A receptor-type tyrosine-protein phosphatase C that is encoded in the genome of human. [PRO:CNA, UniProtKB:P08575]
EC 3.1.3.48;
Leukocyte common antigen;
L-CA;
T200
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-hydroxyphenylglyoxylic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 5-iodo-2-(oxaloamino)benzoic acid | Homo sapiens (human) | Ki | 49.0000 | 1 | 1 |
| 9,10-phenanthrenequinone | Homo sapiens (human) | IC50 | 1.3667 | 3 | 3 |
| oleanolic acid | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| 1,2-naphthoquinone | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| cryptotanshinone | Homo sapiens (human) | IC50 | 41.4000 | 1 | 1 |
| 2-(oxaloamino)benzoic acid | Homo sapiens (human) | Ki | 160.0000 | 1 | 1 |
| illudalic acid | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| variabilin | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
This protein enables 9 target(s):
| Target | Category | Definition |
|---|---|---|
| protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
| transmembrane receptor protein tyrosine phosphatase activity | molecular function | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
| signaling receptor binding | molecular function | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| heparin binding | molecular function | Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732] |
| protein kinase binding | molecular function | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl] |
| ankyrin binding | molecular function | Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. [GOC:mah, ISBN:0198506732] |
| spectrin binding | molecular function | Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. [GOC:mah, ISBN:0198506732] |
| heparan sulfate proteoglycan binding | molecular function | Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. [ISBN:0198506732] |
This protein is located in 12 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| focal adhesion | cellular component | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] |
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| cytoplasmic side of plasma membrane | cellular component | The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| secretory granule membrane | cellular component | The lipid bilayer surrounding a secretory granule. [GOC:mah] |
| bleb | cellular component | A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] |
| membrane raft | cellular component | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| membrane microdomain | cellular component | A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. [PMID:20044567, PMID:26253820] |
This protein is involved in 64 target(s):
| Target | Category | Definition |
|---|---|---|
| MAPK cascade | biological process | An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [PMID:20811974, PMID:9561267] |
| natural killer cell differentiation | biological process | The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. [GOC:add, ISBN:0781735149] |
| negative regulation of T cell mediated cytotoxicity | biological process | Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149] |
| positive regulation of T cell mediated cytotoxicity | biological process | Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149] |
| negative regulation of cytokine-mediated signaling pathway | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway. [GOC:hjd] |
| hematopoietic progenitor cell differentiation | biological process | The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] |
| positive regulation of immunoglobulin production | biological process | Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. [GOC:add] |
| positive regulation of humoral immune response mediated by circulating immunoglobulin | biological process | Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. [GOC:add] |
| negative regulation of protein kinase activity | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. [GOC:go_curators] |
| protein dephosphorylation | biological process | The process of removing one or more phosphoric residues from a protein. [GOC:hb] |
| negative regulation of cell adhesion involved in substrate-bound cell migration | biological process | The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction. [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486] |
| leukocyte cell-cell adhesion | biological process | The attachment of a leukocyte to another cell via adhesion molecules. [GOC:go_curators] |
| cell surface receptor signaling pathway | biological process | The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling] |
| response to gamma radiation | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. [GOC:tair_curators] |
| regulation of gene expression | biological process | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018] |
| dephosphorylation | biological process | The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732] |
| B cell differentiation | biological process | The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [GO_REF:0000022, GOC:mah] |
| T cell differentiation | biological process | The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. [GO_REF:0000022, GOC:jid, GOC:mah] |
| positive regulation of B cell proliferation | biological process | Any process that activates or increases the rate or extent of B cell proliferation. [GOC:mah] |
| negative regulation of protein autophosphorylation | biological process | Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. [GOC:mah] |
| regulation of interleukin-8 production | biological process | Any process that modulates the frequency, rate, or extent of interleukin-8 production. [GOC:mah] |
| negative regulation of interleukin-2 production | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. [GOC:mah] |
| positive regulation of interleukin-2 production | biological process | Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. [GOC:mah] |
| positive regulation of tumor necrosis factor production | biological process | Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120] |
| heterotypic cell-cell adhesion | biological process | The attachment of a cell to a cell of a different type via adhesion molecules. [GOC:add] |
| B cell proliferation | biological process | The expansion of a B cell population by cell division. Follows B cell activation. [GOC:jl] |
| positive regulation of T cell proliferation | biological process | Any process that activates or increases the rate or extent of T cell proliferation. [GOC:ai] |
| T cell activation | biological process | The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149] |
| gamma-delta T cell differentiation | biological process | The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex. [CL:0000798, GOC:jl] |
| positive regulation of MAPK cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators] |
| cell cycle phase transition | biological process | The cell cycle process by which a cell commits to entering the next cell cycle phase. [GOC:mtg_cell_cycle] |
| positive thymic T cell selection | biological process | The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death. [ISBN:0781735149, PMID:12414722] |
| negative thymic T cell selection | biological process | The process of elimination of immature T cells in the thymus which react strongly with self-antigens. [ISBN:0781735149, PMID:12414722] |
| positive regulation of gamma-delta T cell differentiation | biological process | Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation. [GOC:go_curators] |
| positive regulation of protein kinase activity | biological process | Any process that activates or increases the frequency, rate or extent of protein kinase activity. [GOC:go_curators] |
| regulation of receptor signaling pathway via JAK-STAT | biological process | Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT. [GOC:bf] |
| alpha-beta T cell proliferation | biological process | The expansion of an alpha-beta T cell population by cell division. [GOC:ai] |
| positive regulation of alpha-beta T cell proliferation | biological process | Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. [GOC:ai] |
| positive regulation of isotype switching to IgG isotypes | biological process | Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes. [GOC:jid] |
| bone marrow development | biological process | The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. [GOC:add, ISBN:0781735149] |
| stem cell development | biological process | The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. [CL:0000034, GOC:isa_complete] |
| positive regulation of peptidyl-tyrosine phosphorylation | biological process | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai] |
| negative regulation of peptidyl-tyrosine phosphorylation | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai] |
| regulation of phagocytosis | biological process | Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. [GOC:ai] |
| positive regulation of phagocytosis | biological process | Any process that activates or increases the frequency, rate or extent of phagocytosis. [GOC:ai] |
| positive regulation of calcium-mediated signaling | biological process | Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. [GOC:ai] |
| T cell receptor signaling pathway | biological process | The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. [GOC:add] |
| B cell receptor signaling pathway | biological process | The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. [GOC:add] |
| regulation of T cell receptor signaling pathway | biological process | Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai] |
| positive regulation of antigen receptor-mediated signaling pathway | biological process | Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. [GOC:ai] |
| release of sequestered calcium ion into cytosol | biological process | The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929] |
| defense response to virus | biological process | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai] |
| regulation of cell cycle | biological process | Any process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb] |
| positive regulation of Fc receptor mediated stimulatory signaling pathway | biological process | Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. [GOC:BHF, GOC:dph, GOC:tb] |
| regulation of protein tyrosine kinase activity | biological process | Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. [GOC:dph, GOC:tb] |
| negative regulation of ERK1 and ERK2 cascade | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986] |
| positive regulation of ERK1 and ERK2 cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah] |
| extrinsic apoptotic signaling pathway | biological process | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] |
| negative regulation of microglial cell activation | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] |
| response to aldosterone | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17644563] |
| DN2 thymocyte differentiation | biological process | The process in which a relatively unspecialized cell acquires the specialized features of a DN2 thymocyte. A DN2 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25-. [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325] |
| positive regulation of hematopoietic stem cell migration | biological process | Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration. [GOC:obol] |
| positive regulation of stem cell proliferation | biological process | Any process that activates or increases the frequency, rate or extent of stem cell proliferation. [GOC:dph] |
| positive regulation of extrinsic apoptotic signaling pathway | biological process | Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis] |