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Beta-1 adrenergic receptor
A beta-1 adrenergic receptor that is encoded in the genome of rat. [OMA:P18090, PRO:DNx]
Synonyms
Beta-1 adrenoreceptor;
Beta-1 adrenoceptor
Research
Bioassay Publications (30)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 11 (36.67) | 18.7374 |
| 1990's | 9 (30.00) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (43)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| alprenolol | Rattus norvegicus (Norway rat) | Kapp | 0.0077 | 1 | 1 |
| isoproterenol | Rattus norvegicus (Norway rat) | EC20 | 0.0001 | 1 | 1 |
| bunolol | Rattus norvegicus (Norway rat) | Kapp | 0.0150 | 1 | 1 |
| pindolol | Rattus norvegicus (Norway rat) | Kapp | 0.0140 | 1 | 1 |
| practolol | Rattus norvegicus (Norway rat) | Kapp | 18.0000 | 1 | 1 |
| propranolol | Rattus norvegicus (Norway rat) | Kapp | 0.0110 | 1 | 1 |
| brl 37344 | Rattus norvegicus (Norway rat) | EC20 | 0.1200 | 1 | 1 |
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.Journal of medicinal chemistry, , Apr-20, Volume: 43, Issue:8, 2000
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.Journal of medicinal chemistry, , 10-13, Volume: 59, Issue:19, 2016
Synthesis of a series of compounds related to betaxolol, a new beta 1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence.Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Carbostyril derivatives having potent beta-adrenergic agonist properties.Journal of medicinal chemistry, , Volume: 30, Issue:9, 1987
Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols.Journal of medicinal chemistry, , Volume: 25, Issue:6, 1982
The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.Journal of medicinal chemistry, , 10-13, Volume: 59, Issue:19, 2016
Role of Tyr(356(7.43)) and Ser(190(4.57)) in antagonist binding in the rat beta1-adrenergic receptor.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Synthesis of a series of compounds related to betaxolol, a new beta 1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HTEuropean journal of medicinal chemistry, , Mar-10, Volume: 147, 2018
Role of Tyr(356(7.43)) and Ser(190(4.57)) in antagonist binding in the rat beta1-adrenergic receptor.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Synthesis and adrenergic activity of a new series of N-aryl dicyclopropyl ketone oxime ethers: SAR and stereochemical aspects.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties.Journal of medicinal chemistry, , Volume: 32, Issue:1, 1989
Synthesis of a series of compounds related to betaxolol, a new beta 1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols.Journal of medicinal chemistry, , Volume: 25, Issue:6, 1982
Cardioselectivity of beta-adrenoceptor blocking agents 1. 1-[(4-Hydroxyphenethyl)amino]-3-(aryloxy)propan-2-ols.Journal of medicinal chemistry, , Volume: 22, Issue:6, 1979
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.Journal of medicinal chemistry, , Apr-20, Volume: 43, Issue:8, 2000
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).Journal of medicinal chemistry, , Dec-31, Volume: 41, Issue:27, 1998
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996