Compounds > 1,2,4-tribromobenzene
Page last updated: 2024-12-05

1,2,4-tribromobenzene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,2,4-Tribromobenzene is a white to pale yellow solid with a melting point of 87-88 °C. It is a synthetic compound, meaning it does not occur naturally, and is often used as a starting material for other organic compounds. Synthesis of this compound typically involves bromination of 1,2-dibromobenzene. Due to its structural similarity to other halogenated aromatic compounds, it is a valuable tool in research to study the effects of halogenation on the properties of organic molecules. The compound's importance lies in its potential for use in various applications, such as pharmaceuticals and agrochemicals, but its toxicity and environmental impact necessitate careful evaluation before widespread use. Studies on 1,2,4-tribromobenzene focus on its synthesis, reactivity, and potential applications, as well as its environmental fate and toxicity.'
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Cross-References

ID SourceID
PubMed CID12002
CHEMBL ID3182885
SCHEMBL ID354986
MeSH IDM0087966

Synonyms (35)

Synonym
eoe1kfc260 ,
unii-eoe1kfc260
1,2,4-tribromobenzene ,
benzene, 1,2,4-tribromo-
nsc-62440
615-54-3
nsc62440
benzene,2,4-tribromo-
nsc 62440
ai3-18131
einecs 210-433-9
1,2,4-tribromobenzene, 95%
NCGC00164056-01
NCIOPEN2_008043
inchi=1/c6h3br3/c7-4-1-2-5(8)6(9)3-4/h1-3
AKOS000202446
T0346
NCGC00164056-02
cas-615-54-3
dtxsid5024346 ,
tox21_303231
NCGC00257054-01
dtxcid604346
tox21_201862
NCGC00259411-01
FT-0606249
SCHEMBL354986
1,2,4-tribomobenzene
CHEMBL3182885
mfcd00000062
AS-19311
AMY41764
Q27277271
CS-0157156
SY049331

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" To determine the best way to select predictive groups of genes, we used published microarray data from dose-response studies on six chemicals in rats exposed orally for 5, 14, 28, and 90 days."( Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment.
Barton-Maclaren, TS; Chepelev, NL; Curran, IH; Farmahin, R; Kuo, B; Nong, A; Thomas, RS; Wade, MG; Williams, A; Yauk, CL, 2017)		0.46
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AR proteinHomo sapiens (human)Potency22.00630.000221.22318,912.5098AID743036
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency0.00550.001024.504861.6448AID743215
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency49.26590.001019.414170.9645AID743191
thyroid stimulating hormone receptorHomo sapiens (human)Potency76.95880.001628.015177.1139AID1259385
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency69.00830.000627.21521,122.0200AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's3 (50.00)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.51 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1,2,4-trichlorobenzene
1,2,4-trichlorobenzene : A trichlorobenzene with chloro substituents at positions 1, 2 and 4.		6.9510trichlorobenzene
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		1.9910elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.		1.9510barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
2,3,4,6-tetrachlorophenol
2,3,4,6-tetrachlorophenol: RN given refers to parent cpd; see also record for tetrachlorophenol with locants for chloro groups not specified. 2,3,4,6-tetrachlorophenol : A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 6.		2.1510tetrachlorophenolxenobiotic metabolite
n-nitrosodiphenylamine
N-nitrosodiphenylamine: RN given refers to parent cpd; structure in first source		2.1510phenylhydrazines
1,2,3-trichlorobenzene
trichlorobenzene: commercial grade of trichlorobenzene containing 70% 1,2,4-trichlorobenzene & 30% 1,2,3-trichlorobenzene; see also record for 1,2,4-trichlorobenzene. trichlorobenzene : Any member of the class of chlorobenzenes carrying three chloro substituents at unspecified positions.. 1,2,3-trichlorobenzene : A trichlorobenzene carrying chloro substituents at positions 1, 2 and 3.		1.9910trichlorobenzene
hexabromobenzene
[no description available]		1.9910
1,4-dibromobenzene
[no description available]		2.420dibromobenzene
bromobenzene
[no description available]		2.1510bromoarene;
bromobenzenes;
volatile organic compound		hepatotoxic agent;
mouse metabolite;
non-polar solvent
1,2-dibromobenzene
dibromobenzene : Any member of the class of bromobenzenes that consists of a benzene or a substituted benzene ring carrying two bromo groups at unspecified positions.		1.9910dibromobenzene
pentachlorobenzene
pentachlorobenzene: structure. pentachlorobenzene : A member of the class of pentachlorobenzenes that is benzene in which five of the hydrogens are replaced by chlorines. Now classed as a persistent organic pollutant under the Stockholm Convention.		7.420pentachlorobenzenespersistent organic pollutant
1,3,5-tribromobenzene
[no description available]		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials
Starvation
Lengthy and continuous deprivation of food. (Stedman, 25th ed)		01.9510
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		01.9910
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9910