Transient receptor potential cation channel subfamily V member 3

A transient receptor potential cation channel TRPV3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NET8]

TrpV3;
Vanilloid receptor-like 3;
VRL-3

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cannabinol	Homo sapiens (human)	IC50	9.4000	1	1
cannabichromene	Homo sapiens (human)	IC50	201.0000	1	1
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	IC50	3.0000	1	1
hc 030031	Homo sapiens (human)	IC50	10.0000	1	1
cannabigerol	Homo sapiens (human)	IC50	66.0000	1	1
cannabidivarin	Homo sapiens (human)	IC50	25.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cannabinol	Homo sapiens (human)	EC50	5.3000	1	1
cannabichromene	Homo sapiens (human)	EC50	1.9000	1	1
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	EC50	3.8000	1	1
cannabigerol	Homo sapiens (human)	EC50	1.0000	1	1
cannabidivarin	Homo sapiens (human)	EC50	1.7000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-aminoethoxydiphenyl borate	Homo sapiens (human)	Activity	10.0000	1	1
camphora	Homo sapiens (human)	Activity	100.0000	1	1

This protein enables 2 target(s):

Target	Category	Definition
calcium channel activity	molecular function	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

This protein is located in 3 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is part of 1 target(s):

Target	Category	Definition
receptor complex	cellular component	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

This protein is involved in 5 target(s):

Target	Category	Definition
response to temperature stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. [GOC:hb]
negative regulation of hair cycle	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. [GOC:go_curators, PMID:12230507]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
positive regulation of calcium ion import	biological process	Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. [GOC:BHF]
calcium ion import across plasma membrane	biological process	The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]