Cytochrome P450 2E1

A cytochrome P450 2E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05181]

Synonyms

EC 1.14.14.1;
4-nitrophenol 2-hydroxylase;
1.14.13.n7;
CYPIIE1;
Cytochrome P450-J

Research

Bioassay Publications (21)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (23.81)	29.6817
2010's	14 (66.67)	24.3611
2020's	2 (9.52)	2.80

Compounds (25)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tacrine	Homo sapiens (human)	IC50	0.0750	1	1
carbon tetrachloride	Homo sapiens (human)	IC50	11.0000	1	0
3-hydroxyacetanilide	Homo sapiens (human)	Ki	9,500.0000	1	1
phenethyl isothiocyanate	Homo sapiens (human)	Ki	10.4900	2	2
tranylcypromine	Homo sapiens (human)	IC50	6.2000	1	1
proadifen hydrochloride	Homo sapiens (human)	IC50	19.0000	1	1
pirlindole	Homo sapiens (human)	IC50	36.0000	1	1
6-paradol	Homo sapiens (human)	IC50	21.4000	1	2
gefitinib	Homo sapiens (human)	IC50	0.4600	1	1
tariquidar	Homo sapiens (human)	IC50	100.0000	1	1
bergamottin	Homo sapiens (human)	Ki	40.0000	1	1
orteronel	Homo sapiens (human)	IC50	30.0000	1	1
bibw 2992	Homo sapiens (human)	IC50	0.0140	1	1
vx-770	Homo sapiens (human)	IC50	20.0000	1	1
cct 128930	Homo sapiens (human)	IC50	50.0000	1	1
e-52862	Homo sapiens (human)	IC50	10.0000	2	2
glpg0634	Homo sapiens (human)	IC50	85.0000	1	1
kaf156	Homo sapiens (human)	IC50	6.0000	1	1
(5s,6s,9r)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5h-cyclohepta(b)pyridin-9-yl 4-(2-oxo-2,3-dihydro-1h-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxylate	Homo sapiens (human)	IC50	20.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
hexyl nicotinate	Homo sapiens (human)	Kd	1.4000	1	1
cp-55,940	Homo sapiens (human)	EC50	0.0004	1	1
oky 025	Homo sapiens (human)	Kd	21.0000	1	1
(3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone	Homo sapiens (human)	EC50	0.0005	1	1
CB-13	Homo sapiens (human)	EC50	0.0279	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pai 039	Homo sapiens (human)	Inhibition	83.0000	1	1

Enables

This protein enables 14 target(s):

Target	Category	Definition
monooxygenase activity	molecular function	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. [ISBN:0198506732]
iron ion binding	molecular function	Binding to an iron (Fe) ion. [GOC:ai]
oxidoreductase activity	molecular function	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators]
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	molecular function	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]
4-nitrophenol 2-monooxygenase activity	molecular function	Catalysis of the reaction: 4-nitrophenol + H+ + NADH + O2 = 4-nitrocatechol + H2O + NAD+. [EC:1.14.13.29, RHEA:12568]
oxygen binding	molecular function	Binding to oxygen (O2). [GOC:jl]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
heme binding	molecular function	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
Hsp70 protein binding	molecular function	Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. [ISBN:0198506732]
Hsp90 protein binding	molecular function	Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. [GOC:ai]
aromatase activity	molecular function	Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. [GOC:cb]
long-chain fatty acid omega-1 hydroxylase activity	molecular function	Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. [GOC:nhn, PMID:18577768, PMID:22772592, PMID:24242247, RHEA:60936]
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	molecular function	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]
arachidonic acid epoxygenase activity	molecular function	Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, PMID:18952572]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Involved In

This protein is involved in 12 target(s):

Target	Category	Definition
long-chain fatty acid metabolic process	biological process	The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ajp]
lipid hydroxylation	biological process	The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid. [GOC:hjd, PMID:15658937]
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
steroid metabolic process	biological process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
response to bacterium	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb]
monoterpenoid metabolic process	biological process	The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton. [ISBN:0198547684]
carbon tetrachloride metabolic process	biological process	The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants. [UM-BBD_pathwayID:ctc]
benzene metabolic process	biological process	The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation. [GOC:ai]
4-nitrophenol metabolic process	biological process	The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion. [GOC:jl]
halogenated hydrocarbon metabolic process	biological process	The chemical reactions and pathways involving halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. Halogens include fluorine, chlorine, bromine and iodine. [GOC:ai, GOC:krc]
long-chain fatty acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [PMID:18390550]
epoxygenase P450 pathway	biological process	The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. [GOC:mah, PMID:17979511]