NAD-dependent protein deacetylase sirtuin-3, mitochondrial

An NAD-dependent protein deacetylase sirtuin-3, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NTG7]

Synonyms

hSIRT3;
EC 2.3.1.286;
Regulatory protein SIR2 homolog 3;
SIR2-like protein 3

Research

Bioassay Publications (24)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (16.67)	29.6817
2010's	15 (62.50)	24.3611
2020's	5 (20.83)	2.80

Compounds (17)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
niacinamide	Homo sapiens (human)	IC50	78.4571	7	7
ro 31-8220	Homo sapiens (human)	IC50	3.7000	1	1
4-methylnicotinamide	Homo sapiens (human)	IC50	23.0000	1	1
3-(1-azepanylsulfonyl)-n-(3-bromphenyl)benzamide	Homo sapiens (human)	IC50	50.0000	1	1
cambinol	Homo sapiens (human)	IC50	170.9667	3	3
(4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone	Homo sapiens (human)	IC50	50.0000	1	1
ex 527	Homo sapiens (human)	IC50	55.6571	7	7
panobinostat	Homo sapiens (human)	IC50	20.0000	1	1
panobinostat	Homo sapiens (human)	Ki	10.0000	1	1
quisinostat	Homo sapiens (human)	Ki	10.0000	1	1
srt1720	Homo sapiens (human)	IC50	0.8500	1	1
tenovin-6	Homo sapiens (human)	IC50	58.4500	3	3
n-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide	Homo sapiens (human)	IC50	16.7000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
amiodarone	Homo sapiens (human)	EC50	3.2500	1	1
honokiol	Homo sapiens (human)	EC50	0.1700	1	1
honokiol	Homo sapiens (human)	Kd	1.3150	4	4
resveratrol	Homo sapiens (human)	EC50	177.5950	2	2
srt1460	Homo sapiens (human)	EC50	300.0000	1	1
srt1720	Homo sapiens (human)	EC50	300.0000	1	1
srt2183	Homo sapiens (human)	EC50	300.0000	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
NAD-dependent protein lysine deacetylase activity	molecular function	Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. [GOC:BHF, GOC:mah, RHEA:43636]
sequence-specific DNA binding	molecular function	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. [GOC:jl]
NAD+ binding	molecular function	Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]
NAD-dependent histone deacetylase activity	molecular function	Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone. [PMID:28450737]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 10 target(s):

Target	Category	Definition
chromatin remodeling	biological process	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
protein deacetylation	biological process	The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]
aerobic respiration	biological process	The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. [GOC:das, GOC:jl, ISBN:0140513590]
positive regulation of insulin secretion	biological process	Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]
peptidyl-lysine deacetylation	biological process	The removal of an acetyl group from an acetylated lysine residue in a peptide or protein. [GOC:BHF, GOC:mah]
negative regulation of ERK1 and ERK2 cascade	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986]
positive regulation of superoxide dismutase activity	biological process	Any process that activates or increases the frequency, rate or extent of superoxide dismutase activity. [GOC:TermGenie]
positive regulation of catalase activity	biological process	Any process that activates or increases the frequency, rate or extent of catalase activity. [GOC:TermGenie, PMID:24285797]
positive regulation of ceramide biosynthetic process	biological process	Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process. [GOC:dph]
negative regulation of reactive oxygen species metabolic process	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]

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