Page last updated: 2024-08-07 18:50:51
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
An NAD-dependent protein deacetylase sirtuin-3, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NTG7]
Synonyms
hSIRT3;
EC 2.3.1.286;
Regulatory protein SIR2 homolog 3;
SIR2-like protein 3
Research
Bioassay Publications (24)
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (16.67) | 29.6817 |
2010's | 15 (62.50) | 24.3611 |
2020's | 5 (20.83) | 2.80 |
Compounds (17)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
niacinamide | Homo sapiens (human) | IC50 | 78.4571 | 7 | 7 |
ro 31-8220 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
4-methylnicotinamide | Homo sapiens (human) | IC50 | 23.0000 | 1 | 1 |
3-(1-azepanylsulfonyl)-n-(3-bromphenyl)benzamide | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
cambinol | Homo sapiens (human) | IC50 | 170.9667 | 3 | 3 |
(4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
ex 527 | Homo sapiens (human) | IC50 | 55.6571 | 7 | 7 |
panobinostat | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
panobinostat | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
quisinostat | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
srt1720 | Homo sapiens (human) | IC50 | 0.8500 | 1 | 1 |
tenovin-6 | Homo sapiens (human) | IC50 | 58.4500 | 3 | 3 |
n-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide | Homo sapiens (human) | IC50 | 16.7000 | 1 | 1 |
Drugs with Activation Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
amiodarone | Homo sapiens (human) | EC50 | 3.2500 | 1 | 1 |
honokiol | Homo sapiens (human) | EC50 | 0.1700 | 1 | 1 |
honokiol | Homo sapiens (human) | Kd | 1.3150 | 4 | 4 |
resveratrol | Homo sapiens (human) | EC50 | 177.5950 | 2 | 2 |
srt1460 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
srt1720 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
srt2183 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
Enables
This protein enables 7 target(s):
Target | Category | Definition |
---|---|---|
protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
enzyme binding | molecular function | Binding to an enzyme, a protein with catalytic activity. [GOC:jl] |
NAD-dependent protein lysine deacetylase activity | molecular function | Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. [GOC:BHF, GOC:mah, RHEA:43636] |
sequence-specific DNA binding | molecular function | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. [GOC:jl] |
NAD+ binding | molecular function | Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah] |
NAD-dependent histone deacetylase activity | molecular function | Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone. [PMID:28450737] |
Located In
This protein is located in 3 target(s):
Target | Category | Definition |
---|---|---|
nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
Active In
This protein is active in 1 target(s):
Target | Category | Definition |
---|---|---|
nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
Part Of
This protein is part of 1 target(s):
Target | Category | Definition |
---|---|---|
protein-containing complex | cellular component | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] |
Involved In
This protein is involved in 10 target(s):
Target | Category | Definition |
---|---|---|
chromatin remodeling | biological process | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] |
protein deacetylation | biological process | The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai] |
aerobic respiration | biological process | The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. [GOC:das, GOC:jl, ISBN:0140513590] |
positive regulation of insulin secretion | biological process | Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah] |
peptidyl-lysine deacetylation | biological process | The removal of an acetyl group from an acetylated lysine residue in a peptide or protein. [GOC:BHF, GOC:mah] |
negative regulation of ERK1 and ERK2 cascade | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986] |
positive regulation of superoxide dismutase activity | biological process | Any process that activates or increases the frequency, rate or extent of superoxide dismutase activity. [GOC:TermGenie] |
positive regulation of catalase activity | biological process | Any process that activates or increases the frequency, rate or extent of catalase activity. [GOC:TermGenie, PMID:24285797] |
positive regulation of ceramide biosynthetic process | biological process | Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process. [GOC:dph] |
negative regulation of reactive oxygen species metabolic process | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah] |