene; Gentamicins; Glucocorticoids; Humans; Male; Necrosis; Nephrot

1999
Effect of high dietary cholesterol on gentamicin-induced nephrotoxicity in rabbits.
    Archives of toxicology, 2001, Volume: 75, Issue:5

    Topics: Alkaline Phosphatase; Animals; Anti-Bacterial Agents; Cholesterol, Dietary; Creatinine; Drug Synergi

2001
Metastic gangrene of the lid in Pseudomonas septicemia.
    Annals of ophthalmology, 1975, Volume: 7, Issue:5

    Topics: Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Eyelid Diseases; Female; Gangrene; Gentamicins; H

1975
Progressive necrotizing external otitis: treatment with ticarcillin and tobramycin.
    The Laryngoscope, 1977, Volume: 87, Issue:11

    Topics: Anti-Bacterial Agents; Carbenicillin; Cranial Nerves; Drug Therapy, Combination; Ear, External; Gent

1977
Glucocorticoid and antibiotic effects on hepatic microcirculation and associated host responses in lethal gram-negative bacteremia.
    Laboratory investigation; a journal of technical methods and pathology, 1979, Volume: 40, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Bilirubin; Disseminated Intravascular Coagulation; Drug Therapy, Com

1979
An unusual case of necrotizing otitis externa.
    The Journal of laryngology and otology, 1978, Volume: 92, Issue:3

    Topics: Aged; Facial Paralysis; Gentamicins; Humans; Male; Necrosis; Otitis Externa; Pseudomonas Infections

1978
Gentamicin and tobramycin nephrotoxicity. A morphologic and functional comparison in the rat.
    The American journal of pathology, 1978, Volume: 93, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Creatinine; Cytoplasm; Dose-Response Relationsh

1978
Diffuse necrosis of the renal medulla in an infant.
    Nephron, 1977, Volume: 18, Issue:3

    Topics: Gentamicins; Humans; Infant; Kidney; Kidney Medulla; Male; Necrosis

1977
Management of infected fractures. Osteomyelitis.
    The Veterinary clinics of North America, 1975, Volume: 5, Issue:2

    Topics: Acute Disease; Animals; Anti-Bacterial Agents; Bone Plates; Bone Screws; Bone Transplantation; Chron

1975
Nodular subcutaneous fat necrosis. A manifestation of silent pancreatitis.
    Archives of dermatology, 1975, Volume: 111, Issue:7

    Topics: Adipose Tissue; Alcoholism; Biopsy; Blood; Cephalothin; Diagnosis, Differential; Gentamicins; Humans

1975
Necrotic stomatitis in a dolphin.
    Journal of wildlife diseases, 1975, Volume: 11, Issue:4

    Topics: Animals; Dolphins; Gentamicins; Male; Mouth; Necrosis; Penicillin G Procaine; Stomatitis

1975
Renal damage caused by gentamicin: a study of the effects on renal morphology and urinary enzyme excretion.
    The Journal of pathology, 1976, Volume: 118, Issue:3

    Topics: Acetylglucosaminidase; Alkaline Phosphatase; Animals; Galactosidases; Gentamicins; Kidney; Kidney Di

1976
The protection against gentamicin nephrotoxicity in the streptozotocin-induced diabetic rat is not related to gender.
    Life sciences, 1992, Volume: 51, Issue:22

    Topics: Animals; Creatinine; Diabetes Mellitus, Experimental; Female; Gentamicins; Glomerular Filtration Rat

1992
Epidermal growth factor accelerates renal tissue repair in a model of gentamicin nephrotoxicity in rats.
    The American journal of physiology, 1992, Volume: 263, Issue:5 Pt 2

    Topics: Animals; Cell Division; DNA; Epidermal Growth Factor; Female; Gentamicins; Kidney; Kidney Cortex; Ki

1992
Fatal necrotizing fasciitis of dental origin.
    Journal (Canadian Dental Association), 1992, Volume: 58, Issue:1

    Topics: Adult; Bacteroides Infections; Candidiasis; Cefotaxime; Clindamycin; Cloxacillin; Fasciitis; Female;

1992
Conjunctival necrosis after administration of topical fortified aminoglycosides.
    American journal of ophthalmology, 1991, Jun-15, Volume: 111, Issue:6

    Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Conjunct

1991
Influence of exogenous protease inhibitor (Bowmann-Birk inhibitor) in gentamicin-induced nephrotoxicity in rats.
    Contributions to nephrology, 1990, Volume: 83

    Topics: Animals; Female; Gentamicins; Glomerular Filtration Rate; Kidney Diseases; Necrosis; Proteinuria; Ra

1990
Skin necrosis after injection of aminosides. Arthus reaction, local toxicity, thrombotic process or pathergy?
    Dermatologica, 1990, Volume: 180, Issue:4

    Topics: Arthus Reaction; Drug Eruptions; Female; Gentamicins; Humans; Injections, Intramuscular; Necrosis; N

1990
Protective effect of KCl loading in gentamicin nephrotoxicity.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1990, Volume: 15, Issue:6

    Topics: Animals; Gentamicins; Kidney; Kidney Function Tests; Kidney Tubules, Proximal; Necrosis; Potassium C

1990
[Treatment of suppurative-necrotic processes in the controlled germ-free environment with drug aerosols].
    Khirurgiia, 1990, Issue:9

    Topics: Adult; Aerosols; Aged; Bacterial Infections; Equipment Design; Gentamicins; Humans; Middle Aged; Nec

1990
Phenolsulfonphthalein pharmacokinetics and renal morphologic changes in adult pony mares with gentamicin-induced nephrotoxicosis.
    American journal of veterinary research, 1989, Volume: 50, Issue:11

    Topics: Animals; Epithelium; Female; Gentamicins; Horses; Kidney; Kidney Tubules, Proximal; Microscopy, Elec

1989
Polyaspartic acid prevents experimental aminoglycoside nephrotoxicity.
    The Journal of infectious diseases, 1989, Volume: 159, Issue:5

    Topics: Animals; Drug Therapy, Combination; Gentamicins; Immunoenzyme Techniques; Immunohistochemistry; Kidn

1989
Effects of enteral and intravenous antimicrobial treatment on survival following intestinal ischemia in rats.
    The Journal of surgical research, 1989, Volume: 46, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Drug Therapy, Combination; Gentamicins; Gram-Ne

1989
Gentamicin and gram-negative bacteremia. A synergism for the development of experimental nephrotoxic acute renal failure.
    The Journal of clinical investigation, 1986, Volume: 78, Issue:1

    Topics: Acute Kidney Injury; Animals; Blood Pressure; Drug Synergism; Endotoxins; Escherichia coli; Female;

1986
[Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration].
    The Journal of toxicological sciences, 1988, Volume: 13 Suppl 1

    Topics: Animals; Cefazolin; Cefmetazole; Cefotaxime; Cephaloridine; Drug Administration Schedule; Drug Thera

1988
A focus of tissue necrosis increases renal susceptibility to gentamicin administration.
    Kidney international, 1988, Volume: 33, Issue:1

    Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Female; Gentamicins; Kidney; Necrosis

1988
Gentamicin nephrotoxicity in the setting of acute renal hypoperfusion.
    The American journal of physiology, 1988, Volume: 254, Issue:4 Pt 2

    Topics: Adenine Nucleotides; Animals; Blood Urea Nitrogen; Creatinine; Female; Gentamicins; Kidney; Kidney T

1988
Necrotizing otitis externa (a new aid to management).
    The Journal of laryngology and otology, 1988, Volume: 102, Issue:8

    Topics: Aged; Drug Implants; Female; Gentamicins; Humans; Necrosis; Otitis Externa

1988
Comparative effects of gentamicin, amikacin and dactimicin on excretion of N-acetyl-beta-D-glucosaminidase (NAG) and kidney histological pattern in rats.
    Drugs under experimental and clinical research, 1987, Volume: 13, Issue:12

    Topics: Acetylglucosaminidase; Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Creatinine; Gentam

1987
[Local irritation study with isepamicin].
    The Japanese journal of antibiotics, 1986, Volume: 39, Issue:12

    Topics: Animals; Atrophy; Blood Vessels; Edema; Fibrosis; Gentamicins; Hemorrhage; Injections, Intramuscular

1986
Acute ischemic retinopathy due to gentamicin injection.
    JAMA, 1986, Oct-03, Volume: 256, Issue:13

    Topics: Acute Disease; Gentamicins; Humans; Ischemia; Medication Errors; Necrosis; Retinal Diseases

1986
Exaggerated response to gentamicin-induced nephrotoxicity in Sprague-Dawley rats: identification of a highly sensitive outlier population.
    Toxicologic pathology, 1986, Volume: 14, Issue:2

    Topics: Animals; Blood Urea Nitrogen; Creatinine; Gentamicins; Kidney Diseases; Kidney Tubules; Kinetics; Ma

1986
Limb salvage in a diabetic with necrotizing fasciitis: case report and literature review.
    Foot & ankle, 1986, Volume: 6, Issue:4

    Topics: Ankle; Clindamycin; Debridement; Diabetes Mellitus, Type 1; Fasciitis; Female; Foot; Gentamicins; Hu

1986
Chronic gentamicin nephrotoxicity. Continued tubular injury with preserved glomerular filtration function.
    The American journal of pathology, 1986, Volume: 123, Issue:1

    Topics: Acute Kidney Injury; Autoradiography; Drug Resistance; Gentamicins; Glomerular Filtration Rate; Hist

1986
Effect of amiloride on experimental gentamicin nephrotoxicity.
    Nephron, 1985, Volume: 40, Issue:2

    Topics: Amiloride; Animals; Diet; Drug Interactions; Gentamicins; Inulin; Kidney; Kidney Cortex; Kidney Dise

1985
Modification of experimental gentamicin nephrotoxicity by selective parathyroidectomy.
    The American journal of physiology, 1985, Volume: 249, Issue:6 Pt 2

    Topics: Animals; Blood Urea Nitrogen; Calcium; Calcium, Dietary; Creatinine; Gentamicins; Humans; Kidney; Ki

1985
[Necrotic lesions caused by subcutaneous injections of gentamycin and sisomicin].
    Annales de dermatologie et de venereologie, 1985, Volume: 112, Issue:9

    Topics: Aged; Female; Gentamicins; Humans; Injections, Subcutaneous; Middle Aged; Necrosis; Sisomicin; Skin

1985
Clinical manifestations of halophilic non-cholera Vibrio infections.
    Lancet (London, England), 1974, Nov-30, Volume: 2, Issue:7892

    Topics: Aged; Ampicillin; Cephalothin; Clindamycin; Diarrhea; Feces; Foodborne Diseases; Gangrene; Gentamici

1974
Experimental pseudomonas osteomyelitis: treatment with sisomicin and carbenicillin.
    The Journal of bone and joint surgery. American volume, 1974, Volume: 56, Issue:7

    Topics: Aminoglycosides; Animals; Autopsy; Carbenicillin; Disease Models, Animal; Drug Therapy, Combination;

1974
[Renal tolerance of gentamicin].
    Semaine des hopitaux. Therapeutique, 1974, Volume: 50, Issue:9

    Topics: Animals; Cats; Dogs; Drug Tolerance; Gentamicins; Humans; Kidney Diseases; Necrosis; Rats; Uremia

1974
Tissue antibiotic penetration in streptococcal gangrene.
    The Johns Hopkins medical journal, 1973, Volume: 133, Issue:1

    Topics: Amputation, Surgical; Anti-Bacterial Agents; Cephalothin; Debridement; Gangrene; Gentamicins; Humans

1973
Intestinal stenosis and enterocyst formation as late complications of neonatal necrotizing enterocolitis.
    Journal of pediatric surgery, 1973, Volume: 8, Issue:4

    Topics: Clostridium Infections; Colectomy; Colon, Sigmoid; Colonic Diseases; Colostomy; Cysts; Enterocolitis

1973
Necrotizing enterocolitis. An emerging entity in the regional infant intensive care facility.
    Archives of surgery (Chicago, Ill. : 1960), 1974, Volume: 109, Issue:2

    Topics: Ampicillin; Apgar Score; Birth Weight; Catheterization; Disseminated Intravascular Coagulation; Ente

1974
Nosocomial colonization with Klebsiella, type 26, in a neonatal intensive-care unit associated with an outbreak of sepsis, meningitis, and necrotizing enterocolitis.
    The Journal of pediatrics, 1974, Volume: 85, Issue:3

    Topics: Brain; Cephalothin; Cross Infection; Culture Media; Disease Outbreaks; Drug Resistance, Microbial; E

1974
Ecthyma gangrenosum: full thickness nasal slough.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1973, Volume: 98, Issue:3

    Topics: Carbenicillin; Cartilage; Debridement; Ecthyma; Female; Gangrene; Gentamicins; Humans; Infant, Newbo

1973
Nephrotoxicity of gentamicin.
    Laboratory investigation; a journal of technical methods and pathology, 1974, Volume: 30, Issue:1

    Topics: Acid Phosphatase; Acute Kidney Injury; Animals; Anuria; Blood Urea Nitrogen; Body Weight; Dose-Respo

1974
Granulomatous disease with acid-fast bacilli.
    Archives of disease in childhood, 1971, Volume: 46, Issue:250

    Topics: Antibodies; Bacteria; Bone Diseases; Child, Preschool; Female; Gentamicins; Granuloma; Humans; Lymph

1971
[Use of 8-mercaptoadenine for the prevention of nephrotoxic effects of some antibiotics].
    Antibiotiki, 1969, Volume: 14, Issue:11

    Topics: Acid Phosphatase; Animals; Fats; Gentamicins; Guinea Pigs; Kanamycin; Kidney; Kidney Diseases; Mice;

1969