Proteins > Sodium/potassium-transporting ATPase subunit alpha-1
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Sodium/potassium-transporting ATPase subunit alpha-1
A sodium/potassium-transporting ATPase subunit alpha-1 that is encoded in the genome of dog. [OMA:P50997, PRO:DNx]
Synonyms
Na(+)/K(+) ATPase alpha-1 subunit;
EC 7.2.2.13;
Sodium pump subunit alpha-1
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| digitoxin | Canis lupus familiaris (dog) | IC50 | 0.0080 | 1 | 1 |
| digoxin | Canis lupus familiaris (dog) | IC50 | 0.5000 | 2 | 2 |
| digitoxigenin | Canis lupus familiaris (dog) | IC50 | 0.5000 | 2 | 2 |
| istaroxime | Canis lupus familiaris (dog) | IC50 | 0.1400 | 1 | 1 |
17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity relationships, and molecular modeling of the Na(+),K(+)-ATPase receptor.Journal of medicinal chemistry, , Jun-15, Volume: 43, Issue:12, 2000
Synthesis, cardiotonic activity, and structure-activity relationships of 17 beta-guanylhydrazone derivatives of 5 beta-androstane-3 beta, 14 beta-diol acting on the Na+,K(+)-ATPase receptor.Journal of medicinal chemistry, , Oct-10, Volume: 40, Issue:21, 1997
17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity relationships, and molecular modeling of the Na(+),K(+)-ATPase receptor.Journal of medicinal chemistry, , Jun-15, Volume: 43, Issue:12, 2000
Synthesis, cardiotonic activity, and structure-activity relationships of 17 beta-guanylhydrazone derivatives of 5 beta-androstane-3 beta, 14 beta-diol acting on the Na+,K(+)-ATPase receptor.Journal of medicinal chemistry, , Oct-10, Volume: 40, Issue:21, 1997