| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Amentia
[description not available] | 0 | 3.01 | 1 | 0 |
Dementia
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. | 0 | 3.01 | 1 | 0 |
Infarct
[description not available] | 0 | 2.41 | 1 | 0 |
Injury, Ischemia-Reperfusion
[description not available] | 0 | 4.74 | 27 | 0 |
Reperfusion Injury
Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA. | 0 | 4.74 | 27 | 0 |
Cardiac Hypertrophy
Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix. | 0 | 2.41 | 1 | 0 |
Cardiomegaly
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES. | 0 | 2.41 | 1 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 6.28 | 31 | 0 |
Weight Gain
Increase in BODY WEIGHT over existing weight. | 0 | 2.6 | 1 | 0 |
Cerebral Ischemia
[description not available] | 0 | 5.22 | 17 | 0 |
Brain Ischemia
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION. | 0 | 5.22 | 17 | 0 |
Innate Inflammatory Response
[description not available] | 0 | 4.1 | 12 | 0 |
Cardiovascular Diseases
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. | 0 | 4.31 | 5 | 0 |
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. | 0 | 4.1 | 12 | 0 |
Mouth Ulcer
[description not available] | 0 | 2.6 | 1 | 0 |
Ulcer
A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue. | 0 | 2.6 | 1 | 0 |
Oral Ulcer
A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842) | 0 | 2.6 | 1 | 0 |
Carcinoma, Non-Small Cell Lung
[description not available] | 0 | 2.6 | 1 | 0 |
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. | 0 | 2.6 | 1 | 0 |
Cancer of Lung
[description not available] | 0 | 3.02 | 4 | 0 |
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy. | 0 | 2.6 | 1 | 0 |
Lung Neoplasms
Tumors or cancer of the LUNG. | 0 | 3.02 | 4 | 0 |
2019 Novel Coronavirus Disease
[description not available] | 0 | 2.6 | 1 | 0 |
Apoplexy
[description not available] | 0 | 5.04 | 8 | 0 |
Anterior Choroidal Artery Infarction
[description not available] | 0 | 3.77 | 3 | 0 |
Acute Disease
Disease having a short and relatively severe course. | 0 | 4.42 | 4 | 0 |
Cerebral Infarction
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction). | 0 | 3.77 | 3 | 0 |
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810) | 0 | 10.04 | 8 | 0 |
Atherogenesis
[description not available] | 0 | 3.17 | 4 | 0 |
Alloxan Diabetes
[description not available] | 0 | 3.7 | 9 | 0 |
Diabetes Mellitus, Adult-Onset
[description not available] | 0 | 3.56 | 7 | 0 |
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. | 0 | 3.56 | 7 | 0 |
Atherosclerosis
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA. | 0 | 3.17 | 4 | 0 |
Injury, Myocardial Reperfusion
[description not available] | 0 | 3.9 | 4 | 0 |
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 3.78 | 10 | 0 |
Acute Ischemic Stroke
[description not available] | 0 | 8.04 | 3 | 0 |
Ischemic Stroke
Stroke due to BRAIN ISCHEMIA resulting in interruption or reduction of blood flow to a part of the brain. When obstruction is due to a BLOOD CLOT formed within in a cerebral blood vessel it is a thrombotic stroke. When obstruction is formed elsewhere and moved to block a cerebral blood vessel (see CEREBRAL EMBOLISM) it is referred to as embolic stroke. Wake-up stroke refers to ischemic stroke occurring during sleep while cryptogenic stroke refers to ischemic stroke of unknown origin. | 0 | 3.04 | 3 | 0 |
Cognitive Decline
[description not available] | 0 | 2.63 | 2 | 0 |
Cognition Disorders
Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment. | 0 | 2.54 | 2 | 0 |
Cognitive Dysfunction
Diminished or impaired mental and/or intellectual function. | 0 | 2.63 | 2 | 0 |
Cardiovascular Stroke
[description not available] | 0 | 4.81 | 11 | 0 |
Myocardial Infarction
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). | 0 | 4.81 | 11 | 0 |
Adenocarcinoma, Basal Cell
[description not available] | 0 | 2.15 | 1 | 0 |
Adenocarcinoma
A malignant epithelial tumor with a glandular organization. | 0 | 2.15 | 1 | 0 |
Anterior Cerebral Circulation Infarction
[description not available] | 0 | 2.15 | 1 | 0 |
Blood Diseases
[description not available] | 0 | 2.15 | 1 | 0 |
Hematologic Diseases
Disorders of the blood and blood forming tissues. | 0 | 2.15 | 1 | 0 |
Brain Infarction
Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis. | 0 | 2.15 | 1 | 0 |
Acute Kidney Failure
[description not available] | 0 | 3.16 | 4 | 0 |
Acute Kidney Injury
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions. | 0 | 3.16 | 4 | 0 |
Acute Confusional Senile Dementia
[description not available] | 0 | 4.38 | 4 | 0 |
Acute Onset Vascular Dementia
[description not available] | 0 | 3.09 | 1 | 0 |
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) | 0 | 4.38 | 4 | 0 |
Dementia, Vascular
An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44) | 0 | 3.09 | 1 | 0 |
Brain Hemorrhage
[description not available] | 0 | 2.17 | 1 | 0 |
Brain Swelling
[description not available] | 0 | 2.17 | 1 | 0 |
Carotid Artery Thrombosis
Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX. | 0 | 2.17 | 1 | 0 |
Brain Edema
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6) | 0 | 2.17 | 1 | 0 |
Intracranial Hemorrhages
Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces. | 0 | 2.17 | 1 | 0 |
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). | 0 | 2.17 | 1 | 0 |
Glial Cell Tumors
[description not available] | 0 | 2.69 | 2 | 0 |
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) | 0 | 7.69 | 2 | 0 |
Chronic Kidney Diseases
[description not available] | 0 | 2.94 | 3 | 0 |
Uremia
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms. | 0 | 2.21 | 1 | 0 |
Renal Insufficiency, Chronic
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002) | 0 | 2.94 | 3 | 0 |
Degenerative Disc Disease
[description not available] | 0 | 2.25 | 1 | 0 |
Intervertebral Disc Degeneration
Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates. | 0 | 2.25 | 1 | 0 |
Coronary Artery Stenosis
[description not available] | 0 | 2.08 | 1 | 0 |
Angiogenesis, Pathologic
[description not available] | 0 | 2.53 | 2 | 0 |
Coronary Stenosis
Narrowing or constriction of a coronary artery. | 0 | 2.08 | 1 | 0 |
Injuries, Spinal Cord
[description not available] | 0 | 2.8 | 3 | 0 |
Spinal Cord Injuries
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.). | 0 | 2.8 | 3 | 0 |
Cerebral Infarction, Middle Cerebral Artery
[description not available] | 0 | 3.63 | 8 | 0 |
Dyskinesia Syndromes
[description not available] | 0 | 2.1 | 1 | 0 |
Movement Disorders
Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions. | 0 | 2.1 | 1 | 0 |
Infarction, Middle Cerebral Artery
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction. | 0 | 3.63 | 8 | 0 |
Disease Exacerbation
[description not available] | 0 | 2.52 | 2 | 0 |
Cirrhosis, Liver
[description not available] | 0 | 4.06 | 5 | 0 |
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. | 0 | 4.06 | 5 | 0 |
Encephalopathy, Toxic
[description not available] | 0 | 2.11 | 1 | 0 |
Acute Brain Injuries
[description not available] | 0 | 2.11 | 1 | 0 |
Carbon Monoxide Poisoning
Toxic asphyxiation due to the displacement of oxygen from oxyhemoglobin by carbon monoxide. | 0 | 2.11 | 1 | 0 |
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. | 0 | 2.11 | 1 | 0 |
Hepatocellular Carcinoma
[description not available] | 0 | 2.11 | 1 | 0 |
Cancer of Liver
[description not available] | 0 | 2.45 | 2 | 0 |
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested. | 0 | 2.11 | 1 | 0 |
Liver Neoplasms
Tumors or cancer of the LIVER. | 0 | 2.45 | 2 | 0 |
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways. | 0 | 3.03 | 1 | 0 |
Chronic Illness
[description not available] | 0 | 2.89 | 3 | 0 |
Depression, Endogenous
[description not available] | 0 | 2.13 | 1 | 0 |
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 2.89 | 3 | 0 |
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent. | 0 | 2.13 | 1 | 0 |
Carotid Arteriopathies, Traumatic
[description not available] | 0 | 2.13 | 1 | 0 |
Hyperplasia
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells. | 0 | 2.13 | 1 | 0 |
Fatty Liver, Nonalcoholic
[description not available] | 0 | 2.13 | 1 | 0 |
Non-alcoholic Fatty Liver Disease
Fatty liver finding without excessive ALCOHOL CONSUMPTION. | 0 | 2.13 | 1 | 0 |
Diabetic Angiopathies
VASCULAR DISEASES that are associated with DIABETES MELLITUS. | 0 | 2.13 | 1 | 0 |
Diabetic Glomerulosclerosis
[description not available] | 0 | 2.54 | 2 | 0 |
Diabetic Nephropathies
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE. | 0 | 2.54 | 2 | 0 |
Dehydration
The condition that results from excessive loss of water from a living organism. | 0 | 2.15 | 1 | 0 |
Coronary Heart Disease
[description not available] | 0 | 2.59 | 2 | 0 |
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. | 0 | 2.59 | 2 | 0 |
Complications of Diabetes Mellitus
[description not available] | 0 | 2.15 | 1 | 0 |
Heart Disease, Ischemic
[description not available] | 0 | 3.01 | 4 | 0 |
Myocardial Ischemia
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). | 0 | 3.01 | 4 | 0 |
Benign Neoplasms, Brain
[description not available] | 0 | 2.72 | 2 | 0 |
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. | 0 | 2.72 | 2 | 0 |
Blood Pressure, High
[description not available] | 0 | 2.57 | 2 | 0 |
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. | 0 | 2.57 | 2 | 0 |
Cardiac Toxicity
[description not available] | 0 | 2.98 | 3 | 0 |
Cardiotoxicity
Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION. | 0 | 2.98 | 3 | 0 |
Lung Injury, Acute
[description not available] | 0 | 2.41 | 1 | 0 |
Acute Lung Injury
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological). | 0 | 7.41 | 1 | 0 |
Cirrhosis
[description not available] | 0 | 3.22 | 3 | 0 |
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury. | 0 | 3.22 | 3 | 0 |
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues. | 0 | 2.59 | 2 | 0 |
Coagulation, Disseminated Intravascular
[description not available] | 0 | 2.41 | 1 | 0 |
Disseminated Intravascular Coagulation
A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS. | 0 | 7.41 | 1 | 0 |
Breast Cancer
[description not available] | 0 | 7.9 | 3 | 0 |
Breast Neoplasms
Tumors or cancer of the human BREAST. | 0 | 2.9 | 3 | 0 |
Diabetes Mellitus
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE. | 1 | 4.6 | 1 | 0 |
Diabetic Cardiomyopathies
Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance. | 0 | 2.6 | 1 | 0 |
Cardiac Failure
[description not available] | 0 | 3.01 | 2 | 0 |
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. | 0 | 8.01 | 2 | 0 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 3.01 | 4 | 0 |
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms. | 0 | 2.21 | 1 | 0 |
Experimental Lung Inflammation
Inflammation of any part, segment or lobe, of the lung parenchyma. | 0 | 2.25 | 1 | 0 |
Infections, Staphylococcal
[description not available] | 0 | 2.25 | 1 | 0 |
Pneumonia
Infection of the lung often accompanied by inflammation. | 0 | 7.25 | 1 | 0 |
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS. | 0 | 2.25 | 1 | 0 |
Cancer of Nasopharynx
[description not available] | 0 | 2.25 | 1 | 0 |
Invasiveness, Neoplasm
[description not available] | 0 | 2.86 | 3 | 0 |
Nasopharyngeal Neoplasms
Tumors or cancer of the NASOPHARYNX. | 0 | 2.25 | 1 | 0 |
Asymmetric Diabetic Proximal Motor Neuropathy
[description not available] | 0 | 2.53 | 2 | 0 |
Peripheral Nerve Diseases
[description not available] | 0 | 2.25 | 1 | 0 |
Diabetic Neuropathies
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325) | 1 | 4.53 | 2 | 0 |
Peripheral Nervous System Diseases
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves. | 0 | 2.25 | 1 | 0 |
Arthritis, Degenerative
[description not available] | 0 | 2.25 | 1 | 0 |
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans. | 0 | 2.25 | 1 | 0 |
Acute Liver Injury, Drug-Induced
[description not available] | 0 | 3.31 | 6 | 0 |
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | 0 | 3.31 | 6 | 0 |
Diffuse Large B-Cell Lymphoma
[description not available] | 0 | 7.31 | 1 | 0 |
Lymphoma, Large B-Cell, Diffuse
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. | 0 | 2.31 | 1 | 0 |
Brain Hemorrhage, Cerebral
[description not available] | 0 | 2.31 | 1 | 0 |
Cerebral Hemorrhage
Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA. | 0 | 2.31 | 1 | 0 |
Encephalopathy, Traumatic
[description not available] | 0 | 2.31 | 1 | 0 |
Brain Injuries, Traumatic
A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain. | 0 | 2.31 | 1 | 0 |
Plasma Cell Tumor
[description not available] | 0 | 2.31 | 1 | 0 |
Plasmacytoma
Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. | 0 | 7.31 | 1 | 0 |
Nephrotic Syndrome
A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction. | 0 | 7.31 | 1 | 0 |
Choroid Neovascularization
[description not available] | 0 | 2.61 | 2 | 0 |
Hyperlipemia
[description not available] | 0 | 2.51 | 2 | 0 |
Hyperlipidemias
Conditions with excess LIPIDS in the blood. | 0 | 2.51 | 2 | 0 |
Age-Related Macular Degeneration
[description not available] | 0 | 7.82 | 3 | 0 |
Macular Degeneration
Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms. | 0 | 7.82 | 3 | 0 |
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply. | 0 | 2.97 | 4 | 0 |
Anoxemia
[description not available] | 0 | 2.8 | 3 | 0 |
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms. | 0 | 2.8 | 3 | 0 |
Pulmonary Arterial Remodeling
[description not available] | 0 | 2.83 | 3 | 0 |
Pulmonary Hypertension
[description not available] | 0 | 2.54 | 2 | 0 |
Hypertension, Pulmonary
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. | 0 | 2.54 | 2 | 0 |
Acute Myelogenous Leukemia
[description not available] | 0 | 2.17 | 1 | 0 |
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES. | 0 | 2.17 | 1 | 0 |
Carcinoma, Epidermoid
[description not available] | 0 | 2.17 | 1 | 0 |
Cancer of Mouth
[description not available] | 0 | 2.17 | 1 | 0 |
Metastase
[description not available] | 0 | 2.17 | 1 | 0 |
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) | 0 | 2.17 | 1 | 0 |
Mouth Neoplasms
Tumors or cancer of the MOUTH. | 0 | 2.17 | 1 | 0 |
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. | 0 | 2.17 | 1 | 0 |
Alcoholic Liver Diseases
[description not available] | 0 | 2.17 | 1 | 0 |
Liver Diseases, Alcoholic
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS. | 0 | 2.17 | 1 | 0 |
Bone Fractures
[description not available] | 0 | 2.17 | 1 | 0 |
Fractures, Bone
Breaks in bones. | 0 | 2.17 | 1 | 0 |
Allergic Reaction
[description not available] | 0 | 2.21 | 1 | 0 |
Hypersensitivity
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen. | 0 | 2.21 | 1 | 0 |
Cancer of Colon
[description not available] | 0 | 2.21 | 1 | 0 |
Colonic Neoplasms
Tumors or cancer of the COLON. | 0 | 2.21 | 1 | 0 |
Acute Promyelocytic Leukemia
[description not available] | 0 | 2.21 | 1 | 0 |
Leukemia, Promyelocytic, Acute
An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION. | 0 | 2.21 | 1 | 0 |
Chronic Kidney Failure
[description not available] | 0 | 2.21 | 1 | 0 |
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. | 0 | 2.21 | 1 | 0 |
Proteinuria
The presence of proteins in the urine, an indicator of KIDNEY DISEASES. | 0 | 2.55 | 2 | 0 |
Amyloid Deposits
[description not available] | 0 | 2.08 | 1 | 0 |
Hepatitis
INFLAMMATION of the LIVER. | 0 | 2.08 | 1 | 0 |
Aneurysm, Aortic
[description not available] | 0 | 2.1 | 1 | 0 |
Aortic Aneurysm
An abnormal balloon- or sac-like dilatation in the wall of AORTA. | 0 | 7.1 | 1 | 0 |
Alveolitis, Fibrosing
[description not available] | 0 | 2.1 | 1 | 0 |
Pulmonary Fibrosis
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. | 0 | 7.1 | 1 | 0 |
Oral Submucous Fibrosis
Irreversible FIBROSIS of the submucosal tissue of the MOUTH. | 0 | 7.11 | 1 | 0 |
Ureteral Obstruction
Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy. | 0 | 7.11 | 1 | 0 |
Blood Poisoning
[description not available] | 0 | 2.11 | 1 | 0 |
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK. | 0 | 2.11 | 1 | 0 |
Benign Neoplasms
[description not available] | 0 | 2.13 | 1 | 0 |
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. | 0 | 2.13 | 1 | 0 |
Cardiac Remodeling, Ventricular
[description not available] | 0 | 2.05 | 1 | 0 |
Blood Clot
[description not available] | 0 | 2.46 | 2 | 0 |
Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel. | 0 | 7.46 | 2 | 0 |
Brain Inflammation
[description not available] | 0 | 2.05 | 1 | 0 |
Encephalitis
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition. | 0 | 2.05 | 1 | 0 |
Amnesia, Anterograde
Loss of the ability to form new memories beyond a certain point in time. This condition may be organic or psychogenic in origin. Organically induced anterograde amnesia may follow CRANIOCEREBRAL TRAUMA; SEIZURES; ANOXIA; and other conditions which adversely affect neural structures associated with memory formation (e.g., the HIPPOCAMPUS; FORNIX (BRAIN); MAMMILLARY BODIES; and ANTERIOR THALAMIC NUCLEI). (From Memory 1997 Jan-Mar;5(1-2):49-71) | 0 | 2.06 | 1 | 0 |
Diabetic Feet
[description not available] | 0 | 2.06 | 1 | 0 |
Active Hyperemia
[description not available] | 0 | 2.06 | 1 | 0 |
Ache
[description not available] | 0 | 2.06 | 1 | 0 |
Hyperemia
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous). | 0 | 2.06 | 1 | 0 |
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. | 0 | 2.06 | 1 | 0 |
Diabetic Foot
Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION. | 0 | 2.06 | 1 | 0 |
Cirrhoses, Experimental Liver
[description not available] | 0 | 2.71 | 3 | 0 |
Left Ventricular Dysfunction
[description not available] | 0 | 2.06 | 1 | 0 |
Ventricular Dysfunction, Left
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall. | 0 | 2.06 | 1 | 0 |
Ischemia
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION. | 0 | 2.07 | 1 | 0 |
Sarcoma, Epithelioid
[description not available] | 0 | 2.01 | 1 | 0 |
Sarcoma
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant. | 0 | 2.01 | 1 | 0 |
Idiopathic Parkinson Disease
[description not available] | 0 | 2.91 | 1 | 0 |
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) | 0 | 2.91 | 1 | 0 |
Sarcoma 180
An experimental sarcoma of mice. | 0 | 2.02 | 1 | 0 |
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) | 0 | 2.02 | 1 | 0 |
Chronic Lung Injury
[description not available] | 0 | 2.03 | 1 | 0 |
Acute Respiratory Distress Syndrome
[description not available] | 0 | 2.03 | 1 | 0 |
Respiratory Distress Syndrome
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA. | 0 | 2.03 | 1 | 0 |
Liver Dysfunction
[description not available] | 0 | 2.44 | 2 | 0 |
Liver Diseases
Pathological processes of the LIVER. | 0 | 2.44 | 2 | 0 |
Adhesions, Tissue
[description not available] | 0 | 2.03 | 1 | 0 |
Complication, Postoperative
[description not available] | 0 | 2.03 | 1 | 0 |
Intestinal Diseases
Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM. | 0 | 2.03 | 1 | 0 |
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. | 0 | 2.03 | 1 | 0 |
Cardiac Diseases
[description not available] | 0 | 2.04 | 1 | 0 |
Heart Diseases
Pathological conditions involving the HEART including its structural and functional abnormalities. | 0 | 2.04 | 1 | 0 |
Age-Related Memory Disorders
[description not available] | 0 | 2.39 | 2 | 0 |
Memory Disorders
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions. | 0 | 2.39 | 2 | 0 |
Cataract, Membranous
[description not available] | 0 | 1.98 | 1 | 0 |
Cataract
Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed) | 0 | 6.98 | 1 | 0 |
Ventricular Fibrillation
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST. | 0 | 1.98 | 1 | 0 |
Carbon Tetrachloride Poisoning
Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE. | 0 | 1.99 | 1 | 0 |
Leukemia L 1210
[description not available] | 0 | 1.98 | 1 | 0 |
Experimental Neoplasms
[description not available] | 0 | 1.98 | 1 | 0 |
Gastric Ulcer
[description not available] | 0 | 1.97 | 1 | 0 |
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS). | 0 | 1.97 | 1 | 0 |