Proteins > Ribosomal protein S6 kinase alpha-2
Page last updated: 2024-08-07 13:33:24

Ribosomal protein S6 kinase alpha-2

A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15349]

Synonyms

S6K-alpha-2;
EC 2.7.11.1;
90 kDa ribosomal protein S6 kinase 2;
p90-RSK 2;
p90RSK2;
MAP kinase-activated protein kinase 1c;
MAPK-activated protein kinase 1c;
MAPKAP kinase 1c;
MAPKAPK-1c;
Ribosomal S6 kinase 3;
RSK

Research

Bioassay Publications (13)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (53.85)29.6817
2010's4 (30.77)24.3611
2020's2 (15.38)2.80

Compounds (80)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
staurosporineHomo sapiens (human)IC500.000222
at13148Homo sapiens (human)IC500.012010
bi d1870Homo sapiens (human)IC500.4367413
cep-28122Homo sapiens (human)IC500.007011
at 9283Homo sapiens (human)IC500.001011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd10.000022
imatinibHomo sapiens (human)Kd10.000044
pyrazolanthroneHomo sapiens (human)Kd2.200011
staurosporineHomo sapiens (human)Kd0.081655
gefitinibHomo sapiens (human)Kd10.000044
lestaurtinibHomo sapiens (human)Kd0.572544
vatalanibHomo sapiens (human)Kd10.000044
ruboxistaurinHomo sapiens (human)Kd4.412055
canertinibHomo sapiens (human)Kd10.000044
birb 796Homo sapiens (human)Kd10.000044
cyc 202Homo sapiens (human)Kd7.733333
sb 203580Homo sapiens (human)Kd10.000044
enzastaurinHomo sapiens (human)Kd5.110022
erlotinibHomo sapiens (human)Kd10.000044
lapatinibHomo sapiens (human)Kd10.000044
sorafenibHomo sapiens (human)Kd10.000066
pd 173955Homo sapiens (human)Kd10.000022
s 1033Homo sapiens (human)Kd10.000022
bms 387032Homo sapiens (human)Kd10.000044
tandutinibHomo sapiens (human)Kd10.000066
vx-745Homo sapiens (human)Kd10.000044
dasatinibHomo sapiens (human)Kd10.000044
zd 6474Homo sapiens (human)Kd10.000044
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000022
alvocidibHomo sapiens (human)Kd3.780055
bosutinibHomo sapiens (human)Kd6.600022
su 11248Homo sapiens (human)Kd2.334788
jnj-7706621Homo sapiens (human)Kd5.205022
vx680Homo sapiens (human)Kd6.000044
ekb 569Homo sapiens (human)Kd8.933333
axitinibHomo sapiens (human)Kd10.000022
pd 184352Homo sapiens (human)Kd10.000022
bms345541Homo sapiens (human)Kd10.000022
midostaurinHomo sapiens (human)Kd5.283366
ki 20227Homo sapiens (human)Kd10.000022
cp 724714Homo sapiens (human)Kd10.000022
pi103Homo sapiens (human)Kd10.000044
hki 272Homo sapiens (human)Kd7.050022
tofacitinibHomo sapiens (human)Kd4.680055
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000022
cediranibHomo sapiens (human)Kd10.000022
masitinibHomo sapiens (human)Kd10.000022
pazopanibHomo sapiens (human)Kd10.000044
azd 6244Homo sapiens (human)Kd10.000022
su 14813Homo sapiens (human)Kd4.930044
bibw 2992Homo sapiens (human)Kd10.000022
tg100-115Homo sapiens (human)Kd10.000022
pha 665752Homo sapiens (human)Kd10.000022
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd10.000022
brivanibHomo sapiens (human)Kd10.000022
at 7519Homo sapiens (human)Kd10.000022
bi 2536Homo sapiens (human)Kd5.350022
nvp-ast487Homo sapiens (human)Kd5.550044
kw 2449Homo sapiens (human)Kd4.060022
abt 869Homo sapiens (human)Kd10.000044
gw 2580Homo sapiens (human)Kd10.000044
crizotinibHomo sapiens (human)Kd10.000022
chir-265Homo sapiens (human)Kd10.000044
motesanibHomo sapiens (human)Kd10.000044
mln8054Homo sapiens (human)Kd10.000044
GDC-0879Homo sapiens (human)Kd10.000022
gsk 461364Homo sapiens (human)Kd5.600022
azd 1152-hqpaHomo sapiens (human)Kd10.000044
nvp-tae684Homo sapiens (human)Kd0.096522
fedratinibHomo sapiens (human)Kd5.000022
gsk690693Homo sapiens (human)Kd10.000022
gdc 0941Homo sapiens (human)Kd10.000022
plx 4720Homo sapiens (human)Kd10.000022
sgx 523Homo sapiens (human)Kd10.000022
quizartinibHomo sapiens (human)Kd10.000044
incb-018424Homo sapiens (human)Kd5.075022
gsk 1838705aHomo sapiens (human)Kd6.450022
gsk 1363089Homo sapiens (human)Kd7.550022
chir 258Homo sapiens (human)Kd5.155044
nintedanibHomo sapiens (human)Kd5.029022
pp242Homo sapiens (human)Kd10.000022

Enables

This protein enables 7 target(s):

TargetCategoryDefinition
magnesium ion bindingmolecular functionBinding to a magnesium (Mg) ion. [GOC:ai]
protein serine/threonine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
protein serine/threonine/tyrosine kinase activitymolecular functionCatalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [GOC:mah]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein serine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]
ribosomal protein S6 kinase activitymolecular functionCatalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. [GOC:mah, PMID:9822608]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
synapsecellular componentThe junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Involved In

This protein is involved in 7 target(s):

TargetCategoryDefinition
signal transductionbiological processThe cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
chemical synaptic transmissionbiological processThe vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
negative regulation of cell population proliferationbiological processAny process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
intracellular signal transductionbiological processThe process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
positive regulation of apoptotic processbiological processAny process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of cell cyclebiological processAny process that stops, prevents or reduces the rate or extent of progression through the cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]
peptidyl-serine phosphorylationbiological processThe phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037]