Miconazole is a synthetic antifungal agent that belongs to the imidazole class. It is a broad-spectrum antifungal that is effective against a wide range of dermatophytes, yeasts, and molds. Miconazole works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption of the cell membrane leads to the death of the fungus. Miconazole is commonly used to treat skin and nail infections caused by fungi. Miconazole is also used to treat vaginal yeast infections. Its importance lies in its effectiveness against fungal infections, its safety and tolerability, and its availability as a topical and oral medication. Research on miconazole focuses on developing new formulations, understanding its mechanism of action, exploring its potential applications, and investigating its interactions with other drugs.'
Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 4189 |
| CHEMBL ID | 91 |
| CHEBI ID | 82892 |
| CHEBI ID | 6923 |
| SCHEMBL ID | 2866 |
| SCHEMBL ID | 13934598 |
| MeSH ID | M0013758 |
| Synonym |
|---|
| AB00053500-24 |
| AB00053500-25 |
| BRD-A82396632-001-03-0 |
| BRD-A82396632-008-02-7 |
| nsc170986 |
| 22916-47-8 |
| miconazole |
| nsc-170986 |
| monistat |
| minostate |
| 1h-imidazole,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]- |
| imidazole,4-dichloro-.beta.-[(2,4-dichlorobenzyl)oxy]phenethyl]- |
| 1h-imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]- |
| 1h-imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- |
| KBIO1_000156 |
| DIVK1C_000156 |
| 1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1h-imidazole |
| (+-)-1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole |
| daktarin iv |
| miconazol [inn-spanish] |
| brentan |
| 1h-imidazole, 1-2-((2,4-dichlorophenyl)-2-((2,4-dichlorophenyl))methoxy)ethyl)-, (+-)- |
| dactarin |
| miconazolum [inn-latin] |
| 1h-imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- |
| monistat iv |
| brn 0965511 |
| r 18134 |
| einecs 245-324-5 |
| imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- |
| nsc 170986 |
| vusion |
| c18h14cl4n2o |
| monistat-derm |
| ccris 7924 |
| mjr 1762 |
| miconazolo [dcit] |
| imidazole, 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)- |
| SPECTRUM_000965 |
| PRESTWICK_335 |
| NCGC00016770-01 |
| BSPBIO_002033 |
| gyno-daktar(nitrate) |
| florid(nitrate) |
| MCZ , |
| 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole |
| lotrimin af(nitrate) |
| epi-monistat(nitrate) |
| aflorix(nitrate) |
| monista (nitrate) |
| miconazole nitrate salt |
| 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1h-imidazole |
| albistat(nitrate) |
| conofite(nitrate) |
| andergin(nitrate) |
| micantin (nitrate) |
| PRESTWICK2_000067 |
| PRESTWICK3_000067 |
| BPBIO1_000279 |
| AB00053500 |
| 1-[2-(2,4-dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1h-imidazole |
| 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole |
| DB01110 |
| oravig (tn) |
| miconazole (jp17/usp/inn) |
| D00416 |
| monistat (tn) |
| SPECTRUM5_001297 |
| imidazole, 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy) phenethyl)- |
| 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole |
| imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9ci) |
| KBIOGR_000581 |
| NCI60_001380 |
| NCI60_001353 |
| KBIO2_006581 |
| KBIO2_004013 |
| KBIO3_001533 |
| KBIOSS_001445 |
| KBIO2_001445 |
| SPECTRUM4_000061 |
| PRESTWICK0_000067 |
| SPECTRUM3_000507 |
| PRESTWICK1_000067 |
| SPECTRUM2_001048 |
| SPBIO_000976 |
| SPBIO_002174 |
| NINDS_000156 |
| OPREA1_091955 |
| BSPBIO_000253 |
| IDI1_000156 |
| gtpl2449 |
| chembl91 , |
| cid_4189 |
| bdbm31772 |
| 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid |
| HMS2090B21 |
| AKOS001574474 |
| 1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1h-imidazole |
| STK834405 |
| MLS002222203 |
| smr001307249 |
| chebi:82892 , |
| HMS1568M15 |
| NCGC00018294-02 |
| NCGC00018294-04 |
| HMS2095M15 |
| micozole |
| monazole 7 |
| monistat 7 vaginal suppositories |
| femizol-m |
| miconazole-7 |
| (+/-)-miconazole nitrate salt |
| 1-(2,4-dichloro-beta-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole |
| BMSE000924 |
| imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9ci) |
| novo-miconazole vaginal ovules |
| zimycan |
| tox21_110601 |
| cas-22916-47-8 |
| dtxsid6023319 , |
| dtxcid803319 |
| miconazolo |
| miconazolum |
| miconazol |
| HMS2232B14 |
| 1-(2,4-dichlorophenyl)-1-[(2,4-dichlorophenyl)methoxy]-2-imidazolylethane |
| oravig |
| unii-7nno0d7s5m |
| 7nno0d7s5m , |
| miconazole [usp:inn:ban:jan] |
| FT-0628942 |
| NCGC00018294-06 |
| 1-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole |
| S2536 |
| HMS3374J10 |
| miconazole [ep impurity] |
| miconazole [orange book] |
| miconazole [who-dd] |
| (+/-)-1-(2,4-dichloro-b-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole |
| miconazole [usp monograph] |
| miconazole [jan] |
| 1h-imidazole, 1-2-((2,4-dichlorophenyl)-2-((2,4-dichlorophenyl))methoxy)ethyl)-, (+/-)- |
| miconazole [usp impurity] |
| miconazole [inn] |
| miconazole [mi] |
| miconazole [ep monograph] |
| miconazole [vandf] |
| miconazole [mart.] |
| CCG-220067 |
| DL-448 |
| HY-B0454 |
| SCHEMBL2866 |
| AB00053500-23 |
| 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole |
| 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole |
| SCHEMBL13934598 |
| 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-imidazole |
| 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)-phenethyl]imidazole |
| 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole |
| 1-[2,4dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole |
| 1-[2,4-dichloro-.beta.-[(2,4-dichlorobenzyl)oxy]phenethyl]imidazole |
| 1-[2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole # |
| imidazole, 1-(2,4-dichloro-.beta.-((2,4-dichlorobenzyl)oxy)phenethyl)- |
| AE-641/01941016 |
| 1-[2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole |
| DS-1881 |
| AB00053500_27 |
| AB00053500_26 |
| AB00053500_28 |
| mfcd00216019 |
| r18134 |
| r18134 nitrate |
| 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-imidazol |
| HMS3656E14 |
| (+-)-miconazole |
| SR-01000000271-5 |
| sr-01000000271 |
| J-014898 |
| SBI-0051448.P003 |
| 75319-47-0 |
| HMS3712M15 |
| SW196614-4 |
| Q410534 |
| miconazole (monistat) |
| zimybase |
| 1-(2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole |
| 1-[2,4-dichloro-beta-([2,4-dichlorobenzyl]oxy)-phenethyl]imidazole |
| 22916-47-8 (free) |
| 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)-methoxy]ethyl]-1h-imidazole |
| monistat, daktarin iv, miconazolo, miconazolum, dactarin, miconazol, minostate, brentan, florid(nitrate) |
| AKOS016842489 |
| NCGC00018294-08 |
| 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-1h-imidazole |
| A878389 |
| EN300-7370602 |
| SY107559 |
| s02aa13 |
| j02ab01 |
| (rs)-miconazole |
| miconazole (usp:inn:ban:jan) |
| miconazole (ep monograph) |
| chebi:6923 |
| imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- |
| miconazol (inn-spanish) |
| miconazole (mart.) |
| rac-miconazole |
| 1-((2rs)-2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole |
| miconazole (ep impurity) |
| miconazole (usp impurity) |
| g01af04 |
| a01ab09 |
| miconazole (usp monograph) |
| 1-(2-(2,4-dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl)-1h-imidazole |
| rac-1-(2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole |
| d01ac02 |
| a07ac01 |
| miconazolum (inn-latin) |
Miconazole nitrate (MZ) is a BCS class II antifungal poorly water-soluble drug with limited dissolution properties and gastrointestinal side effects. It is a broad-spectrum anti-fungal used in topical preparations.
Miconazole has limited antibacterial properties that include antistaphylococcal activity. Has been implicated in causing thrombocytosis and has a documented case validated by drug rechallenge.
Miconazole was found to suppress HIF-1α protein expression through post-transcriptional regulation in U87MG and MCF-7 cells. The drug also appeared to cause resolution of the cerebral abscess.
Miconazole treatment increased oligodendrocyte maturation and myelin sheath thickness without reducing Aβ plaque deposition, reactive gliosis, and inflammatory factor levels in the mPFC. Miconzole treatment, by eliminating defluorination of 18F-FCWAY, results in effective imaging of brain 5-HT1A receptors.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Miconazole treatment increased oligodendrocyte maturation and myelin sheath thickness without reducing Aβ plaque deposition, reactive gliosis, and inflammatory factor levels in the mPFC." | ( Miconazole Promotes Cooperative Ability of a Mouse Model of Alzheimer Disease. Chen, S; Chen, Y; Ding, S; Feng, W; Marshall, C; Pang, Y; Sheng, C; Shi, J; Wang, Z; Xiao, M; Zhang, Y, 2022) | 2.89 |
| "Miconazole treatment, by eliminating defluorination of 18F-FCWAY, results in effective imaging of brain 5-HT1A receptors in rat. " | ( PET imaging of brain 5-HT1A receptors in rat in vivo with 18F-FCWAY and improvement by successful inhibition of radioligand defluorination with miconazole. Green, MV; Ichise, M; Innis, RB; Liow, JS; Pike, VW; Seidel, J; Tipre, DN; Zoghbi, SS, 2006) | 1.98 |
| "Miconazole treatment reduced the number of denture colonies more efficiently than Z." | ( Miconazole gel compared with Zataria multiflora Boiss. gel in the treatment of denture stomatitis. Abdollahzadeh, S; Amanlou, M; Beitollahi, JM; Tohidast-Ekrad, Z, 2006) | 2.5 |
| "The miconazole-chlorhexidine treated hounds showed significantly greater reductions in pruritus (P < 0.01), erythema (P < 0.001), exudation (P < 0.01) and overall severity (P < 0.001), and in counts of M pachydermatis (P < 0.001), total bacteria (P < 0.001) and coagulase-positive staphylococci (P < 0.001), when compared to the selenium sulphide treated group." | ( Comparison of two shampoos for treatment of Malassezia pachydermatis-associated seborrhoeic dermatitis in basset hounds. Bond, R; Ellis, JW; Lloyd, DH; Rose, JF, 1995) | 0.77 |
| "Miconazole treatment increased the mean arterial pressure in control rats, while 14-day phenobarbital treatment normalized the mean arterial pressure in insulin-resistant rats." | ( Cytochrome P450 activity and endothelial dysfunction in insulin resistance. Hoenig, M; Katakam, PV; Miller, AW; Ujhelyi, MR, ) | 0.85 |
| "The miconazole-treated patients remained clinically free of mycosis for 252 out of 264 treatment days, while the placebo-treated patients remained free of mycosis for only 263 out or 338 treatment days (p = 0.0001)." | ( Prophylactic treatment with miconazole in patients highly predisposed to fungal infection. A placebo-controlled double-blind study. Brincker, H, 1978) | 1.03 |
| "Miconazole-treated rats that were killed after surviving the 2-week observation period had minimal histopathological changes, and the organisms present did not exhibit the same staining characteristics, nor were they isolated like those in the placebo-treated group." | ( Evaluation of miconazole therapy in experimental disseminated candidiasis in laboratory rats. Balk, MW; Crumrine, MH; Fischer, GW, 1978) | 1.34 |
| "Miconazole treatment resulted in a significantly increased ratio of 6 beta-OHF/17-OHCS." | ( D-glucaric acid excretion in critical care patients--comparison with 6 beta-hydroxycortisol excretion and serum gamma-glutamyltranspeptidase activity and relation to multiple drug therapy. Dennhardt, R; Heinemeyer, G; Klaiber, HR; Lestau, P; Roots, I, 1986) | 0.99 |
| "Miconazole and AmB pretreatment irreversibly depressed PMN random migration and chemotaxis under agarose but did not influence superoxide anion production." | ( Miconazole and amphotericin B alter polymorphonuclear leukocyte functions and membrane fluidity in similar fashions. Akabane, T; Komiyama, A; Masuda, M; Matsuoka, T; Murata, K; Yamazaki, M; Yasui, K, 1988) | 2.44 |
| "Treatment with miconazole resulted in a significant reduction of biofilm metabolic activity for all strains." | ( Miconazole activity against Candida biofilms developed on acrylic discs. Dorocka-Bobkowska, B; Duzgunes, N; Gebremedhin, S; Konopka, K; Prylinski, M, 2014) | 2.18 |
| "Pretreatment with miconazole oral gel caused a strong inhibition of the CYP2D6-dependent metabolism and moderate inhibition of the CYP3A4-dependent metabolism of oxycodone." | ( Miconazole oral gel increases exposure to oral oxycodone by inhibition of CYP2D6 and CYP3A4. Grönlund, J; Hagelberg, N; Laine, K; Neuvonen, PJ; Olkkola, KT; Saari, TI, 2011) | 2.14 |
| "Treatment with miconazole nitrate 0.25% was as safe as with ointment base alone." | ( Diaper dermatitis: a therapeutic dilemma. Results of a double-blind placebo controlled trial of miconazole nitrate 0.25%. Concannon, P; Gisoldi, E; Grossman, R; Phillips, S, ) | 0.69 |
| "Pretreatment with miconazole, an inhibitor of CYP450 epoxygenase, at 10(-6) M decreased the basal diameter by 14+/-1% (n=6, p<0.01) and augmented the vasoconstrictor action of Ang II (7+/-3% of control diameter at 10(-8) M, p<0.001 vs." | ( Involvement of cytochrome P450 metabolites in the vascular action of angiotensin II on the afferent arterioles. Abe, M; Arima, S; Chiba, Y; Endo, Y; Ito, O; Ito, S; Kohagura, K; Omata, K, 2001) | 0.63 |
| "Treatment with miconazole intrathecally (10-90 mg/week, total 565 mg) and intravenously (200-1200 mg/day, total 70.4 g) was begun on November 23." | ( [Successful treatment of Candida meningitis with miconazole]. Fukui, S; Hayashi, H; Matsushima, Y; Tabata, H, 1990) | 0.87 |
Miconazole nitrate 1200 mg is effective in the treatment of VVC, with good compliance and few adverse effects. Physicians should be cautious about thrombocytopenic purpura.
The dermatopharmacokinetic method determined the bioequivalence of two products simultaneously in 24 healthy subjects, as a function of Cmax and AUC(0-1) parameters. The results of the PK-PD analysis indicated that the enhanced pharmacological response under miconazole co-administration was simply caused by a pharmacokinetic change.
The drug-drug interaction (DDI) risk of phenytoin with several topical formulations of micona was assessed.
| Excerpt | Reference | Relevance |
|---|---|---|
| "The clinically important polyene antibiotic amphotericin B, in combination with two antifungal imidazole compounds, clotrimazole and miconazole, was studied in vitro." | ( In vitro studies of amphotericin B in combination with the imidazole antifungal compounds clotrimazole and miconazole. Beezer, AE; Cosgrove, RF; Miles, RJ, 1978) | 0.68 |
| "Two recent antifungal agents, miconazole and ketoconazole, were combined with three tissue conditioners and tested in vitro for their effects on the growth of Candida albicans." | ( The effectiveness, in vitro, of miconazole and ketoconazole combined with tissue conditioners in inhibiting the growth of Candida albicans. Quinn, DM, 1985) | 0.84 |
| "A total of 440 fresh clinical isolates of yeasts from cancer patients were tested by an agar dilution technique against miconazole, miconazole nitrate, and ketoconazole individually and combined with 5 micrograms of rifampin per ml." | ( In vitro activities of miconazole, miconazole nitrate, and ketoconazole alone and combined with rifampin against Candida spp. and Torulopsis glabrata recovered from cancer patients. Moody, MR; Morris, MJ; Schimpff, SC; Young, VM, 1980) | 0.78 |
| "We compared the in vitro antifungal action of amphotericin B (AmB) used alone or in combination with a second polyene antibiotic or with miconazole or ketoconazole." | ( Antifungal action of amphotericin B in combination with other polyene or imidazole antibiotics. Brajtburg, J; Kobayashi, D; Kobayashi, GS; Medoff, G, 1982) | 0.47 |
| "The effect of drugs in combination on the growth of Candida glabrata was studied in solid medium by demonstration of reduced or enhanced growth, and in liquid medium by determination of interaction indices." | ( The effect of antifungal drugs in combination on the growth of Candida glabrata in solid and liquid media. Kerridge, D; Siau, H, 1998) | 0.3 |
| "Ten expressed human CYPs and human liver microsomes were used in the experiments for the identification of enzymes responsible for zonisamide metabolism and for the prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data, respectively." | ( Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data. Kitada, M; Kiuchi, M; Nakamura, H; Nakasa, H; Ohmori, S; Ono, S; Tsutsui, M, 1998) | 0.3 |
| "We demonstrated that: (1) zonisamide is metabolized by recombinant CYP3A4, CYP2C19 and CYP3A5, (2) the metabolism is inhibited to a variable extent by known CYP3A4/5 substrates and/or inhibitors in human liver microsomes, and (3) in vitro-in vivo predictive calculations suggest that several compounds demonstrating CYP3A4-affinity might cause in vivo drug-drug interactions with zonisamide." | ( Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data. Kitada, M; Kiuchi, M; Nakamura, H; Nakasa, H; Ohmori, S; Ono, S; Tsutsui, M, 1998) | 0.3 |
| " Its ability to be systemically absorbed and interact with other drugs has previously been recorded but is not universally known." | ( Miconazole oral gel and drug interactions. Oliver, RJ; Pemberton, MN; Theaker, ED, 2004) | 1.77 |
| "This article reviews the in vitro metabolic and the in vivo pharmacokinetic drug-drug interactions with antifungal drugs, including fluconazole, itraconazole, micafungin, miconazole, and voriconazole." | ( [Drug-drug interaction of antifungal drugs]. Niwa, T; Shiraga, T; Takagi, A, 2005) | 0.52 |
| "Inhibition of cytochrome P450 (CYP) is a principal mechanism for metabolism-based drug-drug interactions (DDIs)." | ( Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds. Burdette, D; Dunklee, MB; Fahmi, O; Heinle, L; Hyland, R; Lee, C; Miller, H; Smith, D; Thurston, A; Zientek, M, ) | 0.13 |
| " This is partly explained by multiple drug use causing drug-drug interactions." | ( Serotonin syndrome during treatment with low dose of escitalopram associated with miconazole mucoadhesive tablet: a suspected drug interaction. Baptista, G; Eiden, C; Jeandel, C; Monguillot, P; Philibert, C, 2012) | 0.6 |
| "To determine and compare antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans." | ( In vitro antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans. Apratim, A; Chopde, N; Khade, MN; Khadtare, YR; Pharande, A; Shah, SS, 2012) | 0.82 |
| "Two tissue conditioners Viscogel and GC Soft combined with nystatin, miconazole and fluconazole were tested against Candida albicans using agar core inhibition diameter assay." | ( In vitro antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans. Apratim, A; Chopde, N; Khade, MN; Khadtare, YR; Pharande, A; Shah, SS, 2012) | 0.84 |
| " The rapid improvement observed with Travocort treatment, combined with favourable safety and tolerability, results in higher patient satisfaction, and therefore, can be an effective tool to increase treatment adherence in patients with dermatomycoses accompanied by inflammatory signs and symptoms." | ( Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids. Veraldi, S, 2013) | 0.39 |
| " When miconazole was combined with polymyxin B nonapeptide (PMBN), in order to increase the bacterial wall permeability, DETA/NO caused a prolonged bacteriostatic response that lasted for up to 24 h." | ( The antibacterial effect of nitric oxide against ESBL-producing uropathogenic E. coli is improved by combination with miconazole and polymyxin B nonapeptide. Bang, CS; Karlsson, M; Kinnunen, A; Önnberg, A; Persson, K; Söderquist, B, 2014) | 1.09 |
| "This was an open-label, randomized, crossover, drug-drug interaction study conducted over three menstrual cycles in healthy women with regular menses." | ( Effects of concurrent vaginal miconazole treatment on the absorption and exposure of Nestorone® (segesterone acetate) and ethinyl estradiol delivered from a contraceptive vaginal ring: a randomized, crossover drug-drug interaction study. Alami, M; Creasy, G; Han, L; Hoskin, E; Kumar, N; Merkatz, R; Plagianos, M; Roberts, K; Simmons, KB; Variano, B, 2018) | 0.77 |
| "The drug-drug interaction (DDI) risk of phenytoin with several topical formulations of miconazole is still unclear." | ( Risk prediction of drug-drug interaction potential of phenytoin and miconazole topical formulations. Bi, C; Cao, X; Cui, S; Jiang, L; Li, W; Liu, Y; Wang, X; Wang, Z, 2021) | 1.08 |
Miconazole and itraconazole possess adequate membrane permeability, but only slight water solubility, which limits their bioavailability and antifungal effect. MN-SLN was more efficient in the treatment of candidiasis with enhanced oral bioavailability.
| Excerpt | Reference | Relevance |
|---|---|---|
| "In order to find ways to increase the usually very low bioavailability of praziquantel, the effect of cytochrome P-450 inhibitors on the metabolism of praziquantel was investigated in rats." | ( Inhibitory effects of cimetidine ketoconazole and miconazole on the metabolism of praziquantel. Diekmann, HW; Overbosch, D; Schneidereit, M, 1989) | 0.53 |
| " The data suggests that the ionic form of miconazole dissolves as easily in the nail plate as the free base and, therefore, topical bioavailability can be enhanced by decreasing the formulation pH thereby increasing drug solubility." | ( Penetration of the human nail plate: the effects of vehicle pH on the permeation of miconazole. Flynn, GL; Marvel, JR; Walters, KA, 1985) | 0.76 |
| " These results are interpreted in terms of bioavailability of the active substances." | ( Imidazoles and benzoyl peroxide: a comparative trial of two treatment schedules. Decroix, J; Tennstedt, D; Van Neste, D, 1986) | 0.27 |
| " Tape stripping the drug-treated site in conjunction with a bioassay is therefore a useful approach in the determination of bioavailability of topical antifungal agents." | ( In vivo pharmacokinetics and pharmacodynamics of topical ketoconazole and miconazole in human stratum corneum. Corlett, J; Jorgensen, C; Pershing, LK, 1994) | 0.52 |
| " The toxicity was probably due to drug supersaturation, thereby increasing the bioavailability of the antimycotics." | ( Cyclodextrin inclusion complexes of antimycotics intended to act in the oral cavity--drug supersaturation, toxicity on TR146 cells and release from a delivery system. Bjerregaard, S; Jacobsen, J; Pedersen, M, 1999) | 0.3 |
| "The relationship between the serum concentration and the pharmacological effect of disopyramide was investigated quantitatively to estimate the extent of its oral bioavailability (EBA(p." | ( Bioavailability assessment of disopyramide using pharmacokinetic-pharmacodynamic (PK-PD) modeling in the rat. Iwanaga, K; Kakemi, M; Maekawa, C; Miyazaki, M; Morimoto, K, 2000) | 0.31 |
| "P-glycoprotein (P-gp) is an efflux transporter involved in limiting the oral bioavailability and tissue penetration of a variety of structurally divergent molecules." | ( Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Dantzig, AH; Ekins, S; Kim, RB; Lan, LB; Leake, BF; Schuetz, EG; Schuetz, JD; Shepard, RL; Wikel, JH; Winter, MA; Wrighton, SA; Yasuda, K, 2002) | 0.31 |
| " The inclusion complexes, which show better dissolution profiles than those with the corresponding physical mixtures, could lead to an increase of the oral bioavailability of MICO." | ( Effect of acidic ternary compounds on the formation of miconazole/cyclodextrin inclusion complexes by means of supercritical carbon dioxide. Barillaro, V; Bertholet, P; Delattre, L; Evrard, B; Henry de Hassonville, S; Piel, G; Ziemon, E, 2004) | 0.57 |
| " The results of the study indicate that CPLX shows improved dissolution properties and a higher relative oral bioavailability compared with PHYS and MICO." | ( Oral bioavailability in pigs of a miconazole/hydroxypropyl-gamma-cyclodextrin/L-tartaric acid inclusion complex produced by supercritical carbon dioxide processing. Barillaro, V; Delattre, L; Evrard, B; Piell, G, 2005) | 0.61 |
| "To measure the solubility of four drugs in human gastric aspirates, canine gastric aspirates (CGF) and simulated gastric fluids in order to propose a medium for estimating intragastric drug solubility relevant to a bioavailability study in the fasted state." | ( Estimation of intragastric solubility of drugs: in what medium? Kalantzi, L; Pastelli, E; Psachoulias, D; Reppas, C; Vertzoni, M, 2007) | 0.34 |
| "6 is comparatively the most efficient way to get an estimate of drug solubility in the fasting gastric contents during a bioavailability study." | ( Estimation of intragastric solubility of drugs: in what medium? Kalantzi, L; Pastelli, E; Psachoulias, D; Reppas, C; Vertzoni, M, 2007) | 0.34 |
| " Studies show, however, that the addition of a topical corticosteroid to imidazole therapy increases the bioavailability and prolongs the activity of the antimycotic, while rapidly reducing inflammatory symptoms." | ( The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses. Friedrich, M; Havlickova, B, 2008) | 0.35 |
| "New drug substances from early development are often poorly water-soluble, which causes poor bioavailability upon peroral administration and hampers drug administration through other routes such as the parenteral or ocular routes." | ( Miconazole nanosuspensions: Influence of formulation variables on particle size reduction and physical stability. Cerdeira, AM; Gander, B; Mazzotti, M, 2010) | 1.8 |
| " Although it is often assumed that use of the oral miconazole gel is acceptable with concomitant warfarin, because of the low bioavailability following buccal administration, drug-drug interactions have been reported following such use." | ( Warfarin and miconazole oral gel interactions: analysis and therapy recommendations based on clinical data and a pharmacokinetic model. Miki, A; Ohtani, H; Sawada, Y, 2011) | 0.99 |
| "Miconazole and itraconazole possess adequate membrane permeability, but only slight water solubility, which limits their bioavailability and antifungal effect." | ( Formulation and drying of miconazole and itraconazole nanosuspensions. Cerdeira, AM; Gander, B; Mazzotti, M, 2013) | 2.13 |
| " Isoconazole nitrate (ISN) is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, a rapid rate of absorption and low systemic exposure potential." | ( Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids. Veraldi, S, 2013) | 0.39 |
| " A CPC delivery-controlled system, transported in polymer nanofibers (PVP/PMMA), was developed to increase the bioavailability of the drug in contact with the oral mucosa." | ( Antifungal effect of electrospun nanofibers containing cetylpyridinium chloride against Candida albicans. Borsatti, MA; Oliveira, AM; Santos, VA; Viera, PV; Zanin, MH, 2014) | 0.4 |
| " An in vivo pharmacokinetic study revealed that the bioavailability was enhanced by >2." | ( Miconazole-loaded solid lipid nanoparticles: formulation and evaluation of a novel formula with high bioavailability and antifungal activity. Aljaeid, BM; Hosny, KM, 2016) | 1.88 |
| "MN-SLN was more efficient in the treatment of candidiasis with enhanced oral bioavailability and could be a promising carrier for the oral delivery of miconazole." | ( Miconazole-loaded solid lipid nanoparticles: formulation and evaluation of a novel formula with high bioavailability and antifungal activity. Aljaeid, BM; Hosny, KM, 2016) | 2.08 |
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| " Moreover, pharmacokinetic studies in SD rats showed that A33 exhibited favourable pharmacokinetic properties, with a bioavailability of 77." | ( Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. Cheng, M; Su, X; Sun, N; Sun, Y; Tian, L; Yin, W; Zhang, C; Zhao, D; Zhao, L; Zhao, S; Zheng, Y, 2021) | 0.62 |
| " However, additional bioavailability and toxicity studies must be carried out before these products can be used for the chemical control of oral biofilms." | ( The antifungal and antibiofilm activity of Cymbopogon nardus essential oil and citronellal on clinical strains of Candida albicans. Cordeiro, LV; de Albuquerque Tavares Carvalho, A; de Figuerêdo Silva, D; de Oliveira Lima, E; de Pontes, MLC; Figueiredo, PTR; Trindade, LA, 2022) | 0.72 |
The yield profile of the miconazole nitrate in the disintegration solutions by means of classical method from FR X, by HPLC dosage was researched. The influence of solubilizers on the aqueous solubility of the itraconazole, ketoconazole and miconzole was investigated in order to enhance theirsolubility for a possible parenteral dosage form.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The drug was administered orally, at a dosage of 1 g three times daily." | ( Treatment of South American blastomycosis (paracoccidioidomycosis) with miconazole by the oral route: an on-going study. do Valle, AC; Lima, NS; Miranda, J; Teixeira, G, 1977) | 0.49 |
| " Data on biotransformation, kinetics and dosage are reported." | ( [Pulmonary mycoses; laboratory diagnosis, antimycotic therapy]. Bartmann, K, 1977) | 0.26 |
| " Miconazole therapy in Candida-infected rats at a dosage of 50 mg/kg per day resulted in 85% survival, and, although 100 mg/kg per day was 100% efficacious, it was a relatively large volume to give intramuscularly to a rat." | ( Evaluation of miconazole therapy in experimental disseminated candidiasis in laboratory rats. Balk, MW; Crumrine, MH; Fischer, GW, 1978) | 1.53 |
| " There have been no published comparisons with nystatin vaginal cream or foaming vaginal tablets - the nystatin dosage form preferred by some clinicians." | ( Miconazole: a review of its antifungal activity and therapeutic efficacy. Avery, GS; Brogden, RN; Pinder, RM; Sawyer, PR; Speight, TM, 1975) | 1.7 |
| " The proposed HPLC methods are applied to the analysis of commercial dosage forms (creams) with solid-phase extraction (SPE) procedure, using a diol sorbent, being found to be a convenient technique for the sample preparation giving quantitative drug recovery." | ( HPLC analysis of imidazole antimycotic drugs in pharmaceutical formulations. Andrisano, V; Cavrini, V; Di Pietra, AM; Gatti, R, ) | 0.13 |
| "5 mg/kg iv dose of warfarin either alone, 1 hr after a single 100 mg/kg ip miconazole dose, or on day 5 of a 6-day 50 mg/kg/12 hr ip miconazole dosing regimen." | ( Effect of miconazole on warfarin disposition in rabbits. Bates, TR; D'Mello, AP; Venkataramanan, RV, ) | 0.76 |
| " The data from such PAFE assays may be useful for determining in vivo treatment regimens, since longer PAFEs may allow for intermittent dosing instead of continuous drug administration." | ( Turbidometric characterization of the postantifungal effect: comparative studies with amphotericin B, 5-fluorocytosine and miconazole on Candida albicans. Ichihara, Y; Kurita, N; Mikami, Y; Miyaji, M; Scalarone, GM; Yazawa, K, ) | 0.34 |
| "Methods based on derivative UV spectrophotometry and high-performance liquid chromatography (HPLC) have been developed for the selective determination of miconazole and econazole in pharmaceutical dosage forms." | ( Analysis of miconazole and econazole in pharmaceutical formulations by derivative UV spectroscopy and liquid chromatography (HPLC). Cavrini, V; Di Pietra, AM; Gatti, R, 1989) | 0.85 |
| " All patients found the single dosage formulation easy to use, and the majority thought the ovule effective as a treatment for their vaginal candidosis." | ( An open study to assess the acceptability and effectiveness of miconazole 1,200 mg single ovule in the treatment of acute vaginal candidosis. Dinsmore, WW; Granger, SE, 1989) | 0.52 |
| " The total Miconazole dosage was 90." | ( [A case of cryptococcal meningitis successfully treated with miconazole and CSF drainage]. Fukui, K; Nakamura, S; Okamura, K; Watanabe, M; Yamamoto, M, 1989) | 0.91 |
| " Progressive increases in miconazole dosage during the treatment periods were required to produce serum levels above the minimum inhibitory concentrations of the fungal isolates." | ( Pseudallescheria boydii brain abscess: association with near-drowning and efficacy of high-dose, prolonged miconazole therapy in patients with multiple abscesses. Borkowski, WJ; Clark, RB; Connolly, TL; Dworzack, DL; Dykstra, M; Horowitz, EA; Hostetler, MK; McKinney, DL; Pugsley, MP; Smith, DL, 1989) | 0.79 |
| "Male Wistar rats were dosed with miconazole, ketoconazole and itraconazole by gastric intubation once daily for up to 7 days." | ( Induction potential of antifungals containing an imidazole or triazole moiety. Miconazole and ketoconazole, but not itraconazole are able to induce hepatic drug metabolizing enzymes of male rats at high doses. Heykants, J; Lavrijsen, K; Meuldermans, W; Thijs, D; Van Houdt, J, 1986) | 0.78 |
| " The pharmacologic profiles, mechanisms of action, pharmacokinetics, clinical indications for use, dosage recommendations, side effects, and drug interactions for these agents are presented." | ( The pharmacology of agents used in the treatment of pulmonary mycoses. Borgers, M; Cauwenbergh, G; Vanden Bossche, H, 1986) | 0.27 |
| " Miconazole was found to be an effective agent in some patients when administered in a dosage of 2400 mg/day." | ( Fungal endophthalmitis in narcotic abusers. Medical and surgical therapy in 10 patients. Billson, F; Clifton-Bligh, P; Gallo, J; Gregory-Roberts, J; Grunstein, H; Playfair, J, 1985) | 1.18 |
| " Amphotericin B and terbinafine possessed intermediate ATP-suppressing activity, and the dose-response and pH-response curves for these compounds suggested their mechanism of ATP suppression differed from that of the active imidazole derivatives." | ( Suppression of ATP in Candida albicans by imidazole and derivative antifungal agents. Abbott, AB; Cheesman, SL; Odds, FC, 1985) | 0.27 |
| " With no amphotericine B available, treatment first started with high dosage of miconazole which had no effect." | ( [A disseminated form of Histoplasma duboisii histoplasmosis in a Zaïre patient (author's transl)]. Lamey, B, ) | 0.36 |
| "The introduction of clotrimazole into the therapy of vaginal Candida and Torulopsis infections has significantly shortened the previously customary duration of treatment and reduced the frequency of dosage of the active ingredient." | ( On the action kinetics of clotrimazole. Plempel, M, 1982) | 0.26 |
| " These findings may have implications for dosing antifungal agents in systemic yeast infections." | ( The postantibiotic effect of antifungal agents against common pathogenic yeasts. Craig, WA; Gudmundsson, S; Turnidge, JD; Vogelman, B, 1994) | 0.29 |
| " The chewing gum reduced the dosage of miconazole for treatment of oral candidosis, and the patients approved the chewing gum as a pleasant medicament." | ( Miconazole chewing gum for treatment of chronic oral candidosis. Holmstrup, P; Pedersen, M; Rassing, MR; Rindum, JL; Stoltze, K, 1993) | 2 |
| " Miconazole at high dosage (60 mg/kg) suppressed mitogen-induced lymphocyte proliferation, otherwise a single dose of any of the drugs had no effect on neutrophil or lymphocyte function irrespective of concentration used." | ( The effects of amphotericin B, fluconazole and miconazole on neutrophil and lymphocyte function in a guinea pig model. Drummond, DC; McCormack, JG; Whitman, LM; Wong, CW, 1995) | 1.46 |
| " This has proved an effective and safe regimen which requires only 50% of the medication used for continuous dosing schedules." | ( Itraconazole in the treatment of onychomycosis: a double-blind comparison with miconazole. De Doncker, P; Haneke, E; Heremans, A; Tajerbashi, M, 1998) | 0.53 |
| " The model predicted doses were identical to the actual doses, regardless of the dosing rates." | ( Bioavailability assessment of disopyramide using pharmacokinetic-pharmacodynamic (PK-PD) modeling in the rat. Iwanaga, K; Kakemi, M; Maekawa, C; Miyazaki, M; Morimoto, K, 2000) | 0.31 |
| " A newly recognized phenomenon known as the post-antifungal effect implies that antifungals, even at sub-therapeutic concentrations, may suppress the virulent attributes of yeasts, especially intra-orally where topical drug levels fluctuate dramatically during dosing intervals." | ( Antimycotic agents in oral candidosis: an overview: 2. Treatment of oral candidosis. Ellepola, AN; Samaranayake, LP, 2000) | 0.31 |
| "5 x 10(-6)) to generate two cumulative dose-response curves (CDRC I and II)." | ( Endothelium-dependent desensitization to angiotensin II in rabbit aorta: the mechanisms involved. Coviello, A; de Bruno, MP; Jerez, S, 2001) | 0.31 |
| "A reversed-phase high performance liquid chromatography (RP-HPLC) method with UV detection is described for the simultaneous determination of metronidazole and miconazole in pharmaceutical dosage forms." | ( Simultaneous determination of metronidazole and miconazole in pharmaceutical dosage forms by RP-HPLC. Akay, C; Cevheroğlu, S; Ozkan, SA; Sentürk, Z, 2002) | 0.77 |
| " Liver mRNA was isolated from rats dosed with six different chemicals, dexamethasone, troleandomycin, miconazole, clotrimazole, and methylclofanapate, which are all known to induce different cytochrome P450 genes, and isoniazid, which does not cause histopathological changes." | ( An evaluation of a low-density DNA microarray using cytochrome P450 inducers. Bertholet, V; Bonnert, TP; de Longueville, F; Dos Santos-Mendes, S; Evrard, S; Jack, A; Meneses-Lorente, G; Pike, A; Remacle, J; Scott-Stevens, P; Sohal, B, 2003) | 0.53 |
| " Different formulations of miconazole nitrate and single as well as multiple dosing were investigated during two separate randomized, open-label, crossover studies." | ( The contraceptive vaginal ring, NuvaRing, and antimycotic co-medication. Dieben, TO; Mulders, TM; van den Heuvel, MW; Verhoeven, CH, 2004) | 0.62 |
| " Limitations include small sample size and dosing regimen." | ( Prevention of onychomycosis reinfection for patients with complete cure of all 10 toenails: results of a double-blind, placebo-controlled, pilot study of prophylactic miconazole powder 2%. St Clair, KR; Warshaw, EM, 2005) | 0.52 |
| " The minimal inhibitory concentration (MIC) values calculated from dose-response curves on agar diffusion-test (Kadłubowski's method), were also examined by analysing the variation (mean x +/- standard error, median Me, mode Mo, Min-Max)." | ( [Susceptibility to itraconazole and miconazole of fungi strains isolated from the vaginal ontocenosis]. Horwatt-Bozyczko, E; Kołtuńska, M; Kurnatowska, A, 2001) | 0.59 |
| " The influence of solubilizers on the aqueous solubility of the itraconazole, ketoconazole and miconazole was investigated in order to enhance their solubility for a possible parenteral dosage form." | ( Aqueous solvent system for the solubilization of azole compounds. Antal, I; Klebovich, I; Kovács, K; Ludányi, K; Stampf, G, 2009) | 0.57 |
| "An intravenous solution is a dosage forms intended for administration into the bloodstream." | ( Composition optimization and stability testing of a parenteral antifungal solution based on a ternary solvent system. Antal, I; Klebovich, I; Kovács, K; Ludányi, K; Stampf, G, 2010) | 0.36 |
| " The aim of the presently reported study was the evaluation of the antimycotic action of two azole compounds--miconazole and itraconazole (Janssen) against 205 Candida strains isolated from the various biological specimens of two groups of patients--hospitalized (group 1) and examined in outpatient clinic (group 2); differentiation of species and codes of these strains; analysis of dose-response curves and parameters of polygons of the azoles minimal inhibitory concentrations (MIC)." | ( [Susceptibility to miconazole and itraconazole of Candida strains isolated from hospitalized and outpatient clinic patients]. Kurnatowska, AK; Kwaśniewska, J, 2009) | 0.89 |
| " Formulation of MN in this dosage form will be more advantageous, producing dual effect: local in the buccal cavity and systemic with rapid absorption." | ( Miconazole nitrate oral disintegrating tablets: in vivo performance and stability study. Ahmed, TA; Badawi, AA; El-Say, KM; Mahmoud, MF; Samy, AM, 2012) | 1.82 |
| "The yield profile of the miconazole nitrate in the disintegration solutions by means of classical method from FR X, by HPLC dosage was researched." | ( Research studies on in vitro and ex vivo yield of the miconazole nitrate from oral biomucoadhesive tablets. Birsan, M; Cojocaru, I; Popovici, I; Scutariu, MM, ) | 0.68 |
| "Evaluate the impact of salt and counterion identity on performance of solid immediate release dosage forms of miconazole and clopidogrel, respectively, in fasted upper gastrointestinal lumen using in-vitro methodologies." | ( In-vitro evaluation of performance of solid immediate release dosage forms of weak bases in upper gastrointestinal lumen: experience with miconazole and clopidogrel salts. Dimopoulou, M; Mourouti, CS; Reppas, C; Symillides, M; Vertzoni, M, 2016) | 0.85 |
| "Miconazole data indicate that salts may adversely affect performance of immediate release dosage forms of weak bases." | ( In-vitro evaluation of performance of solid immediate release dosage forms of weak bases in upper gastrointestinal lumen: experience with miconazole and clopidogrel salts. Dimopoulou, M; Mourouti, CS; Reppas, C; Symillides, M; Vertzoni, M, 2016) | 2.08 |
| " Fluconazole is widely regarded as the antifungal drug of choice since its introduction in 1990 due to its high oral bioavailability, convenient dosing regimen and favourable safety profile." | ( Antifungal peptides: a potential new class of antifungals for treating vulvovaginal candidiasis caused by fluconazole-resistant Candida albicans. Barkham, T; Cheong, JW; Chia, CS; Hill, J; Lau, QY; Ng, FM; Ng, SM; Teo, JW; Yap, YY, 2017) | 0.46 |
| "Approximately 50% of solid oral dosage forms utilize salt forms of the active pharmaceutical ingredient (API)." | ( Impact of Solid-State Form on the Disproportionation of Miconazole Mesylate. Arora, K; Krzyzaniak, JF; Luthra, S; Patel, MA; Shamblin, SL; Taylor, LS, 2018) | 0.73 |
| " In the present work, we aim at the development of a novel miconazole (MCZ) microsponges gel as an attractive dosage form for vaginal candidiasis." | ( Improved vaginal retention and enhanced antifungal activity of miconazole microsponges gel: Formulation development and in vivo therapeutic efficacy in rats. Awad, GEA; Makhlouf, AIA; Salah, S, 2018) | 0.96 |
| " Furthermore, no association was found between categories of dosage of vaginal antimycotics and spontaneous abortions." | ( Vaginal antimycotics and the risk for spontaneous abortions. Daniel, S; Koren, G; Levy, A; Lunenfeld, E; Rotem, R, 2018) | 0.48 |
| " We unexpectedly discover a new class of aggregating ligands that exhibit negligible interactions with proteins but act as competitive sinks for the free inhibitor, resulting in bell-shaped dose-response curves." | ( Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators. Ahmed, R; Boulton, S; Cheng, X; Melacini, G; Selvaratnam, R; Van, K, 2019) | 0.51 |
| "Nadifloxacin, mometasone furoate and miconazole nitrate are formulated together as a topical antifungal dosage form." | ( A Validated Ultra-Performance Liquid Chromatographic Method for the Simultaneous Determination of Nadifloxacin, Mometasone Furoate and Miconazole Nitrate in Their Combined Dosage Form and Spiked Human Plasma Samples. Amer, SM; Elzanfaly, ES; Tarek, M; Wagdy, HA, 2020) | 1.03 |
| "Topical candidiasis is a known skin fungal infection which is usually treated by conventional dosage forms such as cream, gel, emulgel which are having numerous adverse effects on skin." | ( Development, characterization and evaluation of anti-fungal activity of miconazole based nanogel prepared from biodegradable polymer. Farooq, U; Jamil, QA; Khan, BA; Mehmood, Y; Nazir, I; Qadir, MI; Rasul, A; Riaz, H; Shah, PA; Sher, M, 2020) | 0.79 |
| " For developmental toxicity this requires scaling the in vitro observed dose-response characteristics to in vivo fetal exposure, while integrating maternal in vivo kinetics during pregnancy, in particular transplacental transfer." | ( Integrating in vitro chemical transplacental passage into a generic PBK model: A QIVIVE approach. Fragki, S; Hoogenveen, R; Piersma, AH; Schwillens, P; van Oostrom, C; Zeilmaker, MJ, 2022) | 0.72 |
| " Based on our findings, it could be concluded that the in situ hydrogel formulation using stimuli-responsive polymers could be a viable alternative to the conventional dosage form that can help to reduce the frequency of administration with ease of application to the site of infection, thus will provide better patient compliance." | ( Stimuli-Responsive in situ Spray Gel of Miconazole Nitrate for Vaginal Candidiasis. Choudhury, H; Gorain, B; Hsin, YK; Meng, LW; Pandey, M; Thangarajoo, T, 2023) | 1.18 |
| " The proposed method was applied for the determination of ONZ and MIZ in different dosage forms and human plasma samples with high % recoveries and low % RSD values." | ( Green synthesis, characterization, and antimicrobial applications of silver nanoparticles as fluorescent nanoprobes for the spectrofluorimetric determination of ornidazole and miconazole. Aboelkassim, E; Belal, F; El-Domany, RA; Magdy, G, 2022) | 0.91 |
| "Revising the protocol to extend the dosing period may improve the outcomes of surgical NEC after the onset." | ( Does protocol miconazole administration improve mortality and morbidity on surgical necrotizing enterocolitis? Harumatsu, T; Ibara, S; Ieiri, S; Ishihara, C; Kawano, T; Machigashira, S; Matsukubo, M; Murakami, M; Muto, M; Onishi, S; Sugita, K; Tokuhisa, T; Torikai, M; Yamada, K; Yamada, W; Yano, K, 2023) | 1.27 |
| " Therefore, miconazole-loaded nanoparticles/HA represent an innovative non-conventional pharmaceutical dosage form to treat the VVC and recurrent VVC." | ( Miconazole-loaded nanoparticles coated with hyaluronic acid to treat vulvovaginal candidiasis. Araújo, MGF; Barboza, APM; Branquinho, RT; Magalhães, JT; Marques, MBF; Moura, SAL; Quaresma, AV; Santos, SLEN; Silva, FHRD; Silva, GRD; Teixeira, ADR, 2023) | 2.73 |
| Class | Description |
|---|---|
| ether | An organooxygen compound with formula ROR, where R is not hydrogen. |
| imidazoles | A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. |
| dichlorobenzene | Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 39.8107 | 0.6310 | 35.7641 | 100.0000 | AID504339 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 12.5893 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 37.2212 | 0.0030 | 8.7949 | 48.0869 | AID1347053 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 28.1838 | 0.0316 | 37.5844 | 354.8130 | AID504865 |
| PPM1D protein | Homo sapiens (human) | Potency | 41.5437 | 0.0052 | 9.4661 | 32.9993 | AID1347411 |
| TDP1 protein | Homo sapiens (human) | Potency | 18.8120 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| AR protein | Homo sapiens (human) | Potency | 10.2096 | 0.0002 | 21.2231 | 8,912.5098 | AID743036 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 0.0052 | 7.8098 | 29.0929 | AID588855 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 89.1251 | 0.5318 | 15.4358 | 37.6858 | AID504845 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 2.2934 | 0.0123 | 7.9835 | 43.2770 | AID1346984; AID1645841 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 22.9939 | 0.0013 | 10.1577 | 42.8575 | AID1259252; AID1259253; AID1259255; AID1259256 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 11.4554 | 0.0002 | 14.3764 | 60.0339 | AID720691 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 10.0000 | 0.0054 | 28.0263 | 1,258.9301 | AID1346985 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 10.2774 | 0.0002 | 29.3054 | 16,493.5996 | AID743069; AID743075 |
| G | Vesicular stomatitis virus | Potency | 0.1900 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 1.0684 | 0.0010 | 8.3798 | 61.1304 | AID1645840 |
| polyprotein | Zika virus | Potency | 37.2212 | 0.0030 | 8.7949 | 48.0869 | AID1347053 |
| IDH1 | Homo sapiens (human) | Potency | 23.1093 | 0.0052 | 10.8652 | 35.4813 | AID686970 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 7.9433 | 0.0355 | 20.9770 | 89.1251 | AID504332 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 11.8119 | 0.0007 | 23.0674 | 1,258.9301 | AID743085; AID743122 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 7.1669 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 0.1000 | 9.1916 | 31.6228 | AID1346983 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 1.0000 | 0.0020 | 7.5337 | 39.8107 | AID891 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 0.0251 | 0.0025 | 5.8400 | 31.6228 | AID899 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 0.3162 | 0.0063 | 6.9043 | 39.8107 | AID883 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 57.4571 | 0.3548 | 28.0659 | 89.1251 | AID504847 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 32.6427 | 0.0041 | 9.9848 | 25.9290 | AID504444 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 4.4668 | 0.0178 | 9.6374 | 44.6684 | AID588834 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 11.3588 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743067 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 6.7016 | 0.1683 | 16.4040 | 67.0158 | AID720504 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 7.0795 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 12.5893 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 12.5893 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 12.5893 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.2202 | 0.0079 | 8.2332 | 1,122.0200 | AID2546 |
| geminin | Homo sapiens (human) | Potency | 12.0747 | 0.0046 | 11.3741 | 33.4983 | AID624296; AID624297 |
| Vpr | Human immunodeficiency virus 1 | Potency | 63.0957 | 1.5849 | 19.6264 | 63.0957 | AID651644 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 8.7005 | 0.0056 | 12.3677 | 36.1254 | AID624032 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 0.5012 | 0.0316 | 10.2792 | 39.8107 | AID884; AID885 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0089 | 0.8913 | 12.0676 | 28.1838 | AID1487 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 6.3096 | 0.3162 | 12.7657 | 31.6228 | AID881 |
| Interferon beta | Homo sapiens (human) | Potency | 31.2053 | 0.0033 | 9.1582 | 39.8107 | AID1347411; AID1645842 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 0.1900 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 12.4293 | 0.0023 | 19.5956 | 74.0614 | AID651631; AID720552 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 2.7136 | 0.0063 | 8.2350 | 39.8107 | AID881; AID883 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 39.8107 | 3.9811 | 46.7448 | 112.2020 | AID720708 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 0.1900 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 0.1900 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 6 | Homo sapiens (human) | IC50 (µMol) | 6.5000 | 4.0000 | 5.2500 | 6.5000 | AID439881 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 (µMol) | 11.9000 | 0.0000 | 0.9453 | 9.9400 | AID1389641; AID1718977 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 (µMol) | 5.3140 | 0.0001 | 1.0076 | 8.7800 | AID625218 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 2.7840 | 0.0000 | 0.8871 | 10.0000 | AID625218 |
| Bile salt export pump | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.1100 | 7.1903 | 10.0000 | AID1449628 |
| Cytochrome P450 1A2 | Mus musculus (house mouse) | IC50 (µMol) | 4.5500 | 4.5500 | 4.5500 | 4.5500 | AID1849453 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 (µMol) | 29.2560 | 0.0000 | 0.5369 | 10.0000 | AID625184 |
| Chymotrypsinogen A | Bos taurus (cattle) | IC50 (µMol) | 125.0000 | 0.9800 | 4.0560 | 7.2000 | AID52776 |
| Beta-lactamase | Escherichia coli K-12 | IC50 (µMol) | 40.0000 | 0.0150 | 2.4657 | 8.0000 | AID43431 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 (µMol) | 27.4300 | 0.0001 | 0.5453 | 10.0000 | AID625186 |
| Cytochrome P450 1A2 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 4.5500 | 4.5500 | 4.5500 | 4.5500 | AID1849448 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (human) | Ki | 0.2430 | 0.0380 | 0.3969 | 1.6250 | AID53377 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 (µMol) | 4.5500 | 0.0001 | 1.7740 | 10.0000 | AID1849443 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 (µMol) | 4.1600 | 0.0002 | 1.6789 | 8.6800 | AID625185 |
| Heme oxygenase 1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 25.4000 | 1.1000 | 4.3200 | 10.0000 | AID1799166 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 (µMol) | 2.0000 | 0.0640 | 4.0126 | 10.0000 | AID150754; AID681128 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 98.4000 | 3.5000 | 5.6067 | 6.9300 | AID681138 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 2.9390 | 0.0004 | 1.8773 | 10.0000 | AID625207 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.9150 | 0.0032 | 2.2887 | 9.3160 | AID625207 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 (µMol) | 4.3360 | 0.0000 | 1.2326 | 7.7930 | AID625152 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 1.5420 | 0.0000 | 0.6902 | 10.0000 | AID625152 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 (µMol) | 3.1970 | 0.0000 | 1.1546 | 7.5858 | AID625154 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.4460 | 0.0000 | 0.7951 | 9.1201 | AID625154 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 (µMol) | 3.0000 | 0.0002 | 2.3185 | 10.0000 | AID150752; AID150755; AID681122 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 40.9300 | 0.0200 | 2.3594 | 8.5900 | AID681142; AID681143 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 (µMol) | 12.6350 | 0.0002 | 1.4681 | 9.0000 | AID625204 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 7.2960 | 0.0001 | 1.3391 | 9.9840 | AID625204 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 (µMol) | 0.4938 | 0.0001 | 1.7536 | 10.0000 | AID1389644; AID1634154; AID1783793; AID1849447; AID428564; AID54923; AID625251 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 (µMol) | 3.9660 | 0.0000 | 1.4421 | 7.3470 | AID625201 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 1.4870 | 0.0001 | 0.8074 | 10.0000 | AID625201 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 (µMol) | 2.8110 | 0.0000 | 1.8940 | 8.5470 | AID625196 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 1.5890 | 0.0000 | 0.9306 | 10.0000 | AID625196 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 (µMol) | 1.3200 | 0.0000 | 2.0151 | 10.0000 | AID1849446; AID625249 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 (µMol) | 3.9710 | 0.0000 | 1.4039 | 10.0000 | AID625151 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.9560 | 0.0000 | 0.5972 | 9.1201 | AID625151 |
| Aromatase | Homo sapiens (human) | IC50 (µMol) | 0.6000 | 0.0000 | 1.2904 | 10.0000 | AID479369 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 (µMol) | 19.1000 | 0.0000 | 2.8005 | 10.0000 | AID1849444; AID625248 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | IC50 (µMol) | 5.4820 | 0.0023 | 3.2415 | 8.0600 | AID625206 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 4.1110 | 0.0030 | 2.3098 | 6.0450 | AID625206 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 (µMol) | 12.5040 | 0.0000 | 0.7472 | 8.0000 | AID625253 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 4.1680 | 0.0000 | 0.6518 | 10.0000 | AID625253 |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | IC50 (µMol) | 3.7000 | 0.0537 | 3.0757 | 10.0000 | AID1184068; AID1184069; AID1389644; AID1718979 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 (µMol) | 7.0890 | 0.0010 | 1.9794 | 14.1600 | AID625228 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 4.7260 | 0.0003 | 1.2185 | 8.9270 | AID625228 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 (µMol) | 2.8110 | 0.0002 | 1.8742 | 10.0000 | AID625196 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.5890 | 0.0001 | 0.9490 | 10.0000 | AID625196 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 (µMol) | 3.5980 | 0.0000 | 1.2380 | 8.1590 | AID625202 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 1.6420 | 0.0002 | 0.7257 | 10.0000 | AID625202 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 (µMol) | 11.4720 | 0.0003 | 1.3833 | 8.4000 | AID625190 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 6.5550 | 0.0001 | 0.7396 | 10.0000 | AID625190 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 (µMol) | 3.1540 | 0.0001 | 1.0104 | 9.9280 | AID625153 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.6680 | 0.0000 | 0.5405 | 7.7600 | AID625153 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 (µMol) | 7.8000 | 0.2000 | 4.7130 | 10.0000 | AID150753; AID681119 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 22.2000 | 2.1000 | 4.3150 | 7.4800 | AID681137 |
| Substance-K receptor | Homo sapiens (human) | IC50 (µMol) | 4.8390 | 0.0001 | 3.1210 | 9.5530 | AID625227 |
| Substance-K receptor | Homo sapiens (human) | Ki | 1.6130 | 0.0001 | 1.9242 | 9.7930 | AID625227 |
| Cannabinoid receptor 1 | Homo sapiens (human) | IC50 (µMol) | 21.0500 | 0.0001 | 0.2753 | 10.0000 | AID625235 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 16.6140 | 0.0001 | 0.5077 | 9.6000 | AID625235 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 (µMol) | 6.2470 | 0.0003 | 1.8473 | 9.2250 | AID625252 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 3.1240 | 0.0001 | 0.8363 | 10.0000 | AID625252 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 (µMol) | 15.2700 | 0.0001 | 1.1423 | 9.3280 | AID625255 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 5.3540 | 0.0000 | 0.4362 | 10.0000 | AID625255 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 (µMol) | 18.6590 | 0.0000 | 0.9332 | 10.0000 | AID625193 |
| Heme oxygenase 2 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 25.4000 | 1.1000 | 4.4833 | 10.0000 | AID1799166 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 (µMol) | 2.9390 | 0.0008 | 1.5416 | 20.0000 | AID625207 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.9150 | 0.0003 | 1.4656 | 10.0000 | AID625207 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 (µMol) | 0.2630 | 0.0009 | 1.2304 | 10.0000 | AID625229 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 (µMol) | 6.7500 | 0.0220 | 2.2987 | 10.0000 | AID625270 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 6.6370 | 0.0006 | 2.1973 | 10.0000 | AID625270 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 (µMol) | 3.0460 | 0.0002 | 0.7568 | 8.8970 | AID625200 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 1.4970 | 0.0000 | 0.3609 | 10.0000 | AID625200 |
| Substance-P receptor | Homo sapiens (human) | IC50 (µMol) | 6.8130 | 0.0000 | 0.0952 | 6.8130 | AID625226 |
| Substance-P receptor | Homo sapiens (human) | Ki | 3.7160 | 0.0000 | 0.7936 | 8.7470 | AID625226 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 (µMol) | 3.9070 | 0.0001 | 0.8801 | 8.8500 | AID625192 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 1.1160 | 0.0000 | 0.3855 | 10.0000 | AID625192 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 (µMol) | 5.3140 | 0.0001 | 1.0302 | 9.0000 | AID625218 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 2.7840 | 0.0001 | 0.9549 | 10.0000 | AID625218 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 (µMol) | 11.4720 | 0.0005 | 1.4835 | 7.8000 | AID625190 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 6.5550 | 0.0003 | 1.2967 | 9.2440 | AID625190 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 (µMol) | 17.8000 | 0.0060 | 1.6251 | 10.0000 | AID717846 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 (µMol) | 14.2530 | 0.0007 | 1.5594 | 10.0000 | AID625195 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 8.0020 | 0.0000 | 1.0609 | 9.7920 | AID625195 |
| Adenosine receptor A1 | Homo sapiens (human) | IC50 (µMol) | 12.5190 | 0.0002 | 0.6818 | 7.7010 | AID625194 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 7.3030 | 0.0002 | 0.9316 | 10.0000 | AID625194 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 (µMol) | 0.7780 | 0.0001 | 0.8645 | 8.7096 | AID625222 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.4140 | 0.0000 | 0.7048 | 8.1930 | AID625222 |
| Melanocortin receptor 4 | Homo sapiens (human) | IC50 (µMol) | 12.4480 | 0.0002 | 0.6413 | 6.1900 | AID625148 |
| Melanocortin receptor 4 | Homo sapiens (human) | Ki | 11.9700 | 0.0000 | 0.3086 | 4.8860 | AID625148 |
| Melanocortin receptor 5 | Homo sapiens (human) | IC50 (µMol) | 22.6070 | 0.0009 | 1.2566 | 9.5180 | AID625149 |
| Melanocortin receptor 5 | Homo sapiens (human) | Ki | 21.2060 | 0.0005 | 3.5265 | 8.9290 | AID625149 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 (µMol) | 8.9790 | 0.0000 | 2.3983 | 10.0000 | AID1164257; AID1181454; AID1849445; AID625247 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 (µMol) | 25.8440 | 0.0001 | 0.9950 | 10.0000 | AID625244 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 (µMol) | 6.0590 | 0.0001 | 0.8133 | 10.0000 | AID625163 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 2.4600 | 0.0000 | 0.4197 | 10.0000 | AID625163 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 (µMol) | 3.1990 | 0.0001 | 1.0178 | 8.7960 | AID625254 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 1.0860 | 0.0000 | 0.6020 | 10.0000 | AID625254 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 (µMol) | 3.3870 | 0.0002 | 0.7521 | 8.0140 | AID625161 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 1.1940 | 0.0000 | 0.5978 | 9.9300 | AID625161 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 (µMol) | 6.5940 | 0.0000 | 1.2011 | 10.0000 | AID625162 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 2.6370 | 0.0000 | 0.3624 | 10.0000 | AID625162 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 (µMol) | 5.5450 | 0.0001 | 1.1873 | 8.9125 | AID625217 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 3.5290 | 0.0003 | 0.7693 | 10.0000 | AID625217 |
| Melanocortin receptor 3 | Homo sapiens (human) | IC50 (µMol) | 18.4850 | 0.0012 | 0.0166 | 0.0832 | AID625147 |
| Melanocortin receptor 3 | Homo sapiens (human) | Ki | 16.1320 | 0.0001 | 0.2452 | 2.8650 | AID625147 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 (µMol) | 2.8110 | 0.0000 | 1.8194 | 10.0000 | AID625196 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.5890 | 0.0000 | 0.9650 | 10.0000 | AID625196 |
| Type-2 angiotensin II receptor | Homo sapiens (human) | IC50 (µMol) | 23.9860 | 0.0001 | 0.0289 | 0.2000 | AID625209 |
| Type-2 angiotensin II receptor | Homo sapiens (human) | Ki | 7.7790 | 0.0002 | 0.5650 | 7.7790 | AID625209 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 (µMol) | 10.8870 | 0.0017 | 0.8381 | 5.4200 | AID625221 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 5.0550 | 0.0002 | 0.5229 | 10.0000 | AID625221 |
| Beta-lactamase TEM | Escherichia coli | IC50 (µMol) | 125.0000 | 0.0019 | 1.7618 | 10.0000 | AID1616742 |
| Cholinesterase | Equus caballus (horse) | IC50 (µMol) | 5.5500 | 0.0000 | 2.2214 | 9.4000 | AID1389642; AID1718976 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 (µMol) | 1.7010 | 0.0007 | 1.8419 | 46.0000 | AID625256 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 1.3520 | 0.0002 | 1.1115 | 8.0280 | AID625256 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 (µMol) | 0.2000 | 0.0500 | 1.4390 | 4.0000 | AID322753 |
| Indoleamine 2,3-dioxygenase 2 | Mus musculus (house mouse) | IC50 (µMol) | 6.7000 | 1.5000 | 5.0875 | 8.2000 | AID717845 |
| Calcium release-activated calcium channel protein 1 | Homo sapiens (human) | IC50 (µMol) | 63.5000 | 0.5000 | 4.2500 | 9.8000 | AID1330309; AID1330311 |
| methionyl-tRNA synthetase, putative | Trypanosoma brucei brucei TREU927 | IC50 (µMol) | 12.2990 | 0.1475 | 2.2098 | 8.7250 | AID651971; AID651989 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Cytochrome P450 2C9 | Homo sapiens (human) | Kd | 0.0730 | 0.0730 | 0.0730 | 0.0730 | AID1300321 |
| Aromatase | Rattus norvegicus (Norway rat) | EC50 (µMol) | 0.4000 | 0.0550 | 0.8350 | 4.1000 | AID54068 |
| Cytochrome P450 144 | Mycobacterium tuberculosis CDC1551 | Kd | 3.1933 | 0.3600 | 2.5990 | 5.3000 | AID1799791 |
| Steroid C26-monooxygenase | Mycobacterium tuberculosis CDC1551 | Kd | 3.1933 | 0.1000 | 2.5967 | 6.1000 | AID1799791 |
| Steroid C26-monooxygenase | Mycobacterium tuberculosis CDC1551 | Kd | 3.1933 | 0.3600 | 2.5990 | 5.3000 | AID1799791 |
| Mycocyclosin synthase | Mycobacterium tuberculosis H37Rv | Kd | 0.0730 | 0.0730 | 1.5547 | 6.0000 | AID1300321 |
| Lanosterol 14-alpha demethylase | Mycobacterium tuberculosis H37Rv | Kd | 0.2000 | 0.2000 | 0.4200 | 1.3000 | AID572699 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 0.1950 | 0.1950 | 3.6679 | 18.6960 | AID540270 |
| Epoxide hydrolase 1 | Rattus norvegicus (Norway rat) | E100 | 84.0000 | 6.2000 | 6.2000 | 6.2000 | AID208343 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 0.1950 | 0.1950 | 4.9920 | 98.5000 | AID540268 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043 | Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1303001 | Fungicidal activity against Candida albicans MTCC 3018 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1180305 | Antimicrobial activity against Cryptococcus neoformans NCIM-3378 after 20 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID310100 | Antifungal activity against Aspergillus fumigatus by disc diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine. |
| AID1738741 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Lanosterol level at 2 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1849447 | Inhibition of CYP3A4 in human liver Microsome using midazolam as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID1888311 | Antifungal activity against fluconazole resistant Candida albicans strain 17# assessed as fungal growth inhibition measured after 72 hrs in presence of naftifine by CLSI protocol based liquid medium dilution method | |||
| AID1310544 | Antifungal activity against Candida aaseri MTCC 1962 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1327749 | Antimicrobial activity against Candida albicans MTCC183 measured after 24 hrs by well-diffusion method | |||
| AID1146956 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 2% formulation administered vaginally bid for 4 days measured 6 hrs post last dose relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID257544 | Antifungal activity against Candida albicans | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID310055 | Antimicrobial activity against Candida glabrata 123 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23 | Synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to P450(14DM) by molecular docking and MM/PBSA method. |
| AID1237445 | Antimicrobial activity against Escherichia coli MTCC 739 incubated for 24 hrs at 37 degC by well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID554714 | Antimicrobial activity against Candida krusei NZCDC 89.102 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1575914 | Fungicidal activity against Issatchenkia hanoiensis MTCC 4755 assessed as fungal killing incubated for 24 hrs | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID376662 | Antifungal activity against Cladosporium cucumerinum after 3 days | 2006 | Journal of natural products, May, Volume: 69, Issue:5 | Bioactive diterpenes from the fruits of Detarium microcarpum. |
| AID310054 | Antimicrobial activity against Candida albicans 3038 after 48 hrs | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23 | Synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to P450(14DM) by molecular docking and MM/PBSA method. |
| AID1758038 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 1.7%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1575878 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as inhibition of bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1184070 | Inhibition of mouse IDO1 expressed in mouse P815B cells using L-tryptophan substrate incubated for 18 hrs by HPLC based cellular assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. |
| AID406956 | Therapeutic index, ratio of CC50 for human K562 cells to MIC90 for Candida albicans ATCC 10261 | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID1267320 | Antifungal activity against Pichia kudriavzevii MTCC 3020 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1320273 | Antimicrobial activity against Staphylococcus aureus MLS-16 MTCC 96 incubated for 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A diastereoselective synthesis of tetrahydro- and dihydro-pyrido[2,3-c]coumarin derivatives via a one-pot three-component Povarov reaction catalyzed by bismuth(III) chloride. |
| AID211162 | Antifungal activity against Trichophyton asteroides was determined in vitro | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1310555 | Fungicidal activity against Candida albicans MTCC 227 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1293885 | Antifungal activity against Cryptococcus neoformans NCIM 576 after 48 hrs by agar cup plate method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation. |
| AID47880 | Antimycotic activity against Candida parapsilosis was evaluated as compound concentration at which no macroscopic signs of fungal growth were detected | 1999 | Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14 | Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine with potent antitumor and antimicrobial activity. |
| AID48245 | Compound is evaluated for geometric mean of MIC values of Candida species | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1268254 | Antifungal activity against Candida albicans MTCC 854 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID150751 | Inhibition of P-glycoprotein using ATPase in MDR1 membranes | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID593900 | Antimicrobial activity against Aspergillus niger ATCC 6275 by broth dilution method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | Synthesis and biological evaluation of tetracyclic thienopyridones as antibacterial and antitumor agents. |
| AID1268271 | Fungicidal activity against Candida albicans MTCC 3958 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID284512 | Antimicrobial activity against Candida pseudotropicalis | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Chemoenzymatic synthesis and antimicrobial activity evaluation of monoglucosyl diglycerides. |
| AID375813 | Antifungal activity against Candida albicans NCIM 3471 by agar plate assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents. |
| AID681119 | TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID1315456 | Antifungal activity against Candida albicans MTCC 854 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1130380 | Antifungal activity against Aspergillus fumigatus assessed as growth inhibition in sabouraud broth after 14 days | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID1758020 | Hemolytic activity in rabbit RBC assessed as hemolysis ratio at 4 ug/ml measured after 3 hrs by microplate reader assay relative to control | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1291277 | Fungicidal activity against Candida albicans MTCC 3958 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID551060 | Antifungal activity against Cryptococcus neoformans assessed as appearance of macroscopically visible colonies after 48 and 72 hrs by standard agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. |
| AID294191 | Antibacterial activity against Escherichia coli ATCC 25922 at 100 ug/ml by diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8 | Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers. |
| AID1150038 | Antifungal activity against Cryptococcus neoformans assessed as lowest dose level for total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1337798 | Antibacterial activity against Escherichia coli NCIM 2688 measured after 8 hrs | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID85361 | Inhibition of Vaginal Candida (C-60 strain) infection in Hamsters, estimated as Percent Area under curve at 0.01 % concentration after 4 days of administration | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID406950 | Antifungal activity against Candida parapsilosis ATCC 22019 at 35 degC after 48 hrs by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID462897 | Cytotoxicity against MDCK cells at >10 uM | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs. |
| AID382728 | Antimicrobial activity against Candida albicans ATCC 10231 after 24 hrs by microdilution assay | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1130384 | Antifungal activity against Erysipelothrix insidiosa assessed as growth inhibition in sabouraud broth after 14 days | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID554707 | Antimicrobial activity against Candida krusei NZCDC 89.021 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID48258 | 90% inhibitory activity against Candida. species (40 clinical isolates) determined at pH-7.2 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1600771 | Bactericidal activity against Pseudomonas aeruginosa MTCC 2453 assessed as reduction in bacterial survival incubated for 24 hrs followed by transfer of microbial suspension to agar plates and measured at 24 hrs post transfer by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID244792 | Antifungal activity to cause 99% reduction of surviving cells range is equal to 4-32 | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID1625248 | Antifungal activity against Microsporum gypseum by colorimetric broth microdilution method | 2019 | Journal of natural products, 04-26, Volume: 82, Issue:4 | Trichothecenes from a Soil-Derived Trichoderma brevicompactum. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1268259 | Antifungal activity against Candida albicans MTCC 7315 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1075995 | Antifungal activity against Candida albicans NCIM 3471 by standard agar method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Synthesis, antileishmanial activity and docking study of N'-substitutedbenzylidene-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetohydrazides. |
| AID1196915 | Fungicidal activity against Microsporum canis B68128 | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents. |
| AID1133312 | Antifungal activity against Candida albicans ATCC 14053 assessed as lowest concentration required for total inhibition by broth dilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID479369 | Inhibition of human placental microsome CYP19 | 2010 | Bioorganic & medicinal chemistry letters, May-15, Volume: 20, Issue:10 | Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). |
| AID1133314 | Antibacterial activity against Staphylococcus aureus ATCC 12600 assessed as lowest concentration required for total inhibition by broth microdilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID1738716 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as ergosterol level at 0.125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1156866 | Antimicrobial activity against Trichophyton mentagrophytes after 96 hrs by microbroth dilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents. |
| AID717846 | Inhibition of mouse Ido1 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. |
| AID1337846 | Antifungal activity against Aspergillus niger NCIM 1196 by standard agar method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1133315 | Antibacterial activity against Streptococcus faecalis ATCC 14506 assessed as lowest concentration required for total inhibition by broth microdilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID609825 | Antifungal activity against Aspergillus flavus | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | The novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation. |
| AID1146968 | Antifungal activity against Trichophyton mentagrophytes infected in guinea pig assessed as noninfected animals at 0.5% formulation in steryl alcohol, cetyl alcohol, Span 60, Tween 60, propylene glycol, mineral oil, and water administered qd for 5 days mea | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID454196 | Antifungal activity against Fusarium oxysporum NCIM 1332 by standard agar plate method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents. |
| AID1684668 | Inhibition of biofilm formation in Staphylococcus aureus MTCC 92 incubated for 24 hrs by crystal violet staining based microtiter plate method | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID214807 | Antifungal activity against Trichophyton mentagrophytes | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents. |
| AID1391548 | Fungicidal activity against Candida aaseri MTCC 1962 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1595101 | Antifungal activity against Candida albicans MTCC183 assessed as reduction in fungal cell growth incubated for 24 to 48 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1146999 | Antifungal activity against Epidermophyton floccosum assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1133317 | Antibacterial activity against Erysipelothrix insidiosa ATCC 19414 assessed as lowest concentration required for total inhibition by broth microdilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID1738701 | Antifungal activity against Candida albicans ATCC SC5314 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1291251 | Antimicrobial activity against Candida albicans MTCC 3017 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1391541 | Fungicidal activity against Candida albicans MTCC 1637 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1684681 | Fungicidal activity against Candida krusei MTCC 3020 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1379941 | Antifungal activity against Candida sake clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
| AID1268247 | Antifungal activity against Candida albicans MTCC 3017 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1303004 | Fungicidal activity against Candida albicans MTCC 7315 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID463441 | Antimicrobial activity against Fusarium solani after 7 days | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: indolenyl sulfonamide derivatives. |
| AID1293881 | Antifungal activity against Candida albicans NCIM 3471 after 48 hrs by agar cup plate method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation. |
| AID486967 | Antifungal activity against Aspergillus fumigatus after 72 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID1738724 | Hemolytic activity in rabbit RBC assessed as hemolysis ratio at 2 ug/ml measured after 3 hrs relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1600762 | Antibacterial activity against Escherichia coli MTCC 739 assessed as reduction in bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID1302965 | Antimicrobial activity against Staphylococcus aureus MTCC 96 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
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| AID1327756 | Antimicrobial activity against Candida albicans MTCC4748 measured after 24 hrs by well-diffusion method | |||
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| AID1575921 | Ratio of MFC to MIC against Candida albicans MTCC 4748 | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
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| AID1446846 | Antifungal activity against Candida albicans MTCC 4748 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID1310558 | Fungicidal activity against Candida albicans MTCC 3017 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1315462 | Antifungal activity against Candida albicans MTCC 7315 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID289623 | Antifungal activity against Trichophyton tonsurans after 7 days | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines. |
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| AID1063464 | Cytotoxicity against human FADU cells assessed as concentration required to decrease cell viability incubated for 24 hrs followed by compound washout measured after 18 hrs by resazurin dye-based assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. |
| AID593813 | Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 by broth dilution method | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | Synthesis and biological evaluation of tetracyclic thienopyridones as antibacterial and antitumor agents. |
| AID1598719 | Binding affinity to Triton-X 100 assessed as line broadening at 150 uM by 1H-NMR spectra analysis | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10 | Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators. |
| AID406952 | Antifungal activity against Candida albicans ATCC 10261 at 35 degC after 48 to 96 hrs by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
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| AID1394700 | Retention time of the compound at 0.4 mM by HPLC analysis | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1327754 | Antimicrobial activity against Candida glabrata MTCC3019 measured after 24 hrs by well-diffusion method | |||
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| AID1854971 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv incubated for 24 hrs and measured by MTT assay | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis. |
| AID554717 | Antimicrobial activity against Saccharomyces cerevisiae isolate ADdelta overexpressing Abc1p after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID257548 | Antifungal activity against Aspergillus fumigatus | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID1758039 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 2 ug/ml after 16 hrs by GC-MS analysis (Rvb = 1.7%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1265644 | Antifungal activity against Candida parapsilosis clinical isolate after 24 hrs by sabouraud dextrose broth based microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. |
| AID1758047 | Anti-biofilm activity in Candida albicans CPCC400616 assessed as inhibition of biofilm formation incubated for 24 hrs with 3 hrs precultured fungal suspension by XTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1267310 | Antifungal activity against Candida albicans MTCC 227 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID311798 | Antifungal activity against Alternaria alternata DSM 2006 by microdilution technique | 2007 | Journal of natural products, Nov, Volume: 70, Issue:11 | Minor sesquiterpene lactones from Centaurea pullata and their antimicrobial activity. |
| AID1391543 | Fungicidal activity against Candida albicans MTCC 3018 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1337848 | Antifungal activity against Cryptococcus neoformans NCIM 576 by standard agar method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID696184 | Antifungal activity against Candida albicans MTCC 227 after 2 to 3 days by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 22, Issue:21 | Synthesis, anti-inflammatory and antimicrobial evaluation of novel 1-acetyl-3,5-diaryl-4,5-dihydro (1H) pyrazole derivatives bearing urea, thiourea and sulfonamide moieties. |
| AID1291281 | Fungicidal activity against Candida aaseri MTCC 1962 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID150755 | Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID1291253 | Antimicrobial activity against Candida albicans MTCC 227 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1759388 | Antifungal activity against Aspergillus niger MTCC 404 assessed as zone of inhibition at 36 uM incubated for 2 days by cross streak plate method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents. |
| AID1332996 | Antifungal activity against Fusarium oxysporum M42 after 72 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones. |
| AID766645 | Antifungal activity against Candida albicans MTCC 4748 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID752003 | Antifungal activity against Aspergillus flavus NCIM 539 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9 | Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity. |
| AID1133310 | Antifungal activity against Trichophyton mentagrophytes assessed as lowest concentration required for total inhibition broth dilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID1147010 | Antifungal activity against Candida albicans infected in mouse assessed as noninfected animals at 2% formulation in modified PEG 400 solution administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID747575 | Antifungal activity against Aspergillus niger MTCC 282 after 30 hrs by serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties. |
| AID327200 | Antifungal activity against Aspergillus fumigatus after 72 hrs | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Synthesis of new N-phenylpyrazole derivatives with potent antimicrobial activity. |
| AID1758035 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Obtusifoliol level at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID249258 | Antifungal activity to cause 99% reduction of surviving cells in 90% isolates | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID691209 | Antifungal activity against Fusarium solani MTCC 350 after 2 to 3 days by modified agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. |
| AID1315477 | Fungicidal activity against Candida albicans MTCC 854 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1310567 | Fungicidal activity against Issatchenkia hanoiensis MTCC 4755 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1150047 | Antibacterial activity against Staphylococcus haemolyticus assessed as lowest dose level for total inhibition of bacterial growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID554724 | Fold resistant, ratio of MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Candida krusei ERG11C to MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Abc1p | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1147004 | Antibacterial activity against Staphylococcus aureus No. 14154 assessed as growth inhibition by broth microdilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID26810 | Partition coefficient (logP) | 1985 | Journal of medicinal chemistry, Aug, Volume: 28, Issue:8 | Structural features of imidazole derivatives that enhance styrene oxide hydrolase activity in rat hepatic microsomes. |
| AID416041 | Fungicidal activity against tebuconazole-adapted wild type Colletotrichum graminicola CgM2 assessed as inhibition of radial growth rate at 23 degC in darkness | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacy. |
| AID1504831 | Antifungal activity against Trichophyton mentagrophytes ATCC 28185 after 72 hrs by agar dilution method | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12 | Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis. |
| AID1575920 | Ratio of MFC to MIC against Candida albicans MTCC 3018 | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID336891 | Antifungal activity against Aspergillus fumigatus MSU-SM 920 after 2 to 4 days | |||
| AID416040 | Fungicidal activity against tebuconazole-nonadapted wild type Colletotrichum graminicola CgM2 assessed as inhibition of radial growth rate at 23 degC in darkness | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacy. |
| AID249325 | Minimum inhibitory concentration to inhibit 90% of the isolates | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID1267329 | Inhibition of ergosterol biosynthesis in Candida parapsilosis MTCC 1744 assessed as mean ergosterol content at 16 ug/ml after 20 hrs by spectrophotometric analysis (Rvb=1.62 +/- 0.08 ug/ml) | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1283270 | Inhibition of CYP51 in Dhcr7-deficient mouse Neuro2a cells assessed as decrease in 7-DHC levels at 1 uM by LC-MS/GC-MS analysis | 2016 | Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3 | The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts. |
| AID1713521 | Antimicrobial activity against Staphylococcus aureus MTCC 96 assessed as inhibition zone measured after 24 hrs incubation by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A simple, one pot synthesis of furo[3,2-c]chromenes and evaluation of antimicrobial activity. |
| AID1575918 | Ratio of MFC to MIC against Candida albicans MTCC 227 | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1303005 | Fungicidal activity against Candida parapsilosis MTCC 1744 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1684699 | Antifungal activity against Candida albicans MTCC 183 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID125959 | Minimum inhibitory concentration against Microsporum gypseum at a pH of 5.7 using SDB medium | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID43563 | Fold decrease in IC50 vs beta-lactamase on pre-incubation | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID1684689 | Fungicidal activity against Candida albicans MTCC 227 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1557082 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID45344 | In vitro antifungal activity against 40 strains of Candida albicans at pH 5.8 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID311797 | Antifungal activity against Fusarium tricinctum CBS 514478 by microdilution technique | 2007 | Journal of natural products, Nov, Volume: 70, Issue:11 | Minor sesquiterpene lactones from Centaurea pullata and their antimicrobial activity. |
| AID532561 | Antifungal activity against Saccharomyces cerevisiae BY4741 assessed as growth rate at 0.5 ug/ml (Rvb = 0.144%) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID1738721 | Antibiofilm activity against FCZ-Resistant Candida albicans CPCC400616 assessed as sessile minimum inhibitory concentration of biofilm formation at 50% after 6 hrs by XTT assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID670554 | Antifungal activity against Candida albicans MTCC 7315 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID202868 | Antifungal activity against Saccharomyces cerevisiae ATCC 7754 | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Rational design of antimicrobial agents: antifungal activity of alk(en)yl dihydroxybenzoates and dihydroxyphenyl alkanoates. |
| AID1575877 | Antibacterial activity against Micrococcus luteus MTCC 2470 assessed as inhibition of bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID226461 | Geometric mean for the above three species of Candida, tested in EMEM medium | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1758016 | Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1267315 | Antifungal activity against Candida albicans MTCC 4748 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1162423 | Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 after 48 hrs by two-fold broth dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | A new efficient route to 7-aryl-6-fluoro-8-nitroquinolones as potent antibacterial agents. |
| AID19468 | Partition coefficient (logP) | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID218572 | Fold increase in IC50 vs beta-lactamase with 10x increased enzyme | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID1738718 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as ergosterol level at 2 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1332997 | Antifungal activity against Saccharomyces cerevisiae SH20 after 72 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones. |
| AID1291276 | Fungicidal activity against Candida albicans MTCC 3018 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1180301 | Antimicrobial activity against Aspergillus flavus NCIM-539 after 20 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID1315478 | Fungicidal activity against Candida albicans MTCC 1637 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1758037 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 1.7%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1575890 | Antifungal activity against Candida albicans MTCC 7315 assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID403460 | Antifungal activity against Cladosporium cucumerinum at 10 ug | 1998 | Journal of natural products, Dec, Volume: 61, Issue:12 | Use of on-flow LC/1H NMR for the study of an antioxidant fraction from Orophea enneandra and isolation of a polyacetylene, lignans, and a tocopherol derivative. |
| AID766648 | Antifungal activity against Candida albicans MTCC 3017 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID752002 | Antifungal activity against Aspergillus niger NCIM 1196 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9 | Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity. |
| AID381888 | Antimicrobial activity against Alternaria alternata DMS2006 by serial dilution technique | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | A novel sesquiterpene lactone from Centaurea pullata: structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties. |
| AID1394716 | Fungistatic activity against fluconazole-resistant Candida albicans ATCC 64550 at 4 times MIC incubated for overnight flowed by replating and measured after 24 hrs | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1575892 | Antifungal activity against Candida glabrata MTCC 3019 assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1058357 | Antimicrobial activity against Klebsiella planticola MTCC 530 after 24 hrs by well diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID1394699 | Antifungal activity against fluconazole-resistant Candida albicans ATCC 64550 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1327750 | Antimicrobial activity against Candida albicans MTCC227 measured after 24 hrs by well-diffusion method | |||
| AID338272 | Antimicrobial activity against Pseudomonas aeruginosa DSM 1117 after 18 hrs by twofold serial dilution method | 1994 | Journal of natural products, Dec, Volume: 57, Issue:12 | Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays. |
| AID554722 | Fold resistant, ratio of MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Saccharomyces cerevisiae ERG11 to MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Abc1p | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID249316 | In vitro concentration causing 50% inhibition of Candida albicans with percentage of resistant strains %R = 33.33 (MIC > 64 ug/mL) at a range of 0.062-2 ug/mL | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies. |
| AID589646 | Antifungal activity against Aspergillus flavus | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents. |
| AID1557080 | Antifungal activity against Candida glabrata 192 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID48250 | Inhibitory activity against Candida. species. (40 clinical isolates), determined at pH-7.2 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID333794 | Antimicrobial activity against Saccharomyces cerevisiae | 2004 | Journal of natural products, Dec, Volume: 67, Issue:12 | Thiobutacin, a novel antifungal and antioomycete antibiotic from Lechevalieria aerocolonigenes. |
| AID1595129 | Antifungal activity against Candida albicans MTCC 227 assessed as reduction in fungal cell growth incubated for 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1391533 | Antifungal activity against Candida parapsilosis MTCC 1744 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1267328 | Inhibition of ergosterol biosynthesis in Candida parapsilosis MTCC 1744 assessed as mean ergosterol content at 8 ug/ml after 20 hrs by spectrophotometric analysis (Rvb=1.62 +/- 0.08 ug/ml) | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID746919 | Selectivity index, ratio of CC50 for african green monkey Vero cells to IC50 for amastigotes of Leishmania donovani | 2013 | Bioorganic & medicinal chemistry letters, May-15, Volume: 23, Issue:10 | Chemotherapy of leishmaniasis. Part XII: design, synthesis and bioevaluation of novel triazole integrated phenyl heteroterpenoids as antileishmanial agents. |
| AID1888313 | Antifungal activity against fluconazole resistant Candida albicans strain 103 assessed as fungal growth inhibition measured after 72 hrs in presence of naftifine by CLSI protocol based liquid medium dilution method | |||
| AID1291257 | Antimicrobial activity against Candida albicans MTCC 3958 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID406959 | Antifungal activity against dermatophytes at 28 degC after 7 days by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID406955 | Therapeutic index, ratio of CC50 for human U937 cells to MIC90 for Candida albicans ATCC 10261 | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID1758026 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 0.03125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.3%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID289622 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by micro-broth dilution technique | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines. |
| AID289315 | Antibacterial activity against Escherichia coli ATCC 23556 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives. |
| AID1389613 | Reversal of scopolamine-induced cognitive function impairment in ICR mouse assessed as escape latency time at 100 mg/kg, po dosed 30 mins prior to scopolamine treatment by Morris water maze test (Rvb = 48.6 +/- 4.4 secs) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID554729 | Inhibition of Candida krusei ABC1 expressed in Saccharomyces cerevisiae isolate ADdelta at 0.026 nM | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID361199 | Antifungal activity against Candida albicans ATCC 26790 | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Two novel cyclic peptides with antifungal activity from the cyanobacterium Tolypothrix byssoidea (EAWAG 195). |
| AID1267316 | Antifungal activity against Candida albicans MTCC 7315 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1713523 | Antimicrobial activity against Staphylococcus aureus MLS-16 MTCC 2940 assessed as inhibition zone measured after 24 hrs incubation by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A simple, one pot synthesis of furo[3,2-c]chromenes and evaluation of antimicrobial activity. |
| AID1379939 | Antifungal activity against Candida krusei clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
| AID572693 | Binding affinity to Mycobacterium smegmatis ATCC 700084 CYP51 in presence of 0.5 M NaCl at pH7.5 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID1302972 | Antimicrobial activity against Candida albicans MTCC 3017 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID356949 | Antimicrobial activity against Candida albicans ATCC 10231 after 24 hrs by agar dilution method | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Five new steroidal saponins from Solanum chrysotrichum leaves and their antimycotic activity. |
| AID257547 | Antifungal activity against Trichophyton mentagrophytes | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID1758034 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Obtusifoliol level at 2 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1575904 | Antifungal activity against Candida krusei MTCC 3020 assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1600758 | Antibacterial activity against Bacillus subtilis MTCC 121 assessed as reduction in bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID1302969 | Antimicrobial activity against Klebsiella planticola MTCC 530 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID49281 | In vitro antifungal activity against 40 strains of Candida albicans at pH 5.8; value ranges from <0.25 to 8 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID1315480 | Fungicidal activity against Candida albicans MTCC 3018 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1758005 | Antifungal activity against Candida krusei AS2.1045 measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1133320 | Lipophilic-hydrophilic balance, Rm of the compound assessed as change in compound Rm to miconazole Rm by reverse-phase TLC method | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID1759391 | Antifungal activity against Saccharomyces cerevisiae MTCC 1344 assessed as zone of inhibition at 48 uM incubated for 2 days by cross streak plate method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID1268269 | Fungicidal activity against Candida albicans MTCC 3017 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID381891 | Antimicrobial activity against Aspergillus ochraceus ATCC 12066 by serial dilution technique | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | A novel sesquiterpene lactone from Centaurea pullata: structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties. |
| AID1389620 | Hepatotoxicity in ICR mouse assessed as serum AST activity at 100 mg/kg, ig after 8 hrs (Rvb = 96.5 +/- 9.3 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID740185 | Antifungal activity against Aspergillus niger NCIM 1196 by agar method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Microwave assisted nano (ZnO-TiO2) catalyzed synthesis of some new 4,5,6,7-tetrahydro-6-((5-substituted-1,3,4-oxadiazol-2-yl)methyl)thieno[2,3-c]pyridine as antimicrobial agents. |
| AID1695865 | Antifungal activity against Aspergillus niger NCIM 1196 incubated for 48 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID381889 | Antimicrobial activity against Aspergillus flavus ATCC 9643 by serial dilution technique | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | A novel sesquiterpene lactone from Centaurea pullata: structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties. |
| AID1291252 | Antimicrobial activity against Candida albicans MTCC 183 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1389634 | Hepatotoxicity in ICR mouse assessed as serum AST activity at 10 mg/kg, ig after 36 hrs (Rvb = 85.0 +/- 7.2 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID78118 | In vivo inhibition of topical Trichophyton infection in Guinea Pig after drug administration | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1184075 | Inhibition of IDO1 (unknown origin) at highest soluble concentration using L-tryptophan substrate incubated for 60 mins by HPLC | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. |
| AID486966 | Antifungal activity against Trichophyton mentagrophytes after 96 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID380199 | Antifungal activity against Mycotypha microspora at 50 ug/disk | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6 | A new tyrosine kinase inhibitor from the marine brown alga Stypopodium zonale. |
| AID1300880 | Antifungal activity against Candida tropicalis clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1391540 | Fungicidal activity against Candida albicans MTCC 854 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID759604 | Antifungal activity against Cryptococcus neoformans NCIM 576 assessed as growth inhibition by agar dilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | A novel amalgamation of 1,2,3-triazoles, piperidines and thieno pyridine rings and evaluation of their antifungal activity. |
| AID1302985 | Antimicrobial activity against Candida albicans MTCC 854 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1849450 | Inhibition of CYP2C19 in rat liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID45508 | Inhibitory activity against Candida albicans (40 clinical isolates), determined at pH-7.2 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1738736 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Obtusifoliol level at 2 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1616744 | Inhibition of bacterial Beta-lactamase TEM-1 G238S mutant pre-incubated for 5 mins before addition of chromogenic beta-lactamase substrate CENTA by spectrophotometry | 2019 | Journal of medicinal chemistry, 11-14, Volume: 62, Issue:21 | Protein Stability Effects in Aggregate-Based Enzyme Inhibition. |
| AID214822 | Antifungal activity against Trichophyton rubrum | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID609824 | Antifungal activity against Fusarium solani | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | The novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation. |
| AID1146960 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 0.5% formulation administered vaginally bid for 4 days measured 6 hrs post last dose relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1302968 | Antimicrobial activity against Micrococcus luteus MTCC 2470 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID43431 | Compound was tested for the inhibition of beta-lactamase | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID1315479 | Fungicidal activity against Candida albicans MTCC 3017 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID49650 | In vitro antifungal activity against Candida albicans GB | 1983 | Journal of medicinal chemistry, Mar, Volume: 26, Issue:3 | Synthesis of (E)-1-(5-chlorothien-2-yl)-2-(1H-imidazol-1-yl)ethanone 2,6-dichlorophenylhydrazone hydrochloride, a novel, orally active antifungal agent. |
| AID532552 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring human CYP51 assessed as growth rate at 1 ug/ml (Rvb = 0.157%) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID336237 | Antimicrobial activity against Candida albicans at 10 ug/disk | |||
| AID1146996 | Antifungal activity against Trichophyton concentricum assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID45134 | Compound was evaluated for inhibitory activity against Candida albicans | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18 | New antifungals selected by molecular topology. |
| AID1315457 | Antifungal activity against Candida albicans MTCC 1637 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1237446 | Antimicrobial activity against Klebsiella planticola MTCC 530 incubated for 24 hrs at 37 degC by well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID670551 | Antifungal activity against Candida aaseri MTCC 1962 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID1153405 | Antimicrobial activity against Micrococcus luteus MTCC 2470 after 24 hrs by well diffusion method | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID85360 | Inhibition of Vaginal Candida (C-43 strain) infection in Hamsters, estimated as Percent Area under curve at 0.25 % concentration after 8 days of administration | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1634152 | Lipophilicity, log D of compound at pH 7.4 | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16 | Strategies for the development of highly selective cytochrome P450 inhibitors: Several CYP targets in current research. |
| AID717840 | Inhibition of mouse Tdo2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation at 100 uM after 45 mins by spectrophotometric analysis relative to control | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. |
| AID1315461 | Antifungal activity against Candida albicans MTCC 4748 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID381894 | Antimicrobial activity against Penicillium ochrochloron ATCC 9112 by serial dilution technique | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | A novel sesquiterpene lactone from Centaurea pullata: structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties. |
| AID289619 | Antibacterial activity against Staphylococcus aureus after 24 hrs by micro-broth dilution technique | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines. |
| AID1849448 | Inhibition of CYP1A2 in rat liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID1147017 | Antifungal activity against Candida albicans infected in mouse assessed as noninfected animals at 0.5% formulation in neat PEG 400 solution administered vaginally bid for 4 days measured 6 hrs post last dose relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1389623 | Hepatotoxicity in ICR mouse assessed as serum ALT activity at 50 mg/kg, ig after 8 hrs (Rvb = 31.9 +/- 2.1 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1147015 | Antifungal activity against Candida albicans infected in mouse assessed as noninfected animals at 1% formulation in neat PEG 400 solution administered vaginally bid for 4 days measured 6 hrs post last dose relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID356328 | Antifungal activity against Aspergillus fumigatus IFM 41236 after 48 to 96 hrs by broth microdilution method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species. |
| AID244975 | Minimum inhibitory concentration to inhibit Candida parapsilosis ATCC 22019 | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID550050 | Antifungal activity against Candida albicans assessed as inhibition of visible growth after 48 hrs by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Conventional and microwave assisted synthesis of 2-oxo-4-substituted aryl-azetidine derivatives of benzotriazole: a new class of biological compounds. |
| AID691210 | Antifungal activity against Aspergillus flavus MTCC 277 after 2 to 3 days by modified agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. |
| AID1389631 | Hepatotoxicity in ICR mouse assessed as serum ALT activity at 10 mg/kg, ig after 36 hrs (Rvb = 31.7 +/- 1.7 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1575927 | Induction of ROS generation in Candida albicans MTCC 3017 assessed as accumulation of intracellular ROS level by measuring fluorescence intensity at 5 to 25 ug/ml after 24 hrs by DCFH-DA probe based fluorimetric assay | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1268261 | Antifungal activity against Candida aaseri MTCC 1962 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1738717 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as ergosterol level at 0.5 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1758063 | Hemolytic activity in rabbit RBC measured after 3 hrs by microplate reader assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1315488 | Fungicidal activity against Issatchenkia hanoiensis MTCC 4755 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1196914 | Fungicidal activity against Trichophyton rubrum B68183 | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents. |
| AID1058359 | Antimicrobial activity against Escherichia coli MTCC 739 after 24 hrs by well diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID1738705 | Antifungal activity against clinical isolate Candida glabrata measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID444274 | Antifungal activity against phytopathogenic Cladosporium cucumerinum by bioautographic TLC assay | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Stereoselective total synthesis of a potent natural antifungal compound (6S)-5,6,dihydro-6-[(2R)-2-hydroxy-6-phenyl hexyl]-2H-pyran-2-one. |
| AID377232 | Antifungal activity against Epidermophyton floccosum after 24 hrs | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Known and novel terpenes from Buddleja globosa displaying selective antifungal activity against dermatophytes. |
| AID406958 | Antifungal activity against fluconazole-sensitive Candida albicans Fe40 at 35 degC after 48 hrs by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID356329 | Antifungal activity against Aspergillus nidulans IFM 5396 after 48 to 96 hrs by broth microdilution method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species. |
| AID1738707 | Antifungal activity against Aspergillus fumigatus CGMCC 3.7795 measured after 72 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1310541 | Antifungal activity against Candida albicans MTCC 4748 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1390622 | Antifungal activity against Candida albicans MTCC 3017 after 24 hrs by agar well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | A novel templates of piperazinyl-1,2-dihydroquinoline-3-carboxylates: Synthesis, anti-microbial evaluation and molecular docking studies. |
| AID406954 | Cytotoxicity against human K562 cells after assessed as reduction of cell viability 24 hrs by MTT assay | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID1446851 | Antifungal activity against Candida krusei MTCC 3020 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID1237443 | Antimicrobial activity against Micrococcus luteus MTCC 2470 incubated for 24 hrs at 37 degC by well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID1379938 | Antifungal activity against Candida tropicalis clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
| AID1310565 | Fungicidal activity against Candida glabrata MTCC 3019 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID348629 | Antibacterial activity against Bacillus subtilis ATCC 6633 at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID377240 | Antifungal activity against Scytalidium dimidiatum at 1000 ug/ml after 24 hrs | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Known and novel terpenes from Buddleja globosa displaying selective antifungal activity against dermatophytes. |
| AID550051 | Antifungal activity against Aspergillus fumigatus assessed as inhibition of visible growth after 48 hrs by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Conventional and microwave assisted synthesis of 2-oxo-4-substituted aryl-azetidine derivatives of benzotriazole: a new class of biological compounds. |
| AID1153410 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 2453 after 24 hrs by well diffusion method | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID759607 | Antifungal activity against Fusarium oxysporum NCIM 1332 assessed as growth inhibition by agar dilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | A novel amalgamation of 1,2,3-triazoles, piperidines and thieno pyridine rings and evaluation of their antifungal activity. |
| AID1738731 | Antibiofilm activity against FCZ-Resistant Candida albicans CPCC400616 assessed as sessile minimum inhibitory concentration of biofilm formation at 80% after 24 hrs by XTT assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID1849455 | Inhibition of CYP2C19 in mouse liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID1634151 | Partition coefficient, log P of the compound | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16 | Strategies for the development of highly selective cytochrome P450 inhibitors: Several CYP targets in current research. |
| AID1849445 | Inhibition of CYP2C19 in human liver Microsome using omeprazole as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID1758023 | Metabolic stability in mouse liver microsomes assessed as half life | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID48274 | Tested In vitro for antifungal activity against Candida species. at pH 7.2 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID453204 | Permeability in human skin after 48 hrs by Franz cell permeability assay | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1 | Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. |
| AID1600773 | Fungicidal activity against Candida albicans MTCC 3017 assessed as reduction in fungal survival incubated for 24 hrs followed by transfer of microbial suspension to agar plates and measured at 24 hrs post transfer by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID1416194 | Antifungal activity against Candida utilis by two-fold serial dilution method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8 | Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration. |
| AID1133313 | Antifungal activity against Cryptococcus neoformans assessed as lowest concentration required for total inhibition by broth dilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID1300878 | Antifungal activity against Candida albicans clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1391532 | Antifungal activity against Candida albicans MTCC 7315 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID257546 | Antifungal activity against Sporothrix schenckii | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID1310539 | Antifungal activity against Candida albicans MTCC 3018 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID49962 | Antifungal activity against Candida glabrata after 48 hr incubation | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation. |
| AID1268256 | Antifungal activity against Candida albicans MTCC 3018 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1575907 | Fungicidal activity against Candida albicans MTCC 227 assessed as fungal killing incubated for 24 hrs | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID49121 | Inhibitory activity against the Candida albicans (40 clinical isolates), determined at pH-7.2 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1180302 | Fungicidal activity against Aspergillus flavus NCIM-539 after 48 to 72 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID1315484 | Fungicidal activity against Candida parapsilosis MTCC 1744 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1446841 | Antifungal activity against Candida albicans MTCC 854 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID289316 | Antifungal activity against Candida albicans ATCC 10145 after 48 hrs | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives. |
| AID55190 | Minimum inhibitory concentration towards Cryptococcus neoformans | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID55190 | Minimum inhibitory concentration towards Cryptococcus neoformans | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID1310563 | Fungicidal activity against Candida parapsilosis MTCC 1744 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID463437 | Antimicrobial activity against Trichophyton longifusum after 7 days | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: indolenyl sulfonamide derivatives. |
| AID211169 | Minimum inhibitory concentration towards Trichophyton mentagrophytes | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID211169 | Minimum inhibitory concentration towards Trichophyton mentagrophytes | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID1738728 | Antibiofilm activity against FCZ-Resistant Candida albicans CPCC400616 assessed as sessile minimum inhibitory concentration of biofilm formation at 80% after 1.5 hrs by XTT assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1303009 | Fungicidal activity against Issatchenkia hanoiensis MTCC 4755 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1394707 | Antifungal activity against fluconazole-resistant Candida albicans TTSH-CALB01 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1327757 | Antimicrobial activity against Issatchenkia hanoiensis MTCC4755 measured after 24 hrs by well-diffusion method | |||
| AID1310540 | Antifungal activity against Candida albicans MTCC 3958 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID382875 | Antifungal activity against Candida albicans 685 after 48 hrs | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives. |
| AID551056 | Antifungal activity against Candida albicans assessed as macroscopically visible colonies after 48 and 72 hrs by standard agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. |
| AID372243 | Fungistatic activity against Candida albicans CHK21 after 24 to 48 hrs by broth microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1156865 | Antimicrobial activity against Sporothrix schenckii after 72 hrs by microbroth dilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents. |
| AID50323 | Antifungal activity against Candida neoformans after 48 hr incubation | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation. |
| AID1758067 | Fungicidal activity against Candida albicans CPCC400616 at 2 ug/ml incubated for 24 hrs and measured after 24 hrs culturing on PDA plate by time-kill kinetics analysis | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID380196 | Antifungal activity against Eurotium repens at 50 ug/disk | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6 | A new tyrosine kinase inhibitor from the marine brown alga Stypopodium zonale. |
| AID39671 | Antifungal activity against Aspergillus fumigatus | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID39671 | Antifungal activity against Aspergillus fumigatus | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID554723 | Fold resistant, ratio of MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Candida albicans ERG11A to MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Abc1p | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID490029 | Antifungal activity against Candida glabrata at 200 ug/ml after 7 days | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Some new biologically active metal-based sulfonamide. |
| AID717845 | Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. |
| AID462891 | Inhibition of protein farnesyltransferase by continuous fluorescence assay | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs. |
| AID1575884 | Antifungal activity against Candida albicans MTCC 3017 assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1330311 | Inhibition of Orai1-mediated store operated Ca2+ entry in human MDA-MB-231 cells assessed as reduction in BAPTA-induced Ca2+ depletion-stimulated SOCE activity preincubated for 15 mins followed by BAPTA addition in presence of extracellular Ca2+ by PBX-ba | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca |
| AID209120 | Antibacterial activity against Streptococcus pyogenes | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID696185 | Antifungal activity against Aspergillus niger MTCC 281 after 2 to 3 days by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 22, Issue:21 | Synthesis, anti-inflammatory and antimicrobial evaluation of novel 1-acetyl-3,5-diaryl-4,5-dihydro (1H) pyrazole derivatives bearing urea, thiourea and sulfonamide moieties. |
| AID382705 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID1367733 | Antifungal activity against Candida albicans MTCC 3017 | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Potential antimicrobial agents from triazole-functionalized 2H-benzo[b][1,4]oxazin-3(4H)-ones. |
| AID1695866 | Antifungal activity against Penicillium chrysogenum NCIM 723 incubated for 48 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID382685 | Antimicrobial activity against Escherichia coli ATCC 25922 at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID1058362 | Antimicrobial activity against Micrococcus luteus MTCC 2470 after 24 hrs by well diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID1302997 | Fungicidal activity against Candida albicans MTCC 227 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID589644 | Antifungal activity against Candida albicans | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents. |
| AID1575887 | Antifungal activity against Candida albicans MTCC 1637 assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1267321 | Antifungal activity against Issatchenkia hanoiensis MTCC 4755 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID376234 | Antifungal activity against Mycotypha microspora at 50 ug/disk | 2000 | Journal of natural products, Jul, Volume: 63, Issue:7 | New natural product isolation and comparison of the secondary metabolite content of three distinct samples of the sea hare Aplysia dactylomela from tenerife. |
| AID1276545 | Antifungal activity against hypersusceptible Candida albicans DSY2621 mutant after overnight incubation by MTT based bioautography method | 2015 | Journal of natural products, Dec-24, Volume: 78, Issue:12 | Anti-Candida Cassane-Type Diterpenoids from the Root Bark of Swartzia simplex. |
| AID1557079 | Antifungal activity against Candida glabrata ATCC 2001 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1300321 | Binding affinity to Mycobacterium tuberculosis H37Rv wild type CYP121 by titration assay | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. |
| AID1849444 | Inhibition of CYP2C9 in human liver Microsome using diclofenac as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID372241 | Fungistatic activity against Candida albicans SSK21 after 24 to 48 hrs by broth microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. |
| AID1758046 | Anti-biofilm activity in Candida albicans CPCC400616 assessed as inhibition of biofilm formation incubated for 24 hrs with 1.5 hrs precultured fungal suspension by XTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1595130 | Antifungal activity against Candida glabrata NCIM 3236 assessed as reduction in fungal cell growth incubated for 24 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID1268264 | Antifungal activity against Issatchenkia hanoiensis MTCC 4755 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1327755 | Antimicrobial activity against Candida krusei MTCC3020 measured after 24 hrs by well-diffusion method | |||
| AID1443638 | Critical aggregation concentration assessed as formation of aggregate after 30 mins in presence of triton X-100 by light scattering method | 2017 | Journal of medicinal chemistry, 04-27, Volume: 60, Issue:8 | Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. |
| AID49961 | Antifungal activity against Candida glabrata after 24 hr incubation | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation. |
| AID696187 | Antifungal activity against Aspergillus flavus MTCC 277 after 2 to 3 days by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 22, Issue:21 | Synthesis, anti-inflammatory and antimicrobial evaluation of novel 1-acetyl-3,5-diaryl-4,5-dihydro (1H) pyrazole derivatives bearing urea, thiourea and sulfonamide moieties. |
| AID701459 | Antifungal activity against Trichophyton rubrum | 2012 | Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19 | The biology and chemistry of antifungal agents: a review. |
| AID1150063 | Antibaterial activity against Streptococcus pyogenes assessed as lowest dose required to total inhibition of bacterial growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID575479 | Antifungal activity against 10'7 CFU/ml Candida albicans B2630 infected in vulvovaginitis rat model assessed as fungal burden at 5 mg/kg administered tropically twice daily measured after 3 days | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID298837 | Antifungal activity against Candida albicans by dilution method | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7 | Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase. |
| AID1446849 | Antifungal activity against Candida aaseri MTCC 1962 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID1267297 | Antibacterial activity against Bacillus subtilis MTCC 121 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1146964 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 0.1% formulation administered vaginally bid for 4 days measured 6 hrs post last dose relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1557077 | Antifungal activity against Candida albicans SN152 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID759605 | Antifungal activity against Aspergillus niger NCIM 1196 assessed as growth inhibition by agar dilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | A novel amalgamation of 1,2,3-triazoles, piperidines and thieno pyridine rings and evaluation of their antifungal activity. |
| AID625833 | Antifungal activity against Trichophyton mentagrophytes by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID382689 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID1150056 | Antifungal activity against Mucor species assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1291274 | Fungicidal activity against Candida albicans MTCC 854 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID381895 | Antimicrobial activity against Trichoderma viride IAM5061 by serial dilution technique | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | A novel sesquiterpene lactone from Centaurea pullata: structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties. |
| AID1634153 | Antifungal activity against Candida albicans | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16 | Strategies for the development of highly selective cytochrome P450 inhibitors: Several CYP targets in current research. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1310566 | Fungicidal activity against Candida krusei MTCC 3020 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1684671 | Antifungal activity against Candida glabrata MTCC 3019 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID380200 | Antialgal activity against Chlorella fusca at 50 ug/disk | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6 | A new tyrosine kinase inhibitor from the marine brown alga Stypopodium zonale. |
| AID311792 | Antifungal activity against Aspergillus niger ATCC 6275 by microdilution technique | 2007 | Journal of natural products, Nov, Volume: 70, Issue:11 | Minor sesquiterpene lactones from Centaurea pullata and their antimicrobial activity. |
| AID201551 | Antifungal activity against Saprolegnia species | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID1575926 | Ratio of MFC to MIC against Issatchenkia hanoiensis MTCC 4755 | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1738743 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Eburicol level at 0.03125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID48077 | Antifungal activity against Candida pseudotropicalis; Range is 0.25-4 | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents. |
| AID1302999 | Fungicidal activity against Candida albicans MTCC 1637 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1293883 | Antifungal activity against Aspergillus flavus NCIM 539 after 48 hrs by agar cup plate method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation. |
| AID1291273 | Fungicidal activity against Candida albicans MTCC 227 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1849453 | Inhibition of CYP1A2 in mouse liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID1504832 | Antifungal activity against Trichophyton rubrum ATCC 28188 after 72 hrs by agar dilution method | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12 | Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis. |
| AID532572 | Antifungal activity against wild-type Candida glabrata isolate 21231 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata. |
| AID1267311 | Antifungal activity against Candida albicans MTCC 854 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID298838 | Antifungal activity against Candida pseudotropicalis by dilution method | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7 | Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase. |
| AID1557078 | Antifungal activity against Candida glabrata ATCC 66032 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1758024 | Metabolic stability in mouse liver microsomes assessed as clearance | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID49466 | Activity against Candida albicans ATCC 26278 strain in YNB medium after incorporation of 20 ug per disk expressed as zone size | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Synthesis and biological properties of N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid dipeptides, a novel group of antimicrobial agents. |
| AID1146954 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 2% commercial cream formulation administered vaginally bid for 4 days measured 6 hrs post last dose relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1684674 | Antifungal activity against Candida albicans MTCC 4748 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1291259 | Antimicrobial activity against Candida albicans MTCC 7315 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID382701 | Antimicrobial activity against Enterobacter aerogenes at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID572696 | Binding affinity to Mycobacterium smegmatis ATCC 700084 CYP164A2 in presence of 0.5 M NaCl at pH7.5 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID48462 | Antifungal activity against Candida stellatoidea | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents. |
| AID1598718 | Binding affinity to Triton-X 100 assessed as change in chemical shift at 150 uM by 1H-NMR spectra analysis | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10 | Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators. |
| AID1758044 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Eburicol level at 2 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1181469 | Inhibition of recombinant human CYP2C19 preincubated at 10 uM for 5 mins before fluorescent substrate addition by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
| AID373103 | Antifungal activity against Candida albicans by bioautographic agar overlay method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis and antimicrobial activity of new 1-alkyl/cyclohexyl-3,3-diaryl-1'-methylspiro[azetidine-2,3'-indoline]-2',4-diones. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1416197 | Antifungal activity against Candida albicans by two-fold serial dilution method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8 | Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration. |
| AID1265641 | Antifungal activity against Candida glabrata clinical isolate after 24 hrs by sabouraud dextrose broth based microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. |
| AID48599 | Minimum inhibitory concentration against Candida stellatoidea using eagles minimum essential medium (EMEM) | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1058360 | Antimicrobial activity against Bacillus subtilis MTCC 121 after 24 hrs by well diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID1446848 | Antifungal activity against Candida parapsilosis MTCC 1744 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID1310534 | Antifungal activity against Candida albicans MTCC 183 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID289621 | Antibacterial activity against Klebsiella pneumoniae after 24 hrs by micro-broth dilution technique | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines. |
| AID48277 | Tested in vitro for antifungal activity against Candida species. at pH 5.8 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID48269 | Tested In vitro for antifungal activity against Candida species. at pH 7.2 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID125945 | In vitro antifungal activity against Microsporum canis | 1983 | Journal of medicinal chemistry, Mar, Volume: 26, Issue:3 | Synthesis of (E)-1-(5-chlorothien-2-yl)-2-(1H-imidazol-1-yl)ethanone 2,6-dichlorophenylhydrazone hydrochloride, a novel, orally active antifungal agent. |
| AID106801 | Inhibition of malate dehydrogenase (MDH) | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID348631 | Antibacterial activity against Escherichia coli ATCC 210922 at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID634087 | Antifungal activity against Candida albicans assessed as morphogenetic transformation after 3 hrs by phase-contrast microscopy | 2012 | European journal of medicinal chemistry, Jan, Volume: 47, Issue:1 | Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans. |
| AID681128 | TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID766647 | Antifungal activity against Candida albicans MTCC 3958 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1130389 | Antifungal activity against Candida tropicalis assessed as growth inhibition in sabouraud broth after 14 days in presence of 10% inactivated bovine serum | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID1759389 | Antifungal activity against Aspergillus niger MTCC 404 assessed as zone of inhibition at 48 uM incubated for 2 days by cross streak plate method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents. |
| AID45135 | Compound was evaluated for inhibitory activity against Candida albicans; 1.6-2.0 | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18 | New antifungals selected by molecular topology. |
| AID1738713 | Fungicidal activity against Candida albicans CPCC400616 measured after 48 hrs | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1320272 | Antimicrobial activity against Staphylococcus aureus MTCC 96 incubated for 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A diastereoselective synthesis of tetrahydro- and dihydro-pyrido[2,3-c]coumarin derivatives via a one-pot three-component Povarov reaction catalyzed by bismuth(III) chloride. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1150057 | Antifungal activity against Aspergillus fumigatus assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1268267 | Fungicidal activity against Candida albicans MTCC 854 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1738735 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Obtusifoliol level at 0.5 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID348632 | Antibacterial activity against Escherichia coli ATCC 101038 at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID759608 | Antifungal activity against Candida albicans NCIM 3471 assessed as growth inhibition by agar dilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | A novel amalgamation of 1,2,3-triazoles, piperidines and thieno pyridine rings and evaluation of their antifungal activity. |
| AID1758042 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Eburicol level at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1557088 | Antifungal activity against Candida glabrata 192 assessed as reduction in fungal cell growth incubated for 48 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1575919 | Ratio of MFC to MIC against Candida albicans MTCC 1637 | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID486963 | Antifungal activity against Candida albicans after 48 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID48804 | Minimum inhibitory concentration against Candida tropicalis using eagles minimum essential medium (EMEM) | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID49465 | Activity against Candida albicans ATCC 26278 strain in YNB medium after incorporation of 10 ug per disk expressed as zone size | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Synthesis and biological properties of N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid dipeptides, a novel group of antimicrobial agents. |
| AID532560 | Antifungal activity against Saccharomyces cerevisiae BY4741 assessed as growth rate at 1 ug/ml (Rvb = 0.144%) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID1557085 | Antifungal activity against Candida albicans ATCC 90028 assessed as reduction in fungal cell growth incubated for 48 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1303007 | Fungicidal activity against Candida glabrata MTCC 3019 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1267296 | Antifungal activity against Candida albicans MTCC 3017 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID37583 | Antifungal activity against Aspergillus niger | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents. |
| AID1150037 | Antifungal activity against Trichophyton rubrum assessed as lowest dose level for total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1327760 | Antimicrobial activity against Candida albicans MTCC3018 measured after 24 hrs by well-diffusion method | |||
| AID1389643 | Selectivity index, ratio of IC50 for electric eel AChE to IC50 for equine serum BChE | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1268253 | Antifungal activity against Candida albicans MTCC 227 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1268263 | Antifungal activity against Candida krusei MTCC 3020 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID49288 | In vitro antifungal activity against 40 strains of Candida albicans at pH 7.2; minimum inhibitory concentration; value ranges from <0.25 to 16 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID49645 | In vitro antifungal activity against Candida albicans B | 1983 | Journal of medicinal chemistry, Mar, Volume: 26, Issue:3 | Synthesis of (E)-1-(5-chlorothien-2-yl)-2-(1H-imidazol-1-yl)ethanone 2,6-dichlorophenylhydrazone hydrochloride, a novel, orally active antifungal agent. |
| AID1391547 | Fungicidal activity against Candida parapsilosis MTCC 1744 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID311793 | Antifungal activity against Aspergillus ochraceus ATCC 12066 by microdilution technique | 2007 | Journal of natural products, Nov, Volume: 70, Issue:11 | Minor sesquiterpene lactones from Centaurea pullata and their antimicrobial activity. |
| AID376237 | Antialgal activity against Chlorella fusca at 50 ug/disk | 2000 | Journal of natural products, Jul, Volume: 63, Issue:7 | New natural product isolation and comparison of the secondary metabolite content of three distinct samples of the sea hare Aplysia dactylomela from tenerife. |
| AID1389633 | Hepatotoxicity in ICR mouse assessed as serum AST activity at 10 mg/kg, ig after 22 hrs (Rvb = 99.5 +/- 7.9 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1758015 | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1300881 | Antifungal activity against Candida krusei clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1684666 | Inhibition of biofilm formation in Bacillus subtilis MTCC 121 incubated for 24 hrs by crystal violet staining based microtiter plate method | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID681137 | TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 303, Issue:1 | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. |
| AID378564 | Antimicrobial activity against Eurotium repens at 50 ug/filter disk | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua. |
| AID766639 | Antifungal activity against Issatchenkia hanoiensis MTCC 4755 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID658667 | Antifungal activity against Aspergillus niger by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10 | A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: synthesis, anti-inflammatory and antimicrobial evaluation. |
| AID1391539 | Fungicidal activity against Candida albicans MTCC 227 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1389612 | Reversal of scopolamine-induced cognitive function impairment in po dosed ICR mouse assessed as escape latency dosed 30 mins before scopolamine challenge by Morris water maze test | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID670556 | Antifungal activity against Candida albicans MTCC 854 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID1180304 | Fungicidal activity against Aspergillus niger NCIM-1196 after 48 to 72 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID1738739 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Lanosterol level at 0.125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID395112 | Antifungal activity against Aspergillus fumigatus isolate after 72 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Azole antimicrobial pharmacophore-based tetrazoles: synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents. |
| AID1302989 | Antimicrobial activity against Candida albicans MTCC 4748 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1310561 | Fungicidal activity against Candida albicans MTCC 4748 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1557084 | Antifungal activity against Candida dubliniensis T-99 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID402560 | Antimycotic activity against Trichophyton rubrum ATCC 28188 after 72 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | Antimycotic spirostanol saponins from Solanum hispidum leaves and their structure-activity relationships. |
| AID1738730 | Antibiofilm activity against FCZ-Resistant Candida albicans CPCC400616 assessed as sessile minimum inhibitory concentration of biofilm formation at 80% after 6 hrs by XTT assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1267319 | Antifungal activity against Candida glabrata MTCC 3019 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1546116 | Antifungal activity against Candida tropicalis | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID522129 | Antimicrobial activity against wild type Candida glabrata TG11 by colorimetric microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID1758007 | Antifungal activity against Candida parapsilosis ATCC 22019 measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1147005 | Antibacterial activity against Streptococcus faecalis No. 8043-2 assessed as growth inhibition by broth microdilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1265642 | Antifungal activity against Candida tropicalis clinical isolate after 24 hrs by sabouraud dextrose broth based microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. |
| AID747573 | Antifungal activity against Aspergillus fumigatus MTCC 343 after 30 hrs by serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties. |
| AID1758068 | Anti-biofilm activity in Candida albicans CPCC400616 assessed as inhibition of biofilm formation at 32 ug/ml incubated for 24 hrs with 3 hrs precultured fungal suspension by XTT assay relative to control | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID47875 | Antifungal activity against Candida parapsilosis | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents. |
| AID1133319 | Antifungal activity against Candida albicans in mouse vaginal infection model compound applied intravaginally as 2% formulation in an aqueous propylene glycol cream for 4 days bid | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID249386 | In vitro concentration causing 90% inhibition of Candida albicans with percentage of resistant strains %R = 33.33 (MIC > 64 ug/mL) at a range of 0.062-2 ug/mL | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies. |
| AID395111 | Antifungal activity against Candida albicans isolate after 72 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Azole antimicrobial pharmacophore-based tetrazoles: synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents. |
| AID48598 | Minimum inhibitory concentration against Candida stellatoidea at a pH of 5.7 using SDB medium | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1310542 | Antifungal activity against Candida albicans MTCC 7315 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID766650 | Antifungal activity against Candida albicans MTCC 854 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID402559 | Antimycotic activity against Trichophyton mentagrophytes ATCC 28185 after 72 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | Antimycotic spirostanol saponins from Solanum hispidum leaves and their structure-activity relationships. |
| AID382713 | Antimicrobial activity against Streptococcus pyogenes at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID554725 | Fold resistant, ratio of MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Candida krusei ERG11g to MIC for Saccharomyces cerevisiae isolate ADdelta overexpressing Abc1p | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID747568 | Antifungal activity against Candida albicans MTCC 227 assessed as zone of inhibition at 100 ug/ml after 30 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties. |
| AID1130382 | Antifungal activity against Saprolegnia Sp. assessed as growth inhibition in sabouraud broth after 14 days | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID1600769 | Bactericidal activity against Staphylococcus aureus MTCC 96 assessed as reduction in bacterial survival incubated for 24 hrs followed by transfer of microbial suspension to agar plates and measured at 24 hrs post transfer by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID1738706 | Antifungal activity against Candida parapsilosis ATCC 22019 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
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| AID1684667 | Inhibition of biofilm formation in Staphylococcus aureus MLS16 MTCC 2940 incubated for 24 hrs by crystal violet staining based microtiter plate method | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1310546 | Antifungal activity against Candida krusei MTCC 3020 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID48451 | Tested In vitro for antifungal activity against Candida species. at pH 7.2; (percent of resistant species at 256 ug/mL) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID1738734 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Obtusifoliol level at 0.125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID550052 | Antifungal activity against Aspergillus niger assessed as inhibition of visible growth after 48 hrs by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Conventional and microwave assisted synthesis of 2-oxo-4-substituted aryl-azetidine derivatives of benzotriazole: a new class of biological compounds. |
| AID1310559 | Fungicidal activity against Candida albicans MTCC 3018 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1391526 | Antifungal activity against Candida albicans MTCC 854 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1310564 | Fungicidal activity against Candida aaseri MTCC 1962 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID377239 | Antifungal activity against Scopulariopsis brevicaulis EL 936 at 1000 ug/ml after 24 hrs | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Known and novel terpenes from Buddleja globosa displaying selective antifungal activity against dermatophytes. |
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| AID1146997 | Antifungal activity against Microsporum gypseum assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID359387 | Antifungal activity against Candida albicans 44506 in RPMI-1640 medium after 18 to 24 hrs by twofold broth dilution method | 1992 | Journal of natural products, Nov, Volume: 55, Issue:11 | Antifungal activity of meridine, a natural product from the marine sponge Corticium sp. |
| AID406951 | Antifungal activity against Candida albicans ATCC 10261 at 35 degC after 48 hrs by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID294189 | Antifungal activity against Candida krusei ATCC 6258 by macro-broth dilution assay | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8 | Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers. |
| AID1389618 | Hepatotoxicity in ICR mouse assessed as serum ALT activity at 100 mg/kg, ig after 22 hrs (Rvb = 34.7 +/- 2.0 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1300883 | Antifungal activity against Candida sake clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID670555 | Antifungal activity against Candida albicans MTCC 3958 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID554712 | Antimicrobial activity against Candida krusei IFO0011 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1449628 | Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-taurocholate transport into vesicles incubated for 5 mins by Topcount based rapid filtration method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12 | Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. |
| AID48260 | Percent resistance against all Candida. species (40 clinical isolates) at 256 micro g/mL (pH=7.2), activity is expressed as R%. | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID48422 | Tested In vitro for antifungal activity against Candida species. at pH 7.2; (range is from 0.5 to 1) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID1600764 | Antibacterial activity against Klebsiella planticola MTCC 530 assessed as reduction in bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID1153406 | Antimicrobial activity against Staphylococcus aureus MTCC 96 after 24 hrs by well diffusion method | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID48066 | Antimycotic activity against Candida paratropicalis was evaluated. MIC was defined as compound concentration at which no macroscopic signs of fungal growth were detected. | 1999 | Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14 | Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine with potent antitumor and antimicrobial activity. |
| AID1575880 | Antibacterial activity against Bacillus subtilis MTCC 121 assessed as inhibition of bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1575924 | Ratio of MFC to MIC against Candida glabrata MTCC 3019 | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID49435 | In vitro antifungal activity against 40 strains of Candida albicans at pH 5.8; (percent of resistant species at 256 ug/mL) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID356325 | Antifungal activity against Candida krusei ATCC 6258 after 48 to 96 hrs by broth microdilution method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species. |
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| AID1738720 | Antibiofilm activity against FCZ-Resistant Candida albicans CPCC400616 assessed as sessile minimum inhibitory concentration of biofilm formation at 50% after 3 hrs by XTT assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1394705 | Antifungal activity against fluconazole-resistant Candida albicans ATCC 200955 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
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| AID310103 | Antifungal activity against Cryptococcus neoformans by disc diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine. |
| AID1162421 | Antimicrobial activity against Candida tropicalis ATCC 1369 up to 100 ug/ml after 48 hrs by two-fold broth dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | A new efficient route to 7-aryl-6-fluoro-8-nitroquinolones as potent antibacterial agents. |
| AID338271 | Antimicrobial activity against Escherichia coli DSM 1103 after 18 hrs by twofold serial dilution method | 1994 | Journal of natural products, Dec, Volume: 57, Issue:12 | Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays. |
| AID1267312 | Antifungal activity against Candida albicans MTCC 1637 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID44971 | Antifungal activity against Candida albicans after 24 hr incubation | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation. |
| AID1575889 | Antifungal activity against Candida albicans MTCC 4748 assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1291278 | Fungicidal activity against Candida albicans MTCC 4748 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1337799 | Antibacterial activity against Pseudomonas fluorescens NCIM 2036 measured after 8 hrs | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1130383 | Antifungal activity against Phialophora verrucosa assessed as growth inhibition in sabouraud broth after 14 days | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID1315486 | Fungicidal activity against Candida glabrata MTCC 3019 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID382505 | Antifungal activity against Candida albicans by agar dilution method | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides. |
| AID1557073 | Antifungal activity against Candida albicans SN152 assessed as zone inhibition at 25 ug incubated for 24 hrs by disk diffusion method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID319920 | Antifungal activity against Saccharomyces cerevisiae PTCC 5177 after 24 to 48 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. |
| AID1268268 | Fungicidal activity against Candida albicans MTCC 1637 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID294969 | Antifungal activity against Candida glabrata after 48 hrs by serial dilution method | 2007 | European journal of medicinal chemistry, Oct, Volume: 42, Issue:10 | Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. |
| AID1394713 | Cytotoxicity against human bone marrow cells assessed as inhibition of colony formation | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1684698 | Antifungal activity against Candida albicans MTCC 227 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID378392 | Antimicrobial activity against Penicillium oxalicum at 0.8 ug | 2006 | Journal of natural products, Aug, Volume: 69, Issue:8 | Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products. |
| AID311791 | Antifungal activity against Aspergillus flavus ATCC 9643 by microdilution technique | 2007 | Journal of natural products, Nov, Volume: 70, Issue:11 | Minor sesquiterpene lactones from Centaurea pullata and their antimicrobial activity. |
| AID1133318 | Antibacterial activity against Pasteurella multocida ATCC 19427 assessed as lowest concentration required for total inhibition by broth microdilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID746922 | Antileishmanial activity against amastigotes of Leishmania donovani assessed as inhibition of parasite growth at 40 uM after 72 hrs by luciferase reporter assay | 2013 | Bioorganic & medicinal chemistry letters, May-15, Volume: 23, Issue:10 | Chemotherapy of leishmaniasis. Part XII: design, synthesis and bioevaluation of novel triazole integrated phenyl heteroterpenoids as antileishmanial agents. |
| AID1315483 | Fungicidal activity against Candida albicans MTCC 7315 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1391538 | Fungicidal activity against Candida albicans MTCC 183 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1267309 | Antifungal activity against Candida albicans MTCC 183 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1678799 | Antimalarial activity against chloroquine resistant Plasmodium falciparum | 2020 | RSC medicinal chemistry, Feb-01, Volume: 11, Issue:2 | An epigrammatic status of the ' |
| AID1758018 | Hemolytic activity in rabbit RBC assessed as hemolysis ratio at 1 ug/ml measured after 3 hrs by microplate reader assay relative to control | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1267326 | Inhibition of ergosterol biosynthesis in Candida parapsilosis MTCC 1744 assessed as mean ergosterol content at 2 ug/ml after 20 hrs by spectrophotometric analysis (Rvb=1.62 +/- 0.08 ug/ml) | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1302992 | Antimicrobial activity against Candida aaseri MTCC 1962 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1337800 | Antibacterial activity against of Staphylococcus aureus NCIM 2010 measured after 12 hrs | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1738722 | Antibiofilm activity against FCZ-Resistant Candida albicans CPCC400616 assessed as sessile minimum inhibitory concentration of biofilm formation at 50% after 24 hrs by XTT assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID49120 | Inhibitory activity against the Candida albicans (40 clinical isolates), determined at pH-5.8 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1268270 | Fungicidal activity against Candida albicans MTCC 3018 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID257545 | Antifungal activity against Cryptococcus neoformans | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID1291260 | Antimicrobial activity against Candida parapsilosis MTCC 1744 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1738738 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Lanosterol level at 0.03125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1268255 | Antifungal activity against Candida albicans MTCC 1637 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1738733 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Obtusifoliol level at 0.03125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1310543 | Antifungal activity against Candida parapsilosis MTCC 1744 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1888315 | Antifungal activity against fluconazole resistant Candida albicans strain 904 assessed as fungal growth inhibition measured after 72 hrs in presence of naftifine by CLSI protocol based liquid medium dilution method | |||
| AID70373 | Antibacterial activity against Erysipelothrix insidiosa | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
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| AID1265640 | Antifungal activity against Candida albicans clinical isolate after 24 hrs by sabouraud dextrose broth based microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. |
| AID1389626 | Hepatotoxicity in ICR mouse assessed as serum AST activity at 50 mg/kg, ig after 8 hrs (Rvb = 96.5 +/- 9.3 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID373104 | Antifungal activity against Saccharomyces cerevisiae by bioautographic agar overlay method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis and antimicrobial activity of new 1-alkyl/cyclohexyl-3,3-diaryl-1'-methylspiro[azetidine-2,3'-indoline]-2',4-diones. |
| AID1267318 | Antifungal activity against Candida aaseri MTCC 1962 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID1394708 | Antifungal activity against fluconazole-resistant Candida albicans TTSH-CALB02 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1268252 | Antifungal activity against Candida albicans MTCC 183 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1147020 | Antifungal activity against Candida albicans infected in mouse assessed as noninfected animals at 0.25% formulation in neat PEG 400 solution administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1310554 | Fungicidal activity against Candida albicans MTCC 183 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID378561 | Antimicrobial activity against Escherichia coli at 50 ug/filter disk | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua. |
| AID381893 | Antimicrobial activity against Penicillium funiculosum ATCC 36839 by serial dilution technique | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | A novel sesquiterpene lactone from Centaurea pullata: structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties. |
| AID1684673 | Antifungal activity against Candida parapsilosis MTCC 1745 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID406957 | Antifungal activity against fluconazole-resistant Candida albicans isolated from oropharyngeal or vaginal disease patient after 48 hrs by broth microdilution test | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID1700246 | Antifungal activity against Aspergillus flavus ATCC 204304 | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Synthesis and biological screening of thiosemicarbazones of substituted 3-acetylcoumarins having d-glucose moiety. |
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| AID1391550 | Fungicidal activity against Candida krusei MTCC 3020 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID375816 | Antifungal activity against Aspergillus niger NCIM 1196 by agar plate assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents. |
| AID402561 | Antimycotic activity against Aspergillus niger ATCC 10335 after 24 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | Antimycotic spirostanol saponins from Solanum hispidum leaves and their structure-activity relationships. |
| AID1758064 | Ratio of MFC for Candida albicans CPCC400616 incubated for 48 hrs followed by culturing on PDA plate for 24 hrs to MIC for Candida albicans CPCC400616 measured after 24 hrs | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID392755 | Antifungal activity against Candida albicans 10145 after 2 to 5 days by tube dilution method | 2009 | Bioorganic & medicinal chemistry, Feb-15, Volume: 17, Issue:4 | Synthesis and antimicrobial evaluation of some new substituted purine derivatives. |
| AID1394712 | Cytotoxicity against NHDF assessed as reduction in cell viability after 5 days by CellTiter-Glo assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1575885 | Antifungal activity against Candida albicans MTCC 183 assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID48047 | Minimum inhibitory concentration against Candida parapsilosis at a pH of 5.7 using SDB medium | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID597999 | Antifungal activity against Candida albicans in yeast extract-peptone-glucose medium at 300 ug/ml after 48 hrs by disc diffusion assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Synthesis and evaluation of indole-based new scaffolds for antimicrobial activities--identification of promising candidates. |
| AID1446842 | Antifungal activity against Candida albicans MTCC 1637 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID47877 | Antifungal activity against Candida parapsilosis after 48 hr incubation | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation. |
| AID1337844 | Antifungal activity against Aspergillus flavus NCIM 539 by standard agar method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1713527 | Antimicrobial activity against Klebsiella planticola MTCC 530 assessed as inhibition zone measured after 24 hrs incubation by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A simple, one pot synthesis of furo[3,2-c]chromenes and evaluation of antimicrobial activity. |
| AID401713 | Antifungal activity against Cladosporium cladosporioides at 1 ug by TLC bioassay | 1998 | Journal of natural products, Jul, Volume: 61, Issue:7 | Triterpenes and saponins from Rudgea viburnioides. |
| AID1147016 | Antifungal activity against Candida albicans infected in mouse assessed as noninfected animals at 1% formulation in neat PEG 400 solution administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1150052 | Antifungal activity against Trichophyton rubrum assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1315460 | Antifungal activity against Candida albicans MTCC 3958 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1196913 | Fungicidal activity against Trichophyton mentagrophytes B70554 | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents. |
| AID1150053 | Antifungal activity against Cryptococcus neoformans assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1738703 | Antifungal activity against Cryptococcus neoformans CGMCC2.3161 measured after 72 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID554718 | Antimicrobial activity against Saccharomyces cerevisiae isolate ADdelta overexpressing Saccharomyces cerevisiae ERG11 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID294188 | Antifungal activity against Candida albicans ATCC 10231 by macro-broth dilution assay | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8 | Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers. |
| AID1303002 | Fungicidal activity against Candida albicans MTCC 3958 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1713526 | Antimicrobial activity against Micrococcus luteus MTCC 2470 assessed as inhibition zone measured after 24 hrs incubation by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A simple, one pot synthesis of furo[3,2-c]chromenes and evaluation of antimicrobial activity. |
| AID1738719 | Antibiofilm activity against FCZ-Resistant Candida albicans CPCC400616 assessed as sessile minimum inhibitory concentration of biofilm formation at 50% after 1.5 hrs by XTT assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1268262 | Antifungal activity against Candida glabrata MTCC 3019 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID439881 | Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx at 10 uM by luminescence reporter assay | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Substituted 2-aminothiopen-derivatives: a potential new class of GluR6-antagonists. |
| AID551057 | Antifungal activity against Fusarium oxysporum assessed as macroscopically visible colonies after 48 and 72 hrs by standard agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. |
| AID294968 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by serial dilution method | 2007 | European journal of medicinal chemistry, Oct, Volume: 42, Issue:10 | Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. |
| AID333793 | Antifungal activity against Botrytis cinerea | 2004 | Journal of natural products, Dec, Volume: 67, Issue:12 | Thiobutacin, a novel antifungal and antioomycete antibiotic from Lechevalieria aerocolonigenes. |
| AID1758002 | Antifungal activity against Candida albicans ATCC SC5314 measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID658669 | Antifungal activity against Aspergillus flavus by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10 | A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: synthesis, anti-inflammatory and antimicrobial evaluation. |
| AID1146967 | Antifungal activity against Trichophyton mentagrophytes infected in guinea pig assessed as noninfected animals at 0.5% formulation in steryl alcohol, cetyl alcohol, Span 60, Tween 60, propylene glycol, mineral oil, and water administered qd for 5 days mea | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1302995 | Antimicrobial activity against Issatchenkia hanoiensis MTCC 4755 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1146955 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 2% commercial cream formulation administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID213465 | Zone of inhibition from the edge of a circular filter disk impregnated with test substance, against Ustilago violacea (antifungal activity) | 2002 | Journal of medicinal chemistry, Jul-04, Volume: 45, Issue:14 | Lepadins D-F: antiplasmodial and antitrypanosomal decahydroquinoline derivatives from the tropical marine tunicate Didemnum sp. |
| AID681120 | TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in Caco-2 cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID522126 | Antimicrobial activity against deltacrz1 mutant containing Candida glabrata TG173 complemented with CRZ1 gene by colorimetric microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID1394704 | Antifungal activity against fluconazole-resistant Candida albicans ATCC 96901 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID200324 | Compound was evaluated for inhibitory activity against Saccharomyces cerevisiae | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18 | New antifungals selected by molecular topology. |
| AID490031 | Antifungal activity against Fusarium solani at 200 ug/ml after 7 days | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Some new biologically active metal-based sulfonamide. |
| AID1302967 | Antimicrobial activity against Staphylococcus aureus MLS16 MTCC 2940 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1063218 | Antiproliferative activity against human MUTU-I cells at 10 uM after 24 hrs by Alamar blue assay | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and antiproliferative action of a novel series of maprotiline analogues. |
| AID1758028 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.3%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID54923 | Inhibition of human cytochrome P450 3A4 | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID747569 | Antifungal activity against Candida albicans MTCC 227 after 30 hrs by serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties. |
| AID1320276 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 2453 incubated for 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A diastereoselective synthesis of tetrahydro- and dihydro-pyrido[2,3-c]coumarin derivatives via a one-pot three-component Povarov reaction catalyzed by bismuth(III) chloride. |
| AID1738745 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Eburicol level at 0.5 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1267299 | Antibacterial activity against Klebsiella planticola MTCC 530 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1337785 | Antifungal activity against Fusarium oxysporum NCIM 1332 by standard agar method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1310571 | Induction of ROS accumulation in Candida albicans MTCC 227 sessile cells at 2 to 8 ug/ml incubated for 24 hrs by DCFH-DA dye based microplate reader analysis | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1758036 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 0.03125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 1.7%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID49111 | 50% inhibitory activity against Candida albicans (40 clinical isolates) determined at pH-5.8 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1130392 | Antifungal activity against Sporothrix schenckii assessed as growth inhibition in sabouraud broth after 14 days in presence of 10% inactivated bovine serum | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID537736 | Antifungal activity against yeast AD1-8u expressing Candida albicans CaCdr1p by agar disk diffusion assay | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID1310556 | Fungicidal activity against Candida albicans MTCC 854 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID311988 | Antifungal activity against Cladosporium sphaerospermum after 72 hrs | 2007 | Journal of natural products, Dec, Volume: 70, Issue:12 | Antifungal amides from Piper scutifolium and Piper hoffmanseggianum. |
| AID1090229 | Antifungal activity against Zygosaccharomyces bailii assessed as growth inhibition measured after 48 hr by macrodilution assay | 2005 | Journal of agricultural and food chemistry, Jun-29, Volume: 53, Issue:13 | Naturally occurring antifungal agents against Zygosaccharomyces bailii and their synergism. |
| AID1758048 | Anti-biofilm activity in Candida albicans CPCC400616 assessed as inhibition of biofilm formation incubated for 24 hrs with 6 hrs precultured fungal suspension by XTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID378407 | Antimicrobial activity against Penicillium oxalicum at 1.6 ug | 2006 | Journal of natural products, Aug, Volume: 69, Issue:8 | Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products. |
| AID1302966 | Antimicrobial activity against Bacillus subtilis MTCC 121 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1267300 | Antibacterial activity against Pseudomonas aeruginosa MTCC 2453 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1575893 | Antifungal activity against Issatchenkia hanoiensis MTCC 4755 assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID205796 | Fungicidal concentration on sterol 14-alpha-demethylase | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID1267313 | Antifungal activity against Candida albicans MTCC 3018 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1575882 | Antibacterial activity against Pseudomonas aeruginosa MTCC 2453 assessed as inhibition of bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID595216 | Antipromastigote activity against Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as luciferase activity of viable cells at 20 uM after 72 hrs by luminometry | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Synthesis and evaluation of new furanyl and thiophenyl azoles as antileishmanial agents. |
| AID382506 | Antifungal activity against Candida pseudotropicalis by agar dilution method | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides. |
| AID1302994 | Antimicrobial activity against Candida krusei MTCC 3020 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1758045 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Eburicol level at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1592341 | Antifungal activity against Candida albicans ATCC 7754 after 72 hrs by agar dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities. |
| AID1146962 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 0.2% formulation administered vaginally bid for 4 days measured 6 hrs post last dose relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1389615 | Reversal of scopolamine-induced cognitive function impairment in ICR mouse assessed as escape latency time at 50 mg/kg, po dosed 30 mins prior to scopolamine treatment by Morris water maze test (Rvb = 48.6 +/- 4.4 secs) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1315475 | Fungicidal activity against Candida albicans MTCC 183 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1327752 | Antimicrobial activity against Candida albicans MTCC3958 measured after 24 hrs by well-diffusion method | |||
| AID1758049 | Anti-biofilm activity in Candida albicans CPCC400616 assessed as inhibition of biofilm formation incubated for 24 hrs with 24 hrs precultured fungal suspension by XTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1150054 | Antifungal activity against Candida tropicalis assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1300882 | Antifungal activity against Candida parapsilosis clinical isolate after 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1391546 | Fungicidal activity against Candida albicans MTCC 7315 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID45507 | Inhibitory activity against Candida albicans (40 clinical isolates), determined at pH-5.8 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1300320 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by BACTEC method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. |
| AID717725 | Cytotoxicity against HEK293T cells assessed as decrease in cell viability at 25 uM after 24 hrs by trypan blue exclusion assay | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. |
| AID575459 | Antifungal activity against 5 x 10'6 CFU/ml Trichophyton rubrum B68183 by resazurin based fluorimetry assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID245919 | Cytotoxicity to reduce chronic myeloid leukemia K 562 cells | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID1684679 | Fungicidal activity against Issatchenkia hanoiensis MTCC 4755 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1849452 | Inhibition of CYP3A4 in rat liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID554716 | Antimicrobial activity against Candida krusei NZCDC 90.147 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1310537 | Antifungal activity against Candida albicans MTCC 1637 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID245920 | Cytotoxicity to reduce human histolytic lymphoma U937 cells | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID1315485 | Fungicidal activity against Candida aaseri MTCC 1962 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID681122 | TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID1557083 | Antifungal activity against Candida guilliermondii T-47 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1600767 | Bactericidal activity against Staphylococcus aureus MLS-16 MTCC 2940 assessed as reduction in bacterial survival incubated for 24 hrs followed by transfer of microbial suspension to agar plates and measured at 24 hrs post transfer by agar well diffusion m | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID1130377 | Antifungal activity against Cryptococcus neoformans assessed as growth inhibition in sabouraud broth after 14 days | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID377235 | Antifungal activity against Aspergillus niger ATCC 16404 at 1000 ug/ml after 24 hrs | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Known and novel terpenes from Buddleja globosa displaying selective antifungal activity against dermatophytes. |
| AID1888310 | Antifungal activity against fluconazole resistant Candida albicans strain 901 assessed as decrease in fungal cell density in presence naftifine of by fluorescence microscopy | |||
| AID1302970 | Antimicrobial activity against Escherichia coli MTCC 739 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1636827 | Antifungal activity against Fusarium oxysporum f. sp. betae after 18 hrs by serial microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17 | Synthesis, structure and antimicrobial evaluation of a new gossypol triazole conjugates functionalized with aliphatic chains and benzyloxy groups. |
| AID50322 | Antifungal activity against Candida neoformans after 24 hr incubation | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation. |
| AID1133311 | Antifungal activity against Candida albicans ATCC 10231 assessed as lowest concentration required for total inhibition by broth dilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID1592340 | Antifungal activity against Aspergillus flavus ATCC 204304 measured after 72 hrs by agar dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities. |
| AID1133309 | Antifungal activity against Epidermophyton floccosum assessed as lowest concentration required for total inhibition broth dilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID1267327 | Inhibition of ergosterol biosynthesis in Candida parapsilosis MTCC 1744 assessed as mean ergosterol content at 4 ug/ml after 20 hrs by spectrophotometric analysis (Rvb=1.62 +/- 0.08 ug/ml) | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1146998 | Antifungal activity against Microsporum canis assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1320274 | Antimicrobial activity against Bacillus subtilis MTCC 121 incubated for 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A diastereoselective synthesis of tetrahydro- and dihydro-pyrido[2,3-c]coumarin derivatives via a one-pot three-component Povarov reaction catalyzed by bismuth(III) chloride. |
| AID249259 | Minimum inhibitory concentration to inhibit 50% of the isolates | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID310101 | Antifungal activity against Penicillium marneffei by disc diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine. |
| AID1150061 | Antibaterial activity against Erysipelothrix insidiosa assessed as lowest dose required to total inhibition of bacterial growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID311794 | Antifungal activity against Penicillium funiculosum ATCC 36839 by microdilution technique | 2007 | Journal of natural products, Nov, Volume: 70, Issue:11 | Minor sesquiterpene lactones from Centaurea pullata and their antimicrobial activity. |
| AID1391531 | Antifungal activity against Candida albicans MTCC 4748 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID150753 | Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID1196916 | Fungicidal activity against Sporothrix schenckii B62482 | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents. |
| AID453203 | Lipophilicity, log D of the compound | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1 | Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. |
| AID380198 | Antifungal activity against Ustilago violacea at 50 ug/disk | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6 | A new tyrosine kinase inhibitor from the marine brown alga Stypopodium zonale. |
| AID554933 | Increase in ERG11 mRNA expression in Candida krusei B2399 at 2 times MIC concentration after 1 hr by hot-phenol extraction based Northern blotting | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID1184069 | Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 60 mins in presence of 0.01% Triton-X by HPLC | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. |
| AID1267298 | Antibacterial activity against Escherichia coli MTCC 739 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID150752 | Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID1291256 | Antimicrobial activity against Candida albicans MTCC 3018 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1310560 | Fungicidal activity against Candida albicans MTCC 3958 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID486886 | Antimicrobial activity against Candida albicans ATCC 10231 by agar overlay technique | 2010 | Journal of natural products, Jun-25, Volume: 73, Issue:6 | Dihydro-beta-agarofuran sesquiterpenes and pentacyclic triterpenoids from the root bark of Osyris lanceolata. |
| AID628620 | Antimelanogenic activity in non-melanized Cryptococcus neoformans var. grubii assessed as inhibition of pigmentation at 0.5 ug/mL after 10 days by microtiter plate assay in presence of 1 mM catecholamine | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22 | Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans. |
| AID1491635 | Antifungal activity against Candida albicans VT1406 in cell suspension after 24 hrs by XXT/PMS dye based assay | 2017 | ACS medicinal chemistry letters, Aug-10, Volume: 8, Issue:8 | Branched Peptides: Acridine and Boronic Acid Derivatives as Antimicrobial Agents. |
| AID1678800 | Antimalarial activity against chloroquine sensitive Plasmodium falciparum | 2020 | RSC medicinal chemistry, Feb-01, Volume: 11, Issue:2 | An epigrammatic status of the ' |
| AID1695867 | Antifungal activity against Curvularia lunata NCIM 1131 incubated for 48 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID1291258 | Antimicrobial activity against Candida albicans MTCC 4748 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1758001 | Antifungal activity against Candida albicans CPCC400616 measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1164257 | Inhibition of human recombinant CYP2C19 incubated for 5 mins by fluorescence assay | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9 | Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-Oxyazetidine. |
| AID462895 | Inhibition of protein farnesyltransferase-mediated farnesylation of GFP-tagged H-Ras protein overexpressed in MDCK cells assessed as inhibition of protein localization into golgi and plasma membrane at 10 uM after 48 hrs by Hoechst 34580 staining-based co | 2010 | Journal of medicinal chemistry, Mar-25, Volume: 53, Issue:6 | Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs. |
| AID531537 | Antifungal activity against Candida glabrata clinical isolate obtained from cervicovaginal candidiasis patient assessed as susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay. |
| AID1268266 | Fungicidal activity against Candida albicans MTCC 227 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID752004 | Antifungal activity against Candida albicans NCIM 3471 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9 | Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity. |
| AID1146966 | Antifungal activity against Trichophyton mentagrophytes infected in guinea pig assessed as noninfected animals at 0.5% formulation in steryl alcohol, cetyl alcohol, Span 60, Tween 60, propylene glycol, mineral oil, and water administered qd for 5 days mea | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID1367741 | Fungicidal activity against Candida albicans MTCC 3017 measured after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Potential antimicrobial agents from triazole-functionalized 2H-benzo[b][1,4]oxazin-3(4H)-ones. |
| AID375814 | Antifungal activity against Fusarium oxysporum NCIM 1332 by agar plate assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents. |
| AID1237448 | Antimicrobial activity against Candida albicans MTCC 3017 incubated for 24 hrs at 30 degC by well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID382697 | Antimicrobial activity against Klebsiella pneumoniae at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID1276548 | Antibiofilm activity against Candida albicans CAF2-1 after 48 hrs by XTT assay | 2015 | Journal of natural products, Dec-24, Volume: 78, Issue:12 | Anti-Candida Cassane-Type Diterpenoids from the Root Bark of Swartzia simplex. |
| AID333446 | Antifungal activity against Cladosporium cladosporioides assessed as minimum concentration required to inhibit growth after 72 hrs by TLC | 2004 | Journal of natural products, Nov, Volume: 67, Issue:11 | Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum. |
| AID1575909 | Fungicidal activity against Candida albicans MTCC 3018 assessed as fungal killing incubated for 24 hrs | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1684662 | Inhibition of biofilm formation in Pseudomonas aeruginosa MTCC 2453 incubated for 24 hrs by crystal violet staining based microtiter plate method | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID551059 | Antifungal activity against Aspergillus niger assessed as macroscopically visible colonies after 48 and 72 hrs by standard agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. |
| AID554719 | Antimicrobial activity against Saccharomyces cerevisiae isolate ADdelta overexpressing Candida albicans ERG11A after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID204482 | Antifungal activity against S. schenckii; no data | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID204482 | Antifungal activity against S. schenckii; no data | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID670553 | Antifungal activity against Candida albicans MTCC 183 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID48259 | Resistance against all Candida. species (40 clinical isolates) at 256 micro g/mL (pH=5.8). Activity is expressed as R%. | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1758032 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Obtusifoliol level at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1267317 | Antifungal activity against Candida parapsilosis MTCC 1744 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1575886 | Antifungal activity against Candida albicans MTCC 227 assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID289312 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives. |
| AID356946 | Antimicrobial activity against Trichophyton mentagrophytes ATCC 28185 after 72 hrs by agar dilution method | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Five new steroidal saponins from Solanum chrysotrichum leaves and their antimycotic activity. |
| AID289313 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives. |
| AID1303003 | Fungicidal activity against Candida albicans MTCC 4748 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID206507 | Antibacterial against Staphylococcus hemolyticus | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID489667 | Antifungal activity against Trichophyton longifusum after 7 days | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Metal based biologically active compounds: design, synthesis, and antibacterial/antifungal/cytotoxic properties of triazole-derived Schiff bases and their oxovanadium(IV) complexes. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID1268258 | Antifungal activity against Candida albicans MTCC 4748 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID214276 | Minimum inhibitory concentration against Trichophyton mentagrophytes at a pH of 5.7 using SDB medium | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1738727 | Hemolytic activity in rabbit RBC assessed as hemolysis ratio at 16 ug/ml measured after 3 hrs relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1595131 | Antifungal activity against Candida tropicalis NCIM 3110 assessed as reduction in fungal cell growth incubated for 48 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID310053 | Antimicrobial activity against Candida albicans 3038 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23 | Synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to P450(14DM) by molecular docking and MM/PBSA method. |
| AID1575881 | Antibacterial activity against Escherichia coli MTCC 739 assessed as inhibition of bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID125949 | Minimum inhibitory concentration towards Microsporum canis | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID125949 | Minimum inhibitory concentration towards Microsporum canis | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID554708 | Antimicrobial activity against Candida krusei NZCDC 89.102 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1150036 | Antifungal activity against Trichophyton mentagrophytes assessed as lowest dose level for total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID766643 | Antifungal activity against Candida parapsilosis MTCC 1744 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID625831 | Antifungal activity against Cryptococcus neoformans by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID1184074 | Solubility of the compound in pH 6.5 phosphate buffer containing 5% DMSO | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. |
| AID48444 | Tested in vitro for antifungal activity against Candida species. at pH 5.8; value ranges from <0.25 to 0.25 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID701472 | Antifungal activity against Candida spp | 2012 | Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19 | The biology and chemistry of antifungal agents: a review. |
| AID1210013 | Inhibition of recombinant CYP2J2 (unknown origin)-mediated terfenadine hydroxylation assessed as remaining activity at 30 uM after 5 mins by LC-MS analysis relative to control | 2012 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 40, Issue:5 | Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. |
| AID1150040 | Antifungal activity against Candida albicans assessed as lowest dose level for total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID382874 | Antifungal activity against Candida albicans 685 after 24 hrs | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives. |
| AID289620 | Antibacterial activity against Escherichia coli after 24 hrs by micro-broth dilution technique | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines. |
| AID1237447 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 2453 incubated for 24 hrs at 37 degC by well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID766640 | Antifungal activity against Issatchenkia orientalis MTCC 3020 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1315465 | Antifungal activity against Candida glabrata MTCC 3019 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1758008 | Antifungal activity against Aspergillus fumigatus CMGCC3.7795 measured after 72 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1662683 | Lipophilicity, log P of the compound | 2020 | Journal of medicinal chemistry, 09-24, Volume: 63, Issue:18 | Essential Medicinal Chemistry of Essential Medicines. |
| AID560137 | Antifungal activity against Candida glabrata isolate 21231 at 10 ug after 48 hrs by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth. |
| AID575456 | Cytotoxicity against human MRC5 cells | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID1446852 | Antifungal activity against Issatchenkia hanoiensis MTCC 4755 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID1237444 | Antimicrobial activity against Bacillus subtilis MTCC 121 incubated for 24 hrs at 37 degC by well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID1150050 | Antifungal activity against Microsporum canis assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1291255 | Antimicrobial activity against Candida albicans MTCC 1637 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID463442 | Antimicrobial activity against Candida glabrata after 7 days | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: indolenyl sulfonamide derivatives. |
| AID1310535 | Antifungal activity against Candida albicans MTCC 227 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1446840 | Antifungal activity against Candida albicans MTCC 227 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID554705 | Antimicrobial activity against Candida krusei B2399 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1162424 | Antimicrobial activity against Candida tropicalis ATCC 1369 after 48 hrs by two-fold broth dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | A new efficient route to 7-aryl-6-fluoro-8-nitroquinolones as potent antibacterial agents. |
| AID1147009 | Antifungal activity against Candida albicans infected in mouse assessed as noninfected animals at 2% formulation in modified PEG 400 solution administered vaginally bid for 4 days measured on day 4 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1268278 | Fungicidal activity against Issatchenkia hanoiensis MTCC 4755 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1302983 | Antimicrobial activity against Candida albicans MTCC 183 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1575922 | Ratio of MFC to MIC against Candida albicans MTCC 7315 | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID348628 | Antibacterial activity against Staphylococcus aureus ATCC 61038P at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID1389629 | Hepatotoxicity in ICR mouse assessed as serum ALT activity at 10 mg/kg, ig after 8 hrs (Rvb = 31.9 +/- 2.1 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1330317 | Antagonist activity at Cav2.2 in human SH-SY5Y cells assessed as inhibition of KCl/CaCl2-stimulated Ca2+ flux up to 100 uM after 30 mins in presence of nifedipine by Fuo-4 dye based FLIPR assay | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca |
| AID1268257 | Antifungal activity against Candida albicans MTCC 3958 assessed as inhibition zone after 24 hrs at 30 degC by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1147001 | Antifungal activity against Candida albicans ATCC 14053 assessed as growth inhibition by broth dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1758041 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Eburicol level at 0.03125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID310104 | Antifungal activity against Mucor sp. by disc diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine. |
| AID746921 | Antileishmanial activity against amastigotes of Leishmania donovani assessed as inhibition of parasite growth after 72 hrs by luciferase reporter assay | 2013 | Bioorganic & medicinal chemistry letters, May-15, Volume: 23, Issue:10 | Chemotherapy of leishmaniasis. Part XII: design, synthesis and bioevaluation of novel triazole integrated phenyl heteroterpenoids as antileishmanial agents. |
| AID48251 | Inhibitory activity against Candida. species (40 clinical isolates), determined at pH-5.8 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID214429 | Minimum inhibitory concentration against Trichophyton rubrum at a pH of 5.7 using SDB medium | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1130390 | Antifungal activity against Candida albicans assessed as growth inhibition in sabouraud broth after 14 days in presence of 10% inactivated bovine serum | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID1146958 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 1% formulation administered vaginally bid for 4 days measured 6 hrs post last dose relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1684664 | Inhibition of biofilm formation in Klebsiella planticola MTCC 530 incubated for 24 hrs by crystal violet staining based microtiter plate method | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1684663 | Inhibition of biofilm formation in Escherichia coli MTCC 739 incubated for 24 hrs by crystal violet staining based microtiter plate method | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1320278 | Antimicrobial activity against Candida albicans MTCC 3017 incubated for 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A diastereoselective synthesis of tetrahydro- and dihydro-pyrido[2,3-c]coumarin derivatives via a one-pot three-component Povarov reaction catalyzed by bismuth(III) chloride. |
| AID1130388 | Antifungal activity against Trichophyton mentagrophytes assessed as growth inhibition in sabouraud broth after 14 days in presence of 10% inactivated bovine serum | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID1162422 | Antimicrobial activity against Aspergillus niger ATCC 6275 up to 100 ug/ml after 48 hrs by two-fold broth dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | A new efficient route to 7-aryl-6-fluoro-8-nitroquinolones as potent antibacterial agents. |
| AID352613 | Antifungal activity against Aspergillus fumigatus after 72 hrs by micro broth dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. |
| AID375817 | Antifungal activity against Cryptococcus neoformans NCIM 576 by agar plate assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents. |
| AID382721 | Antimicrobial activity against Candida albicans ATCC 10231 at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID554721 | Antimicrobial activity against Saccharomyces cerevisiae isolate ADdelta overexpressing Candida krusei ERG11g after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID283196 | Susceptibility of polyene-resistant Candida glabrata 21229 isolate at 10 ug by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth. |
| AID1130379 | Antifungal activity against Candida albicans assessed as growth inhibition in sabouraud broth after 14 days | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID1446843 | Antifungal activity against Candida albicans MTCC 3017 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID589643 | Antifungal activity against Cryptococcus neoformans | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents. |
| AID382693 | Antimicrobial activity against Proteus vulgaris at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID1058361 | Antimicrobial activity against Staphylococcus aureus MLS-16 MTCC 2940 after 24 hrs by well diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID49114 | In vitro antifungal activity against 40 strains of Candida albicans at pH 5.8 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID406953 | Cytotoxicity against human U937 cells assessed as reduction of cell viability after 24 hrs by MTT assay | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. |
| AID48272 | Tested in vitro for antifungal activity against Candida species. at pH 5.8 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID1311356 | Antifungal activity against Aspergillus flavus by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis and antimicrobial evaluation of novel ethyl 2-(2-(4-substituted)acetamido)-4-subtituted-thiazole-5-carboxylate derivatives. |
| AID348634 | Antibacterial activity against Pseudomonas aeruginosa ATCC 110442 at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID1150044 | Antifungal activity against Saprolegnia species assessed as lowest dose level for total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1268277 | Fungicidal activity against Candida krusei MTCC 3020 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1291264 | Antimicrobial activity against Issatchenkia hanoiensis MTCC 4755 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID522130 | Antimicrobial activity against Candida glabrata TG162 containing calcineurin deltacnb1 mutant by colorimetric microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID1150048 | Antibacterial activity against Streptococcus pyogenes assessed as lowest dose level for total inhibition of bacterial growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1575901 | Cytotoxicity against human MRC5 cells incubated for 48 hrs by MTT assay | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1882202 | Antifungal activity against Candida albicans incubated for 24 hrs by well diffusion method | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Natural and synthetic β-carboline as a privileged antifungal scaffolds. |
| AID1738726 | Hemolytic activity in rabbit RBC assessed as hemolysis ratio at 8 ug/ml measured after 3 hrs relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID691207 | Antifungal activity against Candida albicans MTCC 227 after 2 to 3 days by modified agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. |
| AID1209990 | Inhibition of CYP2J2-mediated astemizole O-demethylation in human liver microsomes after 8 mins by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 40, Issue:5 | Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. |
| AID1389621 | Hepatotoxicity in ICR mouse assessed as serum AST activity at 100 mg/kg, ig after 22 hrs (Rvb = 99.5 +/- 7.9 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1389614 | Reversal of scopolamine-induced cognitive function impairment in ICR mouse assessed as escape latency time at 10 mg/kg, po dosed 30 mins prior to scopolamine treatment by Morris water maze test (Rvb = 48.6 +/- 4.4 secs) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1713525 | Antimicrobial activity against Candida albicans MTCC 3017 assessed as inhibition zone measured after 24 hrs incubation by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A simple, one pot synthesis of furo[3,2-c]chromenes and evaluation of antimicrobial activity. |
| AID1389616 | Reversal of scopolamine-induced cognitive function impairment in ICR mouse assessed as escape latency time at 15 mg/kg, po dosed 30 mins prior to scopolamine treatment by Morris water maze test (Rvb = 48.6 +/- 4.4 secs) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1391510 | Inhibition of ergosterol in Candida albicans MTCC 183 after 20 hrs by UV spectrophotometric method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1684675 | Antifungal activity against Candida albicans MTCC 3958 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1302988 | Antimicrobial activity against Candida albicans MTCC 3958 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1738742 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Lanosterol level at 8 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID537734 | Antifungal activity against yeast AD1-8u expressing Candida albicans CaMdr1p by agar disk diffusion assay | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID532550 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring human CYP51 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID1849449 | Inhibition of CYP2C9 in rat liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID554711 | Antimicrobial activity against Candida krusei B2399 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1700248 | Antifungal activity against Saccharomyces cerevisiae SH 20 | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Synthesis and biological screening of thiosemicarbazones of substituted 3-acetylcoumarins having d-glucose moiety. |
| AID1156864 | Antimicrobial activity against Cryptococcus neoformans after 72 hrs by microbroth dilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents. |
| AID85364 | Inhibition of Vaginal Candida (C-60 strain) infection in Hamsters, estimated as Percent Area under curve at 0.25 % concentration after 4 days of administration | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID747572 | Antifungal activity against Aspergillus fumigatus MTCC 343 assessed as zone of inhibition at 100 ug/ml after 30 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties. |
| AID1600761 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as reduction in bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID352609 | Antifungal activity against Candida albicans after 48 hrs by micro broth dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. |
| AID1147014 | Antifungal activity against Candida albicans infected in mouse assessed as noninfected animals at 2% formulation in neat PEG 400 solution administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID48591 | Minimum inhibitory concentration against Candida albicans using eagles minimum essential medium (EMEM) | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1133308 | Antifungal activity against Microsporum gypseum assessed as lowest concentration required for total inhibition broth dilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID125947 | Antifungal activity against Microsporum canis | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID125947 | Antifungal activity against Microsporum canis | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID1684661 | Inhibition of biofilm formation in Candida albicans MTCC 3017 incubated for 24 hrs by crystal violet staining based microtiter plate method | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID356326 | Antifungal activity against Cryptococcus neoformans ATCC 90112 after 48 to 96 hrs by broth microdilution method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species. |
| AID554715 | Antimicrobial activity against Candida krusei NZCDC 89.221 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1557075 | Antifungal activity against Candida albicans ATCC 90028 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID589645 | Antifungal activity against Fusarium oxysporum | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents. |
| AID1616740 | Inhibition of bacterial Beta-lactamase TEM-1 M182T mutant pre-incubated for 5 mins before addition of chromogenic beta-lactamase substrate CENTA by spectrophotometry | 2019 | Journal of medicinal chemistry, 11-14, Volume: 62, Issue:21 | Protein Stability Effects in Aggregate-Based Enzyme Inhibition. |
| AID1636826 | Antifungal activity against Fusarium oxysporum f. sp. lycopersici after 18 hrs by serial microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17 | Synthesis, structure and antimicrobial evaluation of a new gossypol triazole conjugates functionalized with aliphatic chains and benzyloxy groups. |
| AID1291272 | Fungicidal activity against Candida albicans MTCC 183 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1394703 | Antifungal activity against fluconazole-resistant Candida albicans ATCC 64124 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID44972 | Antifungal activity against Candida albicans after 48 hr incubation | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation. |
| AID377236 | Antifungal activity against Saccharomyces cerevisiae NCIMB 080178 at 1000 ug/ml after 24 hrs | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Known and novel terpenes from Buddleja globosa displaying selective antifungal activity against dermatophytes. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID125806 | Antifungal activity against Microsporum canis | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID356948 | Antimicrobial activity against Aspergillus niger ATCC 10335 after 48 hrs by agar dilution method | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Five new steroidal saponins from Solanum chrysotrichum leaves and their antimycotic activity. |
| AID49262 | Percent resistance against Candida albicans (40 clinical isolates) at 256 micro g/mL (pH=5.8), activity is expressed as R%. | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1738702 | Antifungal activity against Candida zeylanoides CMGCC2.3739 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1575925 | Ratio of MFC to MIC against Candida krusei MTCC 3020 | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1332995 | Antifungal activity against Candida albicans ATCC 7754 after 72 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones. |
| AID1153411 | Antimicrobial activity against Klebsiella planticola MTCC 530 after 24 hrs by well diffusion method | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID214288 | In vitro antifungal activity against Trichophyton mentagrophytes | 1983 | Journal of medicinal chemistry, Mar, Volume: 26, Issue:3 | Synthesis of (E)-1-(5-chlorothien-2-yl)-2-(1H-imidazol-1-yl)ethanone 2,6-dichlorophenylhydrazone hydrochloride, a novel, orally active antifungal agent. |
| AID348636 | Antimicrobial activity against Candida albicans ATCC 10231 at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID1391544 | Fungicidal activity against Candida albicans MTCC 3958 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID284511 | Antimicrobial activity against Candida albicans | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Chemoenzymatic synthesis and antimicrobial activity evaluation of monoglucosyl diglycerides. |
| AID1391536 | Antifungal activity against Candida krusei MTCC 3020 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID48589 | Minimum inhibitory concentration against Candida albicans at a pH of 5.7 using SDB medium | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID463440 | Antimicrobial activity against Microsporum canis after 7 days | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: indolenyl sulfonamide derivatives. |
| AID746920 | Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, May-15, Volume: 23, Issue:10 | Chemotherapy of leishmaniasis. Part XII: design, synthesis and bioevaluation of novel triazole integrated phenyl heteroterpenoids as antileishmanial agents. |
| AID1446850 | Antifungal activity against Candida glabrata MTCC 3019 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID1446859 | Antibiofilm activity against Candida albicans MTCC 4748 after 24 hrs by crystal violet staining based method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID575464 | Antifungal activity against 5 x 10'6 CFU/ml Candida glabrata B63155 by resazurin based fluorimetry assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID377234 | Antifungal activity against Trichophyton interdigitale EL 5171 after 24 hrs | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Known and novel terpenes from Buddleja globosa displaying selective antifungal activity against dermatophytes. |
| AID1267293 | Antibacterial activity against Micrococcus luteus MTCC 2470 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1302993 | Antimicrobial activity against Candida glabrata MTCC 3019 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID214806 | Antifungal activity against Trichophyton mentagrophytes | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID1327753 | Antimicrobial activity against Candida parapsilosis MTCC1744 measured after 24 hrs by well-diffusion method | |||
| AID1600768 | Bactericidal activity against Micrococcus luteus MTCC 2470 assessed as reduction in bacterial survival incubated for 24 hrs followed by transfer of microbial suspension to agar plates and measured at 24 hrs post transfer by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID1738723 | Hemolytic activity in rabbit RBC assessed as hemolysis ratio at 1 ug/ml measured after 3 hrs relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID355710 | Antifungal activity against Candida albicans MSU-SM 543 after 2 to 4 days | |||
| AID48264 | Tested In vitro for antifungal activity against Candida species. at pH 7.2 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID747570 | Antifungal activity against Aspergillus flavus MTCC 277 assessed as zone of inhibition at 100 ug/ml after 30 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties. |
| AID1738744 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Eburicol level at 0.125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1058358 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 2453 after 24 hrs by well diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID1758003 | Antifungal activity against Candida zeylanoides CMGCC2.3739 measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID595219 | Selectivity index, ratio of CC50 for mouse J774A.1 cells to IC50 for Leishmania donovani MHOM/IN/80/Dd8 amastigotes | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Synthesis and evaluation of new furanyl and thiophenyl azoles as antileishmanial agents. |
| AID1315487 | Fungicidal activity against Candida krusei MTCC 3020 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1150059 | Antifungal activity against Saprolegnia species assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID376227 | Antibacterial activity against Bacillus megaterium at 50 ug/disk | 2000 | Journal of natural products, Jul, Volume: 63, Issue:7 | New natural product isolation and comparison of the secondary metabolite content of three distinct samples of the sea hare Aplysia dactylomela from tenerife. |
| AID332622 | Antifungal activity against Cladosporium cucumerinum assessed as inhibition of spore growth by TLC bioassay | 1995 | Journal of natural products, Jan, Volume: 58, Issue:1 | Isolation of antifungal and larvicidal constituents of Diplolophium buchanani by centrifugal partition chromatography. |
| AID1379940 | Antifungal activity against Candida parapsilosis clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
| AID1575923 | Ratio of MFC to MIC against Candida parapsilosis MTCC 1744 | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1310538 | Antifungal activity against Candida albicans MTCC 3017 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1759380 | Antifungal activity against Saccharomyces cerevisiae MTCC 1344 assessed as zone of inhibition at 24 uM incubated for 2 days by cross streak plate method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents. |
| AID214823 | Antifungal activity against Trichophyton rubrum | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents. |
| AID44979 | Antifungal activity against Candida albicans; Range is 8-16 | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents. |
| AID1150062 | Antibaterial activity against Staphylococcus haemolyticus assessed as lowest dose required to total inhibition of bacterial growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1153409 | Antimicrobial activity against Escherichia coli MTCC 739 after 24 hrs by well diffusion method | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID1180303 | Antimicrobial activity against Aspergillus niger NCIM-1196 after 20 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID658666 | Antifungal activity against Candida albicans by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10 | A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: synthesis, anti-inflammatory and antimicrobial evaluation. |
| AID575463 | Antifungal activity against 5 x 10'6 CFU/ml Candida albicans B2630 by resazurin based fluorimetry assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID155489 | Antifungal activity against Phialophora verrucosa | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID1557076 | Antifungal activity against Candida albicans P-87 assessed as reduction in fungal cell growth incubated for 24 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1849443 | Inhibition of CYP1A2 in human liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID49124 | In vitro antifungal activity against 40 strains of Candida albicans at pH 5.8 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID662995 | Growth inhibition of Mycobacterium tuberculosis H37Rv at 250 ug/mL | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines. |
| AID1058356 | Antimicrobial activity against Candida albicans MTCC 3017 after 24 hrs by well diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID589647 | Antifungal activity against Aspergillus niger | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents. |
| AID1291263 | Antimicrobial activity against Candida krusei MTCC 3020 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID531538 | Antifungal activity against Candida glabrata clinical isolate obtained from cervicovaginal candidiasis patient assessed as susceptible dose-dependent isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay. |
| AID1291262 | Antimicrobial activity against Candida glabrata MTCC 3019 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1389617 | Hepatotoxicity in ICR mouse assessed as serum ALT activity at 100 mg/kg, ig after 8 hrs (Rvb = 31.9 +/- 2.1 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID289624 | Antifungal activity against Microsporum gypseum after 7 days | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines. |
| AID1738729 | Antibiofilm activity against FCZ-Resistant Candida albicans CPCC400616 assessed as sessile minimum inhibitory concentration of biofilm formation at 80% after 3 hrs by XTT assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1268272 | Fungicidal activity against Candida albicans MTCC 4748 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1147000 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition by broth dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID454197 | Antifungal activity against Aspergillus flavus NCIM 539 by standard agar plate method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents. |
| AID1758030 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.3%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID48253 | 50% inhibitory activity against the Candida. species (40 clinical isolates) was determined at pH-7.2 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1394706 | Antifungal activity against fluconazole-resistant Candida albicans NUH-K6004 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID532571 | Antifungal activity against Candida glabrata isolate 21230 with silent mutations in ERG4, ERG5 genes and nonsense mutation in ERG6 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata. |
| AID681138 | TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1b-expressing LLC-PK1 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 303, Issue:1 | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. |
| AID766646 | Antifungal activity against Candida albicans MTCC 3018 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1291254 | Antimicrobial activity against Candida albicans MTCC 854 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1147002 | Antifungal activity against Cryptococcus neoformans assessed as growth inhibition by broth dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1391537 | Antifungal activity against Issatchenkia hanoiensis MTCC 4755 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1180300 | Fungicidal activity against Candida albicans NCIM-3471 after 48 to 72 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID382709 | Antimicrobial activity against Staphylococcus epidermidis at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID1150055 | Antifungal activity against Candida albicans assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID490028 | Antifungal activity against Microsporum canis at 200 ug/ml after 7 days | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Some new biologically active metal-based sulfonamide. |
| AID522127 | Antimicrobial activity against Candida glabrata TG172 containing deltacrz1 mutant by colorimetric microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. |
| AID1315464 | Antifungal activity against Candida aaseri MTCC 1962 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID311989 | Antifungal activity against Cladosporium cladosporioides after 72 hrs | 2007 | Journal of natural products, Dec, Volume: 70, Issue:12 | Antifungal amides from Piper scutifolium and Piper hoffmanseggianum. |
| AID1759377 | Antifungal activity against Aspergillus niger MTCC 404 assessed as zone of inhibition at 24 uM incubated for 2 days by cross streak plate method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents. |
| AID575478 | Antifungal activity against 10'7 CFU/ml Candida albicans B2630 infected in vulvovaginitis rat model assessed as fungal burden at 10 mg/kg administered tropically twice daily measured after 3 days | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID625830 | Antifungal activity against Candida albicans by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID249257 | Antifungal activity to cause 99% reduction of surviving cells in 50% isolates | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID1267294 | Antibacterial activity against Staphylococcus aureus MTCC 96 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1416195 | Antifungal activity against Aspergillus flavus by two-fold serial dilution method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8 | Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration. |
| AID1391542 | Fungicidal activity against Candida albicans MTCC 3017 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1391534 | Antifungal activity against Candida aaseri MTCC 1962 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID532565 | Antifungal activity against wild-type Saccharomyces cerevisiae BY4741 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID665066 | Antitubercular activity against Mycobacterium tuberculosis H37Rv at > 256 ug/mL | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones. |
| AID1150045 | Antifungal activity against Phialophora verrucosa assessed as lowest dose level for total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1150043 | Antifungal activity against Sporothrix schenckii assessed as lowest dose level for total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID670552 | Antifungal activity against Candida glabrata MTCC 3019 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID1557074 | Antifungal activity against ERG11/ERG3 knocked out Candida albicans SN152 assessed as zone of inhibition at 25 ug incubated for 48 hrs by disk diffusion method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1758033 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Obtusifoliol level at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID49264 | Resistance against Candida. albicans (40 clinical isolates) at 256 ug/mL (pH=7.2), activity is expressed as R%. | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1302987 | Antimicrobial activity against Candida albicans MTCC 3018 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1315482 | Fungicidal activity against Candida albicans MTCC 4748 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1684677 | Antifungal activity against Candida albicans MTCC 1637 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1575883 | Antibacterial activity against Klebsiella planticola MTCC 530 assessed as inhibition of bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID352610 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro broth dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. |
| AID348625 | Antibacterial activity against Staphylococcus aureus ATCC 210923 at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID1153407 | Antimicrobial activity against Staphylococcus aureus MLS-16 MTCC 2940 after 24 hrs by well diffusion method | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID1758021 | Hemolytic activity in rabbit RBC assessed as hemolysis ratio at 8 ug/ml measured after 3 hrs by microplate reader assay relative to control | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1315476 | Fungicidal activity against Candida albicans MTCC 227 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1389619 | Hepatotoxicity in ICR mouse assessed as serum ALT activity at 100 mg/kg, ig after 36 hrs (Rvb = 31.7 +/- 1.7 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1718979 | Inhibition of human N-terminal IDO1 expressed in Escherichia coli BL21 A1 cells using L-tryptophan as substrate measured after 30 mins by HPLC analysis | 2021 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 34 | Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies. |
| AID1600763 | Antibacterial activity against Pseudomonas aeruginosa MTCC 2453 assessed as reduction in bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID1293884 | Antifungal activity against Aspergillus niger NCIM 1196 after 48 hrs by agar cup plate method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation. |
| AID1849451 | Inhibition of CYP2D6 in rat liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID1595102 | Antifungal activity against Aspergillus niger MTCC281 assessed as reduction in fungal cell growth incubated for 24 to 48 hrs | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Tetrazole hybrids and their antifungal activities. |
| AID575460 | Antifungal activity against 5 x 10'6 CFU/ml Trichophyton rubrum J941704 by resazurin based fluorimetry assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID1888312 | Antifungal activity against fluconazole resistant Candida albicans strain CaR assessed as fungal growth inhibition measured after 72 hrs in presence of naftifine by CLSI protocol based liquid medium dilution method | |||
| AID1416198 | Antifungal activity against Candida mycoderma by two-fold serial dilution method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8 | Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration. |
| AID572701 | Selectivity ratio, ratio of Kd for Mycobacterium smegmatis ATCC 700084 CYP164A2 to Kd for Mycobacterium tuberculosis CYP121 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID1310536 | Antifungal activity against Candida albicans MTCC 854 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1268265 | Fungicidal activity against Candida albicans MTCC 183 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID377238 | Antifungal activity against Penicillium notatum ATCC 11654 at 1000 ug/ml after 24 hrs | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Known and novel terpenes from Buddleja globosa displaying selective antifungal activity against dermatophytes. |
| AID747574 | Antifungal activity against Aspergillus niger MTCC 282 assessed as zone of inhibition at 100 ug/ml after 30 hrs by cup plate method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties. |
| AID1332994 | Antifungal activity against Aspergillus niger 439 after 72 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones. |
| AID1155374 | Antifungal activity against Cladosporium cladosporioides after 48 hrs | 2014 | Journal of natural products, Jun-27, Volume: 77, Issue:6 | Antifungal and cytotoxic 2-acylcyclohexane-1,3-diones from Peperomia alata and P. trineura. |
| AID1616743 | Inhibition of bacterial Beta-lactamase TEM-1 R164S mutant pre-incubated for 5 mins before addition of chromogenic beta-lactamase substrate CENTA by spectrophotometry | 2019 | Journal of medicinal chemistry, 11-14, Volume: 62, Issue:21 | Protein Stability Effects in Aggregate-Based Enzyme Inhibition. |
| AID554706 | Antimicrobial activity against Candida krusei IFO0011 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID356947 | Antimicrobial activity against Trichophyton rubrum ATCC 28188 after 72 hrs by agar dilution method | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Five new steroidal saponins from Solanum chrysotrichum leaves and their antimycotic activity. |
| AID1268274 | Fungicidal activity against Candida parapsilosis MTCC 1744 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID283195 | Susceptibility of Candida glabrata 21231 isolate at 10 ug by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth. |
| AID348630 | Antibacterial activity against Enterococcus hirae ATCC 101041 at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID1268273 | Fungicidal activity against Candida albicans MTCC 7315 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1389630 | Hepatotoxicity in ICR mouse assessed as serum ALT activity at 10 mg/kg, ig after 22 hrs (Rvb = 34.7 +/- 2.0 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1546115 | Antifungal activity against Candida glabrata | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID537733 | Binding affinity to Candida albicans CaCdr1p expressed in yeast AD1-8u | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID554710 | Antimicrobial activity against Candida krusei NZCDC 90.147 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1075994 | Antifungal activity against Aspergillus niger NCIM 1196 by standard agar method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Synthesis, antileishmanial activity and docking study of N'-substitutedbenzylidene-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetohydrazides. |
| AID1315454 | Antifungal activity against Candida albicans MTCC 227 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1391530 | Antifungal activity against Candida albicans MTCC 3958 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1328348 | Antifungal activity against Candida albicans DSY2621 by MTT assay | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Targeted Isolation of Indolopyridoquinazoline Alkaloids from Conchocarpus fontanesianus Based on Molecular Networks. |
| AID1276547 | Antifungal activity against Candida albicans CAF2-1 after 24 hrs by spectrophotometry based broth dilution assay | 2015 | Journal of natural products, Dec-24, Volume: 78, Issue:12 | Anti-Candida Cassane-Type Diterpenoids from the Root Bark of Swartzia simplex. |
| AID1758043 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Eburicol level at 0.5 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1146995 | Antifungal activity against Trichophyton tonsurans assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1446839 | Antifungal activity against Candida albicans MTCC 183 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID208357 | Maximum enhancement of styrene oxide hydrolase activity was reported at compound concentration of 5e-4 M | 1985 | Journal of medicinal chemistry, Aug, Volume: 28, Issue:8 | Structural features of imidazole derivatives that enhance styrene oxide hydrolase activity in rat hepatic microsomes. |
| AID1446847 | Antifungal activity against Candida albicans MTCC 7315 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID1600766 | Bactericidal activity against Bacillus subtilis MTCC 121 assessed as reduction in bacterial survival incubated for 24 hrs followed by transfer of microbial suspension to agar plates and measured at 24 hrs post transfer by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
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| AID1291282 | Fungicidal activity against Candida glabrata MTCC 3019 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID85365 | Inhibition of Vaginal Candida (C-60 strain) infection in Hamsters, estimated as Percent Area under curve at 0.25 % concentration after 8 days of administration | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1849457 | Inhibition of CYP3A4 in mouse liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID1758040 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as lanosterol level at 8 ug/ml after 16 hrs by GC-MS analysis (Rvb = 1.7%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1265643 | Antifungal activity against Candida krusei clinical isolate after 24 hrs by sabouraud dextrose broth based microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. |
| AID1389628 | Hepatotoxicity in ICR mouse assessed as serum AST activity at 50 mg/kg, ig after 36 hrs (Rvb = 85.0 +/- 7.2 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID717844 | Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation at 20 uM after 45 mins by spectrophotometric analysis relative to control | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. |
| AID1146993 | Antifungal activity against Trichophyton mentagrophytes assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1713522 | Antimicrobial activity against Bacillus subtilis MTCC 121 assessed as inhibition zone measured after 24 hrs incubation by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A simple, one pot synthesis of furo[3,2-c]chromenes and evaluation of antimicrobial activity. |
| AID1684684 | Fungicidal activity against Candida albicans MTCC 3958 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1146994 | Antifungal activity against Trichophyton rubrum assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID572692 | Binding affinity to Mycobacterium smegmatis ATCC 700084 CYP51 at pH7.5 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID747571 | Antifungal activity against Aspergillus flavus MTCC 277 after 30 hrs by serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties. |
| AID309820 | Antifungal activity against Candida sp. | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | New biologically active epidioxysterols from Stereum hirsutum. |
| AID1146957 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 2% formulation administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
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| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID609822 | Antifungal activity against Candida albicans | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | The novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation. |
| AID1337801 | Antibacterial activity against Bacillus subtilis NCIM 2079 measured after 12 hrs | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1758019 | Hemolytic activity in rabbit RBC assessed as hemolysis ratio at 2 ug/ml measured after 3 hrs by microplate reader assay relative to control | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
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| AID434361 | Antifungal activity against Cryptococcus neoformans after 72 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
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| AID1391551 | Fungicidal activity against Issatchenkia hanoiensis MTCC 4755 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID204342 | Antifungal activity against Sporothrix schenck ii | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID382717 | Antimicrobial activity against Streptococcus agalactiae at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID419468 | Antifungal activity against Candida albicans CAI4 at 6 ug/disk after 24 hrs by disk diffusion assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis and evaluations of acridone derivatives using Candida albicans--search for MDR modulators led to the identification of an anti-candidiasis agent. |
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| AID1684672 | Antifungal activity against Candida aaseri MTCC 1962 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1391528 | Antifungal activity against Candida albicans MTCC 3018 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1391524 | Antifungal activity against Candida albicans MTCC 183 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID588210 | Human drug-induced liver injury (DILI) modelling dataset from Ekins et al | 2010 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 38, Issue:12 | A predictive ligand-based Bayesian model for human drug-induced liver injury. |
| AID1557087 | Antifungal activity against Candida glabrata ATCC 66032 assessed as reduction in fungal cell growth incubated for 48 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1310547 | Antifungal activity against Issatchenkia hanoiensis MTCC 4755 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID428564 | Inhibition of CYP3A4 | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. |
| AID1575908 | Fungicidal activity against Candida albicans MTCC 1637 assessed as fungal killing incubated for 24 hrs | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID575461 | Antifungal activity against 5 x 10'6 CFU/ml Trichophyton quinckeanum B68683 by resazurin based fluorimetry assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID44954 | Antifungal activity against Candida albicans was determined in vitro | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones. |
| AID1153412 | Antimicrobial activity against Candida albicans MTCC 3017 after 24 hrs by well diffusion method | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID289115 | Inhibition of CYP450-mediated tangeretin demethylation in Aspergillus niger ATCC 9142 assessed as relative activity at 0.5 mM | 2007 | Journal of natural products, Jun, Volume: 70, Issue:6 | Biotransformation of polymethoxylated flavonoids: access to their 4'-O-demethylated metabolites. |
| AID378562 | Antimicrobial activity against Bacillus megaterium at 50 ug/filter disk | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua. |
| AID554713 | Antimicrobial activity against Candida krusei NZCDC 89.021 after 48 hrs by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID575466 | Antifungal activity against 5 x 10'6 CFU/ml Candida krusei B68404 by resazurin based fluorimetry assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID1303006 | Fungicidal activity against Candida aaseri MTCC 1962 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1592342 | Antifungal activity against Saccharomyces cerevisiae SH 20 after 72 hrs by agar dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities. |
| AID214431 | In vitro antifungal activity against Trichophyton rubrum | 1983 | Journal of medicinal chemistry, Mar, Volume: 26, Issue:3 | Synthesis of (E)-1-(5-chlorothien-2-yl)-2-(1H-imidazol-1-yl)ethanone 2,6-dichlorophenylhydrazone hydrochloride, a novel, orally active antifungal agent. |
| AID1758022 | Hemolytic activity in rabbit RBC assessed as hemolysis ratio at 16 ug/ml measured after 3 hrs by microplate reader assay relative to control | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID49626 | Minimum inhibitory concentration towards Candida albicans | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID49626 | Minimum inhibitory concentration towards Candida albicans | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID78119 | In vivo inhibition of topical Trichophyton infection in Guinea Pig during drug administration | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1180306 | Fungicidal activity against Cryptococcus neoformans NCIM-3378 after 48 to 72 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID1330316 | Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-stimulated Ca2+ flux up to 100 uM after 30 mins by calcium-4 dye based FLIPR assay | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca |
| AID463438 | Antimicrobial activity against Candida albicans after 7 days | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: indolenyl sulfonamide derivatives. |
| AID1180299 | Antimicrobial activity against Candida albicans NCIM-3471 after 20 hrs by two fold serial macrodilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents. |
| AID348635 | Antibacterial activity against Bordetella bronchiseptica ATCC 4617 at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID49436 | In vitro antifungal activity against 40 strains of Candida albicans at pH 7.2; (percent of resistant species (R) at 256 ug/mL) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID1147006 | Antibacterial activity against Streptococcus pyogenes No. 8668 assessed as growth inhibition by broth microdilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1379936 | Antifungal activity against Candida albicans clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
| AID1491636 | Antibiofilm activity against Candida albicans VT1406 after 24 hrs by XXT/PMS dye based assay | 2017 | ACS medicinal chemistry letters, Aug-10, Volume: 8, Issue:8 | Branched Peptides: Acridine and Boronic Acid Derivatives as Antimicrobial Agents. |
| AID1616741 | Inhibition of bacterial Beta-lactamase TEM-1 M182T/G238S mutant pre-incubated for 5 mins before addition of chromogenic beta-lactamase substrate CENTA by spectrophotometry | 2019 | Journal of medicinal chemistry, 11-14, Volume: 62, Issue:21 | Protein Stability Effects in Aggregate-Based Enzyme Inhibition. |
| AID572695 | Binding affinity to Mycobacterium smegmatis ATCC 700084 CYP164A2 at pH7.5 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID1291283 | Fungicidal activity against Candida krusei MTCC 3020 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
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| AID53377 | In vitro inhibition of human Cytochrome P450 17A1 activity | 2003 | Journal of medicinal chemistry, Jun-05, Volume: 46, Issue:12 | Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy. |
| AID1327758 | Antimicrobial activity against Candida albicans MTCC1637 measured after 24 hrs by well-diffusion method | |||
| AID377237 | Antifungal activity against Candida albicans ATCC 10234 at 1000 ug/ml after 24 hrs | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Known and novel terpenes from Buddleja globosa displaying selective antifungal activity against dermatophytes. |
| AID681143 | TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cells | 2002 | Molecular pharmacology, May, Volume: 61, Issue:5 | Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. |
| AID348626 | Antibacterial activity against Staphylococcus aureus NCTC 4163 at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID319919 | Antifungal activity against Candida albicans PTCC 5027 after 24 to 48 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. |
| AID1391545 | Fungicidal activity against Candida albicans MTCC 4748 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1156863 | Antimicrobial activity against Aspergillus fumigatus after 72 hrs by microbroth dilution method | 2014 | European journal of medicinal chemistry, Aug-18, Volume: 83 | Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents. |
| AID1315481 | Fungicidal activity against Candida albicans MTCC 3958 after 24 hrs | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1130387 | Antifungal activity against Microsporum canis assessed as growth inhibition in sabouraud broth after 14 days in presence of 10% inactivated bovine serum | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID1394702 | Antifungal activity against fluconazole-resistant Candida albicans ATCC MYA-573 after overnight incubation by CLSI broth microdilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans. |
| AID1130381 | Antifungal activity against Sporothrix schenckii assessed as growth inhibition in sabouraud broth after 14 days | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID1738715 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as ergosterol level at 0.03125 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID434360 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID532553 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring human CYP51 assessed as growth rate at 0.5 ug/ml (Rvb = 0.157%) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID141780 | Antifungal activity against Mucor fragilis | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents. |
| AID1758031 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as Obtusifoliol level at 0.03125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 0%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1315466 | Antifungal activity against Candida krusei MTCC 3020 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID490025 | Antifungal activity against Trichophyton longifusum at 200 ug/ml after 7 days | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Some new biologically active metal-based sulfonamide. |
| AID1130378 | Antifungal activity against Candida tropicalis assessed as growth inhibition in sabouraud broth after 14 days | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID609823 | Antifungal activity against Aspergillus niger | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | The novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation. |
| AID1738732 | Ratio of hemolysis activity in rabbit RBC to MIC for Candida albicans | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID531540 | Antifungal activity against Candida glabrata clinical isolate overexpressing CDR1 gene obtained from cervicovaginal candidiasis patient assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay. |
| AID378567 | Antimicrobial activity against Chlorella fusca at 50 ug/filter disk | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua. |
| AID70079 | Minimum inhibitory concentration against Epidermophyton floccosum at a pH of 5.7 using SDB medium | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1311355 | Antifungal activity against Candida albicans by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis and antimicrobial evaluation of novel ethyl 2-(2-(4-substituted)acetamido)-4-subtituted-thiazole-5-carboxylate derivatives. |
| AID1209987 | Inhibition of CYP2J2 in human liver microsomes using 7 probe cocktail containing phenacetin, paclitaxel, diclofenac, S-mephenytoin, dextromethorphan, astemizole and midazolam after 8 mins by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 40, Issue:5 | Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. |
| AID337558 | Antifungal activity against Candida albicans after 16 to 19 hrs by disk diffusion assay in presence of 100 ppm ergosterol | 1993 | Journal of natural products, Jan, Volume: 56, Issue:1 | Screening of marine invertebrates for the presence of ergosterol-sensitive antifungal compounds. |
| AID1758029 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 2 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.3%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1147018 | Antifungal activity against Candida albicans infected in mouse assessed as noninfected animals at 0.5% formulation in neat PEG 400 solution administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID486964 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID1684688 | Fungicidal activity against Candida albicans MTCC 183 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID554720 | Antimicrobial activity against Saccharomyces cerevisiae isolate AD overexpressing Candida krusei ERG11C after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID218567 | Fold increase in IC50 vs beta-lactamase with 0.1 mg/mL saponin | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID54068 | In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system. | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines. |
| AID1147003 | Antibacterial activity against Staphylococcus aureus No. 6538 P assessed as growth inhibition by broth microdilution method | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1146959 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 1% formulation administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1276546 | Antifungal activity against Candida albicans CAF2-1 after overnight incubation by MTT based bioautography method | 2015 | Journal of natural products, Dec-24, Volume: 78, Issue:12 | Anti-Candida Cassane-Type Diterpenoids from the Root Bark of Swartzia simplex. |
| AID1268275 | Fungicidal activity against Candida aaseri MTCC 1962 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1684676 | Antifungal activity against Candida albicans MTCC 3018 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID489668 | Antifungal activity against Candida albicans after 7 days | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Metal based biologically active compounds: design, synthesis, and antibacterial/antifungal/cytotoxic properties of triazole-derived Schiff bases and their oxovanadium(IV) complexes. |
| AID336892 | Antifungal activity against Microsporum canis after 2 to 4 days | |||
| AID1600772 | Bactericidal activity against Klebsiella planticola MTCC 530 assessed as reduction in bacterial survival incubated for 24 hrs followed by transfer of microbial suspension to agar plates and measured at 24 hrs post transfer by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID47397 | Antifungal activity against Candida albicans | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID489670 | Antifungal activity against Microsporum canis after 7 days | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Metal based biologically active compounds: design, synthesis, and antibacterial/antifungal/cytotoxic properties of triazole-derived Schiff bases and their oxovanadium(IV) complexes. |
| AID1738737 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Obtusifoliol level at 8 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1391529 | Antifungal activity against Candida albicans MTCC 3017 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1146965 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 0.1% formulation administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID595217 | Antiamastigote activity against Leishmania donovani MHOM/IN/80/Dd8 amastigotes infected in mouse macrophage after 72 hrs by luciferase reporter gene assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Synthesis and evaluation of new furanyl and thiophenyl azoles as antileishmanial agents. |
| AID1184071 | Inhibition of mouse TDO expressed in mouse P815B cells using L-tryptophan substrate incubated for 24 hrs by HPLC based cellular assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. |
| AID489672 | Antifungal activity against Candida glabrata after 7 days | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Metal based biologically active compounds: design, synthesis, and antibacterial/antifungal/cytotoxic properties of triazole-derived Schiff bases and their oxovanadium(IV) complexes. |
| AID1146963 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 0.2% formulation administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID595218 | Cytotoxicity against mouse J774A1 cells assessed as cell viability after 72 hrs by MTT assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Synthesis and evaluation of new furanyl and thiophenyl azoles as antileishmanial agents. |
| AID356322 | Antifungal activity against Candida albicans ATCC 90028 after 48 to 96 hrs by broth microdilution method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species. |
| AID244978 | In-vitro minimum inhibitory concentration against the growth of Trichophyton mentagrophytes | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID1155375 | Antifungal activity against Cladosporium sphaerospermum after 48 hrs | 2014 | Journal of natural products, Jun-27, Volume: 77, Issue:6 | Antifungal and cytotoxic 2-acylcyclohexane-1,3-diones from Peperomia alata and P. trineura. |
| AID519606 | Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | New active drugs against liver stages of Plasmodium predicted by molecular topology. |
| AID1379937 | Antifungal activity against Candida glabrata clinical isolates assessed as inhibition of microbial growth incubated for 24 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity. |
| AID1888314 | Antifungal activity against fluconazole resistant Candida albicans strain 901 assessed as fungal growth inhibition measured after 72 hrs in presence of naftifine by CLSI protocol based liquid medium dilution method | |||
| AID356332 | Antifungal activity against Candida albicans ATCC 90028 at 10 ug/mL after 48 hrs by disk diffusion assay | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species. |
| AID1302991 | Antimicrobial activity against Candida parapsilosis MTCC 1744 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID1738700 | Antifungal activity against Candida albicans CPCC400616 measured after 24 hrs by micro-broth dilution assay | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID378563 | Antimicrobial activity against Microbacterium violaceum at 50 ug/filter disk | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua. |
| AID1849454 | Inhibition of CYP2C9 in mouse liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID575458 | Antifungal activity against 5 x 10'6 CFU/ml Trichophyton mentagrophytes B70554 by resazurin based fluorimetry assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID1320277 | Antimicrobial activity against Klebsiella planticola MTCC 530 incubated for 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A diastereoselective synthesis of tetrahydro- and dihydro-pyrido[2,3-c]coumarin derivatives via a one-pot three-component Povarov reaction catalyzed by bismuth(III) chloride. |
| AID1546114 | Antifungal activity against Candida albicans | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID532528 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring human CYP51 assessed as growth rate at 2 ug/ml (Rvb = 0.157%) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID1713524 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 2453 assessed as inhibition zone measured after 24 hrs incubation by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A simple, one pot synthesis of furo[3,2-c]chromenes and evaluation of antimicrobial activity. |
| AID1291271 | Fungicidal activity against Candida albicans MTCC 3017 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID55014 | Antifungal activity against Cryptococcus neoformans | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID55014 | Antifungal activity against Cryptococcus neoformans | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID1598732 | Binding affinity to Triton-X 100 assessed as line broadening at 150 uM by 1H-NMR analysis | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10 | Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators. |
| AID356324 | Antifungal activity against Candida glabrata ATCC 90030 after 48 to 96 hrs by broth microdilution method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species. |
| AID150756 | Inhibition of P-gp was determined using rhodamine-assay in human CaCo-2 cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID1330309 | Inhibition of Orai1-mediated store operated Ca2+ entry in human MDA-MB-231 cells assessed as reduction of SERCA inhibition-induced ER release preincubated for 15 mins followed by CPA addition by PBX-based FLIPR assay | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca |
| AID1575911 | Fungicidal activity against Candida albicans MTCC 7315 assessed as fungal killing incubated for 24 hrs | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID489671 | Antifungal activity against Fusarium solani after 7 days | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Metal based biologically active compounds: design, synthesis, and antibacterial/antifungal/cytotoxic properties of triazole-derived Schiff bases and their oxovanadium(IV) complexes. |
| AID382725 | Antimicrobial activity against Aspergillus sp. at 480.6 uM by disc-diffusion method | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2 | Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. |
| AID380197 | Antifungal activity against Fusarium oxysporum at 50 ug/disk | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6 | A new tyrosine kinase inhibitor from the marine brown alga Stypopodium zonale. |
| AID359384 | Antifungal activity against Candida albicans 44506 in Sabouraud dextrose broth after 18 to 24 hrs by twofold broth dilution method | 1992 | Journal of natural products, Nov, Volume: 55, Issue:11 | Antifungal activity of meridine, a natural product from the marine sponge Corticium sp. |
| AID454199 | Antifungal activity against Cryptococcus neoformans NCIM 576 by standard agar plate method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents. |
| AID1150051 | Antifungal activity against Trichophyton mentagrophytes assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1150058 | Antifungal activity against Sporothrix schenckii assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1600759 | Antibacterial activity against Staphylococcus aureus MLS-16 MTCC 2940 assessed as reduction in bacterial growth incubated for 24 hrs by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID375815 | Antifungal activity against Aspergillus flavus NCIM 539 by agar plate assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents. |
| AID141789 | Antifungal activity against Mucor species | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID1684669 | Antifungal activity against Issatchenkia hanoiensis MTCC 4755 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1391525 | Antifungal activity against Candida albicans MTCC 227 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID1592339 | Antifungal activity against Aspergillus niger ATCC 439 measured after 72 hrs by agar dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities. |
| AID1758014 | Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1268276 | Fungicidal activity against Candida glabrata MTCC 3019 assessed as microbial killing after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation. |
| AID1389644 | Inhibition of human recombinant IDO1 using L-tryptophan as substrate after 30 mins by fluorimetric analysis | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID211167 | Antifungal activity against Trichophyton mentagrophytes | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID211167 | Antifungal activity against Trichophyton mentagrophytes | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID1575902 | Inhibition of CYP51 in Candida albicans MTCC 3017 assessed as reduction in ergosterol level incubated for 20 hrs by UV-visible spectrophotometry analysis | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1713528 | Antimicrobial activity against Escherichia coli MTCC 739 assessed as inhibition zone measured after 24 hrs incubation by well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A simple, one pot synthesis of furo[3,2-c]chromenes and evaluation of antimicrobial activity. |
| AID554709 | Antimicrobial activity against Candida krusei NZCDC 89.221 after 48 hrs by liquid microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID1738740 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Lanosterol level at 0.5 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID150754 | Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID244787 | Antifungal activity to inhibit Candida parapsilosis ATCC 22019 | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16 | Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. |
| AID560139 | Antifungal activity against Candida glabrata isolate 22853 at 10 ug after 48 hrs by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth. |
| AID249459 | Ratio of the in vitro minimal inhibitory to that of bifonazole against Candida albicans (MIC(compound)/MIC(bifonazole)) | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies. |
| AID1557086 | Antifungal activity against Candida albicans SN152 assessed as reduction in fungal cell growth incubated for 48 hrs by MTT based broth double dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. |
| AID1477763 | Antifungal activity against drug resistant Candida albicans DF2672R after 24 hrs by two fold serial dilution method | 2017 | Journal of medicinal chemistry, 12-28, Volume: 60, Issue:24 | Semisynthesis and Biological Evaluation of Xanthone Amphiphilics as Selective, Highly Potent Antifungal Agents to Combat Fungal Resistance. |
| AID52776 | Compound was tested for the inhibition of Chymotrypsinogen | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. |
| AID766641 | Antifungal activity against Candida aaseri MTCC 1962 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID588209 | Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset | 2010 | Chemical research in toxicology, Jul-19, Volume: 23, Issue:7 | Developing structure-activity relationships for the prediction of hepatotoxicity. |
| AID1738714 | Ratio of MFC for fungicidal activity against Candida albicans CPCC400616 to MIC for Antifungal activity against Candida albicans CPCC400616 | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID575457 | Antifungal activity against 5 x 10'6 CFU/ml Microsporum canis B68128 by resazurin based fluorimetry assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID1315455 | Antifungal activity against Candida albicans MTCC 183 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1315458 | Antifungal activity against Candida albicans MTCC 3017 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID289314 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives. |
| AID1443635 | Critical aggregation concentration assessed as formation of aggregate after 30 mins by light scattering method | 2017 | Journal of medicinal chemistry, 04-27, Volume: 60, Issue:8 | Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. |
| AID1330315 | Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated Ca2+ flux up to 100 uM after 30 mins by calcium-4 dye based FLIPR assay | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca |
| AID338270 | Antimicrobial activity against Candida albicans DSM 1665 after 18 hrs by twofold serial dilution method | 1994 | Journal of natural products, Dec, Volume: 57, Issue:12 | Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays. |
| AID1150041 | Antifungal activity against Mucor species assessed as lowest dose level for total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1389622 | Hepatotoxicity in ICR mouse assessed as serum AST activity at 100 mg/kg, ig after 36 hrs (Rvb = 85.0 +/- 7.2 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1391527 | Antifungal activity against Candida albicans MTCC 1637 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID376233 | Antifungal activity against Fusarium oxysporum at 50 ug/disk | 2000 | Journal of natural products, Jul, Volume: 63, Issue:7 | New natural product isolation and comparison of the secondary metabolite content of three distinct samples of the sea hare Aplysia dactylomela from tenerife. |
| AID56602 | Compound is evaluated for geometric mean of MIC values of dermatophytes | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID376232 | Antifungal activity against Eurotium repens at 50 ug/disk | 2000 | Journal of natural products, Jul, Volume: 63, Issue:7 | New natural product isolation and comparison of the secondary metabolite content of three distinct samples of the sea hare Aplysia dactylomela from tenerife. |
| AID1700245 | Antifungal activity against Aspergillus niger ATCC 439 | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Synthesis and biological screening of thiosemicarbazones of substituted 3-acetylcoumarins having d-glucose moiety. |
| AID49125 | In vitro antifungal activity against 40 strains of Candida albicans at pH 7.2 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID454198 | Antifungal activity against Aspergillus niger NCIM 1196 by standard agar plate method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents. |
| AID1684670 | Antifungal activity against Candida krusei MTCC 3020 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID572699 | Binding affinity to Mycobacterium tuberculosis CYP51 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID1575888 | Antifungal activity against Candida albicans MTCC 3018 assessed as inhibition of fungal growth incubated for 24 hrs by agar well diffusion method | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID1390630 | Fungicidal activity against Candida albicans MTCC 3017 incubated for 24 hrs followed by microbial sample growth Sabouraud dextrose agar plates | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | A novel templates of piperazinyl-1,2-dihydroquinoline-3-carboxylates: Synthesis, anti-microbial evaluation and molecular docking studies. |
| AID1150042 | Antifungal activity against Aspergillus fumigatus assessed as lowest dose level for total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID575465 | Antifungal activity against 5 x 10'6 CFU/ml Candida kefyr B46120 by resazurin based fluorimetry assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. |
| AID1133316 | Antibacterial activity against Corynebacterium acnes ATCC 11828 assessed as lowest concentration required for total inhibition by broth microdilution assay | 1978 | Journal of medicinal chemistry, Dec, Volume: 21, Issue:12 | Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles. |
| AID1888283 | Drug uptake in fluconazole resistant Candida albicans strain 901 in presence of naftifine by fluorescence microscopy | |||
| AID49112 | 50% inhibitory activity against Candida albicans (40 clinical isolates) determined at pH-7.2 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1383235 | Inhibition of heme crystal growth | 2018 | European journal of medicinal chemistry, Apr-10, Volume: 149 | Pyrazole-pyrazoline as promising novel antimalarial agents: A mechanistic study. |
| AID48610 | Antifungal activity against Candida tropicalis | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID1758027 | Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as ergosterol level at 0.125 ug/ml after 16 hrs by GC-MS analysis (Rvb = 98.3%) | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1302971 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 2453 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID200325 | Compound was evaluated for inhibitory activity against Saccharomyces cerevisiae; 1.6-2.0 | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18 | New antifungals selected by molecular topology. |
| AID766644 | Antifungal activity against Candida albicans MTCC 7315 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID70215 | Enhancement of epoxide hydrolase activity | 1985 | Journal of medicinal chemistry, Aug, Volume: 28, Issue:8 | Structural features of imidazole derivatives that enhance styrene oxide hydrolase activity in rat hepatic microsomes. |
| AID1684687 | Fungicidal activity against Candida albicans MTCC 3018 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1130375 | Antifungal activity against Trichophyton mentagrophytes assessed as growth inhibition in sabouraud broth after 14 days | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID376231 | Antifungal activity against Microbotryum violaceae at 50 ug/disk | 2000 | Journal of natural products, Jul, Volume: 63, Issue:7 | New natural product isolation and comparison of the secondary metabolite content of three distinct samples of the sea hare Aplysia dactylomela from tenerife. |
| AID670550 | Antifungal activity against Candida parapsilosis MTCC 1744 after 24 hrs by well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. |
| AID402562 | Antimycotic activity against Candida albicans ATCC 10231 after 48 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | Antimycotic spirostanol saponins from Solanum hispidum leaves and their structure-activity relationships. |
| AID1849446 | Inhibition of CYP2D6 in human liver Microsome using dextromethorphan as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID1446845 | Antifungal activity against Candida albicans MTCC 3958 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID71154 | Zone of inhibition from the edge of a circular filter disk impregnated with test substance, against Eurotium repens (antifungal activity) | 2002 | Journal of medicinal chemistry, Jul-04, Volume: 45, Issue:14 | Lepadins D-F: antiplasmodial and antitrypanosomal decahydroquinoline derivatives from the tropical marine tunicate Didemnum sp. |
| AID1738748 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as inhibition of ergosterol biosynthesis by measuring ergosterol content at 8 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1147011 | Antifungal activity against Candida albicans infected in mouse assessed as noninfected animals at 4% formulation in neat PEG 400 solution administered vaginally bid for 4 days measured 6 hrs post last dose relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID681142 | TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in MDR1-expressing LLC-PK1 cells | 2002 | Molecular pharmacology, May, Volume: 61, Issue:5 | Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. |
| AID257549 | Antifungal activity against Candida parapsilosis | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID245682 | In vitro minimal inhibitory concentration against Candida albicans with percentage of resistant strains %R = 33.33 (MIC > 64 ug/mL) at a range of 0.062-2 ug/mL | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies. |
| AID1575912 | Fungicidal activity against Candida parapsilosis MTCC 1744 assessed as fungal killing incubated for 24 hrs | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2- |
| AID48249 | Inhibitory activity against Candida. species. (40 clinical isolates), determined at pH-5.8 | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents. |
| AID1391549 | Fungicidal activity against Candida glabrata MTCC 3019 incubated for 24 hrs followed by transfer of microbial suspension to Sabouraud dextrose agar plates and measured after 24 hrs post transfer | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID348627 | Antibacterial activity against Staphylococcus aureus ATCC 29213 at 10 ug/disk after 24 to 48 hrs by disc-diffusion method | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. |
| AID532559 | Antifungal activity against Saccharomyces cerevisiae BY4741 assessed as growth rate at 2 ug/ml (Rvb = 0.144%) | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. |
| AID310056 | Antimicrobial activity against Candida glabrata 123 after 48 hrs | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23 | Synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to P450(14DM) by molecular docking and MM/PBSA method. |
| AID454195 | Antifungal activity against Candida albicans NCIM 347 by standard agar plate method | 2010 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2 | One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agents. |
| AID310102 | Antifungal activity against Candida albicans by disc diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine. |
| AID572698 | Selectivity ratio, ratio of Kd for Mycobacterium smegmatis ATCC 700084 CYP164A2 to Kd for Mycobacterium smegmatis ATCC 700084 CYP51 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. |
| AID70206 | In vitro antifungal activity against Epidermophyton floccosum | 1983 | Journal of medicinal chemistry, Mar, Volume: 26, Issue:3 | Synthesis of (E)-1-(5-chlorothien-2-yl)-2-(1H-imidazol-1-yl)ethanone 2,6-dichlorophenylhydrazone hydrochloride, a novel, orally active antifungal agent. |
| AID490026 | Antifungal activity against Candida albicans at 200 ug/ml after 7 days | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Some new biologically active metal-based sulfonamide. |
| AID48453 | Tested in vitro for antifungal activity against Candida species. at pH 5.8; (percent of resistant species at 256 ug/mL) | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID378566 | Antimicrobial activity against Mycotypha microspora at 50 ug/filter disk | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua. |
| AID1759390 | Antifungal activity against Saccharomyces cerevisiae MTCC 1344 assessed as zone of inhibition at 36 uM incubated for 2 days by cross streak plate method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents. |
| AID125942 | Minimum inhibitory concentration against Microsporum canis at a pH of 5.7 using SDB medium | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency. |
| AID1315459 | Antifungal activity against Candida albicans MTCC 3018 after 24 hrs by well diffusion method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Total synthesis and in vitro bioevaluation of clavaminols A, C, H & deacetyl clavaminol H as potential chemotherapeutic and antibiofilm agents. |
| AID1337841 | Antifungal activity against Candida albicans NCIM 3471 by standard agar method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1310562 | Fungicidal activity against Candida albicans MTCC 7315 incubated for 24 hrs | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID1718977 | Inhibition of electric eel AChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by Ellman's method | 2021 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 34 | Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID1783793 | Inhibition of CYP3A4 in human liver microsome using Nifedipine as a substrate incubated for 10 mins in the presence of NADPH by LC-MS/MS analysis | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. |
| AID434363 | Antifungal activity against sTrichophyton mentagrophytes after 96 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID515780 | Intrinsic solubility of the compound in water | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19 | QSAR-based solubility model for drug-like compounds. |
| AID1162425 | Antimicrobial activity against Aspergillus niger ATCC 6275 after 48 hrs by two-fold broth dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | A new efficient route to 7-aryl-6-fluoro-8-nitroquinolones as potent antibacterial agents. |
| AID740186 | Antifungal activity against Candida albicans NCIM 3471 by agar method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Microwave assisted nano (ZnO-TiO2) catalyzed synthesis of some new 4,5,6,7-tetrahydro-6-((5-substituted-1,3,4-oxadiazol-2-yl)methyl)thieno[2,3-c]pyridine as antimicrobial agents. |
| AID48267 | Tested in vitro for antifungal activity against Candida species. at pH 5.8 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID230894 | Ratio of animals cured to that of animals infected, tested in vivo for antifungal activity against cutaneous candidosis in guinea pig; 4/13 | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID1389642 | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by modified Ellman assay | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID336238 | Antimicrobial activity against Trichophyton mentagrophytes at 10 ug/disk | |||
| AID1758025 | Fungicidal activity against Candida albicans CPCC400616 assessed as fungal killing incubated for 48 hrs followed by culturing on PDA plate for 24 hrs | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1320271 | Antimicrobial activity against Micrococcus luteus MTCC 2470 incubated for 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A diastereoselective synthesis of tetrahydro- and dihydro-pyrido[2,3-c]coumarin derivatives via a one-pot three-component Povarov reaction catalyzed by bismuth(III) chloride. |
| AID1327761 | Antimicrobial activity against Candida albicans MTCC7315 measured after 24 hrs by well-diffusion method | |||
| AID356327 | Antifungal activity against Aspergillus fumigatus IFM 41374 after 48 to 96 hrs by broth microdilution method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID1210014 | Inhibition of recombinant CYP2J2 (unknown origin)-mediated astemizole O-demethylation assessed as remaining activity at 30 uM after 5 mins by LC-MS/MS analysis relative to control | 2012 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 40, Issue:5 | Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. |
| AID1320275 | Antimicrobial activity against Escherichia coli MTCC 739 incubated for 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | A diastereoselective synthesis of tetrahydro- and dihydro-pyrido[2,3-c]coumarin derivatives via a one-pot three-component Povarov reaction catalyzed by bismuth(III) chloride. |
| AID1849456 | Inhibition of CYP2D6 in mouse liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis | |||
| AID1684683 | Fungicidal activity against Candida aaseri MTCC 1962 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID45345 | In vitro antifungal activity against 40 strains of Candida albicans at pH 7.2 | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13 | Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. |
| AID625834 | Antifungal activity against Aspergillus fumigatus by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID1738747 | Inhibition of CYP51 in azole-resistant Candida albicans ATCC SC531 assessed as Eburicol level at 8 ug/ml incubated for 16 hrs by LC-MS analysis relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1758004 | Antifungal activity against Cryptococcus neoformans CMGCC2.3161 measured after 72 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID1267295 | Antibacterial activity against Staphylococcus aureus MLS-16 MTCC 2940 after 24 hrs by well diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1 | Synthesis and biological evaluation of novel lipoamino acid derivatives. |
| AID1738725 | Hemolytic activity in rabbit RBC assessed as hemolysis ratio at 4 ug/ml measured after 3 hrs relative to control | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. |
| AID1063217 | Antiproliferative activity against human DG75 cells at 10 uM after 72 hrs by Alamar blue assay | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and antiproliferative action of a novel series of maprotiline analogues. |
| AID244898 | In-vitro minimum inhibitory concentration against the growth of Aspergillus fumigatus | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID1391535 | Antifungal activity against Candida glabrata MTCC 3019 after 24 hrs by well diffusion method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking. |
| AID551058 | Antifungal activity against Aspergillus flavus assessed as macroscopically visible colonies after 48 and 72 hrs by standard agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. |
| AID1389632 | Hepatotoxicity in ICR mouse assessed as serum AST activity at 10 mg/kg, ig after 8 hrs (Rvb = 96.5 +/- 9.3 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1600770 | Bactericidal activity against Escherichia coli MTCC 739 assessed as reduction in bacterial survival incubated for 24 hrs followed by transfer of microbial suspension to agar plates and measured at 24 hrs post transfer by agar well diffusion method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors. |
| AID1311357 | Antifungal activity against Aspergillus niger by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis and antimicrobial evaluation of novel ethyl 2-(2-(4-substituted)acetamido)-4-subtituted-thiazole-5-carboxylate derivatives. |
| AID1150039 | Antifungal activity against Candida tropicalis assessed as lowest dose level for total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1684690 | Fungicidal activity against Candida albicans MTCC 854 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1684685 | Fungicidal activity against Candida albicans MTCC 4748 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID48242 | Antifungal activity against Candida rugosa | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents. |
| AID1310545 | Antifungal activity against Candida glabrata MTCC 3019 incubated for 24 hrs at 30 degC by well diffusion method | 2016 | European journal of medicinal chemistry, Aug-08, Volume: 118 | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. |
| AID352612 | Antifungal activity against Trichophyton mentagrophytes after 96 hrs by micro broth dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. |
| AID1504834 | Antifungal activity against Candida albicans ATCC 10231 after 24 hrs by agar dilution method | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12 | Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis. |
| AID1146961 | Antifungal activity against mixed infection of Candida albicans infected in mouse assessed as noninfected animals at 0.5% formulation administered vaginally bid for 4 days measured on day 7 relative to placebo | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent. |
| AID1389641 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by modified Ellman assay | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1291279 | Fungicidal activity against Candida albicans MTCC 7315 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1389624 | Hepatotoxicity in ICR mouse assessed as serum ALT activity at 50 mg/kg, ig after 22 hrs (Rvb = 34.7 +/- 2.0 U/L) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
| AID1758006 | Antifungal activity against Candida glabrata measured after 24 hrs by broth microdilution assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. |
| AID696186 | Antifungal activity against Fusarium solani MTCC 350 after 2 to 3 days by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 22, Issue:21 | Synthesis, anti-inflammatory and antimicrobial evaluation of novel 1-acetyl-3,5-diaryl-4,5-dihydro (1H) pyrazole derivatives bearing urea, thiourea and sulfonamide moieties. |
| AID1327759 | Antimicrobial activity against Candida albicans MTCC3017 measured after 24 hrs by well-diffusion method | |||
| AID1700247 | Antifungal activity against Candida albicans ATCC 7754 | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Synthesis and biological screening of thiosemicarbazones of substituted 3-acetylcoumarins having d-glucose moiety. |
| AID1291280 | Fungicidal activity against Candida parapsilosis MTCC 1744 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID39542 | Antifungal activity against Aspergillus fumigatus | 1981 | Journal of medicinal chemistry, Nov, Volume: 24, Issue:11 | Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles. |
| AID1150060 | Antifungal activity against Phialophora verrucosa assessed as lowest dose required to total inhibition of fungal growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID658668 | Antifungal activity against Fusarium solani by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10 | A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: synthesis, anti-inflammatory and antimicrobial evaluation. |
| AID1291284 | Fungicidal activity against Issatchenkia hanoiensis MTCC 4755 after 24 hrs by serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID356323 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 to 96 hrs by broth microdilution method | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species. |
| AID1150046 | Antibacterial activity against Erysipelothrix insidiosa assessed as lowest dose level for total inhibition of bacterial growth | 1977 | Journal of medicinal chemistry, Nov, Volume: 20, Issue:11 | Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. |
| AID1303000 | Fungicidal activity against Candida albicans MTCC 3017 after 24 hrs by serial dilution method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID319921 | Antifungal activity against Aspergillus niger PTCC 5012 after 72 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1 | 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. |
| AID48631 | Antifungal activity against Candida tropicalis; Range is 8-16 | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents. |
| AID1634154 | Inhibition of CYP3A4 (unknown origin) | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16 | Strategies for the development of highly selective cytochrome P450 inhibitors: Several CYP targets in current research. |
| AID1130385 | Antifungal activity against Staphylococcus haemolyticus assessed as growth inhibition in sabouraud broth after 14 days | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID1293882 | Antifungal activity against Fusarium oxysporum NCIM 1332 after 48 hrs by agar cup plate method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation. |
| AID519608 | Selectivity index, ratio of TC50 for hepatocytes to IC50 for Plasmodium yoelii | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | New active drugs against liver stages of Plasmodium predicted by molecular topology. |
| AID1291261 | Antimicrobial activity against Candida aaseri MTCC 1962 assessed as growth inhibition after 24 hrs by agar well diffusion method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Synthesis, characterization, antimicrobial and biofilm inhibitory studies of new esterquats. |
| AID1446844 | Antifungal activity against Candida albicans MTCC 3018 after 24 hrs by well diffusion method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Synthesis of novel pyrazolo[3,4-b]quinolinyl acetamide analogs, their evaluation for antimicrobial and anticancer activities, validation by molecular modeling and CoMFA analysis. |
| AID39535 | Antimycotic activity against Aspergillus fumigatus was evaluated as compound minimum inhibitory concentration at which no macroscopic signs of fungal growth were detected. | 1999 | Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14 | Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine with potent antitumor and antimicrobial activity. |
| AID1684680 | Fungicidal activity against Candida glabrata MTCC 3019 | 2021 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 33 | 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. |
| AID1718976 | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by Ellman's method | 2021 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 34 | Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies. |
| AID766642 | Antifungal activity against Candida glabrata MTCC 3019 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID1130391 | Antifungal activity against Aspergillus fumigatus assessed as growth inhibition in sabouraud broth after 14 days in presence of 10% inactivated bovine serum | 1979 | Journal of medicinal chemistry, Aug, Volume: 22, Issue:8 | Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent. |
| AID766649 | Antifungal activity against Candida albicans MTCC 1637 after 24 hrs by well diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Total synthesis and biological evaluation of clavaminol-G and its analogs. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745849 | Viability Counterscreen for CMV-Luciferase Assay of Inhibitors of ATXN expression | |||
| AID1745847 | CMV-Luciferase Counterscreen for Inhibitors of ATXN expression | |||
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745848 | Confirmatory qHTS for Inhibitors of ATXN expression | |||
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745850 | Viability Counterscreen for Confirmatory qHTS for Inhibitors of ATXN expression | |||
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1346628 | Human TRPM2 (Transient Receptor Potential channels) | 2008 | British journal of pharmacology, Mar, Volume: 153, Issue:6 | Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1799791 | Binding Assay from Article 10.1074/jbc.M110.164293: \\Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.\\ | 2010 | The Journal of biological chemistry, Dec-03, Volume: 285, Issue:49 | Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. |
| AID1799166 | In Vitro HO Activity Assay from Article 10.1124/jpet.106.102699: \\Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs.\\ | 2006 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 319, Issue:1 | Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 837 (38.91) | 18.7374 |
| 1990's | 380 (17.67) | 18.2507 |
| 2000's | 399 (18.55) | 29.6817 |
| 2010's | 441 (20.50) | 24.3611 |
| 2020's | 94 (4.37) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (73.14) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 238 (10.31%) | 5.53% |
| Reviews | 122 (5.28%) | 6.00% |
| Case Studies | 374 (16.20%) | 4.05% |
| Observational | 1 (0.04%) | 0.25% |
| Other | 1,574 (68.17%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Investigator-blinded, Active-controlled Phase 3 Study to Prove the Non-inferior Efficacy of a Clotrimazole Ovule (500 mg) Versus a Clotrimazole Vaginal Tablet (500 mg) in Vaginal Candidiasis [NCT00755053] | Phase 3 | 466 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| A Prospective, Case-controlled Randomized Study of Human Reproductive Tract Active Lactobacillus in Adjuvant Treatment of Recurrent Vulvovaginal Candidiasis. [NCT04699240] | Phase 4 | 140 participants (Anticipated) | Interventional | 2020-07-01 | Recruiting | ||
| The First Affiliated Hospital of Guangxi Medical University [NCT03819348] | 1,200 participants (Actual) | Observational | 2003-01-01 | Active, not recruiting | |||
| Randomized, Double-blind, Phase III Study of the Efficacy and Safety of Miconazole Oil Versus Vehicle Oil in the Treatment of Otomycosis, Followed by an Open-label Safety Evaluation [NCT04432376] | Phase 2/Phase 3 | 382 participants (Actual) | Interventional | 2020-07-08 | Completed | ||
| Posaconazole Oral Suspension and Itraconazole Oral Solution in Preventing Invasive Fungal Disease (IFD) in Patients With Hematopoietic Stem Cell Transplantation [NCT03631602] | Phase 2/Phase 3 | 120 participants (Anticipated) | Interventional | 2017-10-01 | Recruiting | ||
| Efflux Pump Mediated Azole Resistance in Candida Albicans Among Neutropenic Patients With Haematological Malignancies [NCT03659162] | 100 participants (Anticipated) | Observational | 2019-02-17 | Not yet recruiting | |||
| Atavistic Chemotherapy and Immunotherapy in Advanced, Metastatic, and Otherwise Incurable and Lethal Cancers Under Conventional Treatments [NCT02366884] | Phase 2 | 250 participants (Anticipated) | Interventional | 2011-07-26 | Recruiting | ||
| Effects of Antimicrobials on the Altered Skin Flora in Patients With Palmar Arsenical Keratosis [NCT03632733] | Phase 2 | 30 participants (Anticipated) | Interventional | 2018-01-21 | Recruiting | ||
| Observational Program Neo-Penotran® Forte [NCT01335373] | 13,024 participants (Actual) | Observational | 2010-10-31 | Completed | |||
| Uptake of the Antifungal Miconazole and Effect on Estrogen Metabolizing Enzymes in Humans [NCT00668538] | 20 participants (Actual) | Interventional | 2008-04-30 | Completed | |||
| HT201309- Human Photoallergy Test [NCT04532164] | Phase 3 | 137 participants (Actual) | Interventional | 2013-06-10 | Completed | ||
| B-Lymphocyte Immunotherapy in Islet Transplantation: Single Subject Modification to Calcineurin-Inhibitor Based Immunosuppression for Initial Islet Graft (CIT-0501) [NCT01049633] | 0 participants | Expanded Access | No longer available | ||||
| A Prospective Randomized, Blinded Parallel Group Study of Clotrimazole Troches vs. Mycelex® Troches (10 mg Troche Five Times a Day for 14 Days) in Patients With Human Insufficiency Virus (HIV) Infection for the Treatment of Oropharyngeal Candidiasis [NCT02184351] | Phase 3 | 187 participants (Actual) | Interventional | 2001-05-31 | Completed | ||
| Clinical Study to Evaluate System Safety and Clinical Performance of the SecuraTM ICD [NCT00526227] | 81 participants (Actual) | Interventional | 2007-10-31 | Completed | |||
| International Pediatric Fungal Network: Multi-Center Studies to Improve Diagnosis and Treatment of Pediatric Candidiasis [NCT01869829] | 750 participants (Actual) | Observational [Patient Registry] | 2015-01-31 | Completed | |||
| Validation of a Novel Diagnostic, Prognostic Assay for Bacterial Vaginosis [NCT02185456] | Early Phase 1 | 200 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting | ||
| "Study Clinical, Multicenter, Phase III, to Evaluate the Efficacy and Safety of Tolnaftate Cream in the Treatment of Patients With Fungal Infections Like Tinea Foot, Tinea and Tinea Crural Body" [NCT01105013] | Phase 3 | 90 participants (Anticipated) | Interventional | 2012-04-30 | Not yet recruiting | ||
| Interferon-gamma as Adjunctive Therapy in Chronic Pulmonary Aspergillosis: a Randomised Feasibility Study [NCT05653193] | Phase 2 | 50 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| A Phase II Trial of Allogeneic Peripheral Blood Stem Cell Transplantation From Family Haploidentical Donors in Patients With Myelodysplastic Syndrome and Acute Leukemia Under Primary Antifungal Prophylaxis With Posaconazole. [NCT03434704] | Phase 2 | 10 participants (Actual) | Interventional | 2018-06-18 | Completed | ||
| Randomized Comparison of β-D-Glucan Surveillance With Preemptive Anidulafungin Versus Standard Care for the Management of Invasive Candidiasis in Surgical Intensive Care Unit Patients [NCT00672841] | 64 participants (Actual) | Interventional | 2008-06-30 | Completed | |||
| Randomized, Double-blind, Phase III Study of the Efficacy and Safety of Miconazole Oil, Active Versus Placebo in the Treatment of Otomycosis [NCT05660382] | Phase 3 | 100 participants (Anticipated) | Interventional | 2023-05-31 | Not yet recruiting | ||
| Prospective 2-Year Longitudinal Study to Assess for Miconazole Resistance in Candida Spp. With Repeated Treatment Courses of 0.25% Miconazole Nitrate Ointment in Neonates and Infants up to 1 Year of Age With Recurrent Moderate-Severe Diaper Dermatitis Com [NCT00702507] | Phase 4 | 200 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| "Dynamic Thoracic Impedance as a Marker for Heart Failure Decompensation: A Pilot Trial of the Dynamic Thoracic Impedance Bed Rest Test" [NCT02134379] | 11 participants (Actual) | Observational | 2014-04-30 | Completed | |||
| REperfusion With Cooling in CerebraL Acute IscheMia II [NCT02411877] | Phase 2 | 0 participants (Actual) | Interventional | 2016-02-29 | Withdrawn(stopped due to It was decided that it was not feasible to continue this study.) | ||
| A Phase 2, Randomized, Double-Blind, Active-Controlled Study to Evaluate the Efficacy and Safety of Miconazole Nitrate 2% + Domiphen Bromide Vaginal Cream in the Treatment of Subjects With Acute Vulvovaginal Candidiasis [NCT04813822] | Phase 2 | 90 participants (Anticipated) | Interventional | 2021-09-13 | Recruiting | ||
| An Individualized Administration Research of Voriconazole Based on CYP2C19 Gene Polymorphism and Therapeutic Drug Monitoring in Chinese Patients With Invasive Pulmonary Infection [NCT04004078] | 314 participants (Actual) | Observational | 2018-03-01 | Completed | |||
| Analysis of the Outcomes of Photoactivated Chromophore for Keratitis Cross _linking for Treatment of Infectious Keratitis [NCT05881187] | 60 participants (Anticipated) | Interventional | 2023-06-15 | Not yet recruiting | |||
| Fluconazole Versus Micafungin in Neonates With Suspected or Culture-proven Candidiasis: a Randomized Pharmacokinetic and Safety Study (TINN Project - Treat Infections iN Neonates) [NCT02145832] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2014-06-30 | Not yet recruiting | ||
| A Randomized, Parallel-Group, Multicentre, Open-Labelled, Active-Controlled Study to Assess the Efficacy, Safety and Tolerability of RV4104A Ointment Versus Bifonazole-Urea Ointment for the Complete Removal of the Clinically Infected Nail Plate Area in Pa [NCT00808366] | 228 participants (Anticipated) | Interventional | 2008-10-31 | Recruiting | |||
| AN OPEN-LABEL, RANDOMISED TRIAL, WITH A THREE-PERIOD CROSSOVER PART IN HEALTHY HIV-NEGATIVE WOMEN TO ASSESS THE DRUG-DRUG INTERACTION POTENTIAL BETWEEN DAPIVIRINE VAGINAL RING-004, CONTAINING 25 MG OF DAPIVIRINE, AND CLOTRIMAZOLE 10 mg/g (1%) ADMINISTERED [NCT02847286] | Phase 1 | 36 participants (Actual) | Interventional | 2015-09-01 | Completed | ||
| An Open Label Study in Healthy Volunteers to Evaluate the Potential for Drug/Drug Interactions Between F901318 and Fluconazole [NCT02730442] | Phase 1 | 20 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Efficacy of Slow Release Clotrimazole Varnish Treating Denture Stomatitis [NCT00835029] | Phase 2 | 13 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis [NCT04308161] | Phase 2 | 45 participants (Anticipated) | Interventional | 2019-11-02 | Recruiting | ||
| Phase 3 Study, Randomized, Double-blind, Parallel to Evaluate Ketoconazole and Betamethasone Dipropionate(Candicort®) Compared to Clotrimazole and Dexamethasone Acetate(Baycuten N®) in Relief of Fungal Infections/Dermatophytosis Symptoms. [NCT02582177] | Phase 3 | 125 participants (Actual) | Interventional | 2019-06-11 | Completed | ||
| Empirical Antifungal Treatment in Neutropenic Patients Stratified by Risk: Prospective Validation of an Algorithm Based on the D-index [NCT00982540] | 28 participants (Actual) | Interventional | 2010-02-28 | Terminated(stopped due to Low accrual) | |||
| Efficacy of Standardized-propolis Extract (EPP-AF®) Gel Formulation as Buccal Antiseptic in Elderly People [NCT02818803] | Phase 3 | 40 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| F901318 - A Phase I, Double-Blind, Placebo Controlled, Multiple Ascending Oral Dose Safety, Tolerability and Pharmacokinetic Study in Healthy Male and Female Subjects [NCT02737371] | Phase 1 | 40 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| A Comparative Open Labeled Clinical Study to Evaluate the Efficacy and Tolerability of Two Different Intravaginal Formulations Containing a Combination of Clindamycin and Clotrimazole in Vaginal Infections [NCT01697826] | Phase 4 | 73 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| ANTIVORIFUNGOL:Strategy of Antifungal Use in Oncohematological Neutropenic Patients. Use of Voriconazole as Early Treatment. [NCT00386802] | Phase 4 | 115 participants (Anticipated) | Interventional | 2006-08-31 | Completed | ||
| Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) [NCT00000676] | Phase 3 | 500 participants | Interventional | Completed | |||
| A Comparative Randomized, Double-blind, Double-Dummy, Multicenter Study of the Efficacy and Safety of Miconazole Lauriad 50mg Administered Once a Day and Mycelex Troches (Clotrimazole 10mg) Administered Five Times a Day in the Treatment of Oropharyngeal C [NCT00390780] | Phase 3 | 578 participants (Actual) | Interventional | 2006-07-31 | Completed | ||
| Vaginal Imaging Study to Evaluate the Effect of Exercise on the Distribution of Miconozole Nitrate OVULE [NCT00194324] | Phase 4 | 12 participants | Interventional | 2004-07-31 | Completed | ||
| An Open Label, Multi-Center Study to Determine the Safety and Pharmacokinetics of Intravenous and Oral APX001 in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia With Neutropenia [NCT03333005] | Phase 1 | 20 participants (Actual) | Interventional | 2017-11-27 | Completed | ||
| Observational Prospective Multicenter Study to Evaluate the Infective Risk in Myelodysplastic Syndrome Patients: Antimicrobial Prophylaxis and Granulocyte Growth Factors. [NCT01951430] | 229 participants (Actual) | Observational | 2014-03-31 | Completed | |||
| The Effect of Topical Chamomile in the Prevention of Chemotherapy-induced Oral Mucositis (a Randomized Controlled Clinical Trial) [NCT04317183] | Phase 2 | 45 participants (Anticipated) | Interventional | 2019-05-15 | Recruiting | ||
| A Multicentre, Randomized, Controlled Study of the Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer Alone for the Trea [NCT01014637] | Phase 4 | 260 participants (Anticipated) | Interventional | 2009-08-31 | Recruiting | ||
| The Role of Fractional CO2 Laser in Consolidation Treatment of Recurrent Vulvovaginal Candidiasis (RVVC) ：a Study Protocol for a Randomized Controlled Trial [NCT04292704] | 205 participants (Anticipated) | Interventional | 2019-12-13 | Recruiting | |||
| Phase III, Multicenter, Randomized, Parallel, Open Label, Controlled and Comparative Study to Evaluate the Efficacy and Safety of the Association of Clotrimazole 200mg and Metronidazole 0,75% (Colpistatin 5DT®) Compared to Gynecological Flagyl®(Metronidaz [NCT02713139] | Phase 3 | 0 participants (Actual) | Interventional | 2013-09-30 | Withdrawn(stopped due to Due to budget limitations, the company decided to withdraw this study.) | ||
| Clotrimazole Enemas for Pouchitis in Children and Adults [NCT00061282] | Phase 1/Phase 2 | 11 participants (Actual) | Interventional | 2002-09-30 | Terminated(stopped due to Funding Horizon) | ||
| Comparative Study of the Efficacy and Safety of LactiSal 1% Vaginal Gel and LactSal 50 mg Vaginal Tablet Versus Clotrimazole 100 mg Vaginal Tablet in the Treatment of Vulvovaginal Candidiasis (VVC) [NCT02907307] | Phase 3 | 0 participants (Actual) | Interventional | 2018-12-31 | Withdrawn(stopped due to Development project stopped) | ||
| Detection of Bloodstream Pathogens in Hematological Malignancies [NCT03896880] | 139 participants (Actual) | Observational | 2020-01-01 | Completed | |||
| Empirical Steroids and/or Antifungals in Immunocompromised Patients With Acute Respiratory Failure From Undetermined Etiology: a Multicenter Double-blind Randomized Controlled Trial [NCT04680884] | Phase 3 | 420 participants (Anticipated) | Interventional | 2020-12-21 | Not yet recruiting | ||
| The Incidence of Invasive Aspergillosis in Acute Myeloid Leukemia [NCT02900430] | 246 participants (Actual) | Observational | 2009-01-31 | Completed | |||
| [NCT00004404] | 20 participants (Anticipated) | Interventional | 1997-04-30 | Completed | |||
| Isolation and Comparative Efficacy of the Combination of beclometasona0, 025% + Gentamicin 0.1% + Clotrimazole 1% Topical Dermatological Cream of GLENMARK PHARMACEUTICALS, in Patients Infected With Acne [NCT01244256] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2007-04-30 | Suspended | ||
| A Double-Blind, Randomized Trial of Monthly Treatment With Topical Metronidazole and Miconazole Co-formulated Vaginal Suppositories Versus Placebo for Preventing Vaginal Infections in HIV-seronegative Women [NCT01230814] | Phase 2 | 234 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Prospective Multicentre Randomized Double-blind Study Comparing Caspofungin to Placebo for the Treatment of ICU Intra-abdominal Candidiasis [NCT03580733] | Phase 3 | 448 participants (Anticipated) | Interventional | 2019-01-01 | Recruiting | ||
| Epidemiological Study About the Clinical and Microbiological Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis. [NCT02248506] | Phase 4 | 56 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Dr. Bill Antifungal Nail Gel Study [NCT04341402] | Phase 2 | 30 participants (Anticipated) | Interventional | 2020-05-01 | Recruiting | ||
| Phase III Study in Hygienic Socks With Antifungal Agent-loaded Microcapsules for Patients With Tinea Pedis [NCT01524432] | Phase 1 | 42 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| A Randomized Multicenter Study of the Efficacy, Safety, and Toleration of Fluconazole or Clotrimazole Troches in the Treatment of Patients With Oropharyngeal Candidiasis in Association With the Acquired Immunodeficiency Syndrome [NCT00002282] | 0 participants | Interventional | Completed | ||||
| Effectiveness of 3% Boric Acid in 70% Alcohol Versus 1% Clotrimazole Solution in Otomycosis Patients: a Randomized Controlled Trial [NCT01547221] | 120 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| Double-blind Evaluation of the Safety and Efficacy of Quadriderme® (Betamethasone Diproprionate, Clotrimazole and Gentamicin) Compared With Betamethasone Diproprionate Combined With Gentamicin Sulfate and With Betamethasone Diproprionate in the Treatment [NCT00671528] | Phase 4 | 3 participants (Actual) | Interventional | 2009-07-31 | Terminated(stopped due to terminated early due to lack of recruitment [only 3 of 207 subjects were enrolled]) | ||
| A Multicenter Cohort Study of the Short and Long-term Safety of Micafungin and Other Parenteral Antifungal Agents [NCT01686607] | 40,110 participants (Actual) | Observational | 2012-10-01 | Completed | |||
| A Randomised Controlled Trial of Single Dose Tinidazole+Fluconazole Versus Longer Courses of Metronidazole+Clotrimazole in the Management of West African Women With Vaginal Discharge [NCT00313131] | Phase 3 | 1,524 participants | Interventional | 2004-01-31 | Completed | ||
| Factors on Therapeutic Drug Monitoring and Safety of Voriconazole in Critically Ill Elderly Patients: A Prospective Observational Study [NCT06137690] | 550 participants (Anticipated) | Observational | 2018-07-01 | Recruiting | |||
| Double Blind Randomized Study of 2% Miconazol Versus 4% Hydroquinone in the Treatment for Melasma. [NCT01661556] | Phase 4 | 60 participants (Anticipated) | Interventional | 2011-10-31 | Recruiting | ||
| An Open-Label Clinical Case Series to Demonstrate Efficacy of the Kendall Skin Wellness System [NCT01724229] | 20 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| An Open-label, Randomized, Three-period Crossover Trial in Healthy HIV-negative Women to Assess the Drug-drug Interaction Between Dapivirine Vaginal Ring-004 and Miconazole Nitrate [NCT01731574] | Phase 1 | 36 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Effectiveness and Safety of Daktacort Feminine Care Cream in the Treatment of Vulvar Candidiasis [NCT01769339] | Phase 4 | 115 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Multicenter Pilot Study to Compare the Efficacy of a Combination of Vaginal Capsules With Acid Boric, L.Gasseri and L.Rhamnosus Versus the Reference Medication in Patients With Vaginal Candidiasis or Bacterial Vaginosis [NCT02860845] | Phase 4 | 48 participants (Actual) | Interventional | 2016-07-12 | Completed | ||
| Dose-Ranging Study of the Efficacy and Safety of Miconazole Oil Used for 7 or 14 Days Compared With Vehicle in the Treatment of Otomycosis [NCT03130738] | Phase 2 | 65 participants (Actual) | Interventional | 2017-04-20 | Completed | ||
| [NCT00004492] | Phase 1/Phase 2 | 20 participants (Anticipated) | Interventional | 1999-10-31 | Completed | ||
| Prospective, Non-interventional, Post-marketing, Multi-center, Single-cohort, Safety (Questionnaire) Investigation of Empecid L Cream (Clotrimazole 1%) [NCT03599323] | 1,033 participants (Actual) | Observational | 2018-07-10 | Completed | |||
| The Use of Campath-1H, Tacrolimus, and Sirolimus Followed by Sirolimus Withdrawal in Renal Transplant Patients [NCT00078559] | Phase 1/Phase 2 | 10 participants (Actual) | Interventional | 2003-11-30 | Completed | ||
| Therapeutic Drug Monitoring of Antifungals in Patients From Intensive Care Units: a Retrospective Study [NCT04502771] | 200 participants (Actual) | Observational | 2018-01-01 | Completed | |||
| Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth (A Randomized Controlled Clinical Trial) [NCT04390854] | Phase 2 | 30 participants (Actual) | Interventional | 2018-07-06 | Completed | ||
| Comparative Evaluation of Two PRF Formulations on Quality of Life and 2D and 3D Assessment of Healing Outcome of Apicomarginal Defects. [NCT04396743] | 32 participants (Anticipated) | Interventional | 2019-12-11 | Recruiting | |||
| A Phase II, Multicenter, Randomized, Open-label, Active Controlled Study to Evaluate the Safety and Efficacy of Micafungin Salvage Mono-therapy Versus Active Control Intravenous Salvage Mono-therapy in Patients With Invasive Aspergillosis [NCT00376337] | Phase 2 | 17 participants (Actual) | Interventional | 2006-06-30 | Terminated(stopped due to Study was stopped due to difficulties in recruitment and changes in standard care for invasive aspergillosis) | ||
| Investigation of Miconazole as an Inhibitor of Endothelium-Derived Hyperpolarizing Factor [NCT00004575] | Phase 1 | 15 participants | Interventional | 2000-02-29 | Completed | ||
| Effect of Blue Light Emitting Diode Therapy on Recurrent Vulvovaginal Candidiasis [NCT05795491] | 60 participants (Anticipated) | Interventional | 2023-04-30 | Enrolling by invitation | |||
| Clinical Evaluation of Glutamine Combined With Topical Corticosteroids in the Treatment of Erosive Oral Lichen Planus [NCT04442633] | 30 participants (Actual) | Interventional | 2019-04-01 | Completed | |||
| Effectiveness of 4% Boric Acid in Distilled Water Versus Clotrimazole Solution in Otomycosis Patients. [NCT04824261] | 100 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | |||
| Phenotypic and Genotypic Characterization of Malassezia Species Isolated From Malassezia Associated Skin Diseases [NCT05476731] | 100 participants (Anticipated) | Observational | 2022-08-31 | Not yet recruiting | |||
| A Phase IIa Randomized, Active-controlled, Double-blind, Dose-escalation Study in Patients With Vulvovaginal Candidiasis to Evaluate Dose Response Relationship of Clinical Efficacy, Safety and Tolerability of Topically Administered ProF-001 [NCT03115073] | Phase 2/Phase 3 | 84 participants (Actual) | Interventional | 2017-04-04 | Completed | ||
| Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis [NCT02328053] | 20 participants (Anticipated) | Interventional | 2014-02-28 | Recruiting | |||
| (1-3)-Beta-D-Glucan Driven vs. Empirical Antifungal Therapy in High Risk Critically Ill Patients A Randomized Study [NCT03117439] | 120 participants (Actual) | Interventional | 2016-07-31 | Completed | |||
| "The Effect of Using Preparations With Maqui Berry Extract in Treating Oral Candidiasis in Patients With Diabetes Mellitus and Systemically Healthy Persons" [NCT05916729] | Phase 4 | 90 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | ||
| An Case-controlled Randomized Study to the Efficacy of Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis [NCT02180828] | Phase 4 | 240 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Randomized Clinical Trial of a Mucoadhesive Gel Containing EPP-AF in Patients Diagnosed With Vulvovaginal Candidiasis [NCT03024502] | Phase 1/Phase 2 | 90 participants (Anticipated) | Interventional | 2018-01-30 | Recruiting | ||
| Pharmacokinetic Evaluation of Sublingual Versus Oral Tacrolimus Administration in Patients Awaiting Kidney Transplantation [NCT00629122] | Phase 4 | 5 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Randomized Multicenter Crossover Study to Compare the Plasmat® Futura Heparin Induced Extracorporeal Lower Density Lipo-Protein (LDL) Precipitation (H.E.L.P.) Apheresis System to the Approved Secura System in the Reduction of LDL-c in Patients With Hyperc [NCT00526058] | 18 participants (Actual) | Interventional | 2007-08-31 | Completed | |||
| Prospective Evaluation of the Effects of Topical Therapy With Sulfamylon® For 5% Topical Solution on Autograft Healing in Subjects With Thermal Injuries Requiring Meshed Autografts: A Comparison to a Historical Control Group [NCT00634166] | Phase 4 | 220 participants (Actual) | Interventional | 2007-09-30 | Terminated(stopped due to FDA request as study could not serve as the confirmatory trial.) | ||
| Randomized Clinical Trial for Treatment of Candidal Vulvovaginitis Using Cumin Seed Extract Vaginal Suppositories. [NCT03005353] | Phase 2/Phase 3 | 100 participants (Actual) | Interventional | 2018-03-01 | Completed | ||
| A Phase III, Multicenter, Randomized, Double-blind, Parallel Group, Active Treatment-controlled Study Assessing the Safety and Efficacy of G238 Compared to Clotrimazole 1% Otic Solution in Patients With Otomycosis [NCT01993823] | Phase 3 | 190 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| Clinical Study of Non-inferiority (Phase 2), Comparing Dapaconazole (BL123 - Biolab Sanus Farmacêutica Ltda.) Versus Miconazole Nitrate (União Química) in Patients With a Single Lesion of Tinea Cruris. [NCT03359070] | Phase 2 | 51 participants (Actual) | Interventional | 2014-01-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||