Page last updated: 2024-08-07 18:32:17
Carbonic anhydrase 6
A carbonic anhydrase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23280]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase VI;
Carbonic anhydrase VI;
CA-VI;
Salivary carbonic anhydrase;
Secreted carbonic anhydrase
Research
Bioassay Publications (77)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (2.60) | 18.7374 |
| 1990's | 2 (2.60) | 18.2507 |
| 2000's | 24 (31.17) | 29.6817 |
| 2010's | 45 (58.44) | 24.3611 |
| 2020's | 4 (5.19) | 2.80 |
Compounds (142)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| protocatechuic acid | Homo sapiens (human) | Ki | 4.7200 | 2 | 2 |
| 4-hydroxybenzoic acid | Homo sapiens (human) | Ki | 252.3562 | 3 | 16 |
| hydrobromic acid | Homo sapiens (human) | Ki | 730.0000 | 1 | 1 |
| cadaverine | Homo sapiens (human) | Ki | 0.7400 | 1 | 1 |
| catechol | Homo sapiens (human) | IC50 | 5.7900 | 1 | 1 |
| catechol | Homo sapiens (human) | Ki | 603.2875 | 6 | 20 |
| hydrochloric acid | Homo sapiens (human) | Ki | 720.0000 | 1 | 1 |
| coumarin | Homo sapiens (human) | Ki | 101.0000 | 2 | 2 |
| salicylic acid | Homo sapiens (human) | Ki | 305.8800 | 3 | 15 |
| gallic acid | Homo sapiens (human) | Ki | 6.1300 | 1 | 1 |
| hydrogen sulfide | Homo sapiens (human) | Ki | 710.0000 | 1 | 1 |
| 4-aminophenol | Homo sapiens (human) | Ki | 480.5429 | 2 | 14 |
| guaiacol | Homo sapiens (human) | Ki | 100.1540 | 1 | 5 |
| cyanic acid | Homo sapiens (human) | Ki | 690.0000 | 1 | 1 |
| carbonic acid | Homo sapiens (human) | Ki | 745.0000 | 1 | 2 |
| hydrogen cyanide | Homo sapiens (human) | Ki | 70.0000 | 1 | 1 |
| thiocyanic acid | Homo sapiens (human) | Ki | 890.0000 | 1 | 1 |
| hydroquinone | Homo sapiens (human) | Ki | 149.7883 | 3 | 18 |
| indole | Homo sapiens (human) | Ki | 3.6300 | 1 | 1 |
| naringenin | Homo sapiens (human) | Ki | 1.1806 | 1 | 5 |
| nitric acid | Homo sapiens (human) | Ki | 760.0000 | 1 | 1 |
| phenol | Homo sapiens (human) | IC50 | 4.6300 | 1 | 1 |
| phenol | Homo sapiens (human) | Ki | 166.9319 | 7 | 21 |
| pyrogallol | Homo sapiens (human) | Ki | 3.1420 | 2 | 5 |
| sulfurous acid | Homo sapiens (human) | Ki | 14,200.0000 | 1 | 1 |
| spermidine | Homo sapiens (human) | Ki | 1.4100 | 1 | 1 |
| spermine | Homo sapiens (human) | Ki | 0.9900 | 1 | 1 |
| sulfuric acid | Homo sapiens (human) | Ki | 9,900.0000 | 1 | 1 |
| thiamine | Homo sapiens (human) | Ki | 0.1757 | 1 | 3 |
| catechin | Homo sapiens (human) | Ki | 4.9100 | 1 | 1 |
| acetaminophen | Homo sapiens (human) | Ki | 197.9615 | 2 | 13 |
| acetazolamide | Homo sapiens (human) | IC50 | 7.4740 | 3 | 5 |
| acetazolamide | Homo sapiens (human) | Ki | 16.1641 | 44 | 98 |
| bumetanide | Homo sapiens (human) | Ki | 18.3242 | 1 | 12 |
| celecoxib | Homo sapiens (human) | Ki | 0.0842 | 4 | 5 |
| chlorthalidone | Homo sapiens (human) | Ki | 1.4875 | 2 | 14 |
| coumaphos | Homo sapiens (human) | Ki | 2.2300 | 1 | 1 |
| dichlorphenamide | Homo sapiens (human) | Ki | 39.0560 | 9 | 23 |
| adtn | Homo sapiens (human) | Ki | 14.2300 | 1 | 3 |
| ethoxzolamide | Homo sapiens (human) | Ki | 12.7338 | 12 | 16 |
| furosemide | Homo sapiens (human) | Ki | 14.5745 | 2 | 14 |
| hydrochlorothiazide | Homo sapiens (human) | Ki | 18.6042 | 1 | 12 |
| hydroflumethiazide | Homo sapiens (human) | Ki | 20.3203 | 1 | 12 |
| indapamide | Homo sapiens (human) | Ki | 18.9732 | 2 | 14 |
| mafenide | Homo sapiens (human) | Ki | 7.9631 | 5 | 8 |
| methazolamide | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| methazolamide | Homo sapiens (human) | Ki | 18.1959 | 9 | 11 |
| metolazone | Homo sapiens (human) | Ki | 22.0639 | 1 | 12 |
| resorcinol | Homo sapiens (human) | Ki | 308.9333 | 3 | 15 |
| resveratrol | Homo sapiens (human) | Ki | 8.6300 | 1 | 1 |
| saccharin | Homo sapiens (human) | Ki | 0.9350 | 2 | 2 |
| sulfadiazine | Homo sapiens (human) | IC50 | 12.7203 | 1 | 3 |
| imatinib | Homo sapiens (human) | Ki | 0.3920 | 1 | 1 |
| sulfanilamide | Homo sapiens (human) | IC50 | 14.9040 | 1 | 3 |
| sulfanilamide | Homo sapiens (human) | Ki | 5.9968 | 7 | 10 |
| sulfapyridine | Homo sapiens (human) | IC50 | 14.7253 | 1 | 3 |
| sulfapyridine | Homo sapiens (human) | Ki | 32.8520 | 1 | 4 |
| sulpiride | Homo sapiens (human) | Ki | 2.0072 | 4 | 6 |
| sulthiame | Homo sapiens (human) | Ki | 35.2577 | 3 | 18 |
| trichlormethiazide | Homo sapiens (human) | Ki | 43.9386 | 2 | 26 |
| trientine | Homo sapiens (human) | Ki | 43.0000 | 1 | 1 |
| zonisamide | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| zonisamide | Homo sapiens (human) | Ki | 88.6655 | 8 | 26 |
| sulfamic acid | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| carbostyril | Homo sapiens (human) | Ki | 0.0330 | 2 | 2 |
| 4-toluenesulfonamide | Homo sapiens (human) | IC50 | 13.9350 | 1 | 3 |
| 4-toluenesulfonamide | Homo sapiens (human) | Ki | 20.2674 | 5 | 8 |
| quinethazone | Homo sapiens (human) | Ki | 18.1300 | 1 | 2 |
| veratrole | Homo sapiens (human) | Ki | 234.7000 | 2 | 2 |
| 4-phenylphenol | Homo sapiens (human) | Ki | 31.0825 | 1 | 4 |
| veratric acid | Homo sapiens (human) | Ki | 24.4200 | 1 | 1 |
| benzenearsonic acid | Homo sapiens (human) | Ki | 0.0139 | 1 | 1 |
| benzenesulfonamide | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| benzenesulfonamide | Homo sapiens (human) | Ki | 12.0365 | 2 | 4 |
| 3-hydroxybenzoic acid | Homo sapiens (human) | Ki | 3.1700 | 1 | 1 |
| anisole | Homo sapiens (human) | Ki | 234.7000 | 1 | 1 |
| diethylenetriamine | Homo sapiens (human) | Ki | 11.5000 | 1 | 1 |
| carzenide | Homo sapiens (human) | Ki | 1.6396 | 4 | 5 |
| catechin | Homo sapiens (human) | Ki | 9.7100 | 1 | 1 |
| syringic acid | Homo sapiens (human) | Ki | 7.5500 | 1 | 1 |
| herniarin | Homo sapiens (human) | Ki | 5.5000 | 1 | 1 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | Ki | 76.3000 | 1 | 1 |
| 2-methylcyclohexanone | Homo sapiens (human) | Ki | 427.1000 | 1 | 1 |
| 4-cyanophenol | Homo sapiens (human) | Ki | 203.4649 | 2 | 14 |
| hydrofluoric acid | Homo sapiens (human) | Ki | 600.0000 | 1 | 1 |
| n-(1-naphthyl)ethylenediamine | Homo sapiens (human) | Ki | 0.6400 | 1 | 1 |
| 1,6-diaminohexane | Homo sapiens (human) | Ki | 0.7200 | 1 | 1 |
| benzolamide | Homo sapiens (human) | Ki | 15.6191 | 5 | 9 |
| nitrous acid | Homo sapiens (human) | Ki | 820.0000 | 1 | 1 |
| hydrazoic acid | Homo sapiens (human) | Ki | 70.0000 | 1 | 1 |
| hydroiodic acid | Homo sapiens (human) | Ki | 810.0000 | 1 | 1 |
| 7-ethoxycoumarin | Homo sapiens (human) | Ki | 82.3000 | 1 | 1 |
| dobutamine | Homo sapiens (human) | Ki | 9.4700 | 1 | 1 |
| 2-amino-5,6-dihydroxytetralin | Homo sapiens (human) | Ki | 15.4833 | 1 | 3 |
| foscarnet sodium | Homo sapiens (human) | Ki | 1,810.0000 | 1 | 1 |
| 4-chlorobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| benzeneboronic acid | Homo sapiens (human) | Ki | 25.0004 | 2 | 2 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Homo sapiens (human) | Ki | 0.6378 | 4 | 5 |
| brinzolamide | Homo sapiens (human) | Ki | 0.0084 | 7 | 8 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Homo sapiens (human) | Ki | 0.9492 | 4 | 5 |
| epicatechin | Homo sapiens (human) | Ki | 4.1660 | 1 | 5 |
| methanesulfonamide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 2-aminobenzenesulfonamide | Homo sapiens (human) | Ki | 2.3786 | 4 | 5 |
| 3,7-diazanonane-1,9-diamine | Homo sapiens (human) | Ki | 53.0000 | 1 | 1 |
| sulfamide | Homo sapiens (human) | Ki | 35.0000 | 2 | 2 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Homo sapiens (human) | Ki | 0.6730 | 5 | 6 |
| valdecoxib | Homo sapiens (human) | Ki | 0.4455 | 3 | 4 |
| estrone-3-o-sulfamate | Homo sapiens (human) | Ki | 1.8600 | 1 | 1 |
| 1-naphthylacetylspermine | Homo sapiens (human) | Ki | 0.1100 | 1 | 1 |
| chlorzolamide | Homo sapiens (human) | Ki | 0.1005 | 3 | 4 |
| 4-(2-aminoethyl)benzenesulfonamide | Homo sapiens (human) | Ki | 0.8070 | 4 | 5 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Homo sapiens (human) | Ki | 0.0520 | 4 | 5 |
| lacosamide | Homo sapiens (human) | Ki | 0.4120 | 1 | 1 |
| bortezomib | Homo sapiens (human) | Ki | 4.3800 | 1 | 1 |
| resveratrol | Homo sapiens (human) | Ki | 8.0700 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | Ki | 8.4500 | 1 | 1 |
| hydroxyphenethylferulate | Homo sapiens (human) | Ki | 0.7700 | 1 | 1 |
| 2-hydroxycinnamic acid | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| trans-4-coumaric acid | Homo sapiens (human) | Ki | 6.7200 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Ki | 0.4610 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | Ki | 7.3300 | 1 | 1 |
| 7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | Homo sapiens (human) | Ki | 6.6000 | 1 | 1 |
| quercetin | Homo sapiens (human) | Ki | 4.9500 | 2 | 2 |
| ellagic acid | Homo sapiens (human) | Ki | 7.0600 | 1 | 1 |
| dorzolamide | Homo sapiens (human) | Ki | 39.4685 | 9 | 21 |
| topiramate | Homo sapiens (human) | Ki | 37.4907 | 9 | 21 |
| irosustat | Homo sapiens (human) | Ki | 54.4738 | 2 | 13 |
| 3-cyano-7-hydroxycoumarin | Homo sapiens (human) | Ki | 48.2209 | 1 | 11 |
| famotidine | Homo sapiens (human) | Ki | 0.0982 | 1 | 1 |
| 6-hydroxybenzothiazide-2-sulfonamide | Homo sapiens (human) | Ki | 0.0932 | 3 | 4 |
| tannins | Homo sapiens (human) | Ki | 17.8000 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
In vitro inhibition of α-carbonic anhydrase isozymes by some phenolic compounds.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 21, Issue:14, 2011
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
α-Carbonic anhydrases are strongly activated by spinaceamine derivatives.Bioorganic & medicinal chemistry, , 03-01, Volume: 27, Issue:5, 2019
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.Journal of medicinal chemistry, , 02-11, Volume: 64, Issue:3, 2021
Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Famotidine, an Antiulcer Agent, Strongly Inhibits ACS medicinal chemistry letters, , Oct-11, Volume: 9, Issue:10, 2018
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.Journal of medicinal chemistry, , Nov-26, Volume: 57, Issue:22, 2014
Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Dec-15, Volume: 22, Issue:24, 2014
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:3, 2012
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:1, 2012
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
In vitro inhibition of α-carbonic anhydrase isozymes by some phenolic compounds.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 21, Issue:14, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI.Chemical biology & drug design, , Volume: 74, Issue:6, 2009
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:4, 2014
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:5, 2012
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.Journal of medicinal chemistry, , Apr-24, Volume: 57, Issue:8, 2014
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:5, 2012
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI.Chemical biology & drug design, , Volume: 74, Issue:6, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis, β-glucuronidase inhibition activity, crystal structure, and POM analyses.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:5, 2012
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:5, 2012
Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| carbonate dehydratase activity | molecular function | Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. [EC:4.2.1.1] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|
| detection of chemical stimulus involved in sensory perception of bitter taste | biological process | The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. [GOC:go_curators] |
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |