A sulfotransferase 1E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49888]
ST1E1;
EC 2.8.2.4;
EST-1;
Estrogen sulfotransferase;
Sulfotransferase, estrogen-preferring
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2-naphthol | Homo sapiens (human) | Km | 77.9550 | 2 | 0 |
| 5-hydroxyindole | Homo sapiens (human) | Km | 575.0000 | 1 | 0 |
| 6-hydroxybenzothiazole | Homo sapiens (human) | Km | 170.6500 | 2 | 0 |
| 6-hydroxyindole | Homo sapiens (human) | Km | 2,713.0000 | 1 | 0 |
| 4-hydroxytoremifene | Homo sapiens (human) | Km | 6.4000 | 1 | 1 |
| 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole | Homo sapiens (human) | Km | 1.6000 | 1 | 0 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| estrone sulfotransferase activity | molecular function | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate. [EC:2.8.2.4] |
| steroid binding | molecular function | Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| sulfotransferase activity | molecular function | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. [GOC:curators] |
| flavonol 3-sulfotransferase activity | molecular function | Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate. [EC:2.8.2.25, RHEA:13453] |
| steroid sulfotransferase activity | molecular function | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. [MetaCyc:STEROID-SULFOTRANSFERASE-RXN, RHEA:68460] |
| aryl sulfotransferase activity | molecular function | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. [EC:2.8.2.1] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| nuclear membrane | cellular component | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| ethanol catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. [GOC:ai, ISBN:0198506732] |
| estrogen catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732] |
| steroid metabolic process | biological process | The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684] |
| estrogen metabolic process | biological process | The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732] |
| positive regulation of fat cell differentiation | biological process | Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators] |
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process | biological process | The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [ISBN:0198506732] |
| sulfation | biological process | The addition of a sulfate group to a molecule. [Wikipedia:Sulfation] |