Proteins > Protein farnesyltransferase subunit beta
Page last updated: 2024-08-07 16:45:39
Protein farnesyltransferase subunit beta
A protein that is a translation product of the FNTB gene in cow. [PRO:DNx, UniProtKB:P49355]
Synonyms
FTase-beta;
EC 2.5.1.58;
CAAX farnesyltransferase subunit beta;
Ras proteins prenyltransferase subunit beta
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 8 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| b 581 | Bos taurus (cattle) | IC50 | 0.0210 | 1 | 1 |
| r115777 | Bos taurus (cattle) | IC50 | 0.5503 | 2 | 4 |
| lonafarnib | Bos taurus (cattle) | IC50 | 0.0081 | 3 | 3 |
| tipifarnib | Bos taurus (cattle) | IC50 | 0.0006 | 4 | 4 |
| l 778,123 | Bos taurus (cattle) | IC50 | 0.0485 | 2 | 2 |
| fti 276 | Bos taurus (cattle) | IC50 | 0.0005 | 1 | 1 |
| a 228839 | Bos taurus (cattle) | IC50 | 0.0011 | 3 | 3 |
| lonafarnib | Bos taurus (cattle) | IC50 | 5.0041 | 2 | 4 |
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.Bioorganic & medicinal chemistry letters, , Jan-03, Volume: 15, Issue:1, 2005
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005