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Neuraminidase
A neuraminidase subtype N1 (Influenza A virus) that is encoded in the genome of the H1N1 strain A/Wilson-Smith/1933. [PMID:10864667, PMID:15567494, PMID:15744059, PMID:16140748, PMID:16192481, PMID:7077751, PMID:8560787, PRO:CNA, PRO:DNx, UniProtKB:P034
Synonyms
EC 3.2.1.18
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| mesalamine | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 100.0000 | 1 | 1 |
| 1-hydroxy-2-naphthoic acid | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 100.0000 | 1 | 1 |
| zanamivir | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 0.0017 | 5 | 5 |
| bcx 1812 | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 0.0004 | 2 | 2 |
| gs 4071 | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 0.1851 | 4 | 4 |
| Methylenedioxycinnamic acid | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 100.0000 | 1 | 1 |
| caffeic acid | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 100.0000 | 1 | 1 |
| tamiphosphor | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 0.4977 | 2 | 2 |
Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses.European journal of medicinal chemistry, , Jun-25, Volume: 154, 2018
Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Enhanced anti-influenza agents conjugated with anti-inflammatory activity.Journal of medicinal chemistry, , Oct-11, Volume: 55, Issue:19, 2012
Development of oseltamivir phosphonate congeners as anti-influenza agents.Journal of medicinal chemistry, , Oct-25, Volume: 55, Issue:20, 2012
Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses.European journal of medicinal chemistry, , Jun-25, Volume: 154, 2018
Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
Development of oseltamivir phosphonate congeners as anti-influenza agents.Journal of medicinal chemistry, , Oct-25, Volume: 55, Issue:20, 2012