methadone has been researched along with Necrosis in 14 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective study was conducted on the evolution of serum transaminases in 116 patients infected with hepatitis C virus (HCV), parenteral drug abusers, included for 6 months in treatment programs with methadone, naltrexone or "drug free" regimen." | 9.08 | [Effect of methadone or naltrexone on the course of transaminases in parenteral drug users with hepatitis C virus infection]. ( Gutiérrez Mora, E; Lozano Polo, JL; Martínez Pérez, V; Santamaría Gutiérrez, J; Vada Sánchez, J; Vallejo Correas, JA, 1997) |
| " We present a case of a 23-year-old man who had acute necrosis of the bilateral globi pallidi in the brain and systemic rhabdomyolysis after ingesting methadone and nasally insufflating alprazolam." | 7.79 | Bilateral acute necrosis of the globi pallidi and rhabdomyolysis due to combined methadone and benzodiazepine toxicity. ( Corliss, RF; Mandal, R; Soriano, BJ, 2013) |
| "A prospective study was conducted on the evolution of serum transaminases in 116 patients infected with hepatitis C virus (HCV), parenteral drug abusers, included for 6 months in treatment programs with methadone, naltrexone or "drug free" regimen." | 5.08 | [Effect of methadone or naltrexone on the course of transaminases in parenteral drug users with hepatitis C virus infection]. ( Gutiérrez Mora, E; Lozano Polo, JL; Martínez Pérez, V; Santamaría Gutiérrez, J; Vada Sánchez, J; Vallejo Correas, JA, 1997) |
| " We present a case of a 23-year-old man who had acute necrosis of the bilateral globi pallidi in the brain and systemic rhabdomyolysis after ingesting methadone and nasally insufflating alprazolam." | 3.79 | Bilateral acute necrosis of the globi pallidi and rhabdomyolysis due to combined methadone and benzodiazepine toxicity. ( Corliss, RF; Mandal, R; Soriano, BJ, 2013) |
| " The autopsy and toxicological analyses revealed that death was caused by an overdose of methadone and that the necroses in the groins were fistulas facilitating administration of the drugs directly into larger veins." | 3.68 | Fatal poisoning with intravenously injected methadone and no fresh injection marks found. ( Gregersen, M; Jensen, S, 1991) |
| "Methadone is a widely used therapeutic opioid in narcotic addiction and neuropathic pain syndromes." | 1.36 | Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis. ( Aguirre, N; Bednarczyk, P; Cuenca-Lopez, MD; de Mera, RM; Galindo, MF; Jordán, J; Karachitos, A; Kmita, H; Perez-Alvarez, S; Puerta, E, 2010) |
| " These LAAM-induced changes demonstrated dose- and time-dependence within that dosage range producing mortality." | 1.27 | L-alpha-acetylmethadol-induced tissue alterations in mice. ( Freeman, RW; Harbison, RD; James, RC, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
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| Chabanet, C | 1 |
| Popoff, MR | 1 |
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| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
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| López, F | 1 |
| Jiménez, A | 1 |
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| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
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| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
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| Gai, QY | 3 |
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1 review available for methadone and Necrosis
2 trials available for methadone and Necrosis
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
[Effect of methadone or naltrexone on the course of transaminases in parenteral drug users with hepatitis C virus infection].
Topics: Adult; Female; Hepatitis C; Humans; Liver; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antago | 1997 |
12 other studies available for methadone and Necrosis
| Article | Year |
|---|---|
A possible biomarker for methadone related deaths.
Topics: Adult; Apoptosis; Brain Stem; Caspase 9; Cohort Studies; Female; Forensic Pathology; Forensic Toxico | 2017 |
Necrosis of the intranasal structures and soft palate as a result of heroin snorting: a case series.
Topics: Administration, Intranasal; Adult; Buprenorphine; Female; Heroin; Heroin Dependence; Humans; Male; M | 2013 |
Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis.
Topics: Analgesics, Opioid; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calcium; Casp | 2010 |
Methadone induces CAD degradation and AIF-mediated necrotic-like cell death in neuroblastoma cells.
Topics: Analgesics, Opioid; Animals; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Cell Line, Tumor | 2011 |
Bilateral acute necrosis of the globi pallidi and rhabdomyolysis due to combined methadone and benzodiazepine toxicity.
Topics: Administration, Intranasal; Adult; Alprazolam; Brain; Forensic Pathology; Forensic Toxicology; Glasg | 2013 |
[Oral pain and loss of teeth in a 36-year-old woman].
Topics: Adult; Anti-Bacterial Agents; Antiretroviral Therapy, Highly Active; Combined Modality Therapy; Debr | 2005 |
Necrolytic migratory erythema in an opiate-dependent patient.
Topics: Adolescent; Analgesics, Opioid; Diagnosis, Differential; Erythema; Female; Heroin; Humans; Methadone | 2008 |
L-alpha-acetylmethadol-induced tissue alterations in mice.
Topics: Alanine Transaminase; Animals; Blood Urea Nitrogen; Glutathione; Kidney; Liver; Male; Methadone; Met | 1984 |
Fatal poisoning with intravenously injected methadone and no fresh injection marks found.
Topics: Drug Overdose; Fistula; Forensic Medicine; Humans; Male; Methadone; Necrosis; Photomicrography; Skin | 1991 |
[Complications following parenteral administration of oral methadone solution].
Topics: Abscess; Administration, Oral; Cellulitis; Humans; Infusions, Parenteral; Methadone; Necrosis; Skin; | 1988 |
Teratogenic activity of methadone hydrochloride in mouse and chick embryos.
Topics: Abnormalities, Drug-Induced; Anencephaly; Animals; Brain; Chick Embryo; Embryo, Mammalian; Female; G | 1973 |
The analgesic and anaesthetic actions of tetrafluorobenzene.
Topics: Analgesics; Anesthesia, Inhalation; Anesthetics; Animals; Arrhythmias, Cardiac; Benzene; Blood Press | 1966 |