diphenhydramine has been researched along with Necrosis in 12 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous." | 5.40 | Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval. ( Chang, CC; Chen, CY; Chen, TY; Kuo, SC; Lin, TP; Yeh, YW, 2014) |
| "Diphenhydramine (DPH) is most commonly used via oral, topical, intramuscular (IM) and intravenous (IV) routes for the palliation of pruritus, treatment of extrapyramidal symptoms, management of parkinsonism and for allergic reactions." | 3.85 | Safe Use of Subcutaneous Diphenhydramine in the Inpatient Hospice Unit. ( Chen, A; Cooney, GA; Gonzalez, F; Hickey, T; Levene, R; Loquias, EJ; Roshan, R; Zelhof, R, 2017) |
| "In a comparison with non-irradiated cells, significant apoptosis was found in TCSA, bithionol, chlorpromazine, sparfloxacin and enoxacin at 10(-4) or 10(-5)M as well as 8-MOP as assessed by both annexin V and active caspase-3 stainings, while necrosis occurred in most of these chemicals at 10(-4)M." | 3.74 | Induction of keratinocyte apoptosis by photosensitizing chemicals plus UVA. ( Atarashi, K; Kobayashi, M; Kurita, M; Mori, K; Shimauchi, T; Tokura, Y, 2007) |
| "Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous." | 1.40 | Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval. ( Chang, CC; Chen, CY; Chen, TY; Kuo, SC; Lin, TP; Yeh, YW, 2014) |
| "Treatment with diphenhydramine significantly decreased the blood cTnI levels." | 1.35 | Effect of diphenhydramine on myocardial injury caused by organophosphate poisoning. ( Buyukokuroglu, M; Ciftci, IH; Saglam, H; Sahin, O; Yavuz, Y; Yurumez, Y, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, TY | 1 |
| Yeh, YW | 1 |
| Kuo, SC | 1 |
| Chen, CY | 1 |
| Lin, TP | 1 |
| Chang, CC | 1 |
| Chen, A | 1 |
| Loquias, EJ | 1 |
| Roshan, R | 1 |
| Levene, R | 1 |
| Zelhof, R | 1 |
| Hickey, T | 1 |
| Cooney, GA | 1 |
| Gonzalez, F | 1 |
| Wilson, JR | 1 |
| Hagood, CO | 1 |
| Prather, ID | 1 |
| Kurita, M | 1 |
| Shimauchi, T | 1 |
| Kobayashi, M | 1 |
| Atarashi, K | 1 |
| Mori, K | 1 |
| Tokura, Y | 1 |
| Yavuz, Y | 1 |
| Yurumez, Y | 1 |
| Ciftci, IH | 1 |
| Sahin, O | 1 |
| Saglam, H | 1 |
| Buyukokuroglu, M | 1 |
| Bloksma, N | 1 |
| van de Wiel, P | 1 |
| Hofhuis, F | 1 |
| Kuper, F | 1 |
| Willers, J | 1 |
| Godoy, HM | 1 |
| Diaz Gomez, MI | 1 |
| Castro, JA | 1 |
| Dire, DJ | 1 |
| Hogan, DE | 1 |
| McDonough, J | 1 |
| Claman, HN | 1 |
| Karr, RM | 1 |
| Kohler, PF | 1 |
| Mass, MF | 1 |
| McIntosh, RM | 1 |
| Sams, WM | 1 |
| Small, P | 1 |
| Stanford, RE | 1 |
| Thorne, EG | 1 |
| Tachi, C | 1 |
| Tachi, S | 1 |
| Lindner, HR | 1 |
| Gilbert, EF | 1 |
| Da Silva, A | 1 |
1 review available for diphenhydramine and Necrosis
| Article | Year |
|---|---|
Brown recluse spider bites: a complex problem wound. A brief review and case study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antivenins; Combined Modality Therapy; Dapsone; Debr | 2005 |
1 trial available for diphenhydramine and Necrosis
| Article | Year |
|---|---|
Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic.
Topics: Adult; Anesthetics, Local; Diphenhydramine; Double-Blind Method; Drug Hypersensitivity; Humans; Inje | 1993 |
10 other studies available for diphenhydramine and Necrosis
| Article | Year |
|---|---|
Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval.
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Depression; Diphenhydrami | 2014 |
Safe Use of Subcutaneous Diphenhydramine in the Inpatient Hospice Unit.
Topics: Adult; Aged; Aged, 80 and over; Basal Ganglia Diseases; Diphenhydramine; Female; Hospices; Humans; I | 2017 |
Induction of keratinocyte apoptosis by photosensitizing chemicals plus UVA.
Topics: Anesthetics, Local; Anti-Infective Agents, Local; Antipsychotic Agents; Antitubercular Agents; Apopt | 2007 |
Effect of diphenhydramine on myocardial injury caused by organophosphate poisoning.
Topics: Animals; Cholinesterase Inhibitors; Diphenhydramine; Edema; Fenthion; Heart; Histamine H1 Antagonist | 2008 |
Role of histamine in the antitumour activity of endotoxin.
Topics: Animals; Cimetidine; Diphenhydramine; Endotoxins; Female; Glycoproteins; Histamine; Mice; Mice, Inbr | 1984 |
Relationship between dimethylnitrosamine metabolism or activation and its ability to induce liver necrosis in rats.
Topics: Animals; Biotransformation; Chlorpromazine; Cystamine; Dimethylnitrosamine; Diphenhydramine; In Vitr | 1980 |
Emergency! Acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anorexia Nervosa; Chemical and Drug Induced Liv | 1998 |
Systemic (allergic?) vasculitis.
Topics: Antigen-Antibody Complex; Azathioprine; Complement System Proteins; Creatinine; Diphenhydramine; Ery | 1974 |
Action of antihistamines on the endometrium and the histamine theory of decidual induction.
Topics: Animals; Decidua; Diphenhydramine; Endometrium; Female; Histamine; Histamine H1 Antagonists; Microsc | 1970 |
Henoch-Schöenlein purpura. Report of a fatal case with gastrointestinal hemorrhage and necrosis.
Topics: Adolescent; Chlorpheniramine; Dexamethasone; Diphenhydramine; Gastrointestinal Diseases; Gastrointes | 1966 |