Proteins > Nitric oxide synthase, inducible
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Nitric oxide synthase, inducible
A nitric oxide synthase, inducible that is encoded in the genome of mouse. [OMA:P29477, PRO:DNx]
Synonyms
EC 1.14.13.39;
Inducible NO synthase;
Inducible NOS;
iNOS;
Macrophage NOS;
MAC-NOS;
NOS type II;
Peptidyl-cysteine S-nitrosylase NOS2
Research
Bioassay Publications (43)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (13.95) | 18.2507 |
| 2000's | 10 (23.26) | 29.6817 |
| 2010's | 26 (60.47) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
Compounds (45)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| gallic acid | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| imidazole | Mus musculus (house mouse) | IC50 | 40.0000 | 1 | 1 |
| n-(3-(aminomethyl)benzyl)acetamidine | Mus musculus (house mouse) | IC50 | 0.1770 | 3 | 3 |
| 3-bromo-7-nitroindazole | Mus musculus (house mouse) | IC50 | 2.2000 | 1 | 1 |
| 7-nitroindazole | Mus musculus (house mouse) | IC50 | 45.0000 | 2 | 2 |
| pimagedine | Mus musculus (house mouse) | IC50 | 27.5100 | 2 | 2 |
| 2-aminothiazole | Mus musculus (house mouse) | IC50 | 18.0000 | 2 | 2 |
| indomethacin | Mus musculus (house mouse) | IC50 | 24.3500 | 5 | 5 |
| etiron | Mus musculus (house mouse) | Ki | 0.0052 | 1 | 1 |
| sulforaphane | Mus musculus (house mouse) | IC50 | 0.4000 | 1 | 1 |
| ng-nitroarginine methyl ester | Mus musculus (house mouse) | IC50 | 16.8875 | 4 | 4 |
| 2-phenylimidazole | Mus musculus (house mouse) | IC50 | 1,000.0000 | 1 | 1 |
| sakuranetin | Mus musculus (house mouse) | IC50 | 19.5500 | 1 | 1 |
| s-methylisothiourea sulfate | Mus musculus (house mouse) | IC50 | 1.8000 | 1 | 1 |
| 2-aminoimidazole | Mus musculus (house mouse) | IC50 | 65.0000 | 1 | 1 |
| friedelin | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| taraxerol | Mus musculus (house mouse) | IC50 | 24.2000 | 1 | 1 |
| beta-amyrin acetate | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| taraxerone | Mus musculus (house mouse) | IC50 | 46.5000 | 1 | 1 |
| n(g)-iminoethylornithine | Mus musculus (house mouse) | IC50 | 6.4500 | 2 | 2 |
| n(g)-iminoethylornithine | Mus musculus (house mouse) | Ki | 2.5350 | 2 | 2 |
| parthenolide | Mus musculus (house mouse) | IC50 | 4.5250 | 2 | 2 |
| echinuline | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| omega-n-methylarginine | Mus musculus (house mouse) | IC50 | 16.8500 | 6 | 6 |
| methylinositol | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| delta-n-methylarginine | Mus musculus (house mouse) | IC50 | 25.0000 | 1 | 1 |
| Bardoxolone | Mus musculus (house mouse) | IC50 | 0.0230 | 1 | 1 |
| canavanine | Mus musculus (house mouse) | IC50 | 60.0000 | 2 | 2 |
| nitroarginine | Mus musculus (house mouse) | IC50 | 61.8286 | 7 | 7 |
| nitroarginine | Mus musculus (house mouse) | Ki | 2.4250 | 2 | 2 |
| ergosterol | Mus musculus (house mouse) | IC50 | 30.6000 | 1 | 1 |
| resveratrol | Mus musculus (house mouse) | IC50 | 20.4667 | 3 | 3 |
| n(6)-(1-iminoethyl)lysine | Mus musculus (house mouse) | IC50 | 3.3000 | 1 | 1 |
| n(6)-(1-iminoethyl)lysine | Mus musculus (house mouse) | Ki | 2.1600 | 1 | 1 |
| quercetin | Mus musculus (house mouse) | IC50 | 16.4000 | 1 | 1 |
| spinasterol | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| wogonin | Mus musculus (house mouse) | IC50 | 7.8000 | 1 | 1 |
| prunetin | Mus musculus (house mouse) | IC50 | 10.5000 | 1 | 1 |
| kaempferol 3-o-rhamnoside | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| ergosterol-5,8-peroxide | Mus musculus (house mouse) | IC50 | 6.3000 | 1 | 1 |
| glutinol | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| 4alpha-methylergosta-8,24(28)-dien-3,7,11-trione-26-oic acid | Mus musculus (house mouse) | IC50 | 3.6000 | 1 | 1 |
| tbe 31 | Mus musculus (house mouse) | IC50 | 0.0010 | 1 | 1 |
| antrocamphin a | Mus musculus (house mouse) | IC50 | 7.2000 | 1 | 1 |
| 4,7-dimethoxy-5-methyl-1,3-benzodioxole | Mus musculus (house mouse) | IC50 | 29.1000 | 1 | 1 |
| 3alpha,12alpha-dihydroxy-4alpha-methylergosta-8,24(28)-dien-7,11-dione-26-oic acid | Mus musculus (house mouse) | IC50 | 16.2000 | 1 | 1 |
| 3alpha-hydroxy-4alpha-methylergosta-8,24(28)-dien-7,11-dione-26-oic acid | Mus musculus (house mouse) | IC50 | 9.6000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| arginine | Mus musculus (house mouse) | Km | 9.5000 | 1 | 1 |
Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.European journal of medicinal chemistry, , May-25, Volume: 152, 2018
Selective Acetamidine-Based Nitric Oxide Synthase Inhibitors: Synthesis, Docking, and Biological Studies.ACS medicinal chemistry letters, , Jun-11, Volume: 6, Issue:6, 2015
N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.European journal of medicinal chemistry, , Volume: 44, Issue:7, 2009
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.Bioorganic & medicinal chemistry, , Jun-01, Volume: 16, Issue:11, 2008
Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.Journal of natural products, , Dec-27, Volume: 74, Issue:12, 2011
Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.Journal of natural products, , Sep-23, Volume: 74, Issue:9, 2011
Design and synthesis of 7-alkoxy-4-heteroarylamino-3-quinolinecarbonitriles as dual inhibitors of c-Src kinase and nitric oxide synthase.Bioorganic & medicinal chemistry, , Jun-01, Volume: 16, Issue:11, 2008
The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Novel Pyrazolo[4,3- d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model.Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 25, Issue:11, 2015
Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents.European journal of medicinal chemistry, , Volume: 54, 2012
Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.European journal of medicinal chemistry, , Volume: 47, Issue:1, 2012
Biologically active constituents from the fruiting body of Taiwanofungus camphoratus.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
New diterpenoids and the bioactivity of Erythrophleum fordii.Bioorganic & medicinal chemistry, , Nov-15, Volume: 16, Issue:22, 2008
Approaches toward selective inhibition of nitric oxide synthase.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
Mechanistic studies of inactivation of inducible nitric oxide synthase by amidines.Biochemistry, , Apr-21, Volume: 54, Issue:15, 2015
Examination of N-hydroxylation as a prerequisite mechanism of nitric oxide synthase inactivation.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Conformationally constrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 8, Issue:21, 1998
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.Journal of medicinal chemistry, , Nov-11, Volume: 37, Issue:23, 1994
Octulosonic acid derivatives from Roman chamomile (Chamaemelum nobile) with activities against inflammation and metabolic disorder.Journal of natural products, , Mar-28, Volume: 77, Issue:3, 2014
Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida.Journal of natural products, , Apr-26, Volume: 76, Issue:4, 2013
Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).Bioorganic & medicinal chemistry, , Dec-15, Volume: 20, Issue:24, 2012
Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.Bioorganic & medicinal chemistry, , Nov-01, Volume: 19, Issue:21, 2011
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.Journal of natural products, , Volume: 67, Issue:7, 2004
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998
Design and synthesis of 7-alkoxy-4-heteroarylamino-3-quinolinecarbonitriles as dual inhibitors of c-Src kinase and nitric oxide synthase.Bioorganic & medicinal chemistry, , Jun-01, Volume: 16, Issue:11, 2008
The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI).Bioorganic & medicinal chemistry, , 11-01, Volume: 28, Issue:21, 2020
Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.Journal of natural products, , Sep-23, Volume: 74, Issue:9, 2011
Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.Journal of natural products, , Dec-27, Volume: 74, Issue:12, 2011
Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.Journal of medicinal chemistry, , Nov-11, Volume: 53, Issue:21, 2010
Design, synthesis, and preliminary evaluation of 4-(6-(3-nitroguanidino)hexanamido)pyrrolidine derivatives as potential iNOS inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.Journal of medicinal chemistry, , May-03, Volume: 50, Issue:9, 2007
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.Journal of medicinal chemistry, , Nov-11, Volume: 37, Issue:23, 1994
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).Bioorganic & medicinal chemistry, , Dec-15, Volume: 20, Issue:24, 2012
Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.Journal of medicinal chemistry, , Jul-08, Volume: 53, Issue:13, 2010
Examination of N-hydroxylation as a prerequisite mechanism of nitric oxide synthase inactivation.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.Journal of medicinal chemistry, , Nov-11, Volume: 37, Issue:23, 1994