Compounds > phytol
Page last updated: 2024-09-25

phytol

Cross-References

ID SourceID
PubMed CID145386
SCHEMBL ID22784
MeSH IDM0016825

Synonyms (19)

Synonym
3,7,11,15-tetramethylhexadec-2-en-1-ol
phytol ,
3,7,11,15-tetramethyl-2-hexadecenol
(e)-3,7,11,15-tetramethylhexadec-2-en-1-ol
2-hexadecen-1-ol, 3,7,11,15-tetramethyl-
7541-49-3
123164-54-5
c20h40o
SCHEMBL22784
mfcd00002919
AKOS026676614
3,7,11,15-tetramethyl-2-hexadecenyl alcohol
FT-0771556
DTXSID40859291
FT-0775424
2-hexadecen-1-ol, 3,7,11,15-tetramethyl-; 3,7,11,15-tetramethyl-2-hexadecen-1-ol; 3,7,11,15-tetramethyl-2-hexadecene-1-ol; phytol
(e)-3,7,11,15-tetramethyl-2-hexadecen-1-ol
SY316289
SY057287

Research Excerpts

Overview

ExcerptReference
"Phytol is a diterpene alcohol found abundantly in nature as the phytyl side chain of chlorophylls. "( Matsuda, H; Mikami, K; Narai-Kanayama, A; Seo, Y; Yokosaka, SI; Yoshino, T, 2023)
"Phytol is a diterpene constituent of chlorophyll and has been shown to have several pharmacological properties, particularly in relation to the management of painful inflammatory diseases. "( Antoniolli, AR; Carvalho, AMS; Coutinho, HDM; Heimfarth, L; Menezes, IRA; Oliveira, FS; Pereira, EWM; Picot, L; Quintans, JSS; Quintans-Júnior, LJ, 2020)
"Phytol (PHY) is an acyclic natural diterpene alcohol and a chlorophyll constituent that exhibits several pharmacological effects, such as anticancer, antioxidant, and antimicrobial. "( Ayatollahi, SA; Islam, MT; Islam, T; Khan, MR; Martins, N; Mubarak, MS; Paul, A; Salehi, B; Sharifi-Rad, J; Sifat, N; Zihad, SMNK, 2020)
"Phytol is a diterpene alcohol with demonstrated anticancer effects."( Sheikhbahaei, M; Soltanian, S; Ziasistani, M, 2021)
"Phytol is a side chain of chlorophyll belonging to the side-chain double terpenoid. "( Gao, P; Jiang, Q; Lin, X; Luo, L; Peng, J; Shu, G; Wang, J; Wang, L; Wang, S; Xi, Q; Yang, K; Zhang, Y; Zhou, G; Zhu, X, 2017)
"Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. "( Ahmed, MI; Ali, ES; Apostolov, A; Atanasov, AG; Banach, M; Berindan-Neagoe, I; Billah, MM; Chandra Shill, M; Dey, P; El-Demerdash, A; Gulei, D; Horbańczuk, J; Islam, MA; Islam, MT; Jóźwik, A; Kamal, MA; Karmakar, UK; Khan, IN; Malainer, C; Marchewka, J; Mishra, SK; Mubarak, MS; Nicoletti, F; Pieczynska, MD; Rengasamy, KRR; Shaw, S; Shilpi, JA; Strzałkowska, N; Uddin, SJ; Xiao, J; Yarla, NS; Yele, S; Yeung, AWK; Zengin, G, 2018)
"Phytol is a common food additive and nonmutagenic, with satisfactory safety."( Allegretti, SM; Costa, JP; de Moraes, J; de Oliveira, RN; de Sousa, DP; Freitas, RM; Junior, AL; Pinto, PL, 2014)
"Phytol is a diterpene alcohol of medicinal importance and it also has potential to be used as biofuel. "( Basu, C; Gupta, D; Ip, T; Summers, ML, 2015)
"Phytol (PYT) is a diterpenoid having important biological activity. "( Cardoso Silva, SW; da Conceição Machado, K; da Costa Junior, JS; da Mata, AM; da Silva-Junior, AA; de Alencar, MV; de Carvalho Melo-Cavalcante, AA; de Castro E Sousa, JM; Gomes Júnior, AL; Islam, MT; Lins Rolim, HM; Paz, MF; Streck, L, 2017)
"Phytol is a branched chain fatty alcohol, which is abundantly present in nature as part of the chlorophyll molecule. "( Dacremont, G; Jansen, GA; Rontani, JF; van den Brink, DM; van Miert, JN; Wanders, RJ, 2004)
"Phytol is a branched-chain fatty alcohol that is a naturally occurring precursor of phytanic acid, a fatty acid involved in the pathogenesis of Refsum disease. "( Dacremont, G; Rontani, JF; van den Brink, DM; van Miert, JN; Wanders, RJ, 2005)
"Phytol is a naturally occurring precursor of phytanic acid. "( Ferdinandusse, S; Gloerich, J; Ofman, R; Ruiter, JP; van den Brink, DM; Wanders, RJ, 2006)
"Phytol is a branched, long-chain aliphatic alcohol which has various biological effects. "( Kagoura, M; Matsui, C; Morohashi, M, 1999)

Actions

ExcerptReference
"Phytol was found to cause characteristic apoptotic morphological changes and generation of ROS in A549 cells."( Ray, A; Subramanian, RB; Thakkar, SS; Thakkar, VR; Thakor, P, 2017)
"Phytol induced the increase in PPARalpha-dependent luciferase activity and the degree of in vitro binding of a coactivator, SRC-1, to GST-PPARalpha."( Ebisu, S; Egawa, K; Fushiki, T; Goto, T; Kato, S; Kawada, T; Moriyama, T; Takahashi, N, 2005)

Treatment

ExcerptReference
"Upon phytol-treatment in C3H10T1/2 cells, mir-21a and Smad7 levels were increased and decreased, respectively."( Abhinandan, R; Akshaya, RL; Balagangadharan, K; Pranavadithya, S; Pranavkrishna, S; Sanjeev, G; Selvamurugan, N; Siddabathuni, N; Sidharthan, DS; Srinivasan, S, 2020)
"In phytol-treated cells, elevated level of intracellular reactive oxygen species (ROS) and transient NADH depletion were observed."( Lee, DG; Lee, W; Woo, ER, 2016)
"Treatment with phytol inhibited the expression of microphthalmia-associated transcription factor (MITF) by phosphorylating extracellular signal-regulated protein kinase (ERK)."( Cho, SK; Ko, GA, 2018)

Research

Studies (326)

TimeframeStudies, This Drug (%)All Drugs %
pre-199080 (24.54)18.7374
1990's24 (7.36)18.2507
2000's70 (21.47)29.6817
2010's113 (34.66)24.3611
2020's39 (11.96)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews17 (4.89%)6.00%
Case Studies8 (2.30%)4.05%
Observational0 (0.00%)0.25%
Other323 (92.82%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
tocopherols[no description available]medium160
2,4-di-tert-butylphenol[no description available]medium20alkylbenzene;
phenols		antioxidant;
bacterial metabolite;
marine metabolite
phytanic acid[no description available]medium470branched-chain saturated fatty acid;
long-chain fatty acid;
methyl-branched fatty acid
coenzyme a[no description available]medium40adenosine 3',5'-bisphosphatecoenzyme;
Escherichia coli metabolite;
mouse metabolite
chlorophyll a[no description available]medium430chlorophyll;
methyl ester		cofactor
phytanoyl-coenzyme a[no description available]medium30
margaric acid[no description available]medium10long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
mammalian metabolite
2-hydroxyphytanic acid[no description available]medium102-hydroxy fatty acid
titanium[no description available]medium10titanium group element atom
titanium dioxide[no description available]medium10titanium oxidesfood colouring
zinc oxide[no description available]medium10zinc molecular entity
gallic acid[no description available]medium30trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
d-alpha tocopherol[no description available]medium230alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
n-(3-oxohexanoyl)-3-aminodihydro-2(3h)-furanone[no description available]medium10N-acyl homoserine lactone;
secondary carboxamide
cannabidivarin[no description available]medium10monoterpenoid
cannabichromene[no description available]medium101-benzopyran
linalool[no description available]medium20monoterpenoid;
tertiary alcohol		antimicrobial agent;
fragrance;
plant metabolite;
volatile oil component
cannabinol[no description available]medium10dibenzopyran
cannabidiol[no description available]medium10olefinic compound;
phytocannabinoid;
resorcinols		antimicrobial agent;
plant metabolite
nerolidol[no description available]medium20nerolidol
dronabinol[no description available]medium10benzochromene;
diterpenoid;
phytocannabinoid;
polyketide		cannabinoid receptor agonist;
epitope;
hallucinogen;
metabolite;
non-narcotic analgesic
alpha-pinene[no description available]medium20pineneplant metabolite
cannabigerol[no description available]medium10phytocannabinoid;
resorcinols		anti-inflammatory agent;
antibacterial agent;
antioxidant;
appetite enhancer;
cannabinoid receptor agonist;
neuroprotective agent;
plant metabolite
phytosterols[no description available]medium40
catechin[no description available]medium10catechinantioxidant;
plant metabolite
tannins[no description available]medium10
arbutin[no description available]medium10beta-D-glucoside;
monosaccharide derivative		Escherichia coli metabolite;
plant metabolite
eucalyptol[no description available]medium20
stigmasterol[no description available]medium403beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol		plant metabolite
chlorogenic acid[no description available]medium10cinnamate ester;
tannin		food component;
plant metabolite
quercetin[no description available]medium107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
cellulose[no description available]medium20glycoside
hydrogen[no description available]medium20elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
caryophyllene[no description available]medium60
limonene[no description available]medium30cycloalkene;
p-menthadiene		human metabolite
palmitic acid[no description available]medium90long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite
terpinyl acetate[no description available]medium10p-menthane monoterpenoid
pristanic acid[no description available]medium70branched-chain saturated fatty acid;
long-chain fatty acid;
methyl-branched fatty acid		human metabolite
lactic acid[no description available]medium102-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
lutein[no description available]medium50carotenolfood colouring;
plant metabolite
scopolamine hydrobromide[no description available]medium10
ovalbumin[no description available]medium20
linoleic acid[no description available]medium30octadecadienoic acid;
omega-6 fatty acid		algal metabolite;
Daphnia galeata metabolite;
plant metabolite
methyl palmitate[no description available]medium20fatty acid methyl estermetabolite
muscarine[no description available]medium10monosaccharide
phenol[no description available]medium10phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
rosiglitazone[no description available]medium10aminopyridine;
thiazolidinediones		EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug
4-butyrolactone[no description available]medium10butan-4-olidemetabolite;
neurotoxin
chloroquine[no description available]medium20aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
beta carotene[no description available]medium50carotenoid beta-end derivative;
cyclic carotene		antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A
wortmannin[no description available]medium10acetate ester;
cyclic ketone;
delta-lactone;
organic heteropentacyclic compound		anticoronaviral agent;
antineoplastic agent;
autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector;
Penicillium metabolite;
radiosensitizing agent
D-fructopyranose[no description available]medium10cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
cyclohexanol[no description available]medium20cyclohexanols;
secondary alcohol		solvent
tridecanedioic acid[no description available]medium10alpha,omega-dicarboxylic acidmetabolite
carnitine[no description available]medium20amino-acid betainehuman metabolite;
mouse metabolite
urea[no description available]medium20isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
s-adenosylmethionine[no description available]medium10sulfonium betainehuman metabolite
phosphatidylcholines[no description available]medium201,2-diacyl-sn-glycero-3-phosphocholine
phytenic acid[no description available]medium70diterpenoid
cefotaxime[no description available]medium101,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen
pd 98059[no description available]medium10aromatic amine;
monomethoxyflavone		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector
acetylcysteine[no description available]medium20acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
gamma-aminobutyric acid[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
alpha-terpineol[no description available]medium10terpineolplant metabolite
alpha-linolenic acid[no description available]medium30linolenic acid;
omega-3 fatty acid		micronutrient;
mouse metabolite;
nutraceutical
aromadendrene[no description available]medium10sesquiterpenoid
sesquiterpenes[no description available]medium130
cytochrome c-t[no description available]medium10
9,10-dimethyl-1,2-benzanthracene[no description available]medium10ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
benzo(a)pyrene[no description available]medium10ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
acetaminophen[no description available]medium10acetamides;
phenols		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
ibuprofen[no description available]medium10monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
isophytol[no description available]medium50
prenol[no description available]medium10alkenyl alcohol;
prenols
n-pentanol[no description available]medium20pentanol;
short-chain primary fatty alcohol		human metabolite;
plant metabolite
niacin[no description available]medium10pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
nad[no description available]medium30organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
tryptophan[no description available]medium10erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
mocetinostat[no description available]medium10aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
malondialdehyde[no description available]medium20dialdehydebiomarker
geraniol[no description available]medium403,7-dimethylocta-2,6-dien-1-ol;
monoterpenoid;
primary alcohol		allergen;
fragrance;
plant metabolite;
volatile oil component
uridine[no description available]medium10uridinesdrug metabolite;
fundamental metabolite;
human metabolite
5-fluorouridine[no description available]medium10organofluorine compound;
uridines		mutagen
oligonucleotides[no description available]medium10
flumazenil[no description available]medium10ethyl ester;
imidazobenzodiazepine;
organofluorine compound		antidote to benzodiazepine poisoning;
GABA antagonist
hydroxyl radical[no description available]medium10oxygen hydride;
oxygen radical;
reactive oxygen species
1,1-diphenyl-2-picrylhydrazyl[no description available]medium30
lycopene[no description available]medium10acyclic caroteneantioxidant;
plant metabolite
geranylgeraniol[no description available]medium110geranylgeraniol
mevalonic acid[no description available]medium803,5-dihydroxy-3-methylpentanoic acid
deuterium[no description available]medium70dihydrogen
beta-bisabolene[no description available]medium10beta-bisabolene
digalactosyldiacylglycerol[no description available]medium10
nadp[no description available]medium40
pentadecanoic acid[no description available]medium10long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
food component;
human blood serum metabolite;
plant metabolite
pentadecanal[no description available]medium102,3-saturated fatty aldehyde;
long-chain fatty aldehyde		antimicrobial agent;
plant metabolite;
volatile oil component
squalene[no description available]medium50triterpenehuman metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
verbenol[no description available]medium10monoterpenoid
3-hydroxy-3-methylbutene[no description available]medium10olefinic compound;
tertiary alcohol		animal metabolite;
fragrance;
pheromone;
plant metabolite
hexahydrofarnesylacetone[no description available]medium30ketone
caryophyllene oxide[no description available]medium10epoxidemetabolite
divinyl benzene[no description available]medium10styrenes
pheophytin a[no description available]medium70
molybdenum[no description available]medium10chromium group element atommicronutrient
3-carene[no description available]medium10monoterpene
abscisic acid[no description available]medium102-trans-abscisic acid
terpinolene[no description available]medium10p-menthadieneinsect repellent;
plant metabolite;
sedative;
volatile oil component
2-hexenal, z-isomer[no description available]medium202-hexenalantibacterial agent;
flavouring agent;
plant metabolite
phenylacetaldehyde[no description available]medium10alpha-CH2-containing aldehyde;
phenylacetaldehydes		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
acetaldehyde[no description available]medium10aldehydecarcinogenic agent;
EC 3.5.1.4 (amidase) inhibitor;
electron acceptor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
mutagen;
oxidising agent;
Saccharomyces cerevisiae metabolite;
teratogenic agent
heptadecane[no description available]medium10long-chain alkaneplant metabolite;
volatile oil component
beta-ionone[no description available]medium20iononeantioxidant;
fragrance
beta-cyclocitral[no description available]medium10monoterpenoidbacterial metabolite
chlorophyll b[no description available]medium20chlorophyllcofactor
nonanal[no description available]medium20medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde		human metabolite;
plant metabolite
heptanal[no description available]medium10medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde		biomarker
1-hexanol[no description available]medium20hexanol;
primary alcohol		alarm pheromone;
antibacterial agent;
fragrance;
plant metabolite
germacrene d[no description available]medium10
spathulenol[no description available]medium10
pyrophosphate[no description available]medium10diphosphate ion
phytyl diphosphate[no description available]medium10(E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate
secoxyloganin[no description available]medium10beta-D-glucoside;
dicarboxylic acid monoester;
enoate ester;
methyl ester;
monosaccharide derivative;
pyrans;
secoiridoid glycoside		anti-allergic agent;
antioxidant;
plant metabolite
sweroside[no description available]medium10glycoside
betulinic acid[no description available]medium10hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
lupeol[no description available]medium10pentacyclic triterpenoid;
secondary alcohol		anti-inflammatory drug;
plant metabolite
elemene[no description available]medium10
vanillic acid[no description available]medium10methoxybenzoic acid;
monohydroxybenzoic acid		plant metabolite
azulene[no description available]medium10azulenes;
mancude carbobicyclic parent;
ortho-fused bicyclic arene		plant metabolite;
volatile oil component
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid[no description available]medium50chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
prodigiosin[no description available]medium10
4-vinylguaiacol[no description available]medium10phenolsflavouring agent;
pheromone;
plant metabolite
warfarin[no description available]medium40benzenes;
hydroxycoumarin;
methyl ketone
coumarin[no description available]medium20coumarinsfluorescent dye;
human metabolite;
plant metabolite
guaiacol[no description available]medium10guaiacolsdisinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite
vitamin k 1[no description available]medium70phylloquinones;
vitamin K		cofactor;
human metabolite;
plant metabolite
phenyl acetate[no description available]medium10benzenes;
phenyl acetates
vitamin k semiquinone radical[no description available]medium540
bacteriochlorophylls[no description available]medium20bacteriochlorophyll;
methyl ester
naphthoquinones[no description available]medium410
beta-pinene[no description available]medium10pineneplant metabolite
campesterol[no description available]medium103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C28-steroid;
phytosterols		mouse metabolite
gamma-sitosterol[no description available]medium203beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols		marine metabolite;
plant metabolite
cytellin[no description available]medium20
calamenene[no description available]medium10
lysine[no description available]medium10aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
leucine[no description available]medium20amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
chloroprene[no description available]medium10chloroolefin
vitamin k 3[no description available]medium401,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
3,7,11,15-tetramethyl-1-hexadecanol[no description available]medium30
phthalic acid[no description available]medium20benzenedicarboxylic acidhuman xenobiotic metabolite
pristane[no description available]medium30long-chain alkane;
norterpene		biomarker;
immunological adjuvant
caffeic acid[no description available]medium10caffeic acidgeroprotector;
mouse metabolite
harpagide[no description available]medium10
verminoside[no description available]medium10hydroxycinnamic acidmetabolite
glycosides[no description available]medium20
iridoids[no description available]medium10
fumonisin b1[no description available]medium10diester;
fumonisin;
primary amino compound;
triol		carcinogenic agent;
metabolite
safingol[no description available]medium10amino alcohol
sphingosine[no description available]medium10sphing-4-eninehuman metabolite;
mouse metabolite
farnesol[no description available]medium30farnesolplant metabolite
cycloserine[no description available]medium104-amino-1,2-oxazolidin-3-one;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic;
zwitterion		antiinfective agent;
antimetabolite;
antitubercular agent;
metabolite;
NMDA receptor agonist
thermozymocidin[no description available]medium10alpha-amino fatty acid;
hydroxy monocarboxylic acid;
non-proteinogenic alpha-amino acid;
sphingoid		antifungal agent;
antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor;
fungal metabolite;
immunosuppressive agent
trans-phytol[no description available]medium10diterpenoid;
long-chain primary fatty alcohol		algal metabolite;
plant metabolite;
schistosomicide drug
pilocarpine[no description available]medium10pilocarpineantiglaucoma drug
myristic acid[no description available]medium10long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite
aluminum sulfate[no description available]medium10aluminium sulfate
2-propanol[no description available]medium10secondary alcohol;
secondary fatty alcohol		protic solvent
2-naphthol[no description available]medium30naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
serine[no description available]medium10L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
nalorphine[no description available]medium10morphinane alkaloid
morphine[no description available]medium10morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
retinol[no description available]medium80retinol;
vitamin A		human metabolite;
mouse metabolite;
plant metabolite
menaquinone 6[no description available]medium50
triethylenemelamine[no description available]medium101,3,5-triazinesalkylating agent;
insect sterilant
chloramphenicol[no description available]medium10C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
quinolinic acid[no description available]medium10pyridinedicarboxylic acidEscherichia coli metabolite;
human metabolite;
mouse metabolite;
NMDA receptor agonist
3-hydroxyanthranilic acid[no description available]medium10aminobenzoic acid;
monohydroxybenzoic acid		human metabolite;
mouse metabolite
acetone[no description available]medium10ketone body;
methyl ketone;
propanones;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent
phenindione[no description available]medium10aromatic ketone;
beta-diketone		anticoagulant
iodine[no description available]medium10diatomic iodinenutrient
iodine[no description available]medium10halide anion;
monoatomic iodine		human metabolite
ascorbic acid[no description available]medium40ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
ubiquinone[no description available]medium20
inositol[no description available]medium10cyclitol;
hexol
flavin mononucleotide[no description available]medium10
indophenol[no description available]medium10quinone iminedye
glycine[no description available]medium10alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
acid phosphatase[no description available]medium20
mevastatin[no description available]medium102-pyranones;
carboxylic ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		antifungal agent;
apoptosis inducer;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
fungal metabolite;
Penicillium metabolite
farnesoic acid[no description available]medium10farnesoic acidanimal metabolite
lovastatin[no description available]medium10delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		anticholesteremic drug;
antineoplastic agent;
Aspergillus metabolite;
prodrug
fosfomycin[no description available]medium10epoxide;
phosphonic acids		antimicrobial agent;
EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor
fosmidomycin[no description available]medium10hydroxamic acid;
phosphonic acids		antimicrobial agent;
bacterial metabolite;
EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitor
methyl 6,7-10,11-bis(epoxy)-3,7,11-trimethyl-2-dodecenoate[no description available]medium10
1-naphthol[no description available]medium10naphtholgenotoxin;
human xenobiotic metabolite
phytic acid[no description available]medium20inositol phosphate
dihydrostreptomycin sulfate[no description available]medium10
streptomycin[no description available]medium10antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
clofibric acid[no description available]medium20aromatic ether;
monocarboxylic acid;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
antineoplastic agent;
herbicide;
marine xenobiotic metabolite;
PPARalpha agonist
clofibrate[no description available]medium10aromatic ether;
ethyl ester;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist
erythritol[no description available]medium30butane-1,2,3,4-tetrolantioxidant;
human metabolite;
plant metabolite
xylulose[no description available]medium30xyluloseEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
diadinoxanthin[no description available]medium10triterpenoid
tretinoin[no description available]medium40retinoic acid;
vitamin A		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
am 580[no description available]medium10amidobenzoic acid;
tetralins		antineoplastic agent;
retinoic acid receptor alpha/beta agonist
bexarotene[no description available]medium10benzoic acids;
naphthalenes;
retinoid		antineoplastic agent
geranylgeranylacetone[no description available]medium10
bisphenol a[no description available]medium10bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
methyl farnesoate[no description available]medium10enoate ester;
fatty acid methyl ester;
juvenile hormone		crustacean metabolite
methoprene[no description available]medium10isopropyl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate;
isopropyl ester		juvenile hormone mimic
pyriproxyfen[no description available]medium10aromatic ether;
pyridines		juvenile hormone mimic
zr 777[no description available]medium10farnesane sesquiterpenoid;
terminal acetylenic compound		juvenile hormone mimic
tocotrienols[no description available]medium10diterpenoid
dimethyldioxirane[no description available]medium10
isovaleryl-coenzyme a[no description available]medium10methylbutanoyl-CoA;
short-chain fatty acyl-CoA		mouse metabolite
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
methylene chloride[no description available]medium10chloromethanes;
volatile organic compound		carcinogenic agent;
polar aprotic solvent;
refrigerant
gramicidin a[no description available]medium10
gold[no description available]medium10copper group element atom;
elemental gold
valinomycin[no description available]medium10cyclodepsipeptide;
macrocycle		antimicrobial agent;
antiviral agent;
bacterial metabolite;
potassium ionophore
silicon[no description available]medium10carbon group element atom;
metalloid atom;
nonmetal atom
1,2-diphytanoylphosphatidylcholine[no description available]medium10
carbon monoxide[no description available]medium10carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
heme[no description available]medium10
1-octen-3-ol[no description available]medium20alkenyl alcohol;
medium-chain fatty alcohol		antimicrobial agent;
fungal metabolite;
insect attractant;
volatile oil component
3-hexen-1-ol[no description available]medium10alkenyl alcohol;
homoallylic alcohol;
primary alcohol;
volatile organic compound		plant metabolite
pirinixic acid[no description available]medium10aryl sulfide;
organochlorine compound;
pyrimidines
cycloleucalenol[no description available]medium103beta-sterol;
pentacyclic triterpenoid;
phytosterols
hydroxyethyl methacrylate[no description available]medium10enoate esterallergen;
polymerisation monomer
2,2,5,7,8-pentamethyl-1-hydroxychroman[no description available]medium10
pyrogallol[no description available]medium10benzenetriol;
phenolic donor		plant metabolite
loliolide[no description available]medium10benzofuransmetabolite
4-hydroxybenzaldehyde[no description available]medium20hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
benzofurans[no description available]medium10
decanaldehyde[no description available]medium10medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde		antifungal agent;
fragrance;
plant metabolite
protochlorophyll[no description available]medium10
protochlorophyllide[no description available]medium10
bacteriochlorophylls[no description available]medium30
pheophorbide a[no description available]medium10
pyropheophorbide a[no description available]medium10
3-methylcholanthrene[no description available]medium10ortho- and peri-fused polycyclic arenearyl hydrocarbon receptor agonist;
carcinogenic agent
citral[no description available]medium10enal;
monoterpenoid;
polyprenal		plant metabolite;
volatile oil component
dolichols[no description available]medium10polyterpene
geranylgeranyl pyrophosphate[no description available]medium10geranylgeranyl diphosphatemouse metabolite
menatetrenone[no description available]medium20menaquinoneanti-inflammatory agent;
antioxidant;
bone density conservation agent;
human metabolite;
neuroprotective agent
dinoprostone[no description available]medium20prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
calcitriol[no description available]medium10D3 vitamins;
hydroxycalciol;
triol		antineoplastic agent;
antipsoriatic;
bone density conservation agent;
calcium channel agonist;
calcium channel modulator;
hormone;
human metabolite;
immunomodulator;
metabolite;
mouse metabolite;
nutraceutical
isopentenyl pyrophosphate[no description available]medium30prenol phosphateantigen;
antioxidant;
epitope;
Escherichia coli metabolite;
mouse metabolite;
phosphoantigen
plastoquinone[no description available]medium10plastoquinone
glyceraldehyde 3-phosphate[no description available]medium10glyceraldehyde 3-phosphatemouse metabolite
pyruvic acid[no description available]medium202-oxo monocarboxylic acidcofactor;
fundamental metabolite
neurosporene[no description available]medium10acyclic carotene
isoprene[no description available]medium10alkadiene;
hemiterpene;
volatile organic compound		plant metabolite
pentane[no description available]medium10alkane;
volatile organic compound		non-polar solvent;
refrigerant
1-deoxy-2-pentulose[no description available]medium20deoxypentoseEscherichia coli metabolite
alpha-chymotrypsin[no description available]medium10
fucosterol[no description available]medium10steroid
bornyl acetate[no description available]medium10acetate ester;
monoterpenoid
glyceraldehyde[no description available]medium10aldotriosefundamental metabolite
bezafibrate[no description available]medium10aromatic ether;
monocarboxylic acid amide;
monocarboxylic acid;
monochlorobenzenes		antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic
tetradecanoylphorbol acetate[no description available]medium10acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
n-acetylaspartic acid[no description available]medium10N-acetyl-L-amino acid;
N-acyl-L-aspartic acid		antioxidant;
human metabolite;
mouse metabolite;
nutraceutical;
rat metabolite
aspartic acid[no description available]medium10aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
creatine[no description available]medium10glycine derivative;
guanidines;
zwitterion		geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent;
nutraceutical
cetyl alcohol[no description available]medium10hexadecanol;
long-chain primary fatty alcohol		algal metabolite;
flavouring agent;
human metabolite;
plant metabolite
stearic acid[no description available]medium10long-chain fatty acid;
saturated fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
human metabolite;
plant metabolite
oleanolic acid[no description available]medium10hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
erythrodiol[no description available]medium10diol;
pentacyclic triterpenoid;
primary alcohol;
secondary alcohol		plant metabolite
brassicasterol[no description available]medium103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		algal metabolite;
animal metabolite;
biomarker;
EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor;
human metabolite;
marine metabolite;
plant metabolite;
sterol biosynthesis inhibitor
2-c-methylerythritol 4-phosphate[no description available]medium20tetritol phosphateEscherichia coli metabolite
acetic acid[no description available]medium10monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
zirconium[no description available]medium10titanium group element atom
aluminum[no description available]medium10boron group element atom;
elemental aluminium;
metal atom
alkenes[no description available]medium10
diacetyl[no description available]medium10alpha-diketoneEscherichia coli metabolite;
Saccharomyces cerevisiae metabolite
sulfur[no description available]medium10chalcogen;
nonmetal atom		macronutrient
1-anilino-8-naphthalenesulfonate[no description available]medium10aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
galactose[no description available]medium10D-galactose;
galactopyranose		Escherichia coli metabolite;
mouse metabolite
glycolipids[no description available]medium10
citronellol[no description available]medium10monoterpenoidplant metabolite
pentobarbital[no description available]medium10barbituratesGABAA receptor agonist
beta-damascenone[no description available]medium10apo carotenoid monoterpenoid;
cyclic monoterpene ketone;
enone		fragrance;
plant metabolite;
volatile oil component
allopurinol[no description available]medium10nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
arachidonic acid[no description available]medium10icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
1,2-dipalmitoylphosphatidylcholine[no description available]medium10
3-methyladipic acid[no description available]medium10alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid		human urinary metabolite
calcimycin[no description available]medium10benzoxazole
carmustine[no description available]medium10N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent
amitrole[no description available]medium10aromatic amine;
triazoles		carotenoid biosynthesis inhibitor;
EC 1.11.1.6 (catalase) inhibitor;
herbicide
nitrogen dioxide[no description available]medium10nitrogen oxide
ozone[no description available]medium10elemental molecule;
gas molecular entity;
reactive oxygen species;
triatomic oxygen		antiseptic drug;
disinfectant;
electrophilic reagent;
greenhouse gas;
mutagen;
oxidising agent;
tracer
bromine[no description available]medium10diatomic bromine
phytane[no description available]medium10diterpene
humulene[no description available]medium10alpha-humulene
nicosulfuron[no description available]medium10N-sulfonylurea;
pyridines;
pyrimidines		environmental contaminant;
herbicide;
xenobiotic
clove[no description available]medium10
sabinene[no description available]medium10thujeneplant metabolite
eye[no description available]medium10
hypericum[no description available]medium10penicillanic acids
ants[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Autosome0low10
Abnormalities, Chromosomal0low10
Abnormalities, Chromosome0low10
Abnormalities, Drug-Induced0low20
Absence Seizure0low10
Absence Seizures0low10
Absence Status0low10
Ache0low20
Acute Autoimmune Neuropathy0low10
Acute Confusional Senile Dementia0low10
Acute Infectious Polyneuritis0low10
Acute Inflammatory Demyelinating Polyneuropathy0low10
Acute Inflammatory Demyelinating Polyradiculoneuropathy0low10
Acute Inflammatory Polyneuropathy0low10
Acute Inflammatory Polyradiculoneuropathy0low10
Acute Liver Injury, Drug-Induced0low10
Adjuvant Arthritis0low20
Adrenoleukodystrophy, Autosomal Neonatal Form0low10
Adrenoleukodystrophy, Autosomal, Neonatal Form0low10
Adrenoleukodystrophy, Neonatal0low10
Adult Refsum Disease0low160
African Sleeping Sickness0low10
African Trypanosomiasis0low10
Age-Related Osteoporosis0low30
Allergic Encephalomyelitis0low10
Allergic Encephalomyelitis, Experimental0low10
Allergic Neuritis, Experimental0low10
Allodynia0low10
Allodynia, Mechanical0low10
Allodynia, Tactile0low10
Allodynia, Thermal0low10
Alloxan Diabetes0low10
Alzheimer Dementia0low10
Alzheimer Disease0low10
Alzheimer Disease, Early Onset0low10
Alzheimer Disease, Late Onset0low10
Alzheimer Sclerosis0low10
Alzheimer Syndrome0low10
Alzheimer Type Senile Dementia0low10
Alzheimer-Type Dementia (ATD)0low10
Alzheimer's Disease0low10
Alzheimer's Disease, Focal Onset0low10
Alzheimer's Diseases0low10
Anasarca0low40
Anemia0low10
Anoxemia0low20
Anoxia0low20
Arteriosclerosis0low10
Arthritis, Adjuvant0low20
Arthritis, Adjuvant-Induced0low20
Arthritis, Collagen-Induced0low20
Arthritis, Experimental0low20
Arthritis, Rheumatoid0low10
Ataxia0low10
Ataxia, Appendicular0low10
Ataxia, Limb0low10
Ataxia, Motor0low10
Ataxia, Sensory0low10
Ataxia, Truncal0low10
Ataxy0low10
Atonic Absence Seizure0low10
Atonic Absence Seizures0low10
Atonic Seizure0low10
Atonic Seizures0low10
Autoimmune Disease0low10
Autoimmune Diseases0low10
Autoimmune Encephalomyelitis, Experimental0low10
Autoimmune Experimental Encephalomyelitis0low10
Autoimmune Neuritis, Experimental0low10
Autosomal Chromosome Disorders0low10
Autosome Abnormalities0low10
Benign Neoplasms0low30
Blood Clot0low10
Body Weight0low70
Bone Loss, Age-Related0low30
Bone Loss, Osteoclastic0low20
Bone Resorption0low20
Bordetella pertussis Infection, Respiratory0low100
Brain Diseases, Metabolic, Familial0low10
Brain Diseases, Metabolic, Inborn0low10
Brain Diseases, Metabolic, Inherited0low10
Brain Syndrome, Metabolic, Inborn0low10
Breast Cancer0low20
Breast Carcinoma0low20
Breast Neoplasms0low20
Breast Tumors0low20
Cancer0low30
Cancer of Breast0low20
Cancer of Liver0low10
Cancer of Lung0low20
Cancer of the Breast0low20
Cancer of the Liver0low10
Cancer of the Lung0low20
Cancer, Hepatocellular0low10
Carcinogenesis0low10
Carcinoma0low10
Carcinoma, Anaplastic0low10
Carcinoma, Epidermoid0low10
Carcinoma, Hepatocellular0low10
Carcinoma, Planocellular0low10
Carcinoma, Spindle-Cell0low10
Carcinoma, Squamous0low10
Carcinoma, Squamous Cell0low10
Carcinoma, Undifferentiated0low10
Carcinomatosis0low10
Central Nervous System Inborn Metabolic Diseases0low10
Central Nervous System Inborn Metabolic Disorders0low10
Chemical and Drug Induced Liver Injury0low10
Chemically-Induced Liver Toxicity0low10
Chondrodysplasia Punctata, Rhizomelic0low20
Chondrodysplasia Punctata, Rhizomelic Form0low20
Chromosomal Aberrations0low10
Chromosomal Disorders0low10
Chromosome Aberrations0low10
Chromosome Abnormalities0low10
Chromosome Abnormality Disorders0low10
Chromosome Disorders0low10
Classic Refsum Disease0low160
Clonic Seizure0low10
Clonic Seizures0low10
CNS Metabolic Disorders, Inborn0low10
Cognitive Decline0low10
Cognitive Dysfunction0low10
Cognitive Impairments0low10
Collagen Arthritis0low20
Complex Partial Seizure0low10
Complex Partial Seizures0low10
Complex Partial Status Epilepticus0low10
Congenital Icthyosis Mental Retardation Spasticity Syndrome0low40
Convulsion0low10
Convulsion, Non-Epileptic0low10
Convulsions0low10
Convulsive Seizure0low10
Convulsive Seizures0low10
Coordination Impairment0low10
Cross Infection0low20
Cytogenetic Aberrations0low10
Cytogenetic Abnormalities0low10
Deficiency Diseases0low10
Deficiency, Factor II0low20
Deficiency, Oxygen0low20
Deficiency, Vitamin E0low20
Deficiency, Vitamin K0low10
Degenerative Diseases, Central Nervous System0low10
Degenerative Diseases, Nervous System0low10
Degenerative Diseases, Neurologic0low10
Degenerative Diseases, Spinal Cord0low10
Degenerative Neurologic Diseases0low10
Degenerative Neurologic Disorders0low10
Delayed Effects, Prenatal Exposure0low20
Dementia, Alzheimer Type0low10
Dementia, Presenile0low10
Dementia, Primary Senile Degenerative0low10
Dementia, Senile0low10
Demyelinating Polyradiculoneuropathy, Acute Inflammatory0low10
Diabetes Mellitus, Experimental0low10
Diarrhea0low10
Diathesis0low10
Disease Models, Animal0low110
Disease Resistance0low10
Disease Susceptibility0low10
Diseases, Metabolic0low10
Dropsy0low40
Drug-Induced Abnormalities0low20
Drug-Induced Acute Liver Injury0low10
Drug-Induced Liver Disease0low10
Drug-Induced Liver Injury0low10
Dyscoordination0low10
Dyssynergia0low10
EAN (Experimental Allergic Neuritis)0low10
EAN (Experimental Autoimmune Neuritis)0low10
Early Onset Alzheimer Disease0low10
Edema0low40
EHS Tumor0low10
Encephalomyelitis, Allergic0low10
Encephalomyelitis, Autoimmune, Experimental0low10
Encephalomyelitis, Experimental Autoimmune0low10
Encephalopathies, Metabolic, Inborn0low10
Epileptic Seizure0low10
Epileptic Seizures0low10
Epithelial Neoplasms, Malignant0low10
Epithelial Tumors, Malignant0low10
Epithelioma0low10
Experimental Allergic Encephalomyelitis0low10
Experimental Allergic Neuritis0low10
Experimental Autoimmune Encephalomyelitis0low10
Experimental Autoimmune Neuritis0low10
Experimental Autoimmune Neuropathy0low10
Experimental Diabetes Mellitus0low10
Experimental Mammary Neoplasms0low10
Experimental Sarcoma0low10
Experimental Sarcomas0low10
Extravascular Hemolysis0low10
Factor II Deficiency0low20
FALDH Deficiency0low40
Familial Alzheimer Disease (FAD)0low10
Familial Metabolic Brain Diseases0low10
Familial Metabolic Disorders, Brain0low10
Fatty Aldehyde Dehydrogenase Deficiency0low40
Fatty Aldehyde Dehydrogenase Deficiency Disease0low40
Fever0low10
Fibrosarcoma0low10
Focal Onset Alzheimer's Disease0low10
Generalized Absence Seizure0low10
Generalized Absence Seizures0low10
Generalized Convulsive Status Epilepticus0low10
Generalized Tonic-Clonic Seizures0low10
Genetic Predisposition0low10
Genetic Predisposition to Disease0low10
Genetic Susceptibility0low10
Grand Mal Status Epilepticus0low10
Guillain-Barre Syndrome0low10
Guillain-Barre Syndrome, Familial0low10
Guillain-Barru00E9 Syndrome0low10
Guillaine-Barre Syndrome0low10
Haemolysis0low10
Health Care Associated Infection0low20
Health Care Associated Infections0low20
Healthcare Associated Infections0low20
Hemeralopia Heredoataxia Polyneuritiformis0low160
Hemolysis0low10
Hepatic Cancer0low10
Hepatic Neoplasms0low10
Hepatitis, Drug-Induced0low10
Hepatitis, Toxic0low10
Hepatocellular Cancer0low10
Hepatocellular Carcinoma0low10
Hepatoma0low10
Hereditary Motor And Sensory Neuropathy IV0low160
Hereditary Motor and Sensory Neuropathy Type IV0low160
Hereditary Motor and Sensory Neuropathy, Type IV0low160
Hereditary Type IV Motor and Sensory Neuropathy0low160
Heredopathia Atactica Polyneuritiformis0low160
HMSN 40low160
HMSN IV0low160
HMSN Type IV0low160
Hospital Infections0low20
Human Mammary Carcinoma0low20
Hydrops0low40
Hyper IgD Syndrome0low10
Hyper-IgD Syndrome0low10
Hyperalgesia0low10
Hyperalgesia, Mechanical0low10
Hyperalgesia, Primary0low10
Hyperalgesia, Secondary0low10
Hyperalgesia, Tactile0low10
Hyperalgesia, Thermal0low10
Hyperalgesic Sensations0low10
Hyperalgia0low10
Hyperalgia, Mechanical0low10
Hyperalgia, Primary0low10
Hyperalgia, Secondary0low10
Hyperimmunoglobulinemia D0low10
Hyperimmunoglobulinemia D And Periodic Fever Syndrome0low10
Hyperpipecolatemia0low10
Hyperpipecolic Acidemia0low10
Hyperplasia0low10
Hypoprothrombinemia0low20
Hypoprothrombinemias0low20
Hypoxemia0low20
Hypoxia0low20
Ichthyosis Oligophrenia Syndrome0low40
Ichthyosis, Spastic Neurologic Disorder, and Oligophrenia0low40
Inborn Errors of Metabolism, Brain0low10
Inborn Metabolic Brain Diseases0low10
Inborn Metabolic Brain Disorders0low10
Inborn Metabolic Disorders, Brain0low10
Incoordination0low10
Infection, Cross0low20
Infections, Hospital0low20
Infections, Nosocomial0low20
Infections, Plasmodium0low10
Infections, Staphylococcal0low10
Inflammation0low20
Inflammatory Demyelinating Polyradiculoneuropathy, Acute0low10
Inflammatory Polyneuropathy Acute0low10
Inherited Metabolic Brain Diseases0low10
Inherited Metabolic Disorders, Brain0low10
Innate Inflammatory Response0low20
Insulin Resistance0low10
Insulin Sensitivity0low10
Intravascular Hemolysis0low10
Itching0low10
Jacksonian Seizure0low10
Lack of Coordination0low10
Landry-Guillain-Barre Syndrome0low10
Late Effects, Prenatal Exposure0low20
Late Onset Alzheimer Disease0low10
Leukemia, Lymphocytic0low20
Leukemia, Lymphoid0low20
Lipid Metabolism, Inborn Error0low10
Lipid Metabolism, Inborn Errors0low10
Lipidoses0low10
Lipidosis0low10
Lipoidosis0low10
Liver Cancer0low10
Liver Cancer, Adult0low10
Liver Cell Carcinoma0low10
Liver Cell Carcinoma, Adult0low10
Liver Diseases0low10
Liver Dysfunction0low10
Liver Injury, Drug-Induced0low10
Liver Injury, Drug-Induced, Acute0low10
Liver Neoplasms0low10
Lung Cancer0low20
Lung Neoplasms0low20
Lymphocytic Leukemia0low20
Lymphoid Leukemia0low20
Malaria0low10
Malignancy0low30
Malignant Epithelial Neoplasms0low10
Malignant Neoplasm of Breast0low20
Malignant Neoplasms0low30
Malignant Tumor of Breast0low20
Mammary Cancer0low20
Mammary Carcinoma, Human0low20
Mammary Neoplasm, Human0low20
Mammary Neoplasms, Experimental0low10
Mammary Neoplasms, Human0low20
Marsh Fever0low10
Mechanical Allodynia0low10
Mechanical Hyperalgesia0low10
Mental Deterioration0low10
Metabolic Brain Diseases, Familial0low10
Metabolic Brain Diseases, Inborn0low10
Metabolic Brain Diseases, Inherited0low10
Metabolic Brain Syndrome, Inborn0low10
Metabolic Diseases0low10
Metabolic Diseases, Inborn, Brain0low10
Metabolic Diseases, Inborn, Central Nervous System0low10
Metabolic Disorders, Brain, Inherited0low10
Metabolic Disorders, CNS, Inborn0low10
Metabolic Disorders, Familial, Brain0low10
Mevalonate Kinase Deficiency0low10
Mevalonic Aciduria0low10
Mevalonicaciduria0low10
Mild Cognitive Impairment0low10
Mild Neurocognitive Disorder0low10
Muscle Contraction0low10
Myoclonic Seizure0low10
Myoclonic Seizures0low10
Nagana0low10
Necrosis0low30
Neglected Diseases0low10
Neonatal Adrenoleukodystrophy0low10
Neoplasia0low30
Neoplasm0low30
Neoplasms0low30
Neoplasms, Benign0low30
Neoplasms, Breast0low20
Neoplasms, Experimental Mammary0low10
Neoplasms, Hepatic0low10
Neoplasms, Liver0low10
Neoplasms, Lung0low20
Neoplasms, Malignant Epithelial0low10
Neoplasms, Pulmonary0low20
Nervous System Degenerative Diseases0low10
Neuritis, Autoimmune, Experimental0low10
Neuritis, Experimental Allergic0low10
Neuritis, Experimental Autoimmune0low10
Neurodegenerative Diseases0low10
Neurodegenerative Disorders0low10
Neurologic Degenerative Conditions0low10
Neurologic Degenerative Diseases0low10
Neurologic Diseases, Degenerative0low10
Neuropathy, Hereditary Motor and Sensory, Type IV0low160
Non-Convulsive Status Epilepticus0low10
Non-Epileptic Seizure0low10
Non-Epileptic Seizures0low10
Nonepileptic Seizure0low10
Nonepileptic Seizures0low10
Nosocomial Infections0low20
Obesity0low20
Oncogenesis0low10
Osteoclastic Bone Loss0low20
Osteoporosis0low30
Osteoporosis, Age-Related0low30
Osteoporosis, Involutional0low30
Osteoporosis, Post-Traumatic0low30
Osteoporosis, Senile0low30
Oxygen Deficiency0low20
Pain0low20
Pain, Burning0low20
Pain, Crushing0low20
Pain, Migratory0low20
Pain, Radiating0low20
Pain, Splitting0low20
Palmoplantaris Pustulosis0low10
Paludism0low10
Parasitemia0low10
Partial Seizure0low10
Partial Seizures0low10
Periodic Fever, Dutch Type0low10
Peripheral Nerve Diseases0low10
Peripheral Nervous System Disease0low10
Peripheral Nervous System Diseases0low10
Peripheral Nervous System Disorders0low10
Peripheral Neuropathies0low10
Peroxisomal Disorders0low10
Peroxisomal Dysfunction, General0low10
Peroxisomal Dysfunction, Multiple0low10
Peroxisomal Dysfunction, Single0low10
Pertussis0low100
Petit Mal Convulsion0low10
Petit Mal Status0low10
Phytanic Acid Oxidase Deficiency0low160
Phytanic Acid Storage Disease0low160
Plasmodium Infections0low10
PNS (Peripheral Nervous System) Diseases0low10
PNS Diseases0low10
Polyneuropathy, Acute Inflammatory0low10
Polyneuropathy, Inflammatory Demyelinating, Acute0low10
Polyradiculoneuropathy, Acute Inflammatory0low10
Polyradiculoneuropathy, Acute Inflammatory Demyelinating0low10
Predisposition, Genetic0low10
Pregnancy0low20
Prenatal Exposure Delayed Effects0low20
Presenile Alzheimer Dementia0low10
Primary Senile Degenerative Dementia0low10
Prothrombin Deficiency0low20
Pruritis0low10
Pruritus0low10
Psoriasis0low10
Pulmonary Cancer0low20
Pulmonary Neoplasms0low20
Pustular Psoriasis of Palms and Soles0low10
Pustulosis of Palms and Soles0low10
Pustulosis Palmaris et Plantaris0low10
Pyrexia0low10
Refsum Disease0low160
Refsum Disease, Adult0low160
Refsum Disease, Classic0low160
Refsum Disease, Phytanic Acid Oxidase Deficiency0low160
Refsum Disease, Phytanoyl-CoA Hydroxylase Deficiency0low160
Refsum Syndrome0low160
Refsum-Thiebaut Syndrome0low160
Refsum's Disease0low160
Refsum's Syndrome0low160
Remittent Fever0low10
Resistance, Disease0low10
Rheumatoid Arthritis0low10
Rhizomelic Chondrodysplasia Punctata0low20
Sarcoma0low10
Sarcoma 1800low10
Sarcoma 180, Crocker0low10
Sarcoma, Engelbreth-Holm-Swarm0low10
Sarcoma, Epithelioid0low10
Sarcoma, Experimental0low10
Sarcoma, Jensen0low10
Sarcoma, Soft Tissue0low10
Sarcoma, Spindle Cell0low10
Sarcomas, Experimental0low10
Schistosoma mansoni Infection0low10
Schistosomiasis mansoni0low10
Schistosomiasis, Intestinal0low10
Seizure0low10
Seizures0low10
Seizures, Auditory0low10
Seizures, Clonic0low10
Seizures, Convulsive0low10
Seizures, Epileptic0low10
Seizures, Focal0low10
Seizures, Generalized0low10
Seizures, Gustatory0low10
Seizures, Motor0low10
Seizures, Olfactory0low10
Seizures, Sensory0low10
Seizures, Somatosensory0low10
Seizures, Tonic0low10
Seizures, Tonic-Clonic0low10
Seizures, Vertiginous0low10
Seizures, Vestibular0low10
Seizures, Visual0low10
Senile Dementia, Acute Confusional0low10
Senile Dementia, Alzheimer Type0low10
Senile Osteoporosis0low30
Sensitivity and Specificity0low30
Simple Partial Status Epilepticus0low10
Single Seizure0low10
Sjogren-Larsson Syndrome0low40
Sju00F6gren-Larsson Syndrome0low40
Squamous Cell Carcinoma0low10
Staphylococcal Infections0low10
Staphylococcus aureus Infection0low10
Status Epilepticus0low10
Status Epilepticus, Complex Partial0low10
Status Epilepticus, Electrographic0low10
Status Epilepticus, Generalized0low10
Status Epilepticus, Generalized Convulsive0low10
Status Epilepticus, Grand Mal0low10
Status Epilepticus, Non-Convulsive0low10
Status Epilepticus, Simple Partial0low10
Status Epilepticus, Subclinical0low10
Streptozocin Diabetes0low10
Streptozotocin Diabetes0low10
Suffering, Physical0low20
Susceptibility, Disease0low10
Susceptibility, Genetic0low10
Tactile Allodynia0low10
Thermal Allodynia0low10
Thesaurismosis0low10
Thrombosis0low10
Thrombus0low10
Tonic Clonic Seizure0low10
Tonic Seizure0low10
Tonic Seizures0low10
Tonic-Clonic Seizure0low10
Tonic-Clonic Seizures0low10
Toxic Hepatitis0low10
Tremor, Rubral0low10
Trypanosomiasis, African0low10
Tumorigenesis0low10
Tumors0low30
Tumors, Breast0low20
Uveitis0low10
Vitamin E Deficiency0low20
Vitamin K Deficiency0low10
Whooping Cough0low100

Research Highlights

Safety/Toxicity (3)

ArticleYear
Phytol loaded PLGA nanoparticles regulate the expression of Alzheimer's related genes and neuronal apoptosis against amyloid-β induced toxicity in Neuro-2a cells and transgenic Caenorhabditis elegans.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Volume: 136		2020
Evaluation of toxic, cytotoxic and genotoxic effects of phytol and its nanoemulsion.
Chemosphere, Volume: 177		2017
Toxicity of ozone and nitrogen dioxide to alveolar macrophages: comparative study revealing differences in their mechanism of toxic action.
Journal of toxicology and environmental health, Volume: 19, Issue: 4		1986
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
Evaluation of toxic, cytotoxic and genotoxic effects of phytol and its nanoemulsion.
Chemosphere, Volume: 177		2017
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]