Page last updated: 2024-08-07 15:46:46
Renin
A renin that is encoded in the genome of rat. [OMA:P08424, PRO:DNx]
Synonyms
EC 3.4.23.15;
Angiotensinogenase
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| practolol | Rattus norvegicus (Norway rat) | Ki | 13.5000 | 1 | 2 |
| aliskiren | Rattus norvegicus (Norway rat) | IC50 | 0.0840 | 2 | 2 |
Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Direct renin inhibitors as a new therapy for hypertension.Journal of medicinal chemistry, , Nov-11, Volume: 53, Issue:21, 2010