Proteins > Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
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Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
A rod cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha that is encoded in the genome of cow. [OMA:P11541, PRO:DNx]
Synonyms
GMP-PDE alpha;
EC 3.1.4.35;
PDE V-B1
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tadalafil | Bos taurus (cattle) | IC50 | 4.0500 | 2 | 2 |
| t 1032 | Bos taurus (cattle) | IC50 | 0.0280 | 1 | 1 |
| sophoflavescenol | Bos taurus (cattle) | Ki | 0.0050 | 1 | 1 |
| sildenafil | Bos taurus (cattle) | IC50 | 0.0545 | 6 | 6 |
Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533).Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 20, Issue:1, 2010
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533).Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 20, Issue:1, 2010
Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5(')-sulfonamide moiety of phenyl ring.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors.Bioorganic & medicinal chemistry letters, , Jul-21, Volume: 13, Issue:14, 2003
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003