Proteins > HD2 type histone deacetylase HDA106
Page last updated: 2024-08-07 17:21:33
HD2 type histone deacetylase HDA106
[no definition available]
Synonyms
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 10 (90.91) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamide | Zea mays | IC50 | 0.1000 | 2 | 2 |
| suberoyl bis-hydroxamic acid | Zea mays | IC50 | 0.3200 | 1 | 1 |
| vorinostat | Zea mays | IC50 | 0.2227 | 11 | 11 |
| vorinostat | Zea mays | Ki | 0.1318 | 2 | 2 |
| trapoxin a | Zea mays | IC50 | 0.0100 | 2 | 2 |
| trichostatin a | Zea mays | IC50 | 0.0060 | 11 | 11 |
| trichostatin a | Zea mays | Ki | 0.0044 | 2 | 2 |
| tubacin | Zea mays | IC50 | 2.0000 | 1 | 1 |
| hc toxin | Zea mays | IC50 | 0.1100 | 3 | 3 |
| valproate sodium | Zea mays | IC50 | 128.0000 | 2 | 2 |
Histone deacetylase inhibitors.
Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation.
Journal of medicinal chemistry, , Nov-04, Volume: 42, Issue:22, 1999
Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation.
Journal of medicinal chemistry, , Nov-04, Volume: 42, Issue:22, 1999
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.
Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.
Journal of medicinal chemistry, , Oct-05, Volume: 49, Issue:20, 2006
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates.
Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.
Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Histone deacetylase inhibitors.
Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.
Journal of medicinal chemistry, , Nov-06, Volume: 46, Issue:23, 2003
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.
Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.
Journal of medicinal chemistry, , Apr-25, Volume: 45, Issue:9, 2002
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jun-21, Volume: 44, Issue:13, 2001
Journal of medicinal chemistry, , Oct-05, Volume: 49, Issue:20, 2006
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates.
Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.
Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Histone deacetylase inhibitors.
Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.
Journal of medicinal chemistry, , Nov-06, Volume: 46, Issue:23, 2003
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.
Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.
Journal of medicinal chemistry, , Apr-25, Volume: 45, Issue:9, 2002
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jun-21, Volume: 44, Issue:13, 2001
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jun-21, Volume: 44, Issue:13, 2001
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jun-21, Volume: 44, Issue:13, 2001
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.
Journal of medicinal chemistry, , Oct-05, Volume: 49, Issue:20, 2006
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.
Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004
Histone deacetylase inhibitors.
Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.
Journal of medicinal chemistry, , Nov-06, Volume: 46, Issue:23, 2003
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.
Journal of medicinal chemistry, , Apr-25, Volume: 45, Issue:9, 2002
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.
Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jun-21, Volume: 44, Issue:13, 2001
Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation.
Journal of medicinal chemistry, , Nov-04, Volume: 42, Issue:22, 1999
Journal of medicinal chemistry, , Oct-05, Volume: 49, Issue:20, 2006
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.
Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004
Histone deacetylase inhibitors.
Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.
Journal of medicinal chemistry, , Nov-06, Volume: 46, Issue:23, 2003
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.
Journal of medicinal chemistry, , Apr-25, Volume: 45, Issue:9, 2002
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.
Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jun-21, Volume: 44, Issue:13, 2001
Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation.
Journal of medicinal chemistry, , Nov-04, Volume: 42, Issue:22, 1999
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jun-21, Volume: 44, Issue:13, 2001
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jun-21, Volume: 44, Issue:13, 2001
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004