Proteins > Signal transducer and activator of transcription 3
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Signal transducer and activator of transcription 3
A signal transducer and activator of transcription 3 that is encoded in the genome of mouse. [OMA:P42227, PRO:DNx]
Synonyms
Acute-phase response factor
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| suramin sodium | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| nsc 74859 | Mus musculus (house mouse) | IC50 | 146.3333 | 4 | 6 |
| nf 449 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| bp-1-102 | Mus musculus (house mouse) | IC50 | 13.2500 | 2 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bp-1-102 | Mus musculus (house mouse) | Activity | 0.5040 | 1 | 1 |
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.Proceedings of the National Academy of Sciences of the United States of America, , May-01, Volume: 104, Issue:18, 2007
Design, synthesis and activity of BBI608 derivatives targeting on stem cells.European journal of medicinal chemistry, , May-10, Volume: 151, 2018
Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.ACS medicinal chemistry letters, , Mar-08, Volume: 9, Issue:3, 2018
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011