A thiosulfate sulfurtransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16762]
EC 2.8.1.1;
Rhodanese
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-nonylphenol | Homo sapiens (human) | IC50 | 72.0000 | 1 | 1 |
| albuterol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| aurintricarboxylic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| benzbromarone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| bithionol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| candesartan | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| dichlorophen | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| ethacrynic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| harmalol | Homo sapiens (human) | IC50 | 9.7000 | 1 | 1 |
| hexachlorophene | Homo sapiens (human) | IC50 | 51.0000 | 1 | 1 |
| beta-lapachone | Homo sapiens (human) | IC50 | 0.1200 | 1 | 1 |
| vitamin k 3 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| mesalamine | Homo sapiens (human) | IC50 | 0.2800 | 1 | 1 |
| primaquine | Homo sapiens (human) | IC50 | 2.9000 | 1 | 1 |
| protoporphyrin ix | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cetrimonium bromide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| ampicillin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| purpurin | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| salicylanilide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| benzanilide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| benzethonium chloride | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| evans blue | Homo sapiens (human) | IC50 | 8.7000 | 1 | 1 |
| lithocholic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| plumbagin | Homo sapiens (human) | IC50 | 0.0600 | 1 | 1 |
| gentian violet | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| erythromycin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| agaric acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| ethidium bromide | Homo sapiens (human) | IC50 | 0.8300 | 1 | 1 |
| vancomycin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cetylpyridinium chloride | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| rafoxanide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| paclitaxel | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| closantel | Homo sapiens (human) | IC50 | 100.0000 | 2 | 2 |
| adapalene | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| epigallocatechin gallate | Homo sapiens (human) | IC50 | 7.3000 | 1 | 1 |
| sb 204070a | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| gossypol acetic acid | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| tretinoin | Homo sapiens (human) | IC50 | 91.0000 | 1 | 1 |
| arachidonic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| riboflavin | Homo sapiens (human) | IC50 | 8.8000 | 1 | 1 |
| 4'-methoxychalcone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| curcumin | Homo sapiens (human) | IC50 | 56.0000 | 1 | 1 |
| gossypetin | Homo sapiens (human) | IC50 | 0.3300 | 1 | 1 |
| vitamin d 2 | Homo sapiens (human) | IC50 | 94.0000 | 1 | 1 |
| cholecalciferol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| morin | Homo sapiens (human) | IC50 | 57.0000 | 1 | 1 |
| 4-hydroxychalcone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4'-hydroxychalcone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| phenoxybenzamine hydrochloride | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| nalbuphine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 22,23-dihydroavermectin b(1)a | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| avermectin b(1)a | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| erythrosine | Homo sapiens (human) | IC50 | 9.2000 | 1 | 1 |
| tannins | Homo sapiens (human) | IC50 | 39.0000 | 1 | 1 |
| ly-146032 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 6-o-palmitoylascorbic acid | Homo sapiens (human) | IC50 | 53.0000 | 1 | 1 |
| rifampin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| hematein | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| thiosulfate sulfurtransferase activity | molecular function | Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate. [EC:2.8.1.1, RHEA:16881] |
| 5S rRNA binding | molecular function | Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. [GOC:jl, ISBN:0321000382] |
| 3-mercaptopyruvate sulfurtransferase activity | molecular function | Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. [EC:2.8.1.2] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| sulfur amino acid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. [GOC:ai] |
| cyanate catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid. [ISBN:0198506732] |
| epithelial cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751] |
| rRNA import into mitochondrion | biological process | The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol into the mitochondrial matrix. [GOC:ans, PMID:20691904] |
| rRNA transport | biological process | The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |