Page last updated: 2024-08-07 17:27:36
Carboxylic ester hydrolase
[no definition available]
Synonyms
Research
Bioassay Publications (26)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 14 (53.85) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (23)
Drugs with Inhibition Measurements
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.European journal of medicinal chemistry, , Volume: 52, 2012
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.Bioorganic & medicinal chemistry letters, , May-01, Volume: 18, Issue:9, 2008
NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.European journal of medicinal chemistry, , Volume: 52, 2012
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.Bioorganic & medicinal chemistry, , Apr-15, Volume: 20, Issue:8, 2012
Conformationally restricted carbamate inhibitors of horse serum butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Oct-06, Volume: 8, Issue:19, 1998
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.Bioorganic & medicinal chemistry, , Dec-01, Volume: 19, Issue:23, 2011
Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
Derivatives of oxoisoaporphine alkaloids: a novel class of selective acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 17, Issue:8, 2007
Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum.Bioorganic & medicinal chemistry letters, , Volume: 16, Issue:3, 2006
Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.Bioorganic & medicinal chemistry, , Dec-01, Volume: 19, Issue:23, 2011
Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.Journal of medicinal chemistry, , Nov-21, Volume: 45, Issue:24, 2002
Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001