Fatty acid-binding protein, intestinal

A fatty acid-binding protein, intestinal that is encoded in the genome of human. [PRO:DNx, UniProtKB:P12104]

Fatty acid-binding protein 2;
Intestinal-type fatty acid-binding protein;
I-FABP

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
palmitic acid	Homo sapiens (human)	IC50	1.7000	1	1
1-anilino-8-naphthalenesulfonate	Homo sapiens (human)	Ki	31.1000	1	1
clofibric acid	Homo sapiens (human)	Ki	17.7000	1	1
diclofenac	Homo sapiens (human)	Ki	86.3000	1	1
fenofibrate	Homo sapiens (human)	Ki	6.1000	1	1
flufenamic acid	Homo sapiens (human)	Ki	15.5000	1	1
flurbiprofen	Homo sapiens (human)	Ki	24.1333	2	3
ibuprofen	Homo sapiens (human)	Ki	263.5000	1	1
ketoprofen	Homo sapiens (human)	Ki	82.4000	1	1
ketorolac	Homo sapiens (human)	Ki	9.4000	1	1
meclofenamic acid	Homo sapiens (human)	Ki	8.9000	1	1
bezafibrate	Homo sapiens (human)	Ki	33.0000	1	1
fenofibric acid	Homo sapiens (human)	Ki	1.0000	1	1
11-(dansylamino)undecanoic acid	Homo sapiens (human)	Ki	0.3000	1	1
tolfenamic acid	Homo sapiens (human)	Ki	6.1000	1	1
HTS 01037	Homo sapiens (human)	Ki	6.5700	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1-anilino-8-naphthalenesulfonate	Homo sapiens (human)	Kd	13.3000	1	1
fenofibrate	Homo sapiens (human)	Kd	4.4100	1	1
ketorolac	Homo sapiens (human)	Kd	56.7000	1	1
11-(dansylamino)undecanoic acid	Homo sapiens (human)	Kd	0.3600	1	1
gw 7647	Homo sapiens (human)	Kd	1.3000	1	1
l-165041	Homo sapiens (human)	Kd	7.2000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-phenoxyphenol	Homo sapiens (human)	K1	0.5000	1	1
2-phenoxyphenol	Homo sapiens (human)	K2	0.4000	1	1
2,2'-bisphenol f	Homo sapiens (human)	K1	53.0000	1	1
2,2'-bisphenol f	Homo sapiens (human)	K2	30.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
long-chain fatty acid transmembrane transporter activity	molecular function	Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [ISBN:0198506732]
fatty acid binding	molecular function	Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
long-chain fatty acid binding	molecular function	Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:pm, PMID:12641450]

This protein is located in 3 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
microvillus	cellular component	Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. [ISBN:0815316194]
apical cortex	cellular component	The region that lies just beneath the plasma membrane on the apical edge of a cell. [GOC:bf]

This protein is active in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is involved in 4 target(s):

Target	Category	Definition
fatty acid metabolic process	biological process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]
long-chain fatty acid transport	biological process	The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ai]
intestinal lipid absorption	biological process	A process in which lipids are taken up from the contents of the intestine. [GOC:dos, GOC:sl, PMID:18768481]
fatty acid transport	biological process	The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [GOC:ai]