Proteins > B1 bradykinin receptor
Page last updated: 2024-08-07 16:41:58

B1 bradykinin receptor

A B1 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46663]

Synonyms

B1R;
BK-1 receptor

Research

Bioassay Publications (5)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Compounds (11)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
diacetylfluoresceinHomo sapiens (human)IC5059.640010
coumarin 153Homo sapiens (human)IC5078.211010
2-butyl-6-(butylamino)-1h-benzo(de)isoquinoline-1,3(2h)-dioneHomo sapiens (human)IC5037.154010
coumarin 7Homo sapiens (human)IC503.241010
kallidin, des-arg(10)-Homo sapiens (human)IC500.000911
kallidin, des-arg(10)-Homo sapiens (human)Ki0.000222
bradykinin, leu(8)-des-arg(9)-Homo sapiens (human)Ki0.382011
bradykininHomo sapiens (human)Ki0.010011
3,7-dichloro-N-[3-(1-imidazolyl)propyl]-6-methoxy-1-benzothiophene-2-carboxamideHomo sapiens (human)IC5059.640010
lissamine rhodamine bHomo sapiens (human)IC5059.640010
eln441958Homo sapiens (human)Ki0.000311
nitd 609Homo sapiens (human)IC5030.000011

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
bradykinin receptor activitymolecular functionCombining with bradykinin to initiate a change in cell activity. [GOC:ai]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
peptide bindingmolecular functionBinding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 12 target(s):

TargetCategoryDefinition
negative regulation of protein phosphorylationbiological processAny process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
positive regulation of leukocyte migrationbiological processAny process that activates or increases the frequency, rate, or extent of leukocyte migration. [GOC:add]
inflammatory responsebiological processThe immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
positive regulation of cytosolic calcium ion concentrationbiological processAny process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
protein kinase C-activating G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). [GOC:mah, GOC:signaling]
response to mechanical stimulusbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:hb]
cell migrationbiological processThe controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
negative regulation of cell growthbiological processAny process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
response to lipopolysaccharidebiological processAny process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]
negative regulation of blood pressurebiological processAny process in which the force of blood traveling through the circulatory system is decreased. [GOC:go_curators, GOC:mtg_cardio]
positive regulation of release of sequestered calcium ion into cytosolbiological processAny process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai]
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]