necrostatin-5 has been researched along with Necrosis* in 1 studies
1 other study(ies) available for necrostatin-5 and Necrosis
| Article | Year |
|---|---|
Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5.
Necrostatin-5 (Nec-5) is a novel potent small-molecule inhibitor of necroptosis structurally distinct from previously described Necrostatin-1 (Nec-1), and therefore, represents a new direction for the inhibition of this cellular caspase-independent necrotic cell death mechanism. Here, we describe a series of structural modifications of Nec-5 and the structure-activity relationship (SAR) of Nec-5 series in inhibiting necroptosis. Topics: Apoptosis; Heterocyclic Compounds, 3-Ring; Humans; Jurkat Cells; Necrosis; Nitriles; Pyrimidinones; Structure-Activity Relationship; Sulfides | 2007 |