A deoxyhypusine hydroxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BU89]
hDOHH;
EC 1.14.99.29;
Deoxyhypusine dioxygenase;
Deoxyhypusine monooxygenase;
HEAT-like repeat-containing protein 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2,2'-dipyridyl | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| ciclopirox | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| deferiprone | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| deferoxamine | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| mimosine | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| iron ion binding | molecular function | Binding to an iron (Fe) ion. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| deoxyhypusine monooxygenase activity | molecular function | Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O. [EC:1.14.99.29] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cellular_component | cellular component | A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). [GOC:pdt] |
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| peptidyl-lysine modification to peptidyl-hypusine | biological process | The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine. [GOC:ma, ISBN:0198547684, RESID:AA0116] |