Proteins > N-lysine methyltransferase SMYD2
Page last updated: 2024-08-08 00:18:17

N-lysine methyltransferase SMYD2

An N-lysine methyltransferase SMYD2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRG4]

Synonyms

EC 2.1.1.-;
HSKM-B;
Histone methyltransferase SMYD2;
2.1.1.354;
Lysine N-methyltransferase 3C;
SET and MYND domain-containing protein 2

Research

Bioassay Publications (11)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (63.64)24.3611
2020's4 (36.36)2.80

Compounds (4)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
s-adenosylhomocysteineHomo sapiens (human)IC500.180011
az 505Homo sapiens (human)IC5010.42381111
az 505Homo sapiens (human)Ki0.300011
6,7-dimethoxy-2-(pyrrolidin-1-yl)-n-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amineHomo sapiens (human)IC50100.000011
lly-507Homo sapiens (human)IC500.31351414

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
az 505Homo sapiens (human)Kd167.000033

Enables

This protein enables 9 target(s):

TargetCategoryDefinition
RNA polymerase II complex bindingmolecular functionBinding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. [GOC:txnOH]
p53 bindingmolecular functionBinding to one of the p53 family of proteins. [GOC:hjd]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
lysine N-methyltransferase activitymolecular functionCatalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. [GOC:mah]
protein-lysine N-methyltransferase activitymolecular functionCatalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. [PMID:12054878]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
histone H3K36 methyltransferase activitymolecular functionCatalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein. [GOC:ai]
histone H3 methyltransferase activitymolecular functionCatalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue. [PMID:28450737]
histone H3K4 trimethyltransferase activitymolecular functionCatalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3. [PMID:18375658, RHEA:60260]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 8 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
chromatin remodelingbiological processA dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
heart developmentbiological processThe process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
negative regulation of cell population proliferationbiological processAny process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
peptidyl-lysine monomethylationbiological processThe methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. [RESID:AA0076]
peptidyl-lysine dimethylationbiological processThe methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. [RESID:AA0075]
regulation of DNA damage response, signal transduction by p53 class mediatorbiological processAny process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:jl]
regulation of signal transduction by p53 class mediatorbiological processAny process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie]