Page last updated: 2024-12-06

1,1,2-trichloro-3,3,3-trifluoro-1-propene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,1,2-trichloro-3,3,3-trifluoro-1-propene is a synthetic organic compound with the chemical formula C3HCl3F3. It is a colorless liquid with a pungent odor.

**Importance in Research:**

**1. Synthetic Chemistry:**

* **Building Block for Fluorinated Compounds:** 1,1,2-trichloro-3,3,3-trifluoro-1-propene is a valuable building block for synthesizing various fluorinated compounds. Fluorine substitution can enhance properties like stability, lipophilicity, and biological activity.
* **New Functional Materials:** The compound can be used to synthesize novel functional materials with potential applications in fields like pharmaceuticals, agrochemicals, and electronics.

**2. Pharmacology and Toxicology:**

* **Anesthetic Properties:** Some fluorinated compounds, including those derived from this molecule, have shown anesthetic properties. Research investigates their potential as safer alternatives to conventional anesthetics.
* **Biological Activity:** The presence of fluorine can alter the biological activity of molecules. Researchers investigate how this compound and its derivatives might interact with biological targets.
* **Toxicity Studies:** Understanding the toxicity of this compound is crucial for safety in research and potential applications.

**3. Atmospheric Chemistry:**

* **Greenhouse Gas Emission:** 1,1,2-trichloro-3,3,3-trifluoro-1-propene is a potent greenhouse gas. Its atmospheric fate and potential impact on climate change are studied.

**4. Environmental Chemistry:**

* **Persistence and Bioaccumulation:** Fluorinated compounds can be persistent in the environment and potentially bioaccumulate in organisms. Research investigates the environmental fate and potential risks of this compound.

**Important Note:**

* The specific applications and importance of 1,1,2-trichloro-3,3,3-trifluoro-1-propene depend on the context of the research being conducted.
* It's crucial to handle this compound with appropriate safety precautions due to its potential toxicity.

This compound is a subject of ongoing research in various fields, and its importance is likely to continue evolving as new applications and insights are discovered.

1,1,2-trichloro-3,3,3-trifluoro-1-propene: nephrotoxic cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID67938
SCHEMBL ID242971
MeSH IDM0167533

Synonyms (32)

Synonym
nsc-6824
1,2-trichloro-3,3,3-trifluoropropene
propene,1,2-trichloro-3,3,3-trifluoro-
1-propene,1,2-trichloro-3,3,3-trifluoro-
1,1-trifluoro-2,3,3-trichloropropene
nsc6824
431-52-7
1,2-trichlorotrifluoro-1-propene
propene, 1,1,2-trichloro-3,3,3-trifluoro-
1-propene, 1,1,2-trichloro-3,3,3-trifluoro-
1,1,2-trichloro-3,3,3-trifluoro-1-propene
einecs 207-075-0
1,1,2-trichloro-3,3,3-trifluoropropene
7-methylhexahydro-2h-benzo[b][1,4]dioxepin-3(4h)-one
1,1,2-trichloro-3,3,3-trifluoroprop-1-ene
h2mq7f3kmq ,
unii-h2mq7f3kmq
nsc 6824
2,3,3-trichloro-1,1,1-trifluoro-2-propene
trifluorotrichloropropene
AKOS006229782
FT-0605982
SCHEMBL242971
1,1,2-trichlorotrifluoro-1-propene
1,1,1-trifluoro-2,3,3-trichloro-2-propene
1,1,2-trichloro-3,3,3-trifluoropropene-1
1,1,2-trichloro-3,3,3-trifluoro-1-propene #
1,1,1-trifluoro-2,3,3-trichloropropene
DTXSID8073184
mfcd00013672
cfc 1213xa
1,1,2-trichlorotrifluoroprop-1-ene

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" A combination of high resolution proton nuclear magnetic resonance (1H NMR) spectroscopy of urine, renal histopathology and more routinely used clinical chemistry methods has been used to explore the acute toxic and biochemical effects of S-(1,2-dichlorovinyl)-L-cysteine (DCVC), S-(1,2-dichlorovinyl)-L-homocysteine (DCVHC) and 1,1,2-trichloro-3,3,3-trifluoro-1-propene (TCTFP) up to 48 h following their administration to male Fischer 344 (F344) rats."( Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the Fischer 344 rat.
Anthony, ML; Beddell, CR; Lindon, JC; Nicholson, JK, 1994
)
0.67
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (3)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]