Methionine--tRNA ligase, mitochondrial

A methionyl-tRNA synthetase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96GW9]

EC 6.1.1.10;
Methionyl-tRNA synthetase 2;
Mitochondrial methionyl-tRNA synthetase;
MtMetRS

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
chloramphenicol	Homo sapiens (human)	EC50	7.9000	1	1

This protein enables 2 target(s):

Target	Category	Definition
methionine-tRNA ligase activity	molecular function	Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). [EC:6.1.1.10]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]

This protein is located in 1 target(s):

Target	Category	Definition
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]

This protein is involved in 2 target(s):

Target	Category	Definition
tRNA aminoacylation for protein translation	biological process	The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. [GOC:ma]
methionyl-tRNA aminoacylation	biological process	The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]