Page last updated: 2024-08-07 18:37:20

Cyclin-dependent kinase 7

A cyclin-dependent kinase 7 that is encoded in the genome of human. [PRO:DNx]

Synonyms

EC 2.7.11.22;
EC 2.7.11.23;
39 kDa protein kinase;
p39 Mo15;
CDK-activating kinase 1;
Cell division protein kinase 7;
Serine/threonine-protein kinase 1;
TFIIH basal transcription factor complex kinase subunit

Research

Bioassay Publications (61)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's15 (24.59)29.6817
2010's32 (52.46)24.3611
2020's14 (22.95)2.80

Compounds (273)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gw8510Homo sapiens (human)IC500.317011
nu6102Homo sapiens (human)IC503.766733
indirubinHomo sapiens (human)IC502.200011
staurosporineHomo sapiens (human)IC500.279355
cyc 202Homo sapiens (human)IC500.56351721
2H-pyrazolo[4,3-b]quinoxalin-3-amineHomo sapiens (human)IC5020.000011
6-bromoindirubin-3'-oximeHomo sapiens (human)IC503.500011
purvalanol aHomo sapiens (human)IC500.049713
2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dioneHomo sapiens (human)IC5020.000011
cgp 60474Homo sapiens (human)IC500.200011
cid755673Homo sapiens (human)IC5021.525014
cgp 74514aHomo sapiens (human)IC500.279011
1,4-dimethoxy-10H-acridine-9-thioneHomo sapiens (human)IC5020.000011
bms 387032Homo sapiens (human)IC500.077388
harmineHomo sapiens (human)IC5010.000011
wogoninHomo sapiens (human)IC5012.300011
alvocidibHomo sapiens (human)IC500.336566
su 9516Homo sapiens (human)IC500.905011
arcyriaflavin aHomo sapiens (human)IC5020.000011
palbociclibHomo sapiens (human)IC507.777733
palbociclibHomo sapiens (human)Ki5.000011
cyc 116Homo sapiens (human)Ki10.000022
cvt 313Homo sapiens (human)IC509.200011
jnj 10198409Homo sapiens (human)IC5033.350022
leucettamine bHomo sapiens (human)IC5010.000011
nu 6140Homo sapiens (human)IC502.300011
rgb 286638Homo sapiens (human)IC500.002011
at 7519Homo sapiens (human)IC502.400022
at 7519Homo sapiens (human)Ki2.800011
pf 573228Homo sapiens (human)IC500.598522
crizotinibHomo sapiens (human)IC5010.000011
pha 767491Homo sapiens (human)IC5010.000011
pha 848125Homo sapiens (human)IC500.190033
14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaeneHomo sapiens (human)IC500.025733
p276-00Homo sapiens (human)IC502.870011
cink4Homo sapiens (human)IC5010.000011
ldc067Homo sapiens (human)IC5020.000011
bs 194Homo sapiens (human)IC500.250022
(R)-DRF053Homo sapiens (human)IC500.822011
pf 3758309Homo sapiens (human)IC500.007011
ribociclibHomo sapiens (human)IC5020.000011
bay 1000394Homo sapiens (human)IC500.021055
pha 793887Homo sapiens (human)IC500.010011
abemaciclibHomo sapiens (human)IC502.027044
abemaciclibHomo sapiens (human)Ki3.910011
dinaciclibHomo sapiens (human)IC500.127333
gilteritinibHomo sapiens (human)Ki5.000011
longdaysinHomo sapiens (human)IC5032.000011
bs-181Homo sapiens (human)IC500.066255
on123300Homo sapiens (human)IC506.000011
ldc4297Homo sapiens (human)IC500.003433
ly2857785Homo sapiens (human)IC500.246011
THZ531Homo sapiens (human)IC504.402544
can 508Homo sapiens (human)IC5025.2846413
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)Homo sapiens (human)IC5010.000011
ro 3306Homo sapiens (human)IC5017.400011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
fasudilHomo sapiens (human)Kd30.000011
4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazolineHomo sapiens (human)Kd30.000011
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd16.666733
triciribine phosphateHomo sapiens (human)Kd30.000011
staurosporineHomo sapiens (human)Kd0.045022
picropodophyllinHomo sapiens (human)Kd30.000011
gefitinibHomo sapiens (human)Kd13.536733
lestaurtinibHomo sapiens (human)Kd10.058033
perifosineHomo sapiens (human)Kd30.000011
vatalanibHomo sapiens (human)Kd16.666733
ruboxistaurinHomo sapiens (human)Kd13.900033
canertinibHomo sapiens (human)Kd16.666733
birb 796Homo sapiens (human)Kd6.550022
cyc 202Homo sapiens (human)Kd2.752522
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd16.300022
erlotinibHomo sapiens (human)Kd16.666733
lapatinibHomo sapiens (human)Kd16.666733
sorafenibHomo sapiens (human)Kd7.605044
pd 173955Homo sapiens (human)Kd10.000011
s 1033Homo sapiens (human)Kd20.000022
xl147Homo sapiens (human)Kd30.000011
bms 387032Homo sapiens (human)Kd0.354733
sf 2370Homo sapiens (human)Kd30.000011
tandutinibHomo sapiens (human)Kd13.275044
vx-745Homo sapiens (human)Kd10.000022
dasatinibHomo sapiens (human)Kd16.666733
ha 1100Homo sapiens (human)Kd30.000011
7-epi-hydroxystaurosporineHomo sapiens (human)Kd30.000011
zd 6474Homo sapiens (human)Kd14.700033
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
imd 0354Homo sapiens (human)Kd30.000011
sirolimusHomo sapiens (human)Kd30.000011
alvocidibHomo sapiens (human)Kd0.240333
bosutinibHomo sapiens (human)Kd15.600022
orantinibHomo sapiens (human)Kd30.000011
su 11248Homo sapiens (human)Kd0.548044
palbociclibHomo sapiens (human)Kd30.000011
jnj-7706621Homo sapiens (human)Kd0.760011
vx680Homo sapiens (human)Kd16.666733
cyc 116Homo sapiens (human)Kd30.000011
everolimusHomo sapiens (human)Kd30.000011
ekb 569Homo sapiens (human)Kd20.000022
axitinibHomo sapiens (human)Kd20.000022
abt-100Homo sapiens (human)Kd10.000010
temsirolimusHomo sapiens (human)Kd30.000011
pd 184352Homo sapiens (human)Kd10.000011
on 01910Homo sapiens (human)Kd30.000011
av 412Homo sapiens (human)Kd30.000011
telatinibHomo sapiens (human)Kd30.000011
y-39983Homo sapiens (human)Kd30.000011
cp 547632Homo sapiens (human)Kd30.000011
bms345541Homo sapiens (human)Kd0.680011
lenvatinibHomo sapiens (human)Kd30.000011
pd 0325901Homo sapiens (human)Kd30.000011
midostaurinHomo sapiens (human)Kd15.000044
px-866Homo sapiens (human)Kd30.000011
ripasudilHomo sapiens (human)Kd30.000011
osi 930Homo sapiens (human)Kd30.000011
ki 20227Homo sapiens (human)Kd10.000011
scio-469Homo sapiens (human)Kd30.000011
cp 724714Homo sapiens (human)Kd20.000022
pi103Homo sapiens (human)Kd8.600022
hmn-214Homo sapiens (human)Kd30.000011
tivozanibHomo sapiens (human)Kd30.000011
hki 272Homo sapiens (human)Kd17.550022
tofacitinibHomo sapiens (human)Kd16.666733
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd20.000022
masitinibHomo sapiens (human)Kd23.333323
ly-2157299Homo sapiens (human)Kd30.000011
pazopanibHomo sapiens (human)Kd16.666733
azd 6244Homo sapiens (human)Kd20.000022
su 14813Homo sapiens (human)Kd10.620033
bibw 2992Homo sapiens (human)Kd20.000022
pik 75Homo sapiens (human)Kd0.002511
binimetinibHomo sapiens (human)Kd30.000011
sotrastaurinHomo sapiens (human)Kd30.000011
aee 788Homo sapiens (human)Kd30.000011
saracatinibHomo sapiens (human)Kd30.000011
vx 702Homo sapiens (human)Kd30.000011
crenolanibHomo sapiens (human)Kd30.000011
tg100-115Homo sapiens (human)Kd20.000022
cc 401Homo sapiens (human)Kd30.000011
bms 599626Homo sapiens (human)Kd30.000011
exel-7647Homo sapiens (human)Kd30.000011
volasertibHomo sapiens (human)Kd30.000011
pha 665752Homo sapiens (human)Kd0.130011
azd 7762Homo sapiens (human)Kd30.000011
regorafenibHomo sapiens (human)Kd30.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd18.850022
brivanibHomo sapiens (human)Kd20.000022
mp470Homo sapiens (human)Kd30.000011
rgb 286638Homo sapiens (human)Kd0.154011
np 031112Homo sapiens (human)Kd30.000011
at 7519Homo sapiens (human)Kd2.031922
bms-690514Homo sapiens (human)Kd30.000011
bi 2536Homo sapiens (human)Kd16.750022
inno-406Homo sapiens (human)Kd30.000011
nvp-ast487Homo sapiens (human)Kd0.004622
kw 2449Homo sapiens (human)Kd1.795522
danusertibHomo sapiens (human)Kd0.108011
abt 869Homo sapiens (human)Kd11.933333
azd 8931Homo sapiens (human)Kd30.000011
arq 197Homo sapiens (human)Kd30.000011
azd 1152Homo sapiens (human)Kd30.000011
pf 00299804Homo sapiens (human)Kd30.000011
ridaforolimusHomo sapiens (human)Kd30.000011
ch 4987655Homo sapiens (human)Kd30.000011
6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylprpyl)-3-pyridinecarboxamideHomo sapiens (human)Kd30.000011
cc-930Homo sapiens (human)Kd30.000011
gw 2580Homo sapiens (human)Kd10.000022
tak 285Homo sapiens (human)Kd30.000011
idelalisibHomo sapiens (human)Kd30.000011
crizotinibHomo sapiens (human)Kd15.165022
osi 906Homo sapiens (human)Kd30.000011
chir-265Homo sapiens (human)Kd16.666733
motesanibHomo sapiens (human)Kd16.666733
fostamatinibHomo sapiens (human)Kd30.000011
trametinibHomo sapiens (human)Kd30.000011
mln8054Homo sapiens (human)Kd16.666733
pf-562,271Homo sapiens (human)Kd1.334011
GDC-0879Homo sapiens (human)Kd10.000011
jnj-26483327Homo sapiens (human)Kd30.000011
ly2603618Homo sapiens (human)Kd30.000011
tg100801Homo sapiens (human)Kd30.000011
dactolisibHomo sapiens (human)Kd30.000011
bgt226Homo sapiens (human)Kd30.000012
gsk 461364Homo sapiens (human)Kd18.850022
azd 1152-hqpaHomo sapiens (human)Kd14.133333
nvp-tae684Homo sapiens (human)Kd0.190011
enmd 2076Homo sapiens (human)Kd30.000011
e 7050Homo sapiens (human)Kd30.000011
2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinoneHomo sapiens (human)Kd30.000011
tak-901Homo sapiens (human)Kd0.205011
gdc-0973Homo sapiens (human)Kd30.000011
buparlisibHomo sapiens (human)Kd30.000011
azd 1480Homo sapiens (human)Kd30.000011
azd8330Homo sapiens (human)Kd30.000011
pha 848125Homo sapiens (human)Kd0.285011
ro5126766Homo sapiens (human)Kd30.000011
fedratinibHomo sapiens (human)Kd15.060022
gsk690693Homo sapiens (human)Kd20.000022
14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaeneHomo sapiens (human)Kd0.473011
azd5438Homo sapiens (human)Kd2.332011
pf 04217903Homo sapiens (human)Kd30.000011
gdc 0941Homo sapiens (human)Kd20.000022
icotinibHomo sapiens (human)Kd30.000011
ph 797804Homo sapiens (human)Kd30.000011
kx-01Homo sapiens (human)Kd30.000011
plx 4720Homo sapiens (human)Kd10.000011
mk 5108Homo sapiens (human)Kd30.000011
cx 4945Homo sapiens (human)Kd7.124011
cudc 101Homo sapiens (human)Kd30.000011
arry-614Homo sapiens (human)Kd30.000011
tak 593Homo sapiens (human)Kd30.000011
mln 8237Homo sapiens (human)Kd30.000011
sgx 523Homo sapiens (human)Kd20.000022
bms 754807Homo sapiens (human)Kd30.000011
bms 777607Homo sapiens (human)Kd30.000011
sgi 1776Homo sapiens (human)Kd30.000011
pci 32765Homo sapiens (human)Kd30.000011
ponatinibHomo sapiens (human)Kd30.000011
amg 900Homo sapiens (human)Kd30.000011
mk-1775Homo sapiens (human)Kd30.000011
AMG-208Homo sapiens (human)Kd30.000011
quizartinibHomo sapiens (human)Kd16.666733
at13148Homo sapiens (human)Kd30.000011
tak 733Homo sapiens (human)Kd30.000011
mk 2206Homo sapiens (human)Kd30.000011
sns 314Homo sapiens (human)Kd30.000011
lucitanibHomo sapiens (human)Kd30.000011
pf-04691502Homo sapiens (human)Kd30.000011
n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamideHomo sapiens (human)Kd30.000011
dcc-2036Homo sapiens (human)Kd30.000011
cabozantinibHomo sapiens (human)Kd30.000011
defactinibHomo sapiens (human)Kd1.744011
ly2584702Homo sapiens (human)Kd30.000011
incb-018424Homo sapiens (human)Kd16.650022
poziotinibHomo sapiens (human)Kd30.000011
asp3026Homo sapiens (human)Kd30.000011
entrectinibHomo sapiens (human)Kd30.000011
pexidartinibHomo sapiens (human)Kd30.000011
TAK-580Homo sapiens (human)Kd30.000011
gsk 2126458Homo sapiens (human)Kd30.000011
emd1214063Homo sapiens (human)Kd30.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
pf 3758309Homo sapiens (human)Kd0.003011
gdc 0980Homo sapiens (human)Kd30.000011
azd2014Homo sapiens (human)Kd30.000011
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanolHomo sapiens (human)Kd30.000011
plx4032Homo sapiens (human)Kd30.000011
gsk 1363089Homo sapiens (human)Kd15.001822
arry-334543Homo sapiens (human)Kd30.000011
kin-193Homo sapiens (human)Kd30.000011
mk 2461Homo sapiens (human)Kd30.000011
bay 869766Homo sapiens (human)Kd30.000011
as 703026Homo sapiens (human)Kd30.000011
baricitinibHomo sapiens (human)Kd30.000011
dabrafenibHomo sapiens (human)Kd30.000011
pki 587Homo sapiens (human)Kd30.000011
n-(3-fluoro-4-((1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5 yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamideHomo sapiens (human)Kd30.000011
ribociclibHomo sapiens (human)Kd30.000011
mk-8033Homo sapiens (human)Kd30.000011
pha 793887Homo sapiens (human)Kd0.008011
sb 1518Homo sapiens (human)Kd30.000011
abemaciclibHomo sapiens (human)Kd30.000011
mk-8776Homo sapiens (human)Kd30.000011
afuresertibHomo sapiens (human)Kd30.000012
gsk 1070916Homo sapiens (human)Kd30.000011
jnj38877605Homo sapiens (human)Kd30.000011
dinaciclibHomo sapiens (human)Kd0.411011
gilteritinibHomo sapiens (human)Kd30.000011
alectinibHomo sapiens (human)Kd30.000011
glpg0634Homo sapiens (human)Kd30.000011
encorafenibHomo sapiens (human)Kd30.000011
bms-911543Homo sapiens (human)Kd30.000011
gsk2141795Homo sapiens (human)Kd1.127011
azd8186Homo sapiens (human)Kd30.000011
byl719Homo sapiens (human)Kd30.000011
cep-32496Homo sapiens (human)Kd30.000012
rociletinibHomo sapiens (human)Kd30.000011
ceritinibHomo sapiens (human)Kd30.000011
azd1208Homo sapiens (human)Kd30.000011
vx-509Homo sapiens (human)Kd30.000011
debio 1347Homo sapiens (human)Kd30.000011
volitinibHomo sapiens (human)Kd30.000011
osimertinibHomo sapiens (human)Kd30.000012
at 9283Homo sapiens (human)Kd30.000012
otssp167Homo sapiens (human)Kd0.157011
chir 258Homo sapiens (human)Kd11.733333
osi 027Homo sapiens (human)Kd30.000011
nintedanibHomo sapiens (human)Kd15.150022
bay 80-6946Homo sapiens (human)Kd30.000011
pp242Homo sapiens (human)Kd5.500011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
cyc 202Homo sapiens (human)INH24.500011
olomoucine iiHomo sapiens (human)INH11.400011

Enables

This protein enables 8 target(s):

TargetCategoryDefinition
protein kinase activitymolecular functionCatalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]
protein serine/threonine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
ATP-dependent activity, acting on DNAmolecular functionCatalytic activity that acts to modify DNA, driven by ATP hydrolysis. [GOC:pdt]
RNA polymerase II CTD heptapeptide repeat kinase activitymolecular functionCatalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. [EC:2.7.11.23, GOC:mah, PMID:28248323]
protein serine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]
cyclin-dependent protein serine/threonine kinase activitymolecular functionCyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]

Located In

This protein is located in 7 target(s):

TargetCategoryDefinition
fibrillar centercellular componentA structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]
male germ cell nucleuscellular componentThe nucleus of a male germ cell, a reproductive cell in males. [CL:0000015, GOC:hjd, GOC:mtg_sensu]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
perinuclear region of cytoplasmcellular componentCytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 5 target(s):

TargetCategoryDefinition
cyclin-dependent protein kinase holoenzyme complexcellular componentCyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. [GOC:krc, PMID:11602261]
transcription factor TFIIH core complexcellular componentThe 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD. [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]
transcription factor TFIIH holo complexcellular componentA complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
CAK-ERCC2 complexcellular componentA protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2. [PMID:8692841, PMID:8692842]
transcription factor TFIIK complexcellular componentA transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7. [GOC:mah, PMID:19818408, PMID:22572993]

Involved In

This protein is involved in 10 target(s):

TargetCategoryDefinition
DNA repairbiological processThe process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
transcription by RNA polymerase IIbiological processThe synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
transcription initiation at RNA polymerase II promoterbiological processA transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II. [GOC:mah, GOC:txnOH]
snRNA transcription by RNA polymerase IIbiological processThe synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter. [GOC:jl, ISBN:0321000382]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
protein stabilizationbiological processAny process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai]
cell divisionbiological processThe process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]
regulation of cell cyclebiological processAny process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb]
regulation of G1/S transition of mitotic cell cyclebiological processAny signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]
protein phosphorylationbiological processThe process of introducing a phosphate group on to a protein. [GOC:hb]