Compounds > cyclopentenyl cytosine
Page last updated: 2024-12-06

cyclopentenyl cytosine

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Description

cyclopentenyl cytosine: inhibits CTP synthetase; used in therapy of colonic neoplasms; structure given in first source; RN given refers to the (1R-(1alpha,4beta,5beta))-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID72828
CHEMBL ID63647
SCHEMBL ID10392960
MeSH IDM0133275

Synonyms (25)

Synonym
nsc 375575
2(1h)-pyrimidinone, 4-amino-1-((1r,4r,5s)-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl)-
cyclopentenyl cytosine
2(1h)-pyrimidinone, 4-amino-1-(4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl)-, (1r-(1-alpha,4-beta,5-beta))-
brn 4258358
NCI60_003528
4-amino-1-[(1r,4r,5s)-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2-one
cyclopentenylcytosine
NSC375575 ,
90597-22-1
ce-cyd
2(1h)-pyrimidinone, 4-amino-1-[(1r,4r,5s)-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-
nsc-375575
2(1h)-pyrimidinone,5-dihydroxy- 3-(hydroxymethyl)-2-cyclopenten-1-yl]-
ccyd
cpe-c
cpec
CHEMBL63647 ,
unii-69mo0ndn8k
69mo0ndn8k ,
ccris 1771
bdbm50421707
SCHEMBL10392960
DTXSID70238212
Q27264364

Research Excerpts

Overview

Cyclopentenyl cytosine (CPE-C) is an investigational drug that is active against human solid tumor xenografts. It is a nucleoside-analogue that decreases concentrations of cytidine triphosphate (CTP) in leukemic cells by inhibiting the enzyme CTP synthetase.

ExcerptReferenceRelevance
"Cyclopentenyl cytosine (CPEC) is a carbocyclic cytidine analog inhibitor of CTP synthetase and experimental drug for combination chemotherapy. "( CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinase.
Collins, M; Graves, LM; Huang, M; Wang, Y, 2004)		1.77
"Cyclopentenyl cytosine (CPE-C) is an investigational drug that is active against human solid tumor xenografts. "( Phase I clinical trial of continuous infusion cyclopentenyl cytosine.
Allegra, CJ; Bastian, A; Chen, AP; Dahut, W; Ford, H; Hamilton, JM; Kelley, JA; Politi, PM; Setser, A; Xie, F, 1995)		1.99
"Cyclopentenyl cytosine (CPE-C) is a synthetic carbocyclic nucleoside that possesses diverse antitumor and antiviral activity. "( Reversed-phase high-performance liquid chromatographic determination of the new antitumor agent cyclopentenyl cytosine in biological fluids.
Ford, H; Hartman, NR; Hegedus, L; Kelley, JA, 1997)		1.96
"Cyclopentenyl cytosine (CPEC) is a nucleoside-analogue that decreases the concentrations of cytidine triphosphate (CTP) and deoxycytidine triphosphate (dCTP) in leukemic cells by inhibiting the enzyme CTP synthetase, resulting in a decreased synthesis of RNA and DNA. "( Cyclopentenyl cytosine induces apoptosis and increases cytarabine-induced apoptosis in a T-lymphoblastic leukemic cell-line.
Brinkman, J; Evers, LM; Leen, R; Van Gennip, AH; Van Kuilenburg, AB; Verschuur, AC; Vet, RJ; Voûte, PA, 2001)		3.2

Effects

ExcerptReferenceRelevance
"Cyclopentenyl cytosine (CPEC) has been shown to induce apoptosis in human T lymphoblastic cell lines and T cells from leukaemia patients. "( The pyrimidin analogue cyclopentenyl cytosine induces alloantigen-specific non-responsiveness of human T lymphocytes.
Bemelman, FJ; Nikolaeva, N; ten Berge, IJ; van Lier, RA; Verschuur, A; Yong, SL, 2008)		2.1

Toxicity

ExcerptReferenceRelevance
" Due to CPE-C's in vivo myelotoxicity, it was important to characterize its potential adverse effects on human marrow cells during preclinical development of the drug."( In vitro characterization of the myelotoxicity of cyclopentenyl cytosine.
Du, DL; Grieshaber, CK; Murphy, MJ; Volpe, DA, 1994)		0.54
" In conclusion, the combination of dFdC and CPEC is highly toxic to neuroblastoma in vitro."( Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma.
Bierau, J; Caron, HN; Leen, R; Meinsma, R; van Gennip, AH; van Kuilenburg, AB, 2006)		1.78

Dosage Studied

ExcerptRelevanceReference
" Low dosage of CPEC seems necessary and intensive cardiac monitoring is advisable."( Cyclopentenyl cytosine (CPEC): an overview of its in vitro and in vivo activity.
Gelderblom, H; Guchelaar, HJ; Schimmel, KJ, 2007)		1.78
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (121)

Assay IDTitleYearJournalArticle
AID235601Ratio of minimum drug concentration to ID50 (A2/Aichi/2/68 strain)1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218398Cytotoxicity of compound was determined by reduction in number of viable vero monolayer cells after treatment with 10 ug/mL for 4 days1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID55098Log value for antiviral activity against Cytomegalovirus (AD169) from MRC5 diploid human embryonic lung cells at 10 ug/mL1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID102054Log cell kill at the end of treatment at dose 0.5 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID100236Cytotoxicity was measured against Vaccinia virus VAC in LLC-MK2 (ATCC CRL 7) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID153023Number of 30-day survivors out of 6 mice at dose 1.5 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID55097Log value for antiviral activity against Cytomegalovirus (AD169) from MRC5 diploid human embryonic lung cells at 100 ug/mL1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218395Cytotoxicity of compound was determined by reduction in number of viable vero monolayer cells after treatment with 0.032 ug/mL for 4 days1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218397Cytotoxicity of compound was determined by reduction in number of viable vero monolayer cells after treatment with 1 ug/mL for 4 days1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID100233Cytotoxicity was measured against Monkeypox virus MPX in LLC-MK2 (ATCC CRL 7) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID164600Inhibitory dose of compound required to inhibit cytopathogenic effects of Punta toro virus with adames strain in vero cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID152863Compound was tested for antitumor activity against P388/ara-C leukemia in mouse at dose 1.5 mg/kg administered intraperitoneally in experiment 11988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID96593Log cell kill at the end of treatment to mice1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID55096Log value for antiviral activity against Cytomegalovirus (AD169) from MRC5 diploid human embryonic lung cells at 0.32 ug/mL1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98845Compound was tested for antitumor activity against L1210 leukemia in mouse at dose 1 mg/kg administered subcutaneously in experiment 21988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID131149Compound was tested for antitumor activity against human A549 lung tumor xenografts in athymic mice at dose 2 mg/kg administered subrenal capsule in experiment 21988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218009Compound was tested for antiviral activity against Varicella-Zoster from human diploid foreskin cells in mono layer culture at 0.032 ug/ml1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98863Median percent increase in life span of tumored, treated mice relative to tumored, untreated controls after intraperitoneal dose 4 mg/kg daily (every 4th day)1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID216278In vitro antiviral activity against West Nile Virus.2001Journal of medicinal chemistry, Nov-08, Volume: 44, Issue:23
Enantiomeric synthesis of D- and L-cyclopentenyl nucleosides and their antiviral activity against HIV and West Nile virus.
AID218024Cytotoxicity was measured against Cowpox virus CPX in Vero 76 (ATCC CRL 1587) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID100228Antiviral activity was measured against Monkeypox virus MPX in LLC-MK2 (ATCC CRL 7) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID96591Log cell kill at the end of treatment at dose 1 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98878Compound was tested for its ability to inhibit L1210 cell growth after 72 hr at 0.03 uM concentration1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.
AID218025Cytotoxicity was measured against Monkeypox virus MPX in Vero 76 (ATCC CRL 1587) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID218399Cytotoxicity of compound was determined by reduction in number of viable vero monolayer cells after treatment with 100 ug/mL for 4 days1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235756Therapeutic index was measured against Smallpox virus 7124 in LLC-MK2 (ATCC CRL 7) cell as the ratio of IC50/EC502003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID218396Cytotoxicity of compound was determined by reduction in number of viable vero monolayer cells after treatment with 0.1 ug/mL for 4 days1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98711Compound was tested for antitumor activity against L1210 leukemia in mouse at dose 1 mg/kg administered intraperitoneally in experiment 21988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235605Ratio of minimum drug concentration to ID50 of the compound (Indiana strain)1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID216389Inhibitory dose of compound required to inhibit cytopathogenic effects of vesicular stomatitis RNA virus with indiana strain in L929 cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218027Cytotoxicity was measured against Smallpox virus BSH in Vero 76 (ATCC CRL 1587) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID131155Compound was tested for antitumor activity against human MX-1 mammary tumor xenografts in athymic mice at dose 1.5 mg/kg administered subrenal capsule in experiment 11988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID92457Tested for inhibition of virus-induced cytopathogenic effect and cytotoxicity of compound against influenza virus with A2/Aichi/2/68 strain in MDCK cell1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235758Therapeutic index was measured against Smallpox virus BSH Vero 76 (ATCC CRL 1587) cell as the ratio of IC50/EC502003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID98850Compound was tested for antitumor activity against L1210/ara-C leukemia in mouse at dose 2.25 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID102053Compound was tested for antitumor activity against M5076 leukemia in mouse at dose 0.5 mg/kg administered intraperitoneally in experiment 11988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID96592Log cell kill at the end of treatment at dose 2.25 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID100234Cytotoxicity was measured against Smallpox virus 7124 in LLC-MK2 (ATCC CRL 7) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID55095Log value for antiviral activity against Cytomegalovirus (AD169) from MRC5 diploid human embryonic lung cells at 0.1 ug/mL1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID153019Log cell kill at the end of treatment at dose 1.5 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218012Compound was tested for antiviral activity against Varicella-Zoster from human diploid foreskin cells in mono layer culture at 1 ug/ml1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98847Compound was tested for antitumor activity against L1210 leukemia in mouse at dose 2.25 mg/kg administered intraperitoneally in experiment 21988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218020Antiviral activity was measured against Monkeypox virus MPX in Vero 76 (ATCC CRL 1587) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID218015Compound was tested for antiviral activity against Varicella-Zoster from human diploid foreskin cells in mono layer culture at 3.2 ug/ml1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98879Compound was tested for its ability to inhibit L1210 cell growth after 72 hr at 1000 uM concentration1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.
AID217742In vitro cytotoxicity in vero cells.2001Journal of medicinal chemistry, Nov-08, Volume: 44, Issue:23
Enantiomeric synthesis of D- and L-cyclopentenyl nucleosides and their antiviral activity against HIV and West Nile virus.
AID98848Compound was tested for antitumor activity against L1210/ara-C leukemia in mouse at dose 1.5 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98880Compound was tested for its ability to inhibit L1210 cell growth after 72 hr at 100 uM concentration1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.
AID98861Median percent increase in life span of tumored, treated mice relative to tumored, untreated controls after intraperitoneal dose 0.5 mg/kg daily(for every 3 hr)1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98862Median percent increase in life span of tumored, treated mice relative to tumored, untreated controls after intraperitoneal dose 1 mg/kg daily (1-9 days)1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID215627Binding affinity to uridine kinase from L1210. was determined from the dixon plot1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.
AID131152Compound was tested for antitumor activity against human LOX melanoma tumor xenografts in athymic mice at dose 2.25 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98707Compound was tested for antitumor activity against L1210 leukemia in mouse at dose 1.5 mg/kg administered intracerebrally in experiment 11988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID96931Number of 60-day survivors out of 9 tested at dose 1.5 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98849Compound was tested for antitumor activity against L1210/ara-C leukemia in mouse at dose 1 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID131150Compound was tested for antitumor activity against human LOX melanoma tumor xenografts in athymic mice at dose 1.5 mg/kg administered intraperitoneally in experiment 21988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID100235Cytotoxicity was measured against Smallpox virus BSH in LLC-MK2 (ATCC CRL 7) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID235752Therapeutic index was measured against Cowpox virus CPX in LLC-MK2 (ATCC CRL 7) cell as the ratio of IC50/EC502003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID96930Number of 60-day survivors out of 10 tested at dose 2.25 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98846Compound was tested for antitumor activity against L1210 leukemia in mouse at dose 2.25 mg/kg administered intraperitoneally in experiment 11988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235602Ratio of minimum drug concentration to ID50 of the compound (Adames strain)1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218394Cytotoxicity of compound was determined by reduction in number of viable vero monolayer cells after treatment with 0.01 ug/mL for 4 days1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218014Compound was tested for antiviral activity against Varicella-Zoster from human diploid foreskin cells in mono layer culture at 100 ug/ml1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218023Antiviral activity was measured against Vaccinia virus VAC in Vero 76 (ATCC CRL 1587) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID218008Compound was tested for antiviral activity against Varicella-Zoster from human diploid foreskin cells in mono layer culture at 0.01 ug/ml1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218026Cytotoxicity was measured against Smallpox virus 7124 in Vero 76 (ATCC CRL 1587) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID216399Tested for inhibition of virus-induced cytopathogenic effect and cytotoxicity of compound against vesicular stomatitis RNA virus with indiana strain in L929 cell1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID96929Number of 60-day survivors out of 10 tested at dose 1 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218028Cytotoxicity was measured against Vaccinia virus VAC in Vero 76 (ATCC CRL 1587) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID152861Compound was tested for antitumor activity against P388 leukemia in mouse at dose 1.5 mg/kg administered intraperitoneally in experiment 21988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218019Antiviral activity was measured against Cowpox virus CPX in Vero 76 (ATCC CRL 1587) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID220244Tested for inhibition of virus-induced cytopathogenic effect and cytotoxicity of compound against yellow fever virus with asibi strain vero cell1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235761Therapeutic index was measured against Vaccinia virus VAC in Vero 76 (ATCC CRL 1587) cell as the ratio of IC50/EC502003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID131151Compound was tested for antitumor activity against human LOX melanoma tumor xenografts in athymic mice at dose 1 mg/kg administered intraperitoneally in experiment 11988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235759Therapeutic index was measured against Smallpox virus BSH in LLC-MK2 (ATCC CRL 7) cell as the ratio of IC50/EC502003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID218400Cytotoxicity of compound was determined by reduction in number of viable vero monolayer cells after treatment with 320 ug/mL for 4 days1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID100816Compound was evaluated for the ability to inhibit L1210 tumor cell growth a concentration of 100 uM1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Synthesis of two cyclopentenyl-3-deazapyrimidine carbocyclic nucleosides related to cytidine and uridine.
AID218013Compound was tested for antiviral activity against Varicella-Zoster from human diploid foreskin cells in mono layer culture at 10 ug/ml1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID100229Antiviral activity was measured against Smallpox virus 7124 in LLC-MK2 (ATCC CRL 7) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID215626Inhibition of uridine kinase from L1210 cells was evaluated by measuring the retention of phosphorylated product on DE81 filter papers at 1000 uM1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.
AID98708Compound was tested for antitumor activity against L1210 leukemia in mouse at dose 1.5 mg/kg administered subcutaneously in experiment 11988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID152862Compound was tested for antitumor activity against P388 leukemia in mouse at dose 1 mg/kg administered intraperitoneally in experiment 11988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID55101Log value for antiviral activity against Cytomegalovirus (AD169) from MRC5 diploid human embryonic lung cells at 320 ug/mL1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID220238Inhibitory dose of compound required to inhibit cytopathogenic effects of yellow fever virus with asibi strain in vero cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID94763Tested for inhibition of virus-induced cytopathogenic effect and cytotoxicity of compound against Japanese encephalitis virus with najayama strain in vero cell1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98710Compound was tested for antitumor activity against L1210 leukemia in mouse at dose 1 mg/kg administered intraperitoneally in experiment 11988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235753Therapeutic index was measured against Cowpox virus CPX in Vero 76 (ATCC CRL 1587) cell as the ratio of IC50/EC502003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID98881Compound was tested for its ability to inhibit L1210 cell growth after 72 hr at 500 uM concentration1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.
AID100815Compound was evaluated for the ability to inhibit L1210 tumor cell growth a concentration of 10 uM1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Synthesis of two cyclopentenyl-3-deazapyrimidine carbocyclic nucleosides related to cytidine and uridine.
AID100231Antiviral activity was measured against Vaccinia virus VAC in LLC-MK2 (ATCC CRL 7) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID131156Compound was tested for antitumor activity against human MX-1 mammary tumor xenografts in athymic mice at dose 2.25 mg/kg administered subrenal capsule in experiment 21988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218021Antiviral activity was measured against Smallpox virus 7124 in Vero 76 (ATCC CRL 1587) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID218011Compound was tested for antiviral activity against Varicella-Zoster from human diploid foreskin cells in mono layer culture at 0.32 ug/ml1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218022Antiviral activity was measured against Smallpox virus BSH in Vero 76 (ATCC CRL 1587) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID152864Compound was tested for antitumor activity against P388/ara-C leukemia in mouse at dose 1.5 mg/kg administered intraperitoneally in experiment 21988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID218016Compound was tested for antiviral activity against Varicella-Zoster from human diploid foreskin cells in mono layer culture at 32 ug/ml1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235606Ratio of minimum drug concentration to ID50 of the compound (Najayama strain)1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID215625Inhibition of uridine kinase from L1210 cells was evaluated by measuring the retention of phosphorylated product on DE81 filter papers at 100 uM1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.
AID153020Log cell kill at the end of treatment at dose 1 mg/kg administered intraperitoneally1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID100230Antiviral activity was measured against Smallpox virus BSH in LLC-MK2 (ATCC CRL 7) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID55099Log value for antiviral activity against Cytomegalovirus (AD169) from MRC5 diploid human embryonic lung cells at 1 ug/mL1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235604Ratio of minimum drug concentration to ID50 of the compound(Asibi strain)1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID164601Tested for inhibition of virus-induced cytopathogenic effect and cytotoxicity of compound against Punta toro virus with adames strain in vero cell1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID152792In vitro cytotoxicity in PBM cells.2001Journal of medicinal chemistry, Nov-08, Volume: 44, Issue:23
Enantiomeric synthesis of D- and L-cyclopentenyl nucleosides and their antiviral activity against HIV and West Nile virus.
AID235755Therapeutic index was measured against Monkeypox virus MPX in Vero 76 (ATCC CRL 1587) cell as the ratio of IC50/EC502003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID100818Compound was evaluated for the ability to inhibit L1210 tumor cell growth a concentration of 1 uM1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Synthesis of two cyclopentenyl-3-deazapyrimidine carbocyclic nucleosides related to cytidine and uridine.
AID235754Therapeutic index was measured against Monkeypox virus MPX in LLC-MK2 (ATCC CRL 7) cell as the ratio of IC50/EC502003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID131148Compound was tested for antitumor activity against human A549 lung tumor xenografts in athymic mice at dose 1.5 mg/kg administered subrenal capsule in experiment 11988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID100227Antiviral activity was measured against Cowpox virus CPX in LLC-MK2 (ATCC CRL 7) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID92456Inhibitory dose of compound required to inhibit cytopathogenic effects of influenza virus with A2/Aichi/2/68 strain in MDCK cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235757Therapeutic index was measured against Smallpox virus 7124 in Vero 76 (ATCC CRL 1587) cell as the ratio of IC50/EC502003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID47445In vitro cytotoxicity in CEM cells.2001Journal of medicinal chemistry, Nov-08, Volume: 44, Issue:23
Enantiomeric synthesis of D- and L-cyclopentenyl nucleosides and their antiviral activity against HIV and West Nile virus.
AID100232Cytotoxicity was measured against Cowpox virus CPX in LLC-MK2 (ATCC CRL 7) cell2003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID55102Log value for antiviral activity against Cytomegalovirus (AD169) from MRC5 diploid human embryonic lung cells at 32 ug/mL1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID152622In vitro antiviral activity against HIV-1 in human PBM cells.2001Journal of medicinal chemistry, Nov-08, Volume: 44, Issue:23
Enantiomeric synthesis of D- and L-cyclopentenyl nucleosides and their antiviral activity against HIV and West Nile virus.
AID218017Compound was tested for antiviral activity against Varicella-Zoster from human diploid foreskin cells in mono layer culture at 320 ug/ml1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID55100Log value for antiviral activity against Cytomegalovirus (AD169) from MRC5 diploid human embryonic lung cells at 3.2 ug/mL1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID94762Inhibitory dose of compound required to inhibit cytopathogenic effects of Japanese encephalitis virus with najayama strain in vero cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID235760Therapeutic index was measured against Vaccinia virus VAC in LLC-MK2 (ATCC CRL 7) cell as the ratio of IC50/EC502003Bioorganic & medicinal chemistry letters, Jan-06, Volume: 13, Issue:1
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
AID218010Compound was tested for antiviral activity against Varicella-Zoster from human diploid foreskin cells in mono layer culture at 0.1 ug/ml1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID98709Compound was tested for antitumor activity against L1210 leukemia in mouse at dose 1 mg/kg administered intracerebrally in experiment 21988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (67)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (8.96)18.7374
1990's27 (40.30)18.2507
2000's29 (43.28)29.6817
2010's4 (5.97)24.3611
2020's1 (1.49)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.37 (24.57)
Research Supply Index4.23 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (18.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (1.49%)5.53%
Reviews1 (1.49%)6.00%
Case Studies1 (1.49%)4.05%
Observational0 (0.00%)0.25%
Other64 (95.52%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cytosine
[no description available]		2.610aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		1.9810alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
triphosphoric acid
triphosphoric acid: used as water softener, peptizing agent, emulsifier & dispersing agent; ingredient of cleansers; meat preservative; RN given refers to parent cpd; structure		2.0110acyclic phosphorus acid anhydride;
phosphorus oxoacid
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		2.6830pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
carmustine
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed). carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.		1.9810N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent
dipyridamole
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752). dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.		2.0210piperidines;
pyrimidopyrimidine;
tertiary amino compound;
tetrol		adenosine phosphodiesterase inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor;
platelet aggregation inhibitor;
vasodilator agent
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.3920nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
leflunomide
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.. leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.		2.0210(trifluoromethyl)benzenes;
isoxazoles;
monocarboxylic acid amide		antineoplastic agent;
antiparasitic agent;
EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
hepatotoxic agent;
immunosuppressive agent;
non-steroidal anti-inflammatory drug;
prodrug;
pyrimidine synthesis inhibitor;
tyrosine kinase inhibitor
thymidine
[no description available]		1.9710pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
azauridine
Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.		2.6930N-glycosyl-1,2,4-triazineantimetabolite;
antineoplastic agent;
drug metabolite
glutamine
Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.. L-glutamine : An optically active form of glutamine having L-configuration.. glutamine : An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4.		1.9910amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		1.9910aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
uridine
[no description available]		1.9610uridinesdrug metabolite;
fundamental metabolite;
human metabolite
cytidine monophosphate
Cytidine Monophosphate: Cytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.. cytidine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.		210cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-monophosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
cytidine diphosphate
Cytidine Diphosphate: Cytidine 5'-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate.		210cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-diphosphate		Escherichia coli metabolite;
mouse metabolite
uridine triphosphate
Uridine Triphosphate: Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.		210pyrimidine ribonucleoside 5'-triphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
cytidine
[no description available]		7.95631cytidinesEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cytidine triphosphate
Cytidine Triphosphate: Cytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.		4.35200cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite
cytarabine
[no description available]		3.2560beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		2.0210isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
azacitidine
Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.. 5-azacytidine : An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.		1.9810N-glycosyl-1,3,5-triazine;
nucleoside analogue		antineoplastic agent
deoxycytidine
[no description available]		3.1150pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
azaribine
azaribine: pyrimidine analogue; anti-metabolite used in psoriasis & mycosis fungoides;. azaribine : A N-glycosyl-1,2,4-triazine that is 6-azauridine acetylated at positions 2', 3' and 5' on the sugar ring. It is a prodrug for 6-azauridine and is used for treatment of psoriasis.		2.0110acetate ester;
N-glycosyl-1,2,4-triazine		antipsoriatic;
prodrug
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.		1.9710beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
zalcitabine
Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.		2.0410pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		210azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
ribavirin
Rebetron: Rebetron is tradename		2.67301-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
gemcitabine
gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.		2.9540organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		3.0850adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
psicofuranine
[no description available]		1.9710psicose derivative;
purine nucleoside
2'-deoxycytidine 5'-triphosphate
2'-deoxycytidine 5'-triphosphate: RN given refers to unlabeled parent cpd		2.4202'-deoxycytidine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-triphosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
4-nitrobenzylthioinosine
4-nitrobenzylthioinosine: inhibitor of nucleoside transport; acts on ENT1		2.0210purine nucleoside
3-deazaaristeromycin
3-deazaaristeromycin: antagonist of S-adenosylhomocysteinase		1.9710
neplanocin a
neplanocin A: neplanocins are antitumor antibiotics & carbocyclic analogs of purine nucleosides from Ampullarilla regularis A11079; see also neplanocin B, neplanocin C, neplanocin D & neplanocin F; structure in first source; a potent inhibitor of S-adenosylhomocysteine hydrolase		8.0950
ici 164384
ICI 164384: structure given in first source. ICI-164384 : A 3-hydroxy steroid that is 17beta-estradiol substituted by a 11-[butyl(methyl)amino]-11-oxoundecyl group at position 7R. It is a steroidal antioestrogen that inhibits the cell proliferation of breast-carcinoma cell lines.		1.971017beta-hydroxy steroid;
3-hydroxy steroid;
tertiary carboxamide		anti-estrogen;
antineoplastic agent;
estrogen receptor antagonist
cyclopentenyluracil
cyclopentenyluracil: does not have antiviral acitivity in contrast to cyclopentenylcytosine; RN given refers to (1R-(1alpha,4beta,5beta)-isomer); RN for cpd without isomeric designation not avail 6/91		3.0850
organophosphonates
hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.		2.610divalent inorganic anion;
phosphite ion
tretinoin
Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.		2.0110retinoic acid;
vitamin A		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
mycophenolic acid
Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.		2.01102-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic
afimoxifene
afimoxifene : A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.		1.9710phenols;
tertiary amino compound		antineoplastic agent;
estrogen receptor antagonist;
metabolite
decitabine
[no description available]		1.98102'-deoxyribonucleoside
carbodine
carbodine: RN given refers to (R-(1alpha,2beta,3beta,4alpha))-isomer		2.3720
thioinosine
Thioinosine: Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)		2.0210
tamoxifen
[no description available]		1.9710stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
thiouridine
Thiouridine: A photoactivable URIDINE analog that is used as an affinity label.. 4-thiouridine : A thiouridine in which the oxygen replaced by sulfur is that at C-4.		2.0110nucleoside analogue;
thiouridine		affinity label;
antimetabolite
linoleic acid
Linoleic Acid: A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed). linoleic acid : An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.		1.9910octadecadienoic acid;
omega-6 fatty acid		algal metabolite;
Daphnia galeata metabolite;
plant metabolite
ribose
ribopyranose : The pyranose form of ribose.		2.6930D-ribose;
ribopyranose
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		1.99101,2-diacyl-sn-glycero-3-phosphocholine
3-deazauridine
3-Deazauridine: 4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridinone. Analog of uridine lacking a ring-nitrogen in the 3-position. Functions as an antineoplastic agent.		2.3820N-glycosyl compound
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		1.9710
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone: an interleukin-1beta converting enzyme (ICE)-like protease inhibitor		210
transforming growth factor alpha
Transforming Growth Factor alpha: An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.		1.9710
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		1.97102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
guanosine triphosphate
Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.		210guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
pyrazofurin
pirazofurin : A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.		2.6930C-glycosyl compound;
pyrazoles		antimetabolite;
antimicrobial agent;
antineoplastic agent;
EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		03.4880
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.6630
Cancer of Lung
[description not available]		02.730
Malignant Melanoma
[description not available]		02.3720
Experimental Neoplasms
[description not available]		02.3720
EHS Tumor
[description not available]		01.9710
Experimental Mammary Neoplasms
[description not available]		01.9710
Lung Neoplasms
Tumors or cancer of the LUNG.		02.730
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.3720
Ocular Toxicity
[description not available]		02.610
Adenovirus Infections
[description not available]		02.5220
Ocular Infections
[description not available]		02.5220
Adenoviridae Infections
Virus diseases caused by the ADENOVIRIDAE.		02.5220
Eye Infections
Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.		02.5220
Carotid Arteriopathies, Traumatic
[description not available]		02.4920
Vascular Injuries
[description not available]		02.4920
Neointima
The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.		02.5120
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.7430
Cancer of Pancreas
[description not available]		02.4520
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.4520
Breast Cancer
[description not available]		07.4120
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.4120
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		03.3970
Granulocytic Leukemia
[description not available]		02.4120
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.		02.4120
Benign Neoplasms
[description not available]		03.7921
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.4220
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.7921
Cardiomyopathies, Primary
[description not available]		02.0210
Cardiomyopathies
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).		02.0210
Acute Lymphoid Leukemia
[description not available]		02.9340
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.		02.9340
Experimental Leukemia
[description not available]		01.9810
Blood Pressure, Low
[description not available]		03.3711
Hypotension
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.		03.3711
Glioblastoma with Sarcomatous Component
[description not available]		01.9810
Benign Neoplasms, Brain
[description not available]		01.9810
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		01.9810
Gliosarcoma
Rare mixed tumors of the brain and rarely the spinal cord which contain malignant neuroectodermal (glial) and mesenchymal components, including spindle-shaped fibrosarcoma cells. These tumors are highly aggressive and present primarily in adults as rapidly expanding mass lesions. They may arise in tissue that has been previously irradiated. (From Br J Neurosurg 1995 Apr;9(2):171-8)		01.9810
Astrocytoma, Grade IV
[description not available]		01.9910
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		06.9910
Cancer of Colon
[description not available]		02.3820
Colonic Neoplasms
Tumors or cancer of the COLON.		02.3820
Acute Myelogenous Leukemia
[description not available]		02.6830
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		02.6830
Leukemia, Lymphocytic, T Cell
[description not available]		0210
Leukemia, T-Cell
A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.		0210
ATLL
[description not available]		0210
Leukemia-Lymphoma, Adult T-Cell
Aggressive T-Cell malignancy with adult onset, caused by HUMAN T-LYMPHOTROPIC VIRUS 1. It is endemic in Japan, the Caribbean basin, Southeastern United States, Hawaii, and parts of Central and South America and sub-Saharan Africa.		0210
Leucocythaemia
[description not available]		02.3820
Colorectal Cancer
[description not available]		06.9810
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		02.3820
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		01.9810