A D-aspartate oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99489]
DASOX;
DDO;
EC 1.4.3.1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| benzoic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 2 | 2 |
| malonic acid | Homo sapiens (human) | IC50 | 1,117.0000 | 2 | 2 |
| malonic acid | Homo sapiens (human) | Ki | 153.0000 | 1 | 1 |
| niacin | Homo sapiens (human) | IC50 | 2,778.0000 | 1 | 1 |
| thiophene-3-carboxylic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 3-aminobenzoic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 5-chlorosalicylic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 3-aminopyridine | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 3,5-pyridinedicarboxylic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 3-hydroxypicolinic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 3-hydroxy-1-benzopyran-2-one | Homo sapiens (human) | IC50 | 7,579.0000 | 1 | 1 |
| 6-aminonicotinic acid | Homo sapiens (human) | IC50 | 2,364.0000 | 1 | 1 |
| 5-hydroxynicotinic acid | Homo sapiens (human) | IC50 | 3,351.0000 | 1 | 1 |
| 5-fluorosalicylic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| indole-2-carboxylic acid | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| 2-aminonicotinic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 3-aminopicolinic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 5-bromonicotinic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 5-fluoro-3-pyridinecarboxylic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 5-aminonicotinic acid | Homo sapiens (human) | IC50 | 21.9000 | 1 | 1 |
| 5-aminonicotinic acid | Homo sapiens (human) | Ki | 3.8000 | 1 | 1 |
| crotonic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 3-coumaric acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 3-hydroxyquinolin-2(1h)-one | Homo sapiens (human) | IC50 | 0.4822 | 2 | 4 |
| 6-Chlorobenzo[d]isoxazol-3-ol | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| sun | Homo sapiens (human) | IC50 | 23.4190 | 4 | 7 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| D-aspartate oxidase activity | molecular function | Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide. [RHEA:12512] |
| D-glutamate oxidase activity | molecular function | Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2. [EC:1.4.3.7] |
| FAD binding | molecular function | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| peroxisome | cellular component | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] |
| peroxisomal matrix | cellular component | The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. [GOC:curators, ISBN:0815316194] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| peroxisome | cellular component | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| insemination | biological process | The introduction of semen or sperm into the genital tract of a female. [ISBN:0582227089] |
| grooming behavior | biological process | The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. [GOC:jl, GOC:pr] |
| regulation of cell communication | biological process | Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:dph, GOC:tb] |
| D-amino acid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids. [GOC:ai, GOC:jsg] |
| hormone metabolic process | biological process | The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:jl] |
| nervous system process | biological process | A organ system process carried out by any of the organs or tissues of neurological system. [GOC:ai, GOC:mtg_cardio] |
| aspartate catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. [GOC:go_curators, ISBN:0198506732] |