ketamine has been researched along with Necrosis in 18 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To attain endogenic proof of NMDA receptor type expression in the pancreatic cancer cell lines PaTu8988t and Panc-1 and to investigate the impact of ketamine, s-ketamine, and the NMDA receptor antagonist MK 801 on proliferation, apoptosis, and necrosis in pancreatic carcinoma." | 7.81 | Effects of ketamine, s-ketamine, and MK 801 on proliferation, apoptosis, and necrosis in pancreatic cancer cells. ( Bundscherer, A; Gebhardt, K; Graf, B; Gruber, M; Malsy, M; Wiese, C, 2015) |
| " Therefore, we investigated whether the most widely used preservative of ketamine-benzethonium chloride-enhances the toxicity of S(+)-ketamine in vitro in lymphoma, neuroblastoma cells and primary astrocytes." | 7.76 | Benzethonium increases the cytotoxicity of S(+)-ketamine in lymphoma, neuronal, and glial cells. ( Braun, S; Gaza, N; Hermanns, H; Hollmann, MW; Kremer, D; Küry, P; Stevens, MF; Werdehausen, R, 2010) |
| "Ketamine is a dissociative anaesthetic known to be an N-methyl-D-aspartate receptor blocker." | 5.27 | Ketamine fails to protect against ischaemic neuronal necrosis in the rat. ( Auer, RN; Jensen, ML, 1988) |
| " To attain endogenic proof of NMDA receptor type expression in the pancreatic cancer cell lines PaTu8988t and Panc-1 and to investigate the impact of ketamine, s-ketamine, and the NMDA receptor antagonist MK 801 on proliferation, apoptosis, and necrosis in pancreatic carcinoma." | 3.81 | Effects of ketamine, s-ketamine, and MK 801 on proliferation, apoptosis, and necrosis in pancreatic cancer cells. ( Bundscherer, A; Gebhardt, K; Graf, B; Gruber, M; Malsy, M; Wiese, C, 2015) |
| " Therefore, we investigated whether the most widely used preservative of ketamine-benzethonium chloride-enhances the toxicity of S(+)-ketamine in vitro in lymphoma, neuroblastoma cells and primary astrocytes." | 3.76 | Benzethonium increases the cytotoxicity of S(+)-ketamine in lymphoma, neuronal, and glial cells. ( Braun, S; Gaza, N; Hermanns, H; Hollmann, MW; Kremer, D; Küry, P; Stevens, MF; Werdehausen, R, 2010) |
| "Ketamine has been shown to have neurotoxic properties, when administered neuraxially." | 1.36 | Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells. ( Bauer, I; Braun, S; Durieux, ME; Gaza, N; Hermanns, H; Hollmann, MW; Stevens, MF; Werdehausen, R, 2010) |
| "Ketamine-xylazine is a widely accepted anesthetic combination for laboratory animals." | 1.28 | Tissue response to intramuscular and intraperitoneal injections of ketamine and xylazine in rats. ( Hiben, JR; Hrapkiewicz, KL; Smiler, KL; Stein, S, 1990) |
| "Ketamine is a dissociative anaesthetic known to be an N-methyl-D-aspartate receptor blocker." | 1.27 | Ketamine fails to protect against ischaemic neuronal necrosis in the rat. ( Auer, RN; Jensen, ML, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (27.78) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
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| Shao, J | 1 |
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| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
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| Liu, S | 1 |
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| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
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| Campbell, DA | 1 |
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| Wang, Y | 7 |
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1 review available for ketamine and Necrosis
1 trial available for ketamine and Necrosis
17 other studies available for ketamine and Necrosis
| Article | Year |
|---|---|
Neuroprotective effect of ketamine against TNF-α-induced necroptosis in hippocampal neurons.
Topics: Animals; Cell Line; Cell Survival; Hippocampus; Immunohistochemistry; Ketamine; Male; Mice; Mice, In | 2021 |
Vascular fibrinoid necrosis in the urinary bladder of ketamine abusers: A new finding that may provide a clue to the pathogenesis of ketamine-induced vesicopathy.
Topics: Adult; Cystitis; Female; Humans; Ketamine; Necrosis; Substance-Related Disorders; Urinary Bladder; U | 2019 |
Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells.
Topics: Animals; Apoptosis; Astrocytes; Calcium; Cell Division; Cells, Cultured; Cerebral Cortex; Culture Me | 2015 |
Effects of ketamine, s-ketamine, and MK 801 on proliferation, apoptosis, and necrosis in pancreatic cancer cells.
Topics: Adenocarcinoma; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dizocilpine Maleate; Enzyme-Linked | 2015 |
A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2.
Topics: Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Blood Pressure; C | 2016 |
Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells.
Topics: Anesthetics, Dissociative; Apoptosis; Dose-Response Relationship, Drug; Humans; Jurkat Cells; Ketami | 2010 |
Benzethonium increases the cytotoxicity of S(+)-ketamine in lymphoma, neuronal, and glial cells.
Topics: Analgesics; Animals; Apoptosis; Astrocytes; Benzethonium; Chemistry, Pharmaceutical; Dose-Response R | 2010 |
Perifocal and remote blood-brain barrier disruption in cortical photothrombotic ischemic lesion and its modulation by the choice of anesthesia.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics; Animals; Blood-Brain Barrier; Brain Ischemia; Exc | 2012 |
Hepatic effects of ketamine administration for 2 weeks in rats.
Topics: Analgesics; Anesthetics, Dissociative; Animals; Apoptosis; Calcineurin; Calcineurin Inhibitors; Chem | 2014 |
Early surgical excision and grafting of burns including tangential excision.
Topics: Breast; Burns; Child; Hemorrhage; Humans; Ketamine; Necrosis; Ornipressin; Skin; Skin Transplantatio | 1981 |
Necrotising glomerulopathy in cats euthanased with ketamine hydrochloride and sodium pentobarbitone.
Topics: Animals; Cat Diseases; Cats; Ketamine; Kidney Diseases; Kidney Glomerulus; Necrosis; Pentobarbital | 1982 |
Therapeutic time window and dose response of the beneficial effects of ketamine in experimental head injury.
Topics: Analysis of Variance; Animals; Brain; Brain Edema; Brain Injuries; Cerebral Hemorrhage; Dose-Respons | 1994 |
Excitotoxic neurotoxicity in an in vitro brain slice model.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino | 1995 |
Accidental intra-arterial injection of ketamine.
Topics: Accidents; Adult; Female; Foot; Humans; Injections, Intra-Arterial; Ketamine; Medication Errors; Nec | 1976 |
Tissue response to intramuscular and intraperitoneal injections of ketamine and xylazine in rats.
Topics: Animals; Drug Combinations; Injections, Intramuscular; Injections, Intraperitoneal; Ketamine; Necros | 1990 |
Ketamine fails to protect against ischaemic neuronal necrosis in the rat.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Hippocampus; Ketamine; Male; Necrosis; Rats; Rats, | 1988 |
Muscle necrosis in Syrian hamsters resulting from intramuscular injections of ketamine and xylazine.
Topics: Animals; Cricetinae; Drug Combinations; Female; Injections, Intramuscular; Ketamine; Mesocricetus; M | 1987 |