Page last updated: 2024-08-07 22:44:40
Methionine--tRNA ligase, mitochondrial
A methionyl-tRNA synthetase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96GW9]
Synonyms
EC 6.1.1.10;
Methionyl-tRNA synthetase 2;
Mitochondrial methionyl-tRNA synthetase;
MtMetRS
Research
Bioassay Publications (1)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
Compounds (1)
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| chloramphenicol | Homo sapiens (human) | EC50 | 7.9000 | 1 | 1 |
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| methionine-tRNA ligase activity | molecular function | Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). [EC:6.1.1.10] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| tRNA aminoacylation for protein translation | biological process | The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. [GOC:ma] |
| methionyl-tRNA aminoacylation | biological process | The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510] |