A macrophage-expressed gene 1 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q2M385]
Macrophage gene 1 protein;
Mpg-1;
Perforin-2;
P-2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| embelin | Homo sapiens (human) | IC50 | 0.2100 | 2 | 2 |
| rapanone | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| 5-o-methylembelin | Homo sapiens (human) | IC50 | 9.1000 | 1 | 1 |
| l 663536 | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
This protein enables 1 target(s):
| Target | Category | Definition |
|---|---|---|
| wide pore channel activity | molecular function | Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. [GOC:mtg_transport, ISBN:0815340729] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| cytoplasmic vesicle | cellular component | A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles] |
| phagocytic vesicle | cellular component | A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. [GOC:go_curators, ISBN:0198506732] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| phagocytic vesicle membrane | cellular component | The lipid bilayer surrounding a phagocytic vesicle. [GOC:mah] |
| phagolysosome membrane | cellular component | The lipid bilayer surrounding a phagolysosome. [GOC:dph, PMID:22073313] |
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| adaptive immune response | biological process | An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149] |
| dendritic cell antigen processing and presentation | biological process | The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591] |
| antigen processing and presentation of exogenous peptide antigen | biological process | The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. [GOC:add, ISBN:0781735149] |
| antigen processing and presentation of exogenous peptide antigen via MHC class I | biological process | The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15771591] |
| defense response to bacterium | biological process | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:jl] |
| defense response to Gram-negative bacterium | biological process | Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. [GOC:ai] |
| defense response to Gram-positive bacterium | biological process | Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai] |
| transmembrane transport | biological process | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid] |
| antibacterial innate immune response | biological process | An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. [PMID:16177355, PMID:23006328] |